Affinity Data by PubMed id=26099069

PubMed code 26099069

Found 15 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50106249 (CHEMBL92139 \| [2-(1-Benzenesulfonyl-1H-indol-4-yl)...) Show SMILES CN(C)CCc1cccc2n(ccc12)S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HeLa cells after 60 mins by scintillation spectrometry				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM21358 (2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counter				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM34141 (CHEMBL76237 \| MS-245) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	2.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50106250 (CHEMBL93868 \| N,N-dimethyl-2-(1-(phenylsulfonyl)-1...) Show SMILES CN(C)CCc1cn(c2ccccc12)S(=O)(=O)c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	2.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HeLa cells after 60 mins by scintillation spectrometry				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50300828 (2-(3-(3-fluorophenylsulfonyl)-1H-pyrrolo[2,3-b]pyr...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	4.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells by scintillation counter				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM21354 (2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-y...) Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(Cl)s1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells after 120 mins by scintillation counter				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM21366 ((2-{3-[(3-fluorobenzene)sulfonyl]-1H-indol-1-yl}et...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of radioligand from human 5-HT6 receptor expressed in HeLa cells by scintillation counter				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM34142 (2-ethyl-5-methoxy-N,N-dimethyltryptamine \| CHEMBL2...) Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	16	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50085970 (CHEMBL7318 \| [2-(5-Methoxy-2-phenyl-1H-indol-3-yl)...) Show SMILES COc1ccc2[nH]c(c(CCN(C)C)c2c1)-c1ccccc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor transfected in HEK293 cells after 60 mins by liquid scintillation spectromet...				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (RAT)	BDBM50171234 (CHEMBL365751 \| [2-(5-Chloro-2-methyl-1H-indol-3-yl...) Show SMILES CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12 Show InChI	PDB Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	29	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Displacement of [3H] lysergic acid diethylamide from rat 5-HT6 receptor transfected in HEK293 cells after 60 mins by scintillation counter				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
5-hydroxytryptamine receptor 2B (Homo sapiens (Human))	BDBM50171234 (CHEMBL365751 \| [2-(5-Chloro-2-methyl-1H-indol-3-yl...) Show SMILES CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	245	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Binding affinity to 5-HT2B receptor (unknown origin)				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 7 (Homo sapiens (Human))	BDBM50171234 (CHEMBL365751 \| [2-(5-Chloro-2-methyl-1H-indol-3-yl...) Show SMILES CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Binding affinity to 5-HT7 receptor (unknown origin)				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A/Alpha-2B/Alpha-2C adrenergic receptor (Homo sapiens (Human))	BDBM50171234 (CHEMBL365751 \| [2-(5-Chloro-2-methyl-1H-indol-3-yl...) Show SMILES CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12 Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	Article PubMed	300	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Binding affinity to human recombinant alpha2 adrenergic receptor				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50300828 (2-(3-(3-fluorophenylsulfonyl)-1H-pyrrolo[2,3-b]pyr...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	7.30	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 6 (Homo sapiens (Human))	BDBM50171234 (CHEMBL365751 \| [2-(5-Chloro-2-methyl-1H-indol-3-yl...) Show SMILES CN(C)CCc1c(C)[nH]c2ccc(Cl)cc12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	45	n/a	n/a	n/a	n/a
Universit£ de Caen Basse-Normandie Curated by ChEMBL					Assay Description Agonist activity at 5-HT6 receptor (unknown origin)				J Med Chem 58: 7901-12 (2015) Article DOI: 10.1021/acs.jmedchem.5b00179 BindingDB Entry DOI: 10.7270/Q2M90BGQ
Universit£ de Caen Basse-Normandie Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%