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PubMed code 26264844

Compile data set for download or QSAR
Found 20 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110843
PNG
(CHEMBL3604542)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32+;;;;/m1..../s1
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n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110843
PNG
(CHEMBL3604542)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32+;;;;/m1..../s1
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n/an/a 560n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110892
PNG
(CHEMBL3604537)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O |r|
Show InChI InChI=1S/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31-;;;;/m1..../s1
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n/an/a 1.19E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110895
PNG
(CHEMBL3604540)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32+;;;;/m1..../s1
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n/an/a 1.24E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110892
PNG
(CHEMBL3604537)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O |r|
Show InChI InChI=1S/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31-;;;;/m1..../s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110844
PNG
(CHEMBL3604543)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32-;;;;/m1..../s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110844
PNG
(CHEMBL3604543)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C11H18N5O13P3S.4H3N/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(27-10)2-26-32(25,33)29-31(23,24)28-30(20,21)22;;;;/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,33);4*1H3/t4-,6-,7-,10-,32-;;;;/m1..../s1
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n/an/a 1.44E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110895
PNG
(CHEMBL3604540)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32+;;;;/m1..../s1
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n/an/a 1.49E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50316302
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1
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n/an/a 2.36E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110894
PNG
(CHEMBL3604539)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O |r|
Show InChI InChI=1S/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33-;;;;/m1..../s1
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n/an/a 2.55E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110896
PNG
(CHEMBL3604541)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32-;;;;/m1..../s1
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n/an/a 2.61E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110893
PNG
(CHEMBL3604538)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O |r|
Show InChI InChI=1S/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33+;;;;/m1..../s1
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n/an/a 3.22E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110891
PNG
(CHEMBL3604536)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O |r|
Show InChI InChI=1S/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31+;;;;/m1..../s1
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n/an/a 3.26E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110894
PNG
(CHEMBL3604539)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O |r|
Show InChI InChI=1S/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33-;;;;/m1..../s1
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n/an/a 3.26E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110896
PNG
(CHEMBL3604541)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].C[n+]1cn([C@@H]2O[C@H](CO[P@]([S-])(=O)OP([O-])(=O)CP([O-])([O-])=O)[C@@H](O)[C@H]2O)c2nc(N)nc([O-])c12 |r|
Show InChI InChI=1S/C12H20N5O12P3S.4H3N/c1-16-3-17(9-6(16)10(20)15-12(13)14-9)11-8(19)7(18)5(28-11)2-27-32(26,33)29-31(24,25)4-30(21,22)23;;;;/h3,5,7-8,11,18-19H,2,4H2,1H3,(H6-,13,14,15,20,21,22,23,24,25,26,33);4*1H3/t5-,7-,8-,11-,32-;;;;/m1..../s1
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n/an/a 3.68E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110891
PNG
(CHEMBL3604536)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)OP([O-])([O-])=O |r|
Show InChI InChI=1S/C11H21BN5O13P3.4H3N/c1-16-3-17(8-5(16)9(20)15-11(13)14-8)10-7(19)6(18)4(28-10)2-27-31(12,21)29-33(25,26)30-32(22,23)24;;;;/h3-4,6-7,10,18-19H,2H2,1,12H3,(H,25,26)(H2,22,23,24)(H3,13,14,15,20);4*1H3/t4-,6-,7-,10-,31+;;;;/m1..../s1
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PubMed
n/an/a 4.12E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110893
PNG
(CHEMBL3604538)
Show SMILES [NH4+].[NH4+].[NH4+].[NH4+].[BH3-][P@](=O)(OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1c[n+](C)c2c([O-])nc(N)nc12)OP([O-])(=O)CP([O-])([O-])=O |r|
Show InChI InChI=1S/C12H23BN5O12P3.4H3N/c1-17-3-18(9-6(17)10(21)16-12(14)15-9)11-8(20)7(19)5(29-11)2-28-33(13,27)30-32(25,26)4-31(22,23)24;;;;/h3,5,7-8,11,19-20H,2,4H2,1,13H3,(H,25,26)(H2,22,23,24)(H3,14,15,16,21);4*1H3/t5-,7-,8-,11-,33+;;;;/m1..../s1
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n/an/a 4.47E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50316302
PNG
(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Show InChI InChI=1S/C11H18N5O14P3/c1-15-3-16(8-5(15)9(19)14-11(12)13-8)10-7(18)6(17)4(28-10)2-27-32(23,24)30-33(25,26)29-31(20,21)22/h3-4,6-7,10,17-18H,2H2,1H3,(H6-,12,13,14,19,20,21,22,23,24,25,26)/t4-,6-,7-,10-/m1/s1
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n/an/a 5.72E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110845
PNG
(CHEMBL3351000)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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n/an/a 8.30E+3n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA treated simultaneously with mRNA by luminescence b...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
Eukaryotic translation initiation factor 4E


(Oryctolagus cuniculus)		BDBM50110845
PNG
(CHEMBL3351000)
Show SMILES C[n+]1cn([C@@H]2O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12 |r|
Show InChI InChI=1S/C21H29N10O18P3/c1-29-5-31(15-9(29)17(37)28-21(23)26-15)19-13(35)11(33)7(47-19)3-45-51(40,41)49-52(42,43)48-50(38,39)44-2-6-10(32)12(34)18(46-6)30-4-24-8-14(30)25-20(22)27-16(8)36/h4-7,10-13,18-19,32-35H,2-3H2,1H3,(H8-,22,23,25,26,27,28,36,37,38,39,40,41,42,43)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1
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PubMed
n/an/a 2.50E+4n/an/an/an/an/an/a



University of Warsaw

Curated by ChEMBL


Assay Description
Inhibition of eIF4E-mediated translation in flexi rabbit reticulocyte lysate using luciferase mRNA preincubated for 60 mins before mRNA addition by l...

Bioorg Med Chem 23: 5369-81 (2015)


Article DOI: 10.1016/j.bmc.2015.07.052
BindingDB Entry DOI: 10.7270/Q2DN46V3
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%