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PubMed code 20185312

Compile data set for download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314008
PNG
(CHEMBL1087165 | N-(cyclopropylmethyl)-2,2,2-triflu...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CC4CC4)CC(F)(F)F)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C23H28F6N4/c1-14-9-15(2)19(16(3)10-14)33-8-4-7-32-18(20(23(27,28)29)30-21(32)33)12-31(11-17-5-6-17)13-22(24,25)26/h9-10,17H,4-8,11-13H2,1-3H3
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 8n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314009
PNG
(CHEMBL1087166 | N-(cyclopropylmethyl)-2,2,3,3,3-pe...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CC4CC4)CC(F)(F)C(F)(F)F)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C24H28F8N4/c1-14-9-15(2)19(16(3)10-14)36-8-4-7-35-18(20(23(27,28)29)33-21(35)36)12-34(11-17-5-6-17)13-22(25,26)24(30,31)32/h9-10,17H,4-8,11-13H2,1-3H3
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 14n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314010
PNG
(CHEMBL1087167 | N,N-diallyl-8-mesityl-2-(trifluoro...)
Show SMILES Cc1cc(C)c(N2CCCn3c2nc(c3C(=O)N(CC=C)CC=C)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C23H27F3N4O/c1-6-9-28(10-7-2)21(31)19-20(23(24,25)26)27-22-29(11-8-12-30(19)22)18-16(4)13-15(3)14-17(18)5/h6-7,13-14H,1-2,8-12H2,3-5H3
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 19n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314011
PNG
(CHEMBL1088478 | N-(cyclobutylmethyl)-N-((8-mesityl...)
Show SMILES CCCN(CC1CCC1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C25H35F3N4/c1-5-10-30(15-20-8-6-9-20)16-21-23(25(26,27)28)29-24-31(21)11-7-12-32(24)22-18(3)13-17(2)14-19(22)4/h13-14,20H,5-12,15-16H2,1-4H3
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 21n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314012
PNG
(CHEMBL1088624 | N-(cyclobutylmethyl)-2,2,2-trifluo...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CC4CCC4)CC(F)(F)F)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C24H30F6N4/c1-15-10-16(2)20(17(3)11-15)34-9-5-8-33-19(21(24(28,29)30)31-22(33)34)13-32(14-23(25,26)27)12-18-6-4-7-18/h10-11,18H,4-9,12-14H2,1-3H3
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 27n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314013
PNG
(CHEMBL1088625 | N-(cyclopropylmethyl)-N-((8-mesity...)
Show SMILES CCN(CC1CC1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C23H31F3N4/c1-5-28(13-18-7-8-18)14-19-21(23(24,25)26)27-22-29(19)9-6-10-30(22)20-16(3)11-15(2)12-17(20)4/h11-12,18H,5-10,13-14H2,1-4H3
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 31n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314007
PNG
(CHEMBL1087164 | N-(cyclopropylmethyl)-N-((8-mesity...)
Show SMILES CCCN(CC1CC1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C24H33F3N4/c1-5-9-29(14-19-7-8-19)15-20-22(24(25,26)27)28-23-30(20)10-6-11-31(23)21-17(3)12-16(2)13-18(21)4/h12-13,19H,5-11,14-15H2,1-4H3
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 32n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314015
PNG
(2,2,2-trifluoro-N-((8-mesityl-2-(trifluoromethyl)-...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN(CCc4ccccc4)CC(F)(F)F)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C27H30F6N4/c1-18-14-19(2)23(20(3)15-18)37-12-7-11-36-22(24(27(31,32)33)34-25(36)37)16-35(17-26(28,29)30)13-10-21-8-5-4-6-9-21/h4-6,8-9,14-15H,7,10-13,16-17H2,1-3H3
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 38n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314016
PNG
(CHEMBL1077156 | N-((8-mesityl-2-(trifluoromethyl)-...)
Show SMILES CCCN(CC=C)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C23H31F3N4/c1-6-9-28(10-7-2)15-19-21(23(24,25)26)27-22-29(19)11-8-12-30(22)20-17(4)13-16(3)14-18(20)5/h6,13-14H,1,7-12,15H2,2-5H3
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 48n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314017
PNG
(3,3,3-trifluoro-N-((8-mesityl-2-(trifluoromethyl)-...)
Show SMILES CCCN(CCC(F)(F)F)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C23H30F6N4/c1-5-8-31(11-7-22(24,25)26)14-18-20(23(27,28)29)30-21-32(18)9-6-10-33(21)19-16(3)12-15(2)13-17(19)4/h12-13H,5-11,14H2,1-4H3
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 63n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314014
PNG
(CHEMBL1088626 | N-((8-mesityl-2-(trifluoromethyl)-...)
Show SMILES CCCN(CCc1ccccc1)Cc1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C28H35F3N4/c1-5-13-33(16-12-23-10-7-6-8-11-23)19-24-26(28(29,30)31)32-27-34(24)14-9-15-35(27)25-21(3)17-20(2)18-22(25)4/h6-8,10-11,17-18H,5,9,12-16,19H2,1-4H3
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 67n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314018
PNG
(8-mesityl-3-(piperidin-1-ylmethyl)-2-(trifluoromet...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN4CCCCC4)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C22H29F3N4/c1-15-12-16(2)19(17(3)13-15)29-11-7-10-28-18(14-27-8-5-4-6-9-27)20(22(23,24)25)26-21(28)29/h12-13H,4-11,14H2,1-3H3
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 245n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314019
PNG
(3-((5,6-dihydropyridin-1(2H)-yl)methyl)-8-mesityl-...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN4CCC=CC4)c(nc23)C(F)(F)F)c(C)c1 |c:16|
Show InChI InChI=1S/C22H27F3N4/c1-15-12-16(2)19(17(3)13-15)29-11-7-10-28-18(14-27-8-5-4-6-9-27)20(22(23,24)25)26-21(28)29/h4-5,12-13H,6-11,14H2,1-3H3
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 364n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314021
PNG
(4-((8-mesityl-2-(trifluoromethyl)-5,6,7,8-tetrahyd...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN4CCSCC4)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C21H27F3N4S/c1-14-11-15(2)18(16(3)12-14)28-6-4-5-27-17(13-26-7-9-29-10-8-26)19(21(22,23)24)25-20(27)28/h11-12H,4-10,13H2,1-3H3
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 441n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313996
PNG
(CHEMBL1086164 | N-(cyclopropylmethyl)-8-mesityl-N-...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(nc2N(CCCn12)c1c(C)cc(C)cc1C)C(F)(F)F
Show InChI InChI=1S/C24H31F3N4O/c1-5-9-29(14-18-7-8-18)22(32)20-21(24(25,26)27)28-23-30(10-6-11-31(20)23)19-16(3)12-15(2)13-17(19)4/h12-13,18H,5-11,14H2,1-4H3
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 1.20E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314020
PNG
(4-((8-mesityl-2-(trifluoromethyl)-5,6,7,8-tetrahyd...)
Show SMILES Cc1cc(C)c(N2CCCn3c(CN4CCOCC4)c(nc23)C(F)(F)F)c(C)c1
Show InChI InChI=1S/C21H27F3N4O/c1-14-11-15(2)18(16(3)12-14)28-6-4-5-27-17(13-26-7-9-29-10-8-26)19(21(22,23)24)25-20(27)28/h11-12H,4-10,13H2,1-3H3
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 1.51E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313991
PNG
(8-mesityl-2-methyl-N-phenethyl-N-propyl-5,6,7,8-te...)
Show SMILES CCCN(CCc1ccccc1)C(=O)c1c(C)nc2N(CCCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C28H36N4O/c1-6-14-30(17-13-24-11-8-7-9-12-24)27(33)26-23(5)29-28-31(15-10-16-32(26)28)25-21(3)18-20(2)19-22(25)4/h7-9,11-12,18-19H,6,10,13-17H2,1-5H3
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 1.70E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313995
PNG
(CHEMBL1086163 | N-(cyclopropylmethyl)-2-ethyl-8-me...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(CCCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H36N4O/c1-6-11-27(16-20-9-10-20)24(30)23-21(7-2)26-25-28(12-8-13-29(23)25)22-18(4)14-17(3)15-19(22)5/h14-15,20H,6-13,16H2,1-5H3
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 2.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313990
PNG
(CHEMBL1085431 | N-(cyclobutylmethyl)-8-mesityl-2-m...)
Show SMILES CCCN(CC1CCC1)C(=O)c1c(C)nc2N(CCCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H36N4O/c1-6-11-27(16-21-9-7-10-21)24(30)23-20(5)26-25-28(12-8-13-29(23)25)22-18(3)14-17(2)15-19(22)4/h14-15,21H,6-13,16H2,1-5H3
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PubMed
 3.30E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313989
PNG
(CHEMBL1077158 | N,N-bis(cyclopropylmethyl)-8-mesit...)
Show SMILES Cc1nc2N(CCCn2c1C(=O)N(CC1CC1)CC1CC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H34N4O/c1-16-12-17(2)22(18(3)13-16)28-10-5-11-29-23(19(4)26-25(28)29)24(30)27(14-20-6-7-20)15-21-8-9-21/h12-13,20-21H,5-11,14-15H2,1-4H3
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PubMed
 3.40E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314003
PNG
(CHEMBL1087673 | N-benzyl-N,2-diethyl-8-mesityl-7-o...)
Show SMILES CCN(Cc1ccccc1)C(=O)c1c(CC)nc2N(C(=O)CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H32N4O2/c1-6-22-25(26(33)29(7-2)17-21-11-9-8-10-12-21)30-14-13-23(32)31(27(30)28-22)24-19(4)15-18(3)16-20(24)5/h8-12,15-16H,6-7,13-14,17H2,1-5H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313999
PNG
(CHEMBL1088194 | N-(cyclopropylmethyl)-8-mesityl-2-...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(C)nc2N(C(=O)CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H32N4O2/c1-6-10-26(14-19-7-8-19)23(30)22-18(5)25-24-27(22)11-9-20(29)28(24)21-16(3)12-15(2)13-17(21)4/h12-13,19H,6-11,14H2,1-5H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313993
PNG
(CHEMBL1083823 | N-allyl-8-mesityl-2-methyl-N-propy...)
Show SMILES CCCN(CC=C)C(=O)c1c(C)nc2N(CCCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4O/c1-7-10-25(11-8-2)22(28)21-19(6)24-23-26(12-9-13-27(21)23)20-17(4)14-16(3)15-18(20)5/h7,14-15H,1,8-13H2,2-6H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313997
PNG
(8-mesityl-2-methyl-7-oxo-N,N-dipropyl-5,6,7,8-tetr...)
Show SMILES CCCN(CCC)C(=O)c1c(C)nc2N(C(=O)CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H32N4O2/c1-7-10-25(11-8-2)22(29)21-18(6)24-23-26(21)12-9-19(28)27(23)20-16(4)13-15(3)14-17(20)5/h13-14H,7-12H2,1-6H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314006
PNG
(CHEMBL1077155 | N-butyl-N,2-diethyl-8-mesityl-7-ox...)
Show SMILES CCCCN(CC)C(=O)c1c(CC)nc2N(C(=O)CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4O2/c1-7-10-12-26(9-3)23(30)22-19(8-2)25-24-27(22)13-11-20(29)28(24)21-17(5)14-16(4)15-18(21)6/h14-15H,7-13H2,1-6H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314005
PNG
(CHEMBL1087675 | N,N-diallyl-2-ethyl-8-mesityl-7-ox...)
Show SMILES CCc1nc2N(C(=O)CCn2c1C(=O)N(CC=C)CC=C)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H30N4O2/c1-7-11-26(12-8-2)23(30)22-19(9-3)25-24-27(22)13-10-20(29)28(24)21-17(5)14-16(4)15-18(21)6/h7-8,14-15H,1-2,9-13H2,3-6H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313994
PNG
(CHEMBL1083824 | N-(cyclopropylmethyl)-8-mesityl-2-...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(C)nc2N(CCCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4O/c1-6-10-26(15-20-8-9-20)23(29)22-19(5)25-24-27(11-7-12-28(22)24)21-17(3)13-16(2)14-18(21)4/h13-14,20H,6-12,15H2,1-5H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314022
PNG
(8-mesityl-3-((4-methyl-1,4-diazepan-1-yl)methyl)-2...)
Show SMILES CN1CCCN(Cc2c(nc3N(CCCn23)c2c(C)cc(C)cc2C)C(F)(F)F)CC1
Show InChI InChI=1S/C23H32F3N5/c1-16-13-17(2)20(18(3)14-16)31-10-6-9-30-19(21(23(24,25)26)27-22(30)31)15-29-8-5-7-28(4)11-12-29/h13-14H,5-12,15H2,1-4H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314001
PNG
(8-mesityl-2-methyl-3-(morpholine-4-carbonyl)-5,6-d...)
Show SMILES Cc1nc2N(C(=O)CCn2c1C(=O)N1CCOCC1)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H26N4O3/c1-13-11-14(2)18(15(3)12-13)25-17(26)5-6-24-19(16(4)22-21(24)25)20(27)23-7-9-28-10-8-23/h11-12H,5-10H2,1-4H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314002
PNG
(CHEMBL1088327 | N-(cyclopropylmethyl)-2-ethyl-8-me...)
Show SMILES CCCN(CC1CC1)C(=O)c1c(CC)nc2N(C(=O)CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C25H34N4O2/c1-6-11-27(15-19-8-9-19)24(31)23-20(7-2)26-25-28(23)12-10-21(30)29(25)22-17(4)13-16(3)14-18(22)5/h13-14,19H,6-12,15H2,1-5H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314004
PNG
(2-ethyl-8-mesityl-7-oxo-N,N-dipropyl-5,6,7,8-tetra...)
Show SMILES CCCN(CCC)C(=O)c1c(CC)nc2N(C(=O)CCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C24H34N4O2/c1-7-11-26(12-8-2)23(30)22-19(9-3)25-24-27(22)13-10-20(29)28(24)21-17(5)14-16(4)15-18(21)6/h14-15H,7-13H2,1-6H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50314000
PNG
(3-(4-(2-fluorophenyl)piperazine-1-carbonyl)-8-mesi...)
Show SMILES Cc1nc2N(C(=O)CCn2c1C(=O)N1CCN(CC1)c1ccccc1F)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H30FN5O2/c1-17-15-18(2)24(19(3)16-17)33-23(34)9-10-32-25(20(4)29-27(32)33)26(35)31-13-11-30(12-14-31)22-8-6-5-7-21(22)28/h5-8,15-16H,9-14H2,1-4H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313998
PNG
(CHEMBL1086405 | N,N-diallyl-8-mesityl-2-methyl-7-o...)
Show SMILES Cc1nc2N(C(=O)CCn2c1C(=O)N(CC=C)CC=C)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C23H28N4O2/c1-7-10-25(11-8-2)22(29)21-18(6)24-23-26(21)12-9-19(28)27(23)20-16(4)13-15(3)14-17(20)5/h7-8,13-14H,1-2,9-12H2,3-6H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
Corticotropin-releasing factor receptor 1


(Homo sapiens (Human))		BDBM50313992
PNG
(CHEMBL1083822 | N-benzyl-8-mesityl-2-methyl-N-prop...)
Show SMILES CCCN(Cc1ccccc1)C(=O)c1c(C)nc2N(CCCn12)c1c(C)cc(C)cc1C
Show InChI InChI=1S/C27H34N4O/c1-6-13-29(18-23-11-8-7-9-12-23)26(32)25-22(5)28-27-30(14-10-15-31(25)27)24-20(3)16-19(2)17-21(24)4/h7-9,11-12,16-17H,6,10,13-15,18H2,1-5H3
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>5.00E+3n/an/an/an/an/an/an/an/a



Bristol-Myers Squibb Research& Development

Curated by ChEMBL


Assay Description
Displacement of [125I]Tyr-o-CRF from human CRFR1 expressed in human IMR32 cells

Bioorg Med Chem Lett 20: 1905-9 (2010)


Article DOI: 10.1016/j.bmcl.2010.01.127
BindingDB Entry DOI: 10.7270/Q24Q7V3F
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%