Found 56 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299771
(CHEMBL574093 | N-(4-(6,7-bis(2-methoxyethoxy)quino...)Show SMILES COCCOc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OCCOC Show InChI InChI=1S/C31H31FN4O7/c1-39-14-16-41-28-19-23-25(20-29(28)42-17-15-40-2)33-11-10-26(23)43-27-9-8-21(18-24(27)32)34-30(37)36-13-12-35(31(36)38)22-6-4-3-5-7-22/h3-11,18-20H,12-17H2,1-2H3,(H,34,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50248510
(CHEMBL489326 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H23F2N3O5/c1-36-24-14-19-21(15-25(24)37-2)31-12-9-22(19)38-23-8-7-18(13-20(23)30)33-27(35)28(10-11-28)26(34)32-17-5-3-16(29)4-6-17/h3-9,12-15H,10-11H2,1-2H3,(H,32,34)(H,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50247962
(CHEMBL462232 | N-(3-fluoro-4-(2-(1-methyl-1H-imida...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C27H21FN6O3S/c1-32-15-21(30-16-32)24-14-20-25(38-24)23(9-10-29-20)37-22-8-7-17(13-19(22)28)31-26(35)34-12-11-33(27(34)36)18-5-3-2-4-6-18/h2-10,13-16H,11-12H2,1H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299757
(CHEMBL575713 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C26H23N5O5/c1-34-22-14-19-20(15-23(22)35-2)27-11-10-21(19)36-18-8-9-24(28-16-18)29-25(32)31-13-12-30(26(31)33)17-6-4-3-5-7-17/h3-11,14-16H,12-13H2,1-2H3,(H,28,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299761
(CHEMBL574050 | N-(3-fluoro-4-(7-methoxy-6-(3-morph...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H33F2N5O6/c1-43-30-21-27-25(20-31(30)45-16-2-11-38-14-17-44-18-15-38)28(9-10-36-27)46-29-8-5-23(19-26(29)35)37-32(41)40-13-12-39(33(40)42)24-6-3-22(34)4-7-24/h3-10,19-21H,2,11-18H2,1H3,(H,37,41) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299755
(CHEMBL574864 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H22F2N4O5/c1-36-24-14-19-21(15-25(24)37-2)30-10-9-22(19)38-23-8-5-17(13-20(23)29)31-26(34)33-12-11-32(27(33)35)18-6-3-16(28)4-7-18/h3-10,13-15H,11-12H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299756
(CHEMBL576769 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)c(F)c3)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-22(16-25(24)36-2)29-11-10-23(19)37-18-8-9-21(20(28)14-18)30-26(33)32-13-12-31(27(32)34)17-6-4-3-5-7-17/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299777
(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24498
(3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C26H20FN5O2S2/c1-32-14-20(29-15-32)23-13-19-25(36-23)22(9-10-28-19)34-21-8-7-17(12-18(21)27)30-26(35)31-24(33)11-16-5-3-2-4-6-16/h2-10,12-15H,11H2,1H3,(H2,30,31,33,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50242737
((R,Z)-5-(2,6-dichlorobenzylsulfonyl)-3-((3,5-dimet...)Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(cc23)S(=O)(=O)Cc2c(Cl)cccc2Cl)c(C)c1C(=O)N1CCC[C@@H]1CN1CCCC1 |r| Show InChI InChI=1S/C32H34Cl2N4O4S/c1-19-29(35-20(2)30(19)32(40)38-14-6-7-21(38)17-37-12-3-4-13-37)16-24-23-15-22(10-11-28(23)36-31(24)39)43(41,42)18-25-26(33)8-5-9-27(25)34/h5,8-11,15-16,21,35H,3-4,6-7,12-14,17-18H2,1-2H3,(H,36,39)/b24-16-/t21-/m1/s1 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299760
(CHEMBL582927 | N-(3-fluoro-4-(6-methoxy-7-(piperid...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCC1CCNCC1 Show InChI InChI=1S/C32H32FN5O5/c1-41-29-18-24-26(19-30(29)42-20-21-9-12-34-13-10-21)35-14-11-27(24)43-28-8-7-22(17-25(28)33)36-31(39)38-16-15-37(32(38)40)23-5-3-2-4-6-23/h2-8,11,14,17-19,21,34H,9-10,12-13,15-16,20H2,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299761
(CHEMBL574050 | N-(3-fluoro-4-(7-methoxy-6-(3-morph...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H33F2N5O6/c1-43-30-21-27-25(20-31(30)45-16-2-11-38-14-17-44-18-15-38)28(9-10-36-27)46-29-8-5-23(19-26(29)35)37-32(41)40-13-12-39(33(40)42)24-6-3-22(34)4-7-24/h3-10,19-21H,2,11-18H2,1H3,(H,37,41) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299759
(CHEMBL575076 | N-(4-(6,7-dimethoxyquinolin-4-ylthi...)Show SMILES COc1cc2nccc(Sc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C27H23FN4O4S/c1-35-23-15-21-22(16-24(23)36-2)29-12-11-25(21)37-20-9-5-18(6-10-20)30-26(33)32-14-13-31(27(32)34)19-7-3-17(28)4-8-19/h3-12,15-16H,13-14H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299758
(CHEMBL573768 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccn4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN5O5/c1-35-22-14-17-19(15-23(22)36-2)28-10-8-20(17)37-21-7-6-16(13-18(21)27)30-25(33)32-12-11-31(26(32)34)24-5-3-4-9-29-24/h3-10,13-15H,11-12H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299778
(CHEMBL574870 | N-(4-(6,7-dimethoxyquinazolin-4-ylo...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN5O5/c1-35-22-13-18-20(14-23(22)36-2)28-15-29-24(18)37-21-9-8-16(12-19(21)27)30-25(33)32-11-10-31(26(32)34)17-6-4-3-5-7-17/h3-9,12-15H,10-11H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299767
(CHEMBL574125 | N-(3-fluoro-4-(6-methoxy-7-(3-morph...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H34FN5O6/c1-42-30-21-25-27(22-31(30)44-17-5-12-37-15-18-43-19-16-37)35-11-10-28(25)45-29-9-8-23(20-26(29)34)36-32(40)39-14-13-38(33(39)41)24-6-3-2-4-7-24/h2-4,6-11,20-22H,5,12-19H2,1H3,(H,36,40) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299766
(CHEMBL572389 | N-(3-fluoro-4-(6-methoxy-7-((1-meth...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C33H34FN5O5/c1-37-14-11-22(12-15-37)21-43-31-20-27-25(19-30(31)42-2)28(10-13-35-27)44-29-9-8-23(18-26(29)34)36-32(40)39-17-16-38(33(39)41)24-6-4-3-5-7-24/h3-10,13,18-20,22H,11-12,14-17,21H2,1-2H3,(H,36,40) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299767
(CHEMBL574125 | N-(3-fluoro-4-(6-methoxy-7-(3-morph...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCCCN1CCOCC1 Show InChI InChI=1S/C33H34FN5O6/c1-42-30-21-25-27(22-31(30)44-17-5-12-37-15-18-43-19-16-37)35-11-10-28(25)45-29-9-8-23(20-26(29)34)36-32(40)39-14-13-38(33(39)41)24-6-3-2-4-7-24/h2-4,6-11,20-22H,5,12-19H2,1H3,(H,36,40) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299762
(CHEMBL575698 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4OC)cc3F)c2cc1OC Show InChI InChI=1S/C28H25FN4O6/c1-36-24-7-5-4-6-21(24)32-12-13-33(28(32)35)27(34)31-17-8-9-23(19(29)14-17)39-22-10-11-30-20-16-26(38-3)25(37-2)15-18(20)22/h4-11,14-16H,12-13H2,1-3H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299764
(CHEMBL573974 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H24N4O5/c1-34-24-16-21-22(17-25(24)35-2)28-13-12-23(21)36-20-10-8-18(9-11-20)29-26(32)31-15-14-30(27(31)33)19-6-4-3-5-7-19/h3-13,16-17H,14-15H2,1-2H3,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299763
(CHEMBL574225 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4cccc(F)c4)cc3F)c2cc1OC Show InChI InChI=1S/C27H22F2N4O5/c1-36-24-14-19-21(15-25(24)37-2)30-9-8-22(19)38-23-7-6-17(13-20(23)29)31-26(34)33-11-10-32(27(33)35)18-5-3-4-16(28)12-18/h3-9,12-15H,10-11H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299765
(CHEMBL576752 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-21-22(16-25(24)36-2)29-12-11-23(21)37-20-9-5-18(6-10-20)30-26(33)32-14-13-31(27(32)34)19-7-3-17(28)4-8-19/h3-12,15-16H,13-14H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299770
(CHEMBL574230 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C26H23N5O5/c1-34-22-14-19-20(15-23(22)35-2)27-11-10-21(19)36-24-9-8-17(16-28-24)29-25(32)31-13-12-30(26(31)33)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299769
(CHEMBL575712 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(N5CCCCC5)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C26H28FN5O5/c1-35-23-15-18-20(16-24(23)36-2)28-9-8-21(18)37-22-7-6-17(14-19(22)27)29-25(33)31-12-13-32(26(31)34)30-10-4-3-5-11-30/h6-9,14-16H,3-5,10-13H2,1-2H3,(H,29,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299768
(CHEMBL577369 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4F)cc3F)c2cc1OC Show InChI InChI=1S/C27H22F2N4O5/c1-36-24-14-17-20(15-25(24)37-2)30-10-9-22(17)38-23-8-7-16(13-19(23)29)31-26(34)33-12-11-32(27(33)35)21-6-4-3-5-18(21)28/h3-10,13-15H,11-12H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299771
(CHEMBL574093 | N-(4-(6,7-bis(2-methoxyethoxy)quino...)Show SMILES COCCOc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OCCOC Show InChI InChI=1S/C31H31FN4O7/c1-39-14-16-41-28-19-23-25(20-29(28)42-17-15-40-2)33-11-10-26(23)43-27-9-8-21(18-24(27)32)34-30(37)36-13-12-35(31(36)38)22-6-4-3-5-7-22/h3-11,18-20H,12-17H2,1-2H3,(H,34,37) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299759
(CHEMBL575076 | N-(4-(6,7-dimethoxyquinolin-4-ylthi...)Show SMILES COc1cc2nccc(Sc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C27H23FN4O4S/c1-35-23-15-21-22(16-24(23)36-2)29-12-11-25(21)37-20-9-5-18(6-10-20)30-26(33)32-14-13-31(27(32)34)19-7-3-17(28)4-8-19/h3-12,15-16H,13-14H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299777
(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of c-Met in human DU145 cells assessed as cell scattering |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299777
(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of c-Met in human A549 cells by wound healing assay |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM24485
(3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=S)NC(=O)Cc4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN3O4S/c1-32-23-14-18-20(15-24(23)33-2)28-11-10-21(18)34-22-9-8-17(13-19(22)27)29-26(35)30-25(31)12-16-6-4-3-5-7-16/h3-11,13-15H,12H2,1-2H3,(H2,29,30,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299760
(CHEMBL582927 | N-(3-fluoro-4-(6-methoxy-7-(piperid...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCC1CCNCC1 Show InChI InChI=1S/C32H32FN5O5/c1-41-29-18-24-26(19-30(29)42-20-21-9-12-34-13-10-21)35-14-11-27(24)43-28-8-7-22(17-25(28)33)36-31(39)38-16-15-37(32(38)40)23-5-3-2-4-6-23/h2-8,11,14,17-19,21,34H,9-10,12-13,15-16,20H2,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299777
(CHEMBL573761 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299755
(CHEMBL574864 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H22F2N4O5/c1-36-24-14-19-21(15-25(24)37-2)30-10-9-22(19)38-23-8-5-17(13-20(23)29)31-26(34)33-12-11-32(27(33)35)18-6-3-16(28)4-7-18/h3-10,13-15H,11-12H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299772
(CHEMBL574406 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccncc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN5O5/c1-35-23-14-18-20(15-24(23)36-2)29-10-7-21(18)37-22-4-3-16(13-19(22)27)30-25(33)32-12-11-31(26(32)34)17-5-8-28-9-6-17/h3-10,13-15H,11-12H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299773
(3-cyclohexyl-N-(4-(6,7-dimethoxyquinolin-4-yloxy)-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C5CCCCC5)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C27H29FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h8-11,14-16,18H,3-7,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299766
(CHEMBL572389 | N-(3-fluoro-4-(6-methoxy-7-((1-meth...)Show SMILES COc1cc2c(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)ccnc2cc1OCC1CCN(C)CC1 Show InChI InChI=1S/C33H34FN5O5/c1-37-14-11-22(12-15-37)21-43-31-20-27-25(19-30(31)42-2)28(10-13-35-27)44-29-9-8-23(18-26(29)34)36-32(40)39-17-16-38(33(39)41)24-6-4-3-5-7-24/h3-10,13,18-20,22H,11-12,14-17,21H2,1-2H3,(H,36,40) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299765
(CHEMBL576752 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccc(F)cc4)cc3)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-21-22(16-25(24)36-2)29-12-11-23(21)37-20-9-5-18(6-10-20)30-26(33)32-14-13-31(27(32)34)19-7-3-17(28)4-8-19/h3-12,15-16H,13-14H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299762
(CHEMBL575698 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4OC)cc3F)c2cc1OC Show InChI InChI=1S/C28H25FN4O6/c1-36-24-7-5-4-6-21(24)32-12-13-33(28(32)35)27(34)31-17-8-9-23(19(29)14-17)39-22-10-11-30-20-16-26(38-3)25(37-2)15-18(20)22/h4-11,14-16H,12-13H2,1-3H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299774
(CHEMBL573762 | N-(4-(6,7-dimethoxyquinolin-4-ylami...)Show SMILES COc1cc2nccc(Nc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H24FN5O4/c1-36-24-15-19-21(10-11-29-23(19)16-25(24)37-2)31-22-9-8-17(14-20(22)28)30-26(34)33-13-12-32(27(33)35)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,29,31)(H,30,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299763
(CHEMBL574225 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4cccc(F)c4)cc3F)c2cc1OC Show InChI InChI=1S/C27H22F2N4O5/c1-36-24-14-19-21(15-25(24)37-2)30-9-8-22(19)38-23-7-6-17(13-20(23)29)31-26(34)33-11-10-32(27(33)35)18-5-3-4-16(28)12-18/h3-9,12-15H,10-11H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299775
(3-allyl-N-(4-(6,7-dimethoxyquinolin-4-yloxy)-3-flu...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(CC=C)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C24H23FN4O5/c1-4-9-28-10-11-29(24(28)31)23(30)27-15-5-6-20(17(25)12-15)34-19-7-8-26-18-14-22(33-3)21(32-2)13-16(18)19/h4-8,12-14H,1,9-11H2,2-3H3,(H,27,30) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299764
(CHEMBL573974 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3)c2cc1OC Show InChI InChI=1S/C27H24N4O5/c1-34-24-16-21-22(17-25(24)35-2)28-13-12-23(21)36-20-10-8-18(9-11-20)29-26(32)31-15-14-30(27(31)33)19-6-4-3-5-7-19/h3-13,16-17H,14-15H2,1-2H3,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299768
(CHEMBL577369 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4F)cc3F)c2cc1OC Show InChI InChI=1S/C27H22F2N4O5/c1-36-24-14-17-20(15-25(24)37-2)30-10-9-22(17)38-23-8-7-16(13-19(23)29)31-26(34)33-12-11-32(27(33)35)21-6-4-3-5-18(21)28/h3-10,13-15H,11-12H2,1-2H3,(H,31,34) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 370 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299776
(CHEMBL575490 | N-(4-((6,7-dimethoxyquinolin-4-yl)(...)Show SMILES COc1cc2nccc(N(C)c3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C28H26FN5O4/c1-32(23-11-12-30-22-17-26(38-3)25(37-2)16-20(22)23)24-10-9-18(15-21(24)29)31-27(35)34-14-13-33(28(34)36)19-7-5-4-6-8-19/h4-12,15-17H,13-14H2,1-3H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299779
(CHEMBL573765 | N-(4-(6,7-dimethoxyquinazolin-4-yla...)Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H23FN6O4/c1-36-22-13-18-21(14-23(22)37-2)28-15-29-24(18)31-20-9-8-16(12-19(20)27)30-25(34)33-11-10-32(26(33)35)17-6-4-3-5-7-17/h3-9,12-15H,10-11H2,1-2H3,(H,30,34)(H,28,29,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299772
(CHEMBL574406 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccncc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN5O5/c1-35-23-14-18-20(15-24(23)36-2)29-10-7-21(18)37-22-4-3-16(13-19(22)27)30-25(33)32-12-11-31(26(32)34)17-5-8-28-9-6-17/h3-10,13-15H,11-12H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 630 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299769
(CHEMBL575712 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(N5CCCCC5)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C26H28FN5O5/c1-35-23-15-18-20(16-24(23)36-2)28-9-8-21(18)37-22-7-6-17(14-19(22)27)29-25(33)31-12-13-32(26(31)34)30-10-4-3-5-11-30/h6-9,14-16H,3-5,10-13H2,1-2H3,(H,29,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | 640 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299773
(3-cyclohexyl-N-(4-(6,7-dimethoxyquinolin-4-yloxy)-...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C5CCCCC5)C4=O)cc3F)c2cc1OC Show InChI InChI=1S/C27H29FN4O5/c1-35-24-15-19-21(16-25(24)36-2)29-11-10-22(19)37-23-9-8-17(14-20(23)28)30-26(33)32-13-12-31(27(32)34)18-6-4-3-5-7-18/h8-11,14-16,18H,3-7,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 860 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299778
(CHEMBL574870 | N-(4-(6,7-dimethoxyquinazolin-4-ylo...)Show SMILES COc1cc2ncnc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H22FN5O5/c1-35-22-13-18-20(14-23(22)36-2)28-15-29-24(18)37-21-9-8-16(12-19(21)27)30-25(33)32-11-10-31(26(32)34)17-6-4-3-5-7-17/h3-9,12-15H,10-11H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| Article
PubMed
| n/a | n/a | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299779
(CHEMBL573765 | N-(4-(6,7-dimethoxyquinazolin-4-yla...)Show SMILES COc1cc2ncnc(Nc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C26H23FN6O4/c1-36-22-13-18-21(14-23(22)37-2)28-15-29-24(18)31-20-9-8-16(12-19(20)27)30-25(34)33-11-10-32(26(33)35)17-6-4-3-5-7-17/h3-9,12-15H,10-11H2,1-2H3,(H,30,34)(H,28,29,31) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299780
(CHEMBL574863 | N-(4-((6,7-dimethoxyquinazolin-4-yl...)Show SMILES COc1cc2ncnc(N(C)c3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H25FN6O4/c1-32(25-19-14-23(37-2)24(38-3)15-21(19)29-16-30-25)22-10-9-17(13-20(22)28)31-26(35)34-12-11-33(27(34)36)18-7-5-4-6-8-18/h4-10,13-16H,11-12H2,1-3H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299770
(CHEMBL574230 | N-(6-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cn3)c2cc1OC Show InChI InChI=1S/C26H23N5O5/c1-34-22-14-19-20(15-23(22)35-2)27-11-10-21(19)36-24-9-8-17(16-28-24)29-25(32)31-13-12-30(26(31)33)18-6-4-3-5-7-18/h3-11,14-16H,12-13H2,1-2H3,(H,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM4814
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C Show InChI InChI=1S/C22H27FN4O2/c1-5-27(6-2)10-9-24-22(29)20-13(3)19(25-14(20)4)12-17-16-11-15(23)7-8-18(16)26-21(17)28/h7-8,11-12,25H,5-6,9-10H2,1-4H3,(H,24,29)(H,26,28)/b17-12- | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of GST-tagged c-Met expressed in Sf9 cells |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299756
(CHEMBL576769 | N-(4-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)c(F)c3)c2cc1OC Show InChI InChI=1S/C27H23FN4O5/c1-35-24-15-19-22(16-25(24)36-2)29-11-10-23(19)37-18-8-9-21(20(28)14-18)30-26(33)32-13-12-31(27(32)34)17-6-4-3-5-7-17/h3-11,14-16H,12-13H2,1-2H3,(H,30,33) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299780
(CHEMBL574863 | N-(4-((6,7-dimethoxyquinazolin-4-yl...)Show SMILES COc1cc2ncnc(N(C)c3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)cc3F)c2cc1OC Show InChI InChI=1S/C27H25FN6O4/c1-32(25-19-14-23(37-2)24(38-3)15-21(19)29-16-30-25)22-10-9-17(13-20(22)28)31-26(35)34-12-11-33(27(34)36)18-7-5-4-6-8-18/h4-10,13-16H,11-12H2,1-3H3,(H,31,35) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50299757
(CHEMBL575713 | N-(5-(6,7-dimethoxyquinolin-4-yloxy...)Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)N4CCN(C4=O)c4ccccc4)nc3)c2cc1OC Show InChI InChI=1S/C26H23N5O5/c1-34-22-14-19-20(15-23(22)35-2)27-11-10-21(19)36-18-8-9-24(28-16-18)29-25(32)31-13-12-30(26(31)33)17-6-4-3-5-7-17/h3-11,14-16H,12-13H2,1-2H3,(H,28,29,32) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc
Curated by ChEMBL
| Assay Description
Inhibition of TPR-Met assessed as autophosphorylation |
Bioorg Med Chem Lett 19: 6552-6 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.040
BindingDB Entry DOI: 10.7270/Q2VM4D6R |
More data for this
Ligand-Target Pair | |
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