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PubMed code 25958245

Compile data set for download or QSAR
Found 38 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Scavenger receptor class B member 1


(Mus musculus)		BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088281
PNG
(CHEMBL3427475)
Show SMILES COc1ccc(cc1OC)-c1cc(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCCC2)no1
Show InChI InChI=1S/C27H37N3O5/c1-18(27(32)28-20-9-7-8-10-20)30(22-11-5-4-6-12-22)26(31)17-21-16-24(35-29-21)19-13-14-23(33-2)25(15-19)34-3/h13-16,18,20,22H,4-12,17H2,1-3H3,(H,28,32)
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n/an/a 23n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088195
PNG
(CHEMBL3427497)
Show SMILES O=C(CN(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)NC1CCCC1
Show InChI InChI=1S/C23H30N6O4/c30-21(24-17-6-4-5-7-17)13-28(18-8-2-1-3-9-18)22(31)14-29-26-23(25-27-29)16-10-11-19-20(12-16)33-15-32-19/h10-12,17-18H,1-9,13-15H2,(H,24,30)
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n/an/a 26n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088267
PNG
(CHEMBL3427489)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)
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n/an/a 27n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088283
PNG
(CHEMBL1478888)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C25H36N6O4/c1-17(25(33)26-19-9-7-8-10-19)31(20-11-5-4-6-12-20)23(32)16-30-28-24(27-29-30)18-13-14-21(34-2)22(15-18)35-3/h13-15,17,19-20H,4-12,16H2,1-3H3,(H,26,33)
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n/an/a 55n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088257
PNG
(CHEMBL1612527)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCC2)n1
Show InChI InChI=1S/C24H34N6O4/c1-16(24(32)25-18-8-4-5-9-18)30(19-10-6-7-11-19)22(31)15-29-27-23(26-28-29)17-12-13-20(33-2)21(14-17)34-3/h12-14,16,18-19H,4-11,15H2,1-3H3,(H,25,32)
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n/an/a 110n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088268
PNG
(CHEMBL3427488)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc(F)cc1)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H31FN6O2/c1-16(23(32)25-19-7-5-6-8-19)30(20-9-3-2-4-10-20)21(31)15-29-27-22(26-28-29)17-11-13-18(24)14-12-17/h11-14,16,19-20H,2-10,15H2,1H3,(H,25,32)
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n/an/a 130n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088282
PNG
(CHEMBL3427474)
Show SMILES COc1ccc(cc1OC)-c1nc(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCCC2)co1
Show InChI InChI=1S/C27H37N3O5/c1-18(26(32)28-20-9-7-8-10-20)30(22-11-5-4-6-12-22)25(31)16-21-17-35-27(29-21)19-13-14-23(33-2)24(15-19)34-3/h13-15,17-18,20,22H,4-12,16H2,1-3H3,(H,28,32)
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n/an/a 130n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088275
PNG
(CHEMBL3427481)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc(Cl)cc1)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H31ClN6O2/c1-16(23(32)25-19-7-5-6-8-19)30(20-9-3-2-4-10-20)21(31)15-29-27-22(26-28-29)17-11-13-18(24)14-12-17/h11-14,16,19-20H,2-10,15H2,1H3,(H,25,32)
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n/an/a 170n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088274
PNG
(CHEMBL3427482)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc(Cl)c(Cl)c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H30Cl2N6O2/c1-15(23(33)26-17-7-5-6-8-17)31(18-9-3-2-4-10-18)21(32)14-30-28-22(27-29-30)16-11-12-19(24)20(25)13-16/h11-13,15,17-18H,2-10,14H2,1H3,(H,26,33)
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n/an/a 180n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088278
PNG
(CHEMBL3427478)
Show SMILES COc1cccc(c1)-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C24H34N6O3/c1-17(24(32)25-19-10-6-7-11-19)30(20-12-4-3-5-13-20)22(31)16-29-27-23(26-28-29)18-9-8-14-21(15-18)33-2/h8-9,14-15,17,19-20H,3-7,10-13,16H2,1-2H3,(H,25,32)
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Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088287
PNG
(CHEMBL3427471)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C26H38N6O4/c1-18(26(34)27-20-10-6-4-7-11-20)32(21-12-8-5-9-13-21)24(33)17-31-29-25(28-30-31)19-14-15-22(35-2)23(16-19)36-3/h14-16,18,20-21H,4-13,17H2,1-3H3,(H,27,34)
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n/an/a 200n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088273
PNG
(CHEMBL3427483)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OC(F)(F)Oc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H30F2N6O4/c1-15(23(34)27-17-7-5-6-8-17)32(18-9-3-2-4-10-18)21(33)14-31-29-22(28-30-31)16-11-12-19-20(13-16)36-24(25,26)35-19/h11-13,15,17-18H,2-10,14H2,1H3,(H,27,34)
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Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50069697
PNG
(CHEMBL2356172)
Show SMILES CC(C)NC(=O)Nc1ccc2O[C@@H](CN(C)S(=O)(=O)c3ccc(Cl)cc3)[C@H](C)CN([C@H](C)CO)C(=O)c2c1
Show InChI InChI=1S/C26H35ClN4O6S/c1-16(2)28-26(34)29-20-8-11-23-22(12-20)25(33)31(18(4)15-32)13-17(3)24(37-23)14-30(5)38(35,36)21-9-6-19(27)7-10-21/h6-12,16-18,24,32H,13-15H2,1-5H3,(H2,28,29,34)/t17-,18-,24+/m1/s1
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n/an/a 250n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088272
PNG
(CHEMBL3427484)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccccc1)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H32N6O2/c1-17(23(31)24-19-12-8-9-13-19)29(20-14-6-3-7-15-20)21(30)16-28-26-22(25-27-28)18-10-4-2-5-11-18/h2,4-5,10-11,17,19-20H,3,6-9,12-16H2,1H3,(H,24,31)
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Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088271
PNG
(CHEMBL3427485)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1cccc(F)c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H31FN6O2/c1-16(23(32)25-19-10-5-6-11-19)30(20-12-3-2-4-13-20)21(31)15-29-27-22(26-28-29)17-8-7-9-18(24)14-17/h7-9,14,16,19-20H,2-6,10-13,15H2,1H3,(H,25,32)
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Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088288
PNG
(CHEMBL3427472)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC2CC2)C2CCCCC2)n1
Show InChI InChI=1S/C23H32N6O4/c1-15(23(31)24-17-10-11-17)29(18-7-5-4-6-8-18)21(30)14-28-26-22(25-27-28)16-9-12-19(32-2)20(13-16)33-3/h9,12-13,15,17-18H,4-8,10-11,14H2,1-3H3,(H,24,31)
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n/an/a 420n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088269
PNG
(CHEMBL3427487)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc(C)cc1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H34N6O2/c1-17-12-14-19(15-13-17)23-26-28-29(27-23)16-22(31)30(21-10-4-3-5-11-21)18(2)24(32)25-20-8-6-7-9-20/h12-15,18,20-21H,3-11,16H2,1-2H3,(H,25,32)
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n/an/a 490n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088270
PNG
(CHEMBL3427486)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccccc1F)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H31FN6O2/c1-16(23(32)25-17-9-5-6-10-17)30(18-11-3-2-4-12-18)21(31)15-29-27-22(26-28-29)19-13-7-8-14-20(19)24/h7-8,13-14,16-18H,2-6,9-12,15H2,1H3,(H,25,32)
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n/an/a 620n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50323654
PNG
(CHEMBL1208829 | N-(5-tert-butyl-2-methoxy-3-(methy...)
Show SMILES COc1c(NC(=O)C(=O)c2ccc(OCCN3CCOCC3)c3ccccc23)cc(cc1NS(C)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C30H37N3O7S/c1-30(2,3)20-18-24(28(38-4)25(19-20)32-41(5,36)37)31-29(35)27(34)23-10-11-26(22-9-7-6-8-21(22)23)40-17-14-33-12-15-39-16-13-33/h6-11,18-19,32H,12-17H2,1-5H3,(H,31,35)
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n/an/a 770n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation count...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088284
PNG
(CHEMBL3427468)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC(C)C)C2CCCCC2)n1
Show InChI InChI=1S/C23H34N6O4/c1-15(2)24-23(31)16(3)29(18-9-7-6-8-10-18)21(30)14-28-26-22(25-27-28)17-11-12-19(32-4)20(13-17)33-5/h11-13,15-16,18H,6-10,14H2,1-5H3,(H,24,31)
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n/an/a 810n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088264
PNG
(CHEMBL3427492)
Show SMILES CC(N(C1CCOCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H30N6O5/c1-15(23(31)24-17-4-2-3-5-17)29(18-8-10-32-11-9-18)21(30)13-28-26-22(25-27-28)16-6-7-19-20(12-16)34-14-33-19/h6-7,12,15,17-18H,2-5,8-11,13-14H2,1H3,(H,24,31)
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n/an/a 840n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088265
PNG
(CHEMBL3427491)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(CC2CCCCC2)C(C)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C26H38N6O4/c1-18(26(34)27-21-11-7-8-12-21)31(16-19-9-5-4-6-10-19)24(33)17-32-29-25(28-30-32)20-13-14-22(35-2)23(15-20)36-3/h13-15,18-19,21H,4-12,16-17H2,1-3H3,(H,27,34)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088289
PNG
(CHEMBL3427473)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)N(C)C2CCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C26H38N6O4/c1-18(26(34)30(2)20-10-8-9-11-20)32(21-12-6-5-7-13-21)24(33)17-31-28-25(27-29-31)19-14-15-22(35-3)23(16-19)36-4/h14-16,18,20-21H,5-13,17H2,1-4H3
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n/an/a 1.60E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088194
PNG
(CHEMBL3427498)
Show SMILES C[C@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1 |r|
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088276
PNG
(CHEMBL3427480)
Show SMILES CC(N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccccc1Cl)C(=O)NC1CCCC1
Show InChI InChI=1S/C23H31ClN6O2/c1-16(23(32)25-17-9-5-6-10-17)30(18-11-3-2-4-12-18)21(31)15-29-27-22(26-28-29)19-13-7-8-14-20(19)24/h7-8,13-14,16-18H,2-6,9-12,15H2,1H3,(H,25,32)
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n/an/a 3.80E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088279
PNG
(CHEMBL3427477)
Show SMILES COc1ccc(cc1OC)-c1nc(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCCC2)cs1
Show InChI InChI=1S/C27H37N3O4S/c1-18(26(32)28-20-9-7-8-10-20)30(22-11-5-4-6-12-22)25(31)16-21-17-35-27(29-21)19-13-14-23(33-2)24(15-19)34-3/h13-15,17-18,20,22H,4-12,16H2,1-3H3,(H,28,32)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088286
PNG
(CHEMBL3427470)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)N2CCCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C25H36N6O4/c1-18(25(33)29-14-8-5-9-15-29)31(20-10-6-4-7-11-20)23(32)17-30-27-24(26-28-30)19-12-13-21(34-2)22(16-19)35-3/h12-13,16,18,20H,4-11,14-15,17H2,1-3H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088266
PNG
(CHEMBL3427490)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CC2)n1
Show InChI InChI=1S/C22H30N6O4/c1-14(22(30)23-16-6-4-5-7-16)28(17-9-10-17)20(29)13-27-25-21(24-26-27)15-8-11-18(31-2)19(12-15)32-3/h8,11-12,14,16-17H,4-7,9-10,13H2,1-3H3,(H,23,30)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088285
PNG
(CHEMBL3427469)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC(C)(C)C)C2CCCCC2)n1
Show InChI InChI=1S/C24H36N6O4/c1-16(23(32)25-24(2,3)4)30(18-10-8-7-9-11-18)21(31)15-29-27-22(26-28-29)17-12-13-19(33-5)20(14-17)34-6/h12-14,16,18H,7-11,15H2,1-6H3,(H,25,32)
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n/an/a 1.70E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088258
PNG
(CHEMBL3427493)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C)C(C)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C20H28N6O4/c1-13(20(28)21-15-7-5-6-8-15)25(2)18(27)12-26-23-19(22-24-26)14-9-10-16(29-3)17(11-14)30-4/h9-11,13,15H,5-8,12H2,1-4H3,(H,21,28)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088239
PNG
(CHEMBL3427495)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C2CCCCC2)C(C)(C)C(=O)NC2CCCC2)n1
Show InChI InChI=1S/C26H38N6O4/c1-26(2,25(34)27-19-10-8-9-11-19)32(20-12-6-5-7-13-20)23(33)17-31-29-24(28-30-31)18-14-15-21(35-3)22(16-18)36-4/h14-16,19-20H,5-13,17H2,1-4H3,(H,27,34)
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n/an/a 1.90E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088240
PNG
(CHEMBL3427494)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCN(C)CC2)n1
Show InChI InChI=1S/C25H37N7O4/c1-17(25(34)26-19-7-5-6-8-19)32(20-11-13-30(2)14-12-20)23(33)16-31-28-24(27-29-31)18-9-10-21(35-3)22(15-18)36-4/h9-10,15,17,19-20H,5-8,11-14,16H2,1-4H3,(H,26,34)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088238
PNG
(CHEMBL3427496)
Show SMILES COc1ccc(cc1OC)-c1nnn(CC(=O)N(C(C(C)C)C(=O)NC2CCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C27H40N6O4/c1-18(2)25(27(35)28-20-10-8-9-11-20)33(21-12-6-5-7-13-21)24(34)17-32-30-26(29-31-32)19-14-15-22(36-3)23(16-19)37-4/h14-16,18,20-21,25H,5-13,17H2,1-4H3,(H,28,35)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088277
PNG
(CHEMBL3427479)
Show SMILES COc1ccccc1-c1nnn(CC(=O)N(C(C)C(=O)NC2CCCC2)C2CCCCC2)n1
Show InChI InChI=1S/C24H34N6O3/c1-17(24(32)25-18-10-6-7-11-18)30(19-12-4-3-5-13-19)22(31)16-29-27-23(26-28-29)20-14-8-9-15-21(20)33-2/h8-9,14-15,17-19H,3-7,10-13,16H2,1-2H3,(H,25,32)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50088280
PNG
(CHEMBL3427476)
Show SMILES CC(N(C1CCCCC1)C(=O)Cc1ccccc1)C(=O)NC1CCCC1
Show InChI InChI=1S/C22H32N2O2/c1-17(22(26)23-19-12-8-9-13-19)24(20-14-6-3-7-15-20)21(25)16-18-10-4-2-5-11-18/h2,4-5,10-11,17,19-20H,3,6-9,12-16H2,1H3,(H,23,26)
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n/an/a 3.70E+4n/an/an/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into c...

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
Scavenger receptor class B member 1


(Mus musculus)		BDBM50069751
PNG
(CHEMBL2356114)
Show SMILES C[C@@H](N(C1CCCCC1)C(=O)Cn1nnc(n1)-c1ccc2OCOc2c1)C(=O)NC1CCCC1
Show InChI InChI=1S/C24H32N6O4/c1-16(24(32)25-18-7-5-6-8-18)30(19-9-3-2-4-10-19)22(31)14-29-27-23(26-28-29)17-11-12-20-21(13-17)34-15-33-20/h11-13,16,18-19H,2-10,14-15H2,1H3,(H,25,32)/t16-/m1/s1
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n/an/an/an/a 270n/an/an/an/a



Marquette University

Curated by ChEMBL


Assay Description
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as increase in binding of Alexa-488-labeled HDL particles to cells

Bioorg Med Chem Lett 25: 2594-8 (2015)


Article DOI: 10.1016/j.bmcl.2015.03.074
BindingDB Entry DOI: 10.7270/Q25Q4XTV
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%