Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24198 (3-aminopropylphosphinic derivative, (R)-8 | [(2R)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 4.30 | -47.3 | n/a | n/a | 14 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24195 (3-aminopropylphosphinic derivative, (R)-7 | AZD335...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 5.10 | -46.9 | n/a | n/a | 8.64 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24193 ((3-amino-2-fluoropropyl)phosphinic acid | 3-aminop...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 10 | -45.2 | n/a | n/a | 15 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24196 ((3-amino-2-fluoropropyl)(methyl)phosphinic acid | ...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 14 | -44.4 | n/a | n/a | 23 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24184 ((3-aminopropyl)phosphinic acid | 3-aminopropylphos...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 15 | -44.2 | n/a | n/a | 19 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24185 ((3-aminopropyl)(methyl)phosphinic acid | 3-Apmpa |...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 33 | -42.3 | n/a | n/a | 41 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24191 ((3-amino-2-oxopropyl)phosphinic acid | (3-amino-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 48 | -41.4 | n/a | n/a | 81 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 50 | -41.3 | n/a | n/a | 130 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24194 (3-aminopropylphosphinic derivative, (S)-7 | [(2S)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 70 | -40.4 | n/a | n/a | 250 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 94 | -39.7 | n/a | n/a | 220 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 | 3-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 180 | -38.1 | n/a | n/a | 150 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24192 ((3-amino-2-oxopropyl)(methyl)phosphinic acid | (3-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 200 | -37.9 | n/a | n/a | 270 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24182 (4-amino-3-(4-chlorophenyl)butanoic acid | Baclofen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | 220 | -37.6 | n/a | n/a | 750 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24197 (3-aminopropylphosphinic derivative, (S)-8 | [(2S)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 480 | -35.7 | n/a | n/a | 1.70E+3 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24189 (3-aminopropylphosphinic derivative, (R)-4 | 3-amin...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 840 | -34.3 | n/a | n/a | 600 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Gamma-aminobutyric acid (GABA) B receptor 1/type B receptor subunit 2 [41-940] (Rattus norvegicus (rat)) | BDBM24186 ((3-amino-2-hydroxypropyl)phosphinic acid | 3-amino...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 2.10E+3 | -32.1 | n/a | n/a | 1.10E+3 | n/a | n/a | 7.4 | 22 |
AstraZeneca | Assay Description Inhibition of [3H]GABA binding at GABAB receptor sites in rat brain synaptic membranes by test compounds was measured using a filtration binding assa... | J Med Chem 51: 4315-20 (2008) Article DOI: 10.1021/jm701425k BindingDB Entry DOI: 10.7270/Q2M32T2T | |||||||||||
More data for this Ligand-Target Pair |