BindingDB logo
myBDB logout

PubMed code 24751443

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013911
PNG
(CHEMBL3260533)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F3N3O2/c1-3-33-23(32)24(2,15-17-7-5-4-6-8-17)21-13-14-29-22-20(16-30-31(21)22)18-9-11-19(12-10-18)25(26,27)28/h4-14,16H,3,15H2,1-2H3/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 19n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014040
PNG
(CHEMBL3260514)
Show SMILES CCOC(=O)C(C)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C17H16ClN3O2/c1-3-23-17(22)11(2)15-8-9-19-16-14(10-20-21(15)16)12-4-6-13(18)7-5-12/h4-11H,3H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.20E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013913
PNG
(CHEMBL3260540)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1cnnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H21F3N4O2/c1-3-33-22(32)23(2,13-16-7-5-4-6-8-16)20-15-28-30-21-19(14-29-31(20)21)17-9-11-18(12-10-17)24(25,26)27/h4-12,14-15H,3,13H2,1-2H3/t23-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 20n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013963
PNG
(CHEMBL3260522)
Show SMILES CCOC(=O)C(C)(Cc1cccc(C)c1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H24ClN3O2/c1-4-31-24(30)25(3,15-18-7-5-6-17(2)14-18)22-12-13-27-23-21(16-28-29(22)23)19-8-10-20(26)11-9-19/h5-14,16H,4,15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 40n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013993
PNG
(CHEMBL3260525)
Show SMILES CCOC(=O)C(C)(CC1CCOCC1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H26ClN3O3/c1-3-30-22(28)23(2,14-16-9-12-29-13-10-16)20-8-11-25-21-19(15-26-27(20)21)17-4-6-18(24)7-5-17/h4-8,11,15-16H,3,9-10,12-14H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 63n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013997
PNG
(CHEMBL3260523)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1C)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H24ClN3O2/c1-4-31-24(30)25(3,15-19-8-6-5-7-17(19)2)22-13-14-27-23-21(16-28-29(22)23)18-9-11-20(26)12-10-18/h5-14,16H,4,15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 110n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014036
PNG
(CHEMBL3260508)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)C1CCN(CC1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C28H36N4O4/c1-6-35-25(33)28(5,18-20-10-8-7-9-11-20)23-12-15-29-24-22(19-30-32(23)24)21-13-16-31(17-14-21)26(34)36-27(2,3)4/h7-12,15,19,21H,6,13-14,16-18H2,1-5H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 560n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014043
PNG
(CHEMBL3260510)
Show SMILES CCOC(=O)C(C)(Cc1ccc(cc1)S(C)(=O)=O)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H24ClN3O4S/c1-4-33-24(30)25(2,15-17-5-11-20(12-6-17)34(3,31)32)22-13-14-27-23-21(16-28-29(22)23)18-7-9-19(26)10-8-18/h5-14,16H,4,15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014064
PNG
(CHEMBL3260519)
Show SMILES CCOC(=O)[C@@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-7-5-4-6-8-17)21-13-14-26-22-20(16-27-28(21)22)18-9-11-19(25)12-10-18/h4-14,16H,3,15H2,1-2H3/t24-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50244791
PNG
((2-Fluoro-4-methanesulfonyl-phenyl)-{6-[4-(3-isopr...)
Show SMILES CC(C)c1nc([o+][n-]1)C1CCN(CC1)c1ncnc(Nc2ccc(cc2F)S(C)(=O)=O)c1[N+]([O-])=O
Show InChI InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 3.00E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013914
PNG
(CHEMBL3260518)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-7-5-4-6-8-17)21-13-14-26-22-20(16-27-28(21)22)18-9-11-19(25)12-10-18/h4-14,16H,3,15H2,1-2H3/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 510n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in mouse GLUTag cells assessed as stimulation of GLP1 secretion by CRE-luciferase reporter gene assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013914
PNG
(CHEMBL3260518)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-7-5-4-6-8-17)21-13-14-26-22-20(16-27-28(21)22)18-9-11-19(25)12-10-18/h4-14,16H,3,15H2,1-2H3/t24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 17n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014031
PNG
(CHEMBL3260539)
Show SMILES CC(Cc1ccccc1)(c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C23H20F3N3O2S/c1-22(32(2,30)31,14-16-6-4-3-5-7-16)20-12-13-27-21-19(15-28-29(20)21)17-8-10-18(11-9-17)23(24,25)26/h3-13,15H,14H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 243n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014037
PNG
(CHEMBL3260509)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1nc(no1)C(C)C
Show InChI InChI=1S/C23H25N5O3/c1-5-30-22(29)23(4,13-16-9-7-6-8-10-16)18-11-12-24-20-17(14-25-28(18)20)21-26-19(15(2)3)27-31-21/h6-12,14-15H,5,13H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 880n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013914
PNG
(CHEMBL3260518)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-7-5-4-6-8-17)21-13-14-26-22-20(16-27-28(21)22)18-9-11-19(25)12-10-18/h4-14,16H,3,15H2,1-2H3/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 76n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013913
PNG
(CHEMBL3260540)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1cnnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H21F3N4O2/c1-3-33-22(32)23(2,13-16-7-5-4-6-8-16)20-15-28-30-21-19(14-29-31(20)21)17-9-11-18(12-10-17)24(25,26)27/h4-12,14-15H,3,13H2,1-2H3/t23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 230n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in mouse GLUTag cells assessed as stimulation of GLP1 secretion by CRE-luciferase reporter gene assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013915
PNG
(CHEMBL1081913)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)OCc1nc(no1)-c1ccncc1
Show InChI InChI=1S/C18H24N4O4/c1-18(2,3)25-17(23)22-10-6-14(7-11-22)24-12-15-20-16(21-26-15)13-4-8-19-9-5-13/h4-5,8-9,14H,6-7,10-12H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 6.30E+5n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014002
PNG
(CHEMBL3260529)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccccc1Cl
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-9-5-4-6-10-17)21-13-14-26-22-19(16-27-28(21)22)18-11-7-8-12-20(18)25/h4-14,16H,3,15H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 180n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014039
PNG
(CHEMBL3260543)
Show SMILES CCOC(=O)C(Cc1ccccc1)C1=NC=NC2C1N=CN2c1ccc(OC(F)(F)F)cc1 |c:16,21,t:14|
Show InChI InChI=1S/C23H21F3N4O3/c1-2-32-22(31)18(12-15-6-4-3-5-7-15)19-20-21(28-13-27-19)30(14-29-20)16-8-10-17(11-9-16)33-23(24,25)26/h3-11,13-14,18,20-21H,2,12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.10E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014087
PNG
(CHEMBL3260534)
Show SMILES CCOC(=O)[C@@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F3N3O2/c1-3-33-23(32)24(2,15-17-7-5-4-6-8-17)21-13-14-29-22-20(16-30-31(21)22)18-9-11-19(12-10-18)25(26,27)28/h4-14,16H,3,15H2,1-2H3/t24-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>300n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013909
PNG
(CHEMBL3260505)
Show SMILES CCc1cnc(nc1)N1CCC(CC1)c1nc(COc2ccc(cc2)-n2cnnn2)cs1
Show InChI InChI=1S/C22H24N8OS/c1-2-16-11-23-22(24-12-16)29-9-7-17(8-10-29)21-26-18(14-32-21)13-31-20-5-3-19(4-6-20)30-15-25-27-28-30/h3-6,11-12,14-15,17H,2,7-10,13H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
PDB
UniChem

Patents

Similars
PDB
Article
PubMed
n/an/an/an/a 5.00E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013910
PNG
(CHEMBL3260504)
Show SMILES CC(C)c1noc(n1)N1CCC(COc2ccc(cc2)-c2ccc(nc2)S(C)(=O)=O)CC1
Show InChI InChI=1S/C23H28N4O4S/c1-16(2)22-25-23(31-26-22)27-12-10-17(11-13-27)15-30-20-7-4-18(5-8-20)19-6-9-21(24-14-19)32(3,28)29/h4-9,14,16-17H,10-13,15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 9.00E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013913
PNG
(CHEMBL3260540)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1cnnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C24H21F3N4O2/c1-3-33-22(32)23(2,13-16-7-5-4-6-8-16)20-15-28-30-21-19(14-29-31(20)21)17-9-11-18(12-10-17)24(25,26)27/h4-12,14-15H,3,13H2,1-2H3/t23-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 39n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013912
PNG
(CHEMBL3260536)
Show SMILES COCCN(C)C(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N4O2/c1-26(17-19-7-5-4-6-8-19,25(35)33(2)15-16-36-3)23-13-14-31-24-22(18-32-34(23)24)20-9-11-21(12-10-20)27(28,29)30/h4-14,18H,15-17H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 49n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013912
PNG
(CHEMBL3260536)
Show SMILES COCCN(C)C(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N4O2/c1-26(17-19-7-5-4-6-8-19,25(35)33(2)15-16-36-3)23-13-14-31-24-22(18-32-34(23)24)20-9-11-21(12-10-20)27(28,29)30/h4-14,18H,15-17H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 1n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013916
PNG
(CHEMBL3260535)
Show SMILES COCCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H24ClN3O3/c1-25(24(30)32-15-14-31-2,16-18-6-4-3-5-7-18)22-12-13-27-23-21(17-28-29(22)23)19-8-10-20(26)11-9-19/h3-13,17H,14-16H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013975
PNG
(CHEMBL3260542)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1csc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN2O2S/c1-3-28-22(27)23(2,13-16-7-5-4-6-8-16)20-15-29-21-19(14-25-26(20)21)17-9-11-18(24)12-10-17/h4-12,14-15H,3,13H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 53n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013992
PNG
(CHEMBL3260541)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(ncn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-7-5-4-6-8-17)20-13-14-26-22-21(27-16-28(20)22)18-9-11-19(25)12-10-18/h4-14,16H,3,15H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 62n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013994
PNG
(CHEMBL3260506)
Show SMILES CCOC(=O)C(Cc1c(F)cccc1Cl)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2FN3O2/c1-2-31-23(30)17(12-16-19(25)4-3-5-20(16)26)21-10-11-27-22-18(13-28-29(21)22)14-6-8-15(24)9-7-14/h3-11,13,17H,2,12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.40E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in mouse GLUTag cells assessed as stimulation of GLP1 secretion by CRE-luciferase reporter gene assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014041
PNG
(CHEMBL3260507)
Show SMILES CCOC(=O)C(Cc1c(F)cccc1Cl)c1ccnc2c(cnn12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C24H21ClFN3O4S/c1-3-33-24(30)18(13-17-20(25)5-4-6-21(17)26)22-11-12-27-23-19(14-28-29(22)23)15-7-9-16(10-8-15)34(2,31)32/h4-12,14,18H,3,13H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 1.30E+3n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014044
PNG
(CHEMBL3260516)
Show SMILES Fc1cccc(Cl)c1CCc1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H14Cl2FN3/c21-14-6-4-13(5-7-14)17-12-25-26-15(10-11-24-20(17)26)8-9-16-18(22)2-1-3-19(16)23/h1-7,10-12H,8-9H2
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013912
PNG
(CHEMBL3260536)
Show SMILES COCCN(C)C(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N4O2/c1-26(17-19-7-5-4-6-8-19,25(35)33(2)15-16-36-3)23-13-14-31-24-22(18-32-34(23)24)20-9-11-21(12-10-20)27(28,29)30/h4-14,18H,15-17H2,1-3H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 30n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in mouse GLUTag cells assessed as stimulation of GLP1 secretion by CRE-luciferase reporter gene assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013918
PNG
(CHEMBL3260512)
Show SMILES CCOC(=O)C(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClN3O2/c1-2-29-23(28)19(14-16-6-4-3-5-7-16)21-12-13-25-22-20(15-26-27(21)22)17-8-10-18(24)11-9-17/h3-13,15,19H,2,14H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 16n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013967
PNG
(CHEMBL3260527)
Show SMILES CCOC(=O)C(C)(Cc1cscn1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN4O2S/c1-3-28-20(27)21(2,10-16-12-29-13-24-16)18-8-9-23-19-17(11-25-26(18)19)14-4-6-15(22)7-5-14/h4-9,11-13H,3,10H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 40n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013994
PNG
(CHEMBL3260506)
Show SMILES CCOC(=O)C(Cc1c(F)cccc1Cl)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2FN3O2/c1-2-31-23(30)17(12-16-19(25)4-3-5-20(16)26)21-10-11-27-22-18(13-28-29(21)22)14-6-8-15(24)9-7-14/h3-11,13,17H,2,12H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 200n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014033
PNG
(CHEMBL3260513)
Show SMILES CCOC(=O)C(c1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClN3O2/c1-2-28-22(27)20(16-6-4-3-5-7-16)19-12-13-24-21-18(14-25-26(19)21)15-8-10-17(23)11-9-15/h3-14,20H,2H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 290n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014035
PNG
(CHEMBL3260511)
Show SMILES CCOC(=O)C(C)(CC1CCN(CC1)S(C)(=O)=O)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H29ClN4O4S/c1-4-33-23(30)24(2,15-17-10-13-28(14-11-17)34(3,31)32)21-9-12-26-22-20(16-27-29(21)22)18-5-7-19(25)8-6-18/h5-9,12,16-17H,4,10-11,13-15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 340n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013911
PNG
(CHEMBL3260533)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F3N3O2/c1-3-33-23(32)24(2,15-17-7-5-4-6-8-17)21-13-14-29-22-20(16-30-31(21)22)18-9-11-19(12-10-18)25(26,27)28/h4-14,16H,3,15H2,1-2H3/t24-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 330n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at GPR119 in mouse GLUTag cells assessed as stimulation of GLP1 secretion by CRE-luciferase reporter gene assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013917
PNG
(CHEMBL3260532)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C25H22F3N3O2/c1-3-33-23(32)24(2,15-17-7-5-4-6-8-17)21-13-14-29-22-20(16-30-31(21)22)18-9-11-19(12-10-18)25(26,27)28/h4-14,16H,3,15H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 11n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Mus musculus)		BDBM50013994
PNG
(CHEMBL3260506)
Show SMILES CCOC(=O)C(Cc1c(F)cccc1Cl)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H18Cl2FN3O2/c1-2-31-23(30)17(12-16-19(25)4-3-5-20(16)26)21-10-11-27-22-18(13-28-29(21)22)14-6-8-15(24)9-7-14/h3-11,13,17H,2,12H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 76n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013995
PNG
(CHEMBL3260526)
Show SMILES CCOC(=O)C(C)(Cc1cccnc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN4O2/c1-3-30-22(29)23(2,13-16-5-4-11-25-14-16)20-10-12-26-21-19(15-27-28(20)21)17-6-8-18(24)9-7-17/h4-12,14-15H,3,13H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 73n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013999
PNG
(CHEMBL3260521)
Show SMILES CCOC(=O)C(C)(Cc1ccc(C)cc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C25H24ClN3O2/c1-4-31-24(30)25(3,15-18-7-5-17(2)6-8-18)22-13-14-27-23-21(16-28-29(22)23)19-9-11-20(26)12-10-19/h5-14,16H,4,15H2,1-3H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 140n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013911
PNG
(CHEMBL3260533)
Show SMILES CCOC(=O)[C@](C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H22F3N3O2/c1-3-33-23(32)24(2,15-17-7-5-4-6-8-17)21-13-14-29-22-20(16-30-31(21)22)18-9-11-19(12-10-18)25(26,27)28/h4-14,16H,3,15H2,1-2H3/t24-/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/an/an/a 10n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013990
PNG
(CHEMBL3260531)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)nc1
Show InChI InChI=1S/C23H21ClN4O2/c1-3-30-22(29)23(2,13-16-7-5-4-6-8-16)19-11-12-25-21-18(15-27-28(19)21)17-9-10-20(24)26-14-17/h4-12,14-15H,3,13H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 58n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013998
PNG
(CHEMBL3260528)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1cccc(Cl)c1
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-8-5-4-6-9-17)21-12-13-26-22-20(16-27-28(21)22)18-10-7-11-19(25)14-18/h4-14,16H,3,15H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 130n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014001
PNG
(CHEMBL3260524)
Show SMILES CCOC(=O)C(C)(CC(C)C)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H24ClN3O2/c1-5-27-20(26)21(4,12-14(2)3)18-10-11-23-19-17(13-24-25(18)19)15-6-8-16(22)9-7-15/h6-11,13-14H,5,12H2,1-4H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 170n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014086
PNG
(CHEMBL3260530)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(Cc3ccc(Cl)cc3)cnn12
Show InChI InChI=1S/C25H24ClN3O2/c1-3-31-24(30)25(2,16-19-7-5-4-6-8-19)22-13-14-27-23-20(17-28-29(22)23)15-18-9-11-21(26)12-10-18/h4-14,17H,3,15-16H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013996
PNG
(CHEMBL3260537)
Show SMILES CC(=O)NC(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H21F3N4O/c1-16(32)30-23(2,14-17-6-4-3-5-7-17)21-12-13-28-22-20(15-29-31(21)22)18-8-10-19(11-9-18)24(25,26)27/h3-13,15H,14H2,1-2H3,(H,30,32)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 86n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014000
PNG
(CHEMBL3260538)
Show SMILES Cc1cnc(o1)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C26H21F3N4O/c1-17-15-31-24(34-17)25(2,14-18-6-4-3-5-7-18)22-12-13-30-23-21(16-32-33(22)23)19-8-10-20(11-9-19)26(27,28)29/h3-13,15-16H,14H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 164n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014003
PNG
(CHEMBL3260515)
Show SMILES CCOC(=O)C(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccccc1
Show InChI InChI=1S/C23H21N3O2/c1-2-28-23(27)19(15-17-9-5-3-6-10-17)21-13-14-24-22-20(16-25-26(21)22)18-11-7-4-8-12-18/h3-14,16,19H,2,15H2,1H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 190n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50014022
PNG
(CHEMBL3260520)
Show SMILES CCCC(Cc1ccccc1)(C(=O)OCC)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C26H26ClN3O2/c1-3-15-26(25(31)32-4-2,17-19-8-6-5-7-9-19)23-14-16-28-24-22(18-29-30(23)24)20-10-12-21(27)13-11-20/h5-14,16,18H,3-4,15,17H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 190n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50013958
PNG
(CHEMBL3260517)
Show SMILES CCOC(=O)C(C)(Cc1ccccc1)c1ccnc2c(cnn12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H22ClN3O2/c1-3-30-23(29)24(2,15-17-7-5-4-6-8-17)21-13-14-26-22-20(16-27-28(21)22)18-9-11-19(25)12-10-18/h4-14,16H,3,15H2,1-2H3
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 20n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as stimulation of cAMP production by HTRF assay

Bioorg Med Chem Lett 24: 2383-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.03.023
BindingDB Entry DOI: 10.7270/Q2KP83P1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%