Affinity Data by PubMed id=27131066

PubMed code 27131066

Found 36 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of wild type N-terminal GST-tagged recombinant human RET (658 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50021574 (BMS-907351 \| CABOZANTINIB \| CHEBI:72317 \| Cabomety...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of wild type N-terminal GST-tagged recombinant human RET (658 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.40	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human ALK (1058 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubat...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.70	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ALK C1156Y mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.90	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ALK L1196M mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50362781 (1256580-46-7 \| AF802 \| Alecensa \| Alectinib \| CH54...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	4.80	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of wild type recombinant human RET using Biotin-EGPWLEEEEEAYGWMDF as substrate incubated for 60 mins by TR-FRET assay				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.60	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ALK R1275Q mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ALK G1269A mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.5	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ALK F1174L mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human RET V804M mutant (658 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substr...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assay				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50362781 (1256580-46-7 \| AF802 \| Alecensa \| Alectinib \| CH54...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	19	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assay				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Insulin-like growth factor 1 receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	28	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human IGF-1R (959 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incub...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ALK T1151ins mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Leukocyte tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant LTK (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187715 (CHEMBL3735386) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	49	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assay				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor beta (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	64	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human PDGFRbeta (557 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate in...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human TYRO3 (451 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incuba...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant human c-Src expressed in insect Sf9 cells using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	86	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human FLT3 (564 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Macrophage-stimulating protein receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	93	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human Ron (983 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human KDR (790 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50187714 (CHEMBL3736388) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	126	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assay				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 1 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human FLT1 (783 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant human AXL using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-4 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	213	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human ErbB4 (709 to 991 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
ALK tyrosine kinase receptor (Homo sapiens (Human))	BDBM50158419 (CHEMBL3734798) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	261	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assay				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human EGFR T790M/L858R double mutant (696 residues) expressed in insect Sf21 cells using poly(Glu,Tyr...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Platelet-derived growth factor receptor alpha (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	402	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human PDGFRalpha (550 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate i...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM50021574 (BMS-907351 \| CABOZANTINIB \| CHEBI:72317 \| Cabomety...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	811	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human RET V804M mutant (658 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substr...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of human ErbB2 using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase ABL1 (Mus musculus)	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant mouse ABL (27 to 1123 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate i...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of recombinant ROS1 (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISA				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human FGFR1 (456 to 765 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate ...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Mast/stem cell growth factor receptor Kit (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal GST-tagged recombinant human c-Kit (544 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubat...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50187716 (CHEMBL3735648) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant human c-Met (974 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incuba...				Eur J Med Chem 118: 244-9 (2016) Article DOI: 10.1016/j.ejmech.2016.04.046 BindingDB Entry DOI: 10.7270/Q2Q81G02
Chinese Academy of Sciences Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%