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PubMed code 25268757

Compile data set for download or QSAR
Found 16 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))		BDBM50029090
PNG
(CHEMBL3343301)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1c(OCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C32H42ClN3O10S/c1-18(2)36-11-9-19(10-12-36)31(41)34-27-21(42-13-4-14-43-32-30(40)29(39)28(38)24(16-37)45-32)5-3-6-22(27)44-17-20-15-23(46-35-20)25-7-8-26(33)47-25/h3,5-8,15,18-19,24,28-30,32,37-40H,4,9-14,16-17H2,1-2H3,(H,34,41)/t24-,28-,29+,30-,32-/m1/s1
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PubMed
 0.0900n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029090
PNG
(CHEMBL3343301)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1c(OCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C32H42ClN3O10S/c1-18(2)36-11-9-19(10-12-36)31(41)34-27-21(42-13-4-14-43-32-30(40)29(39)28(38)24(16-37)45-32)5-3-6-22(27)44-17-20-15-23(46-35-20)25-7-8-26(33)47-25/h3,5-8,15,18-19,24,28-30,32,37-40H,4,9-14,16-17H2,1-2H3,(H,34,41)/t24-,28-,29+,30-,32-/m1/s1
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 0.0960n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Lineweaver-Burk analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029091
PNG
(CHEMBL3343299)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1ccccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C23H26ClN3O3S/c1-15(2)27-11-9-16(10-12-27)23(28)25-18-5-3-4-6-19(18)29-14-17-13-20(30-26-17)21-7-8-22(24)31-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,25,28)
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 0.110n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Lineweaver-Burk analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029095
PNG
(CHEMBL3343300)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1c(OCCCO[C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C40H50ClN3O14S/c1-22(2)44-15-13-27(14-16-44)39(49)42-35-29(9-7-10-30(35)53-20-28-19-31(58-43-28)33-11-12-34(41)59-33)50-17-8-18-51-40-38(56-26(6)48)37(55-25(5)47)36(54-24(4)46)32(57-40)21-52-23(3)45/h7,9-12,19,22,27,32,36-38,40H,8,13-18,20-21H2,1-6H3,(H,42,49)/t32-,36-,37+,38-,40-/m1/s1
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 0.25n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029091
PNG
(CHEMBL3343299)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1ccccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C23H26ClN3O3S/c1-15(2)27-11-9-16(10-12-27)23(28)25-18-5-3-4-6-19(18)29-14-17-13-20(30-26-17)21-7-8-22(24)31-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,25,28)
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 0.600n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029090
PNG
(CHEMBL3343301)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1c(OCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C32H42ClN3O10S/c1-18(2)36-11-9-19(10-12-36)31(41)34-27-21(42-13-4-14-43-32-30(40)29(39)28(38)24(16-37)45-32)5-3-6-22(27)44-17-20-15-23(46-35-20)25-7-8-26(33)47-25/h3,5-8,15,18-19,24,28-30,32,37-40H,4,9-14,16-17H2,1-2H3,(H,34,41)/t24-,28-,29+,30-,32-/m1/s1
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 0.870n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Lineweaver-Burk analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029091
PNG
(CHEMBL3343299)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1ccccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C23H26ClN3O3S/c1-15(2)27-11-9-16(10-12-27)23(28)25-18-5-3-4-6-19(18)29-14-17-13-20(30-26-17)21-7-8-22(24)31-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,25,28)
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 18n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Lineweaver-Burk analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029090
PNG
(CHEMBL3343301)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1c(OCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C32H42ClN3O10S/c1-18(2)36-11-9-19(10-12-36)31(41)34-27-21(42-13-4-14-43-32-30(40)29(39)28(38)24(16-37)45-32)5-3-6-22(27)44-17-20-15-23(46-35-20)25-7-8-26(33)47-25/h3,5-8,15,18-19,24,28-30,32,37-40H,4,9-14,16-17H2,1-2H3,(H,34,41)/t24-,28-,29+,30-,32-/m1/s1
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 100n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029095
PNG
(CHEMBL3343300)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1c(OCCCO[C@@H]2O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]2OC(C)=O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C40H50ClN3O14S/c1-22(2)44-15-13-27(14-16-44)39(49)42-35-29(9-7-10-30(35)53-20-28-19-31(58-43-28)33-11-12-34(41)59-33)50-17-8-18-51-40-38(56-26(6)48)37(55-25(5)47)36(54-24(4)46)32(57-40)21-52-23(3)45/h7,9-12,19,22,27,32,36-38,40H,8,13-18,20-21H2,1-6H3,(H,42,49)/t32-,36-,37+,38-,40-/m1/s1
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 160n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029092
PNG
(CHEMBL3343304)
Show SMILES Nc1c(OCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C23H27ClN2O9S/c24-18-6-5-17(36-18)15-9-12(26-35-15)11-33-14-4-1-3-13(19(14)25)31-7-2-8-32-23-22(30)21(29)20(28)16(10-27)34-23/h1,3-6,9,16,20-23,27-30H,2,7-8,10-11,25H2/t16-,20-,21+,22-,23-/m1/s1
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 6.90E+3n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029091
PNG
(CHEMBL3343299)
Show SMILES CC(C)N1CCC(CC1)C(=O)Nc1ccccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C23H26ClN3O3S/c1-15(2)27-11-9-16(10-12-27)23(28)25-18-5-3-4-6-19(18)29-14-17-13-20(30-26-17)21-7-8-22(24)31-21/h3-8,13,15-16H,9-12,14H2,1-2H3,(H,25,28)
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 1.10E+4n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029094
PNG
(CHEMBL3343302)
Show SMILES Nc1ccccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C14H11ClN2O2S/c15-14-6-5-13(20-14)12-7-9(17-19-12)8-18-11-4-2-1-3-10(11)16/h1-7H,8,16H2
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 1.16E+4n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))		BDBM50029093
PNG
(CHEMBL3343303)
Show SMILES Nc1c(OCCCO)cccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2O4S/c18-16-6-5-15(25-16)14-9-11(20-24-14)10-23-13-4-1-3-12(17(13)19)22-8-2-7-21/h1,3-6,9,21H,2,7-8,10,19H2
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 1.83E+4n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of human factor10a assessed as reduction in hydrolysis of chromogenic substrate S-2765 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029093
PNG
(CHEMBL3343303)
Show SMILES Nc1c(OCCCO)cccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C17H17ClN2O4S/c18-16-6-5-15(25-16)14-9-11(20-24-14)10-23-13-4-1-3-12(17(13)19)22-8-2-7-21/h1,3-6,9,21H,2,7-8,10,19H2
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 2.98E+4n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029094
PNG
(CHEMBL3343302)
Show SMILES Nc1ccccc1OCc1cc(on1)-c1ccc(Cl)s1
Show InChI InChI=1S/C14H11ClN2O2S/c15-14-6-5-13(20-14)12-7-9(17-19-12)8-18-11-4-2-1-3-10(11)16/h1-7H,8,16H2
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 3.10E+4n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
Prothrombin


(Bos taurus (Bovine))		BDBM50029092
PNG
(CHEMBL3343304)
Show SMILES Nc1c(OCCCO[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)cccc1OCc1cc(on1)-c1ccc(Cl)s1 |r|
Show InChI InChI=1S/C23H27ClN2O9S/c24-18-6-5-17(36-18)15-9-12(26-35-15)11-33-14-4-1-3-13(19(14)25)31-7-2-8-32-23-22(30)21(29)20(28)16(10-27)34-23/h1,3-6,9,16,20-23,27-30H,2,7-8,10-11,25H2/t16-,20-,21+,22-,23-/m1/s1
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 1.33E+5n/an/an/an/an/an/an/an/a



Consiglio Nazionale delle Ricerche

Curated by ChEMBL


Assay Description
Inhibition of bovine thrombin assessed as reduction in hydrolysis of chromogenic substrate S-2238 by Cheng-Prusoff equation analysis

J Med Chem 57: 8563-75 (2014)


Article DOI: 10.1021/jm5010754
BindingDB Entry DOI: 10.7270/Q2GT5PSQ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%