Affinity Data by PubMed id=19260677

PubMed code 19260677

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21337 (6-Azido-uridine 5-O-Monophosphate \| C6-Uridine Der...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid PDB UniChem Similars	PDB Article PubMed	200	-42.1	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Uridine 5'-monophosphate synthase (Homo sapiens (Human))	BDBM27946 (uridine derivative, 43 \| {[(2R,3S,4R,5R)-5-(6-ethy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	350	-38.3	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM27944 (uridine derivative, 41 \| {[(2R,3S,4R,5R)-5-(6-azid...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	360	-40.5	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21338 (6-Amino-uridine 5-O-Monophosphate \| C6-Uridine Der...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	840	-38.2	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM27945 (uridine derivative, 42 \| {[(2R,3S,4R,5R)-5-(6-amin...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1.14E+4	-31.1	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Uridine 5'-monophosphate synthase (Homo sapiens (Human))	BDBM27945 (uridine derivative, 42 \| {[(2R,3S,4R,5R)-5-(6-amin...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	1.66E+4	-28.4	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM27946 (uridine derivative, 43 \| {[(2R,3S,4R,5R)-5-(6-ethy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	2.90E+4	-28.5	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21335 (6-cyanouridine 5-monophosphate \| C6-Uridine Deriva...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	2.90E+4	-28.5	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Uridine 5'-monophosphate synthase (Homo sapiens (Human))	BDBM27943 (uridine derivative, 39 \| {[(2R,3S,4R,5R)-5-(5-fluo...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	9.80E+4	-23.8	n/a	n/a	n/a	n/a	n/a	7.5	37
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM21339 (6-Methyl-uridine 5-O-Monophosphate \| C6-Uridine De...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	1.34E+5	-24.3	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)
Orotidine 5'-phosphate decarboxylase (Methanobacterium thermoautotrophicum)	BDBM27943 (uridine derivative, 39 \| {[(2R,3S,4R,5R)-5-(5-fluo...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	6.45E+5	-20.0	n/a	n/a	n/a	n/a	n/a	7.5	55
Toronto General Research Institute					Assay Description An enzyme assay method using isothermal titration calorimetry (ITC) was developed to investigate the inhibition kinetics of ODCase. Titrations were p...				J Med Chem 52: 1648-58 (2009) Article DOI: 10.1021/jm801224t BindingDB Entry DOI: 10.7270/Q2RR1WJB
Toronto General Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%