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PubMed code 22233543

Compile data set for download or QSAR
Found 70 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50067584
PNG
((S)-2-{[5-((R)-2-Amino-3-mercapto-propylamino)-bip...)
Show SMILES CSCC[C@H](NC(=O)c1ccc(NC[C@@H](N)CS)cc1-c1ccccc1)C(O)=O
Show InChI InChI=1S/C21H27N3O3S2/c1-29-10-9-19(21(26)27)24-20(25)17-8-7-16(23-12-15(22)13-28)11-18(17)14-5-3-2-4-6-14/h2-8,11,15,19,23,28H,9-10,12-13,22H2,1H3,(H,24,25)(H,26,27)/t15-,19+/m1/s1
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238359
PNG
(3-(4-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-3-5-10(6-4-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238366
PNG
(3-Phenyl-4-cyano-5-(isopropylthio)thiophene-2-carb...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1
Show InChI InChI=1S/C15H13NO2S2/c1-9(2)19-15-11(8-16)12(13(20-15)14(17)18)10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H,17,18)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,8.27,;-.64,7.79,;-1.97,8.56,;-3.3,7.79,;-3.3,6.25,;-1.97,5.48,;-.64,6.25,;.83,5.77,)|
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;1.11,8.43,;-.42,8.59,;-1.33,7.34,;-.7,5.94,;.83,5.77,)|
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238354
PNG
(3-(3-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238358
PNG
(3-(2-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1F |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238368
PNG
(3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-5-10(3)7-11/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238355
PNG
(3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238360
PNG
(3-(3-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-4-3-5-10(6-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238362
PNG
(3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-5-4-6-11(7-10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238372
PNG
(3-(4-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238369
PNG
(3-(2-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1C |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-7-5-4-6-10(11)3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,8.27,;-.64,7.79,;-1.97,8.56,;-3.3,7.79,;-3.3,6.25,;-1.97,5.48,;-.64,6.25,;.83,5.77,)|
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238373
PNG
(3-(3-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-6-9-15(11-16)14-7-4-3-5-8-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238372
PNG
(3-(4-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238365
PNG
(3-(3-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-5-4-6-11(7-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238371
PNG
(3-(2-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc2ccccc2c1
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-8-7-12-5-3-4-6-13(12)9-14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Saccharomyces cerevisiae (Baker's yeast))		BDBM238363
PNG
(3-(2-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccccc1-c1c(sc(SC(C)C)c1C#N)C(O)=O |(5.15,2.8,;3.61,2.8,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,5.77,;1.46,4.37,;.55,3.12,;1.03,1.66,;-.22,.75,;-1.47,1.66,;-2.93,1.18,;-4.02,2.27,;-5.51,1.87,;-3.62,3.76,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;2.49,1.18,;3.63,2.21,;2.81,-.33,)|
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-11(8-17)13(14(22-16)15(18)19)10-6-4-5-7-12(10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;1.11,8.43,;-.42,8.59,;-1.33,7.34,;-.7,5.94,;.83,5.77,)|
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238364
PNG
(3-(4-(Methoxycarbonyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES COC(=O)c1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C17H15NO4S2/c1-9(2)23-17-12(8-18)13(14(24-17)15(19)20)10-4-6-11(7-5-10)16(21)22-3/h4-7,9H,1-3H3,(H,19,20)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238354
PNG
(3-(3-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238375
PNG
(3-(1-Dibenzofuranyl)-4-cyano-5-(isopropylthio)thio...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2oc3ccccc3c12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,8.27,;-.64,7.79,;-1.97,8.56,;-3.3,7.79,;-3.3,6.25,;-1.97,5.48,;-.64,6.25,;.83,5.77,)|
Show InChI InChI=1S/C21H15NO3S2/c1-11(2)26-21-14(10-22)18(19(27-21)20(23)24)13-7-5-9-16-17(13)12-6-3-4-8-15(12)25-16/h3-9,11H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238353
PNG
(3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238368
PNG
(3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-5-10(3)7-11/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238362
PNG
(3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-5-4-6-11(7-10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238360
PNG
(3-(3-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-4-3-5-10(6-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238367
PNG
(3-(4-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(C)cc1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-10(3)5-7-11/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238362
PNG
(3-(3-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1cccc(c1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-5-4-6-11(7-10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238356
PNG
(3-(4-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(F)cc1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238374
PNG
(3-(3-Thienyl)-4-cyano-5-(isopropylthio)thiophene-2...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(Sc2ccsc2)c1C#N
Show InChI InChI=1S/C13H11NO2S4/c1-7(2)18-13-9(5-14)10(11(20-13)12(15)16)19-8-3-4-17-6-8/h3-4,6-7H,1-2H3,(H,15,16)
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Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238372
PNG
(3-(4-Biphenyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C21H17NO2S2/c1-13(2)25-21-17(12-22)18(19(26-21)20(23)24)16-10-8-15(9-11-16)14-6-4-3-5-7-14/h3-11,13H,1-2H3,(H,23,24)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238370
PNG
(3-(1-Naphthyl)-4-cyano-5-(isopropylthio)thiophene-...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc2ccccc12 |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;1.11,8.43,;-.42,8.59,;-1.33,7.34,;-.7,5.94,;.83,5.77,)|
Show InChI InChI=1S/C19H15NO2S2/c1-11(2)23-19-15(10-20)16(17(24-19)18(21)22)14-9-5-7-12-6-3-4-8-13(12)14/h3-9,11H,1-2H3,(H,21,22)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238357
PNG
(3-(3-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(F)c1
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238366
PNG
(3-Phenyl-4-cyano-5-(isopropylthio)thiophene-2-carb...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1
Show InChI InChI=1S/C15H13NO2S2/c1-9(2)19-15-11(8-16)12(13(20-15)14(17)18)10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H,17,18)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238360
PNG
(3-(3-(Trifluoromethyl)phenyl)-4-cyano-5-(isopropyl...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H12F3NO2S2/c1-8(2)23-15-11(7-20)12(13(24-15)14(21)22)9-4-3-5-10(6-9)16(17,18)19/h3-6,8H,1-2H3,(H,21,22)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238368
PNG
(3-(3-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(C)c1
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-6-4-5-10(3)7-11/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238355
PNG
(3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238363
PNG
(3-(2-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccccc1-c1c(sc(SC(C)C)c1C#N)C(O)=O |(5.15,2.8,;3.61,2.8,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,5.77,;1.46,4.37,;.55,3.12,;1.03,1.66,;-.22,.75,;-1.47,1.66,;-2.93,1.18,;-4.02,2.27,;-5.51,1.87,;-3.62,3.76,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;2.49,1.18,;3.63,2.21,;2.81,-.33,)|
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-11(8-17)13(14(22-16)15(18)19)10-6-4-5-7-12(10)20-3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238361
PNG
(3-(4-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccc(cc1)-c1c(sc(SC(C)C)c1C#N)C(O)=O
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-12(8-17)13(14(22-16)15(18)19)10-4-6-11(20-3)7-5-10/h4-7,9H,1-3H3,(H,18,19)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238366
PNG
(3-Phenyl-4-cyano-5-(isopropylthio)thiophene-2-carb...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1
Show InChI InChI=1S/C15H13NO2S2/c1-9(2)19-15-11(8-16)12(13(20-15)14(17)18)10-6-4-3-5-7-10/h3-7,9H,1-2H3,(H,17,18)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238358
PNG
(3-(2-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1F |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238354
PNG
(3-(3-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1cccc(Cl)c1
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-4-3-5-10(16)6-9/h3-6,8H,1-2H3,(H,18,19)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta


(Trypanosoma brucei brucei)		BDBM238369
PNG
(3-(2-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1C |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-7-5-4-6-10(11)3/h4-7,9H,1-3H3,(H,18,19)
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Assay Description
Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238355
PNG
(3-(2-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1Cl |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238358
PNG
(3-(2-Fluorophenyl)-4-cyano-5-(isopropylthio)thioph...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1F |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C15H12FNO2S2/c1-8(2)20-15-10(7-17)12(13(21-15)14(18)19)9-5-3-4-6-11(9)16/h3-6,8H,1-2H3,(H,18,19)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238369
PNG
(3-(2-Tolyl)-4-cyano-5-(isopropylthio)thiophene-2-c...)
Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccccc1C |(-5.51,1.87,;-4.02,2.27,;-3.62,3.76,;-2.93,1.18,;-1.47,1.66,;-.22,.75,;1.03,1.66,;2.49,1.18,;3.63,2.21,;2.81,-.33,;.55,3.12,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;1.46,4.37,;.83,5.77,;1.73,7.02,;3.27,6.86,;3.89,5.45,;2.99,4.21,;3.61,2.8,)|
Show InChI InChI=1S/C16H15NO2S2/c1-9(2)20-16-12(8-17)13(14(21-16)15(18)19)11-7-5-4-6-10(11)3/h4-7,9H,1-3H3,(H,18,19)
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Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM238363
PNG
(3-(2-Methoxyphenyl)-4-cyano-5-(isopropylthio)thiop...)
Show SMILES COc1ccccc1-c1c(sc(SC(C)C)c1C#N)C(O)=O |(5.15,2.8,;3.61,2.8,;2.99,4.21,;3.89,5.45,;3.27,6.86,;1.73,7.02,;.83,5.77,;1.46,4.37,;.55,3.12,;1.03,1.66,;-.22,.75,;-1.47,1.66,;-2.93,1.18,;-4.02,2.27,;-5.51,1.87,;-3.62,3.76,;-.99,3.12,;-1.9,4.37,;-2.67,5.7,;2.49,1.18,;3.63,2.21,;2.81,-.33,)|
Show InChI InChI=1S/C16H15NO3S2/c1-9(2)21-16-11(8-17)13(14(22-16)15(18)19)10-6-4-5-7-12(10)20-3/h4-7,9H,1-3H3,(H,18,19)
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PubMed
n/an/a>5.00E+4n/an/an/an/an/an/a



Centre de Recherche de Gif



Assay Description
Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...

J Enzyme Inhib Med Chem 28: 163-71 (2013)


Article DOI: 10.3109/14756366.2011.643302
BindingDB Entry DOI: 10.7270/Q2319TSJ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%