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PubMed code 28921985

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein Mdm4


(Homo sapiens (Human))		BDBM50241617
PNG
(CHEMBL4068667)
Show SMILES CC(CC(=O)N[C@@H](Cc1ccc(OCCCNc2ccccn2)cc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H31N3O4/c1-20(22-8-3-2-4-9-22)18-26(31)30-24(27(32)33)19-21-11-13-23(14-12-21)34-17-7-16-29-25-10-5-6-15-28-25/h2-6,8-15,20,24H,7,16-19H2,1H3,(H,28,29)(H,30,31)(H,32,33)/t20?,24-/m0/s1
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n/an/a 3.30n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241630
PNG
(CHEMBL4065471)
Show SMILES OC(=O)[C@H](Cc1ccc(OCCCNc2ccccn2)cc1)NC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C38H37N3O4/c42-36(28-38(30-13-4-1-5-14-30,31-15-6-2-7-16-31)32-17-8-3-9-18-32)41-34(37(43)44)27-29-20-22-33(23-21-29)45-26-12-25-40-35-19-10-11-24-39-35/h1-11,13-24,34H,12,25-28H2,(H,39,40)(H,41,42)(H,43,44)/t34-/m0/s1
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n/an/a 4.60n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241631
PNG
(CHEMBL4095983)
Show SMILES OC(=O)[C@H](Cc1ccc(OCCCNc2ccccn2)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C32H33N3O4/c36-31(23-28(25-10-3-1-4-11-25)26-12-5-2-6-13-26)35-29(32(37)38)22-24-15-17-27(18-16-24)39-21-9-20-34-30-14-7-8-19-33-30/h1-8,10-19,28-29H,9,20-23H2,(H,33,34)(H,35,36)(H,37,38)/t29-/m0/s1
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n/an/a 6.10n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241631
PNG
(CHEMBL4095983)
Show SMILES OC(=O)[C@H](Cc1ccc(OCCCNc2ccccn2)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C32H33N3O4/c36-31(23-28(25-10-3-1-4-11-25)26-12-5-2-6-13-26)35-29(32(37)38)22-24-15-17-27(18-16-24)39-21-9-20-34-30-14-7-8-19-33-30/h1-8,10-19,28-29H,9,20-23H2,(H,33,34)(H,35,36)(H,37,38)/t29-/m0/s1
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n/an/a 7.90n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241618
PNG
(CHEMBL4064911)
Show SMILES OC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C31H29NO4/c33-30(21-28(25-12-6-2-7-13-25)26-14-8-3-9-15-26)32-29(31(34)35)20-23-16-18-27(19-17-23)36-22-24-10-4-1-5-11-24/h1-19,28-29H,20-22H2,(H,32,33)(H,34,35)/t29-/m0/s1
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n/an/a 9.20n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241623
PNG
(CHEMBL4102803)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO4/c26-20-13-11-17(12-14-20)15-22(24(28)29)25-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22,26H,15-16H2,(H,25,27)(H,28,29)/t22-/m1/s1
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n/an/a 9.60n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241627
PNG
(CHEMBL4105199)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C31H29NO4/c1-36-30(35)28(21-23-17-19-27(33)20-18-23)32-29(34)22-31(24-11-5-2-6-12-24,25-13-7-3-8-14-25)26-15-9-4-10-16-26/h2-20,28,33H,21-22H2,1H3,(H,32,34)/t28-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241621
PNG
(CHEMBL4095042)
Show SMILES OC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H22ClNO3/c25-20-13-11-17(12-14-20)15-22(24(28)29)26-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22H,15-16H2,(H,26,27)(H,28,29)/t22-/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241629
PNG
(CHEMBL4100348)
Show SMILES OC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H22N2O5/c27-23(16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19)25-22(24(28)29)15-17-11-13-20(14-12-17)26(30)31/h1-14,21-22H,15-16H2,(H,25,27)(H,28,29)/t22-/m0/s1
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n/an/a 14n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241626
PNG
(CHEMBL4080951)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C25H25NO4/c1-30-25(29)23(16-18-12-14-21(27)15-13-18)26-24(28)17-22(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22-23,27H,16-17H2,1H3,(H,26,28)/t23-/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241626
PNG
(CHEMBL4080951)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C25H25NO4/c1-30-25(29)23(16-18-12-14-21(27)15-13-18)26-24(28)17-22(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22-23,27H,16-17H2,1H3,(H,26,28)/t23-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241628
PNG
(CHEMBL4084848)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO4/c26-20-13-11-17(12-14-20)15-22(24(28)29)25-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22,26H,15-16H2,(H,25,27)(H,28,29)/t22-/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241627
PNG
(CHEMBL4105199)
Show SMILES COC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C31H29NO4/c1-36-30(35)28(21-23-17-19-27(33)20-18-23)32-29(34)22-31(24-11-5-2-6-12-24,25-13-7-3-8-14-25)26-15-9-4-10-16-26/h2-20,28,33H,21-22H2,1H3,(H,32,34)/t28-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241622
PNG
(CHEMBL4074577)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO3/c26-23(25-22(24(27)28)16-18-10-4-1-5-11-18)17-21(19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,21-22H,16-17H2,(H,25,26)(H,27,28)/t22-/m0/s1
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n/an/a 43n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241620
PNG
(CHEMBL4073512)
Show SMILES Nc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccccc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C24H24N2O3/c25-20-13-11-17(12-14-20)15-22(24(28)29)26-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22H,15-16,25H2,(H,26,27)(H,28,29)/t22-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241618
PNG
(CHEMBL4064911)
Show SMILES OC(=O)[C@H](Cc1ccc(OCc2ccccc2)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C31H29NO4/c33-30(21-28(25-12-6-2-7-13-25)26-14-8-3-9-15-26)32-29(31(34)35)20-23-16-18-27(19-17-23)36-22-24-10-4-1-5-11-24/h1-19,28-29H,20-22H2,(H,32,33)(H,34,35)/t29-/m0/s1
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n/an/a 56n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241621
PNG
(CHEMBL4095042)
Show SMILES OC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H22ClNO3/c25-20-13-11-17(12-14-20)15-22(24(28)29)26-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22H,15-16H2,(H,26,27)(H,28,29)/t22-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241629
PNG
(CHEMBL4100348)
Show SMILES OC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H22N2O5/c27-23(16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19)25-22(24(28)29)15-17-11-13-20(14-12-17)26(30)31/h1-14,21-22H,15-16H2,(H,25,27)(H,28,29)/t22-/m0/s1
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MMDB

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n/an/a 88n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241630
PNG
(CHEMBL4065471)
Show SMILES OC(=O)[C@H](Cc1ccc(OCCCNc2ccccn2)cc1)NC(=O)CC(c1ccccc1)(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C38H37N3O4/c42-36(28-38(30-13-4-1-5-14-30,31-15-6-2-7-16-31)32-17-8-3-9-18-32)41-34(37(43)44)27-29-20-22-33(23-21-29)45-26-12-25-40-35-19-10-11-24-39-35/h1-11,13-24,34H,12,25-28H2,(H,39,40)(H,41,42)(H,43,44)/t34-/m0/s1
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n/an/a 94n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50392532
PNG
(CHEMBL2152332)
Show SMILES COc1ccc(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |r,t:6|
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
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MMDB

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n/an/a 108n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241619
PNG
(CHEMBL4092607)
Show SMILES CC(C)(C)Oc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccccc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C28H31NO4/c1-28(2,3)33-23-16-14-20(15-17-23)18-25(27(31)32)29-26(30)19-24(21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-17,24-25H,18-19H2,1-3H3,(H,29,30)(H,31,32)/t25-/m0/s1
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MMDB

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n/an/a 115n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241623
PNG
(CHEMBL4102803)
Show SMILES OC(=O)[C@@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO4/c26-20-13-11-17(12-14-20)15-22(24(28)29)25-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22,26H,15-16H2,(H,25,27)(H,28,29)/t22-/m1/s1
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n/an/a 136n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241622
PNG
(CHEMBL4074577)
Show SMILES OC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO3/c26-23(25-22(24(27)28)16-18-10-4-1-5-11-18)17-21(19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,21-22H,16-17H2,(H,25,26)(H,27,28)/t22-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241617
PNG
(CHEMBL4068667)
Show SMILES CC(CC(=O)N[C@@H](Cc1ccc(OCCCNc2ccccn2)cc1)C(O)=O)c1ccccc1 |r|
Show InChI InChI=1S/C27H31N3O4/c1-20(22-8-3-2-4-9-22)18-26(31)30-24(27(32)33)19-21-11-13-23(14-12-21)34-17-7-16-29-25-10-5-6-15-28-25/h2-6,8-15,20,24H,7,16-19H2,1H3,(H,28,29)(H,30,31)(H,32,33)/t20?,24-/m0/s1
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MMDB

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n/an/a 142n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241620
PNG
(CHEMBL4073512)
Show SMILES Nc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccccc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C24H24N2O3/c25-20-13-11-17(12-14-20)15-22(24(28)29)26-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22H,15-16,25H2,(H,26,27)(H,28,29)/t22-/m0/s1
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n/an/a 207n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241628
PNG
(CHEMBL4084848)
Show SMILES OC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CC(c1ccccc1)c1ccccc1 |r|
Show InChI InChI=1S/C24H23NO4/c26-20-13-11-17(12-14-20)15-22(24(28)29)25-23(27)16-21(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-22,26H,15-16H2,(H,25,27)(H,28,29)/t22-/m0/s1
PDB
MMDB

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n/an/a 215n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241619
PNG
(CHEMBL4092607)
Show SMILES CC(C)(C)Oc1ccc(C[C@H](NC(=O)CC(c2ccccc2)c2ccccc2)C(O)=O)cc1 |r|
Show InChI InChI=1S/C28H31NO4/c1-28(2,3)33-23-16-14-20(15-17-23)18-25(27(31)32)29-26(30)19-24(21-10-6-4-7-11-21)22-12-8-5-9-13-22/h4-17,24-25H,18-19H2,1-3H3,(H,29,30)(H,31,32)/t25-/m0/s1
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MMDB

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n/an/a 401n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50241616
PNG
(CHEMBL3347643)
Show SMILES CCOc1cc(\C=C2\C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC |c:9|
Show InChI InChI=1S/C22H21ClN2O5/c1-4-29-19-12-15(11-18(23)21(19)30-13-20(26)28-3)10-17-14(2)24-25(22(17)27)16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3/b17-10-
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n/an/a 847n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
Protein Mdm4


(Homo sapiens (Human))		BDBM50392532
PNG
(CHEMBL2152332)
Show SMILES COc1ccc(C2=N[C@@H]([C@@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1 |r,t:6|
Show InChI InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM4 in human SH-SY5Y cells assessed as reduction in MDM4 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic ...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
E3 ubiquitin-protein ligase Mdm2


(Homo sapiens (Human))		BDBM50241616
PNG
(CHEMBL3347643)
Show SMILES CCOc1cc(\C=C2\C(C)=NN(C2=O)c2ccccc2)cc(Cl)c1OCC(=O)OC |c:9|
Show InChI InChI=1S/C22H21ClN2O5/c1-4-29-19-12-15(11-18(23)21(19)30-13-20(26)28-3)10-17-14(2)24-25(22(17)27)16-8-6-5-7-9-16/h5-12H,4,13H2,1-3H3/b17-10-
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n/an/a>1.00E+3n/an/an/an/an/an/a



Universit£ degli Studi di Napoli Federico II

Curated by ChEMBL


Assay Description
Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic as...

J Med Chem 60: 8115-8130 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00912
BindingDB Entry DOI: 10.7270/Q2348NJ0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%