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PubMed code 24440478

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447747
PNG
(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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n/an/a 0.0250n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447748
PNG
(CHEMBL3113271)
Show SMILES Fc1cccc(c1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-1-3-13(17(14)21)15-6-8-22-18(24-15)27-9-11-28(12-10-27)19(29)25-16-5-2-7-23-26-16/h1-8H,9-12H2,(H,25,26,29)
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n/an/a 0.0720n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447745
PNG
(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447747
PNG
(CHEMBL3113272)
Show SMILES Fc1ccc(F)c(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-15(21)14(12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447746
PNG
(CHEMBL3113273)
Show SMILES Fc1ccc(cc1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-3-13(12-15(14)21)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447745
PNG
(CHEMBL3113274)
Show SMILES Fc1cc(F)cc(c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-10-13(11-15(21)12-14)16-3-5-22-18(24-16)27-6-8-28(9-7-27)19(29)25-17-2-1-4-23-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447749
PNG
(CHEMBL3113270)
Show SMILES Fc1ccc(c(F)c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447746
PNG
(CHEMBL3113273)
Show SMILES Fc1ccc(cc1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-3-13(12-15(14)21)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447749
PNG
(CHEMBL3113270)
Show SMILES Fc1ccc(c(F)c1)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)12-13)16-5-7-22-18(24-16)27-8-10-28(11-9-27)19(29)25-17-2-1-6-23-26-17/h1-7,12H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447748
PNG
(CHEMBL3113271)
Show SMILES Fc1cccc(c1F)-c1ccnc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-14-4-1-3-13(17(14)21)15-6-8-22-18(24-15)27-9-11-28(12-10-27)19(29)25-16-5-2-7-23-26-16/h1-8H,9-12H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447750
PNG
(CHEMBL3113269)
Show SMILES Fc1ccc(c(F)c1)-c1cc(ncn1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)10-13)16-11-18(23-12-22-16)27-6-8-28(9-7-27)19(29)25-17-2-1-5-24-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447750
PNG
(CHEMBL3113269)
Show SMILES Fc1ccc(c(F)c1)-c1cc(ncn1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)10-13)16-11-18(23-12-22-16)27-6-8-28(9-7-27)19(29)25-17-2-1-5-24-26-17/h1-5,10-12H,6-9H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447751
PNG
(CHEMBL3113268)
Show SMILES Fc1ccc(c(F)c1)-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-15-3-4-16(17(22)13-15)14-5-7-23-19(12-14)27-8-10-28(11-9-27)20(29)25-18-2-1-6-24-26-18/h1-7,12-13H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447751
PNG
(CHEMBL3113268)
Show SMILES Fc1ccc(c(F)c1)-c1ccnc(c1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-15-3-4-16(17(22)13-15)14-5-7-23-19(12-14)27-8-10-28(11-9-27)20(29)25-18-2-1-6-24-26-18/h1-7,12-13H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447753
PNG
(CHEMBL3113266)
Show SMILES Fc1ccc(c(F)c1)-c1cc(ccn1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-14-3-4-16(17(22)12-14)18-13-15(5-7-23-18)27-8-10-28(11-9-27)20(29)25-19-2-1-6-24-26-19/h1-7,12-13H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447754
PNG
(CHEMBL3113265)
Show SMILES Fc1ccc(c(F)c1)-c1cccc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-14-6-7-15(16(22)13-14)17-3-1-5-19(24-17)27-9-11-28(12-10-27)20(29)25-18-4-2-8-23-26-18/h1-8,13H,9-12H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447755
PNG
(CHEMBL3113264)
Show SMILES Fc1ccc(c(F)c1)-c1nccc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)12-13)18-22-7-5-17(25-18)27-8-10-28(11-9-27)19(29)24-16-2-1-6-23-26-16/h1-7,12H,8-11H2,(H,24,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447753
PNG
(CHEMBL3113266)
Show SMILES Fc1ccc(c(F)c1)-c1cc(ccn1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-14-3-4-16(17(22)12-14)18-13-15(5-7-23-18)27-8-10-28(11-9-27)20(29)25-19-2-1-6-24-26-19/h1-7,12-13H,8-11H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447755
PNG
(CHEMBL3113264)
Show SMILES Fc1ccc(c(F)c1)-c1nccc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C19H17F2N7O/c20-13-3-4-14(15(21)12-13)18-22-7-5-17(25-18)27-8-10-28(11-9-27)19(29)24-16-2-1-6-23-26-16/h1-7,12H,8-11H2,(H,24,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447754
PNG
(CHEMBL3113265)
Show SMILES Fc1ccc(c(F)c1)-c1cccc(n1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-14-6-7-15(16(22)13-14)17-3-1-5-19(24-17)27-9-11-28(12-10-27)20(29)25-18-4-2-8-23-26-18/h1-8,13H,9-12H2,(H,25,26,29)
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Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1 [30-579]


(Rattus norvegicus (rat))		BDBM50447752
PNG
(CHEMBL3113267)
Show SMILES Fc1ccc(c(F)c1)-c1cncc(c1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-15-3-4-17(18(22)11-15)14-10-16(13-23-12-14)27-6-8-28(9-7-27)20(29)25-19-2-1-5-24-26-19/h1-5,10-13H,6-9H2,(H,25,26,29)
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 74n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of rat FAAH using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
Fatty-acid amide hydrolase 1


(Homo sapiens (Human))		BDBM50447752
PNG
(CHEMBL3113267)
Show SMILES Fc1ccc(c(F)c1)-c1cncc(c1)N1CCN(CC1)C(=O)Nc1cccnn1
Show InChI InChI=1S/C20H18F2N6O/c21-15-3-4-17(18(22)11-15)14-10-16(13-23-12-14)27-6-8-28(9-7-27)20(29)25-19-2-1-5-24-26-19/h1-5,10-13H,6-9H2,(H,25,26,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 140n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd

Curated by ChEMBL


Assay Description
Apparent inhibition of human FAAH expressed in CHOK1 cells using AMCAA as substrate after 30 mins by fluorescence assay

Bioorg Med Chem 22: 1468-78 (2014)


Article DOI: 10.1016/j.bmc.2013.12.023
BindingDB Entry DOI: 10.7270/Q20C4X77
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%