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PubMed code 8289188

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Delta-type opioid receptor


(MOUSE)		BDBM50043721
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Br)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43BrN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 0.0280n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50001468
PNG
((S)-3-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phen...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C37H52N8O10/c1-19(2)30(36(54)40-18-28(39)47)45-37(55)31(20(3)4)44-35(53)27(17-29(48)49)43-34(52)26(16-22-9-7-6-8-10-22)42-32(50)21(5)41-33(51)25(38)15-23-11-13-24(46)14-12-23/h6-14,19-21,25-27,30-31,46H,15-18,38H2,1-5H3,(H2,39,47)(H,40,54)(H,41,51)(H,42,50)(H,43,52)(H,44,53)(H,45,55)(H,48,49)/t21-,25+,26+,27+,30+,31+/m1/s1
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n/an/a 0.160n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50453313
PNG
(CHEMBL2372329)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H35N5O7S2/c1-28(2)23(33-24(36)19(29)12-17-8-10-18(34)11-9-17)26(38)30-14-22(35)31-20(13-16-6-4-3-5-7-16)25(37)32-21(27(39)40)15-41-42-28/h3-11,19-21,23,34H,12-15,29H2,1-2H3,(H,30,38)(H,31,35)(H,32,37)(H,33,36)(H,39,40)/t19-,20-,21-,23-/m0/s1
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n/an/a 0.320n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043720
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43ClN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 0.510n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043725
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43FN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 0.710n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50043725
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43FN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 0.710n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043721
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Br)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43BrN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043723
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43IN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 1.20n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043724
PNG
((S)-2-({(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H44N6O8S2/c1-37(2)31(43-32(46)26(38)17-24-13-15-25(44)16-14-24)35(49)39-20-30(45)40-27(18-22-9-5-3-6-10-22)33(47)42-29(21-52-53-37)34(48)41-28(36(50)51)19-23-11-7-4-8-12-23/h3-16,26-29,31,44H,17-21,38H2,1-2H3,(H,39,49)(H,40,45)(H,41,48)(H,42,47)(H,43,46)(H,50,51)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 1.40n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001683
PNG
(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O
Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453313
PNG
(CHEMBL2372329)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H35N5O7S2/c1-28(2)23(33-24(36)19(29)12-17-8-10-18(34)11-9-17)26(38)30-14-22(35)31-20(13-16-6-4-3-5-7-16)25(37)32-21(27(39)40)15-41-42-28/h3-11,19-21,23,34H,12-15,29H2,1-2H3,(H,30,38)(H,31,35)(H,32,37)(H,33,36)(H,39,40)/t19-,20-,21-,23-/m0/s1
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n/an/a 12n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards delta opioid receptor was determined in rat brain using [H]-[p-Cl-Phe4]-DPDPE as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50043725
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43FN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50043720
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43ClN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50043724
PNG
((S)-2-({(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H44N6O8S2/c1-37(2)31(43-32(46)26(38)17-24-13-15-25(44)16-14-24)35(49)39-20-30(45)40-27(18-22-9-5-3-6-10-22)33(47)42-29(21-52-53-37)34(48)41-28(36(50)51)19-23-11-7-4-8-12-23/h3-16,26-29,31,44H,17-21,38H2,1-2H3,(H,39,49)(H,40,45)(H,41,48)(H,42,47)(H,43,46)(H,50,51)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 82.7n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043720
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43ClN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 83n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50043720
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Cl)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43ClN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50043724
PNG
((S)-2-({(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H44N6O8S2/c1-37(2)31(43-32(46)26(38)17-24-13-15-25(44)16-14-24)35(49)39-20-30(45)40-27(18-22-9-5-3-6-10-22)33(47)42-29(21-52-53-37)34(48)41-28(36(50)51)19-23-11-7-4-8-12-23/h3-16,26-29,31,44H,17-21,38H2,1-2H3,(H,39,49)(H,40,45)(H,41,48)(H,42,47)(H,43,46)(H,50,51)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043725
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(F)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43FN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50043721
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Br)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43BrN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50453313
PNG
(CHEMBL2372329)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H35N5O7S2/c1-28(2)23(33-24(36)19(29)12-17-8-10-18(34)11-9-17)26(38)30-14-22(35)31-20(13-16-6-4-3-5-7-16)25(37)32-21(27(39)40)15-41-42-28/h3-11,19-21,23,34H,12-15,29H2,1-2H3,(H,30,38)(H,31,35)(H,32,37)(H,33,36)(H,39,40)/t19-,20-,21-,23-/m0/s1
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n/an/a 180n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50453313
PNG
(CHEMBL2372329)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C28H35N5O7S2/c1-28(2)23(33-24(36)19(29)12-17-8-10-18(34)11-9-17)26(38)30-14-22(35)31-20(13-16-6-4-3-5-7-16)25(37)32-21(27(39)40)15-41-42-28/h3-11,19-21,23,34H,12-15,29H2,1-2H3,(H,30,38)(H,31,35)(H,32,37)(H,33,36)(H,39,40)/t19-,20-,21-,23-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043724
PNG
((S)-2-({(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccccc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H44N6O8S2/c1-37(2)31(43-32(46)26(38)17-24-13-15-25(44)16-14-24)35(49)39-20-30(45)40-27(18-22-9-5-3-6-10-22)33(47)42-29(21-52-53-37)34(48)41-28(36(50)51)19-23-11-7-4-8-12-23/h3-16,26-29,31,44H,17-21,38H2,1-2H3,(H,39,49)(H,40,45)(H,41,48)(H,42,47)(H,43,46)(H,50,51)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043721
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(Br)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43BrN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50001683
PNG
(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O
Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1
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n/an/a 620n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50001683
PNG
(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O
Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1
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n/an/a 620n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50043723
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43IN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50001468
PNG
((S)-3-((S)-2-{(R)-2-[(S)-2-Amino-3-(4-hydroxy-phen...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(=O)NCC(N)=O
Show InChI InChI=1S/C37H52N8O10/c1-19(2)30(36(54)40-18-28(39)47)45-37(55)31(20(3)4)44-35(53)27(17-29(48)49)43-34(52)26(16-22-9-7-6-8-10-22)42-32(50)21(5)41-33(51)25(38)15-23-11-13-24(46)14-12-23/h6-14,19-21,25-27,30-31,46H,15-18,38H2,1-5H3,(H2,39,47)(H,40,54)(H,41,51)(H,42,50)(H,43,52)(H,44,53)(H,45,55)(H,48,49)/t21-,25+,26+,27+,30+,31+/m1/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50043723
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43IN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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n/an/a 1.60E+3n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor was determined in rat brain using [3H]CTOP as radioligand

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)		BDBM50043723
PNG
((S)-2-{[(4R,7S)-13-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Show SMILES CC1(C)SSC[C@H](NC(=O)[C@H](Cc2ccc(I)cc2)NC(=O)CNC(=O)[C@@H]1NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H43IN6O8S2/c1-37(2)31(44-32(47)26(39)16-22-10-14-25(45)15-11-22)35(50)40-19-30(46)41-27(17-23-8-12-24(38)13-9-23)33(48)43-29(20-53-54-37)34(49)42-28(36(51)52)18-21-6-4-3-5-7-21/h3-15,26-29,31,45H,16-20,39H2,1-2H3,(H,40,50)(H,41,46)(H,42,49)(H,43,48)(H,44,47)(H,51,52)/t26-,27-,28-,29-,31-/m0/s1
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University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against delta opioid receptor of electrically induced smooth muscle contraction of mouse vas deferens

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50001683
PNG
(13-[2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-7...)
Show SMILES CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@H](Cc2ccccc2)C(=O)N[C@H]1C(O)=O
Show InChI InChI=1S/C30H39N5O7S2/c1-29(2)23(34-25(38)20(31)14-18-10-12-19(36)13-11-18)27(40)32-16-22(37)33-21(15-17-8-6-5-7-9-17)26(39)35-24(28(41)42)30(3,4)44-43-29/h5-13,20-21,23-24,36H,14-16,31H2,1-4H3,(H,32,40)(H,33,37)(H,34,38)(H,35,39)(H,41,42)/t20-,21+,23-,24-/m0/s1
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PubMed
n/an/a 7.30E+3n/an/an/an/an/an/a



University of Arizona

Curated by ChEMBL


Assay Description
Inhibitory concentration against electrically evoked contractions of guinea pig ileum longitudinal muscle-myenteric plexus

J Med Chem 37: 146-50 (1994)


BindingDB Entry DOI: 10.7270/Q2TX3G09
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%