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PubMed code 8295213

Compile data set for download or QSAR
Found 59 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010747
PNG
(CHEMBL543201 | CHEMBL78777 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc(CC)c2)c1 |w:10.10|
Show InChI InChI=1S/C17H21N3/c1-3-13-7-5-9-15(11-13)19-17(18)20-16-10-6-8-14(4-2)12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 8n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010758
PNG
(CHEMBL312600 | N,N'-Bis-(2-iodo-phenyl)-guanidine)
Show SMILES NC(Nc1ccccc1I)=Nc1ccccc1I |w:10.11|
Show InChI InChI=1S/C13H11I2N3/c14-9-5-1-3-7-11(9)17-13(16)18-12-8-4-2-6-10(12)15/h1-8H,(H3,16,17,18)
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n/an/a 13n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010760
PNG
(CHEMBL310170 | N,N'-Bis-(2-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccccc1NC(N)=Nc1ccccc1CC |w:11.12|
Show InChI InChI=1S/C17H21N3/c1-3-13-9-5-7-11-15(13)19-17(18)20-16-12-8-6-10-14(16)4-2/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 14n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043978
PNG
(CHEMBL315051 | N,N'-Di-indan-4-yl-guanidine)
Show SMILES NC(Nc1cccc2CCCc12)=Nc1cccc2CCCc12 |w:12.14|
Show InChI InChI=1S/C19H21N3/c20-19(21-17-11-3-7-13-5-1-9-15(13)17)22-18-12-4-8-14-6-2-10-16(14)18/h3-4,7-8,11-12H,1-2,5-6,9-10H2,(H3,20,21,22)
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n/an/a 29n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM81982
PNG
(CAS_97-39-2 | DITOLYLGUANIDINE | DTG | Di-o-tolylg...)
Show SMILES Cc1ccccc1NC(N)=Nc1ccccc1C |w:10.11|
Show InChI InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 31n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010784
PNG
(CHEMBL81070 | N,N'-Bis-(4-bromo-phenyl)-guanidine)
Show SMILES NC(Nc1ccc(Br)cc1)=Nc1ccc(Br)cc1 |w:10.11|
Show InChI InChI=1S/C13H11Br2N3/c14-9-1-5-11(6-2-9)17-13(16)18-12-7-3-10(15)4-8-12/h1-8H,(H3,16,17,18)
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n/an/a 33n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043950
PNG
(CHEMBL90508 | N-(2-Iodo-phenyl)-N'-naphthalen-1-yl...)
Show SMILES NC(Nc1ccccc1I)=Nc1cccc2ccccc12 |w:10.11|
Show InChI InChI=1S/C17H14IN3/c18-14-9-3-4-10-16(14)21-17(19)20-15-11-5-7-12-6-1-2-8-13(12)15/h1-11H,(H3,19,20,21)
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n/an/a 40n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010739
PNG
(CHEMBL79437 | N,N'-Bis-(3-propyl-phenyl)-guanidine)
Show SMILES CCCc1cccc(NC(N)=Nc2cccc(CCC)c2)c1 |w:11.11|
Show InChI InChI=1S/C19H25N3/c1-3-7-15-9-5-11-17(13-15)21-19(20)22-18-12-6-10-16(14-18)8-4-2/h5-6,9-14H,3-4,7-8H2,1-2H3,(H3,20,21,22)
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n/an/a 42n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010791
PNG
(CHEMBL309603 | N,N'-Di-m-tolyl-guanidine)
Show SMILES Cc1cccc(NC(N)=Nc2cccc(C)c2)c1 |w:9.9|
Show InChI InChI=1S/C15H17N3/c1-11-5-3-7-13(9-11)17-15(16)18-14-8-4-6-12(2)10-14/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 43n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043968
PNG
(CHEMBL91713 | N-(3-Ethyl-phenyl)-N'-naphthalen-1-y...)
Show SMILES CCc1cccc(NC(N)=Nc2cccc3ccccc23)c1 |w:10.10|
Show InChI InChI=1S/C19H19N3/c1-2-14-7-5-10-16(13-14)21-19(20)22-18-12-6-9-15-8-3-4-11-17(15)18/h3-13H,2H2,1H3,(H3,20,21,22)
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n/an/a 54n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010806
PNG
(CHEMBL78306 | N,N'-Bis-(5,6,7,8-tetrahydro-naphtha...)
Show SMILES NC(Nc1cccc2CCCCc12)=Nc1cccc2CCCCc12 |w:13.15|
Show InChI InChI=1S/C21H25N3/c22-21(23-19-13-5-9-15-7-1-3-11-17(15)19)24-20-14-6-10-16-8-2-4-12-18(16)20/h5-6,9-10,13-14H,1-4,7-8,11-12H2,(H3,22,23,24)
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n/an/a 59n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043963
PNG
(CHEMBL88660 | N-(3-Ethyl-phenyl)-4-phenyl-piperidi...)
Show SMILES CCc1cccc(c1)N=C(N)N1CCC(CC1)c1ccccc1 |w:8.8|
Show InChI InChI=1S/C20H25N3/c1-2-16-7-6-10-19(15-16)22-20(21)23-13-11-18(12-14-23)17-8-4-3-5-9-17/h3-10,15,18H,2,11-14H2,1H3,(H2,21,22)
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n/an/a 60n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043955
PNG
(CHEMBL88932 | N-Naphthalen-1-yl-N'-m-tolyl-guanidi...)
Show SMILES Cc1cccc(NC(N)=Nc2cccc3ccccc23)c1 |w:9.9|
Show InChI InChI=1S/C18H17N3/c1-13-6-4-9-15(12-13)20-18(19)21-17-11-5-8-14-7-2-3-10-16(14)17/h2-12H,1H3,(H3,19,20,21)
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Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043977
PNG
(CHEMBL543434 | CHEMBL91628 | N,N'-Bis-(3-ethyl-phe...)
Show SMILES CCc1cccc(c1)N=C(N)N(C)c1cccc(CC)c1 |w:8.8|
Show InChI InChI=1S/C18H23N3/c1-4-14-8-6-10-16(12-14)20-18(19)21(3)17-11-7-9-15(5-2)13-17/h6-13H,4-5H2,1-3H3,(H2,19,20)
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n/an/a 82n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010755
PNG
(CHEMBL280243 | N,N'-Bis-(2-isopropyl-phenyl)-guani...)
Show SMILES CC(C)c1ccccc1NC(N)=Nc1ccccc1C(C)C |w:12.13|
Show InChI InChI=1S/C19H25N3/c1-13(2)15-9-5-7-11-17(15)21-19(20)22-18-12-8-6-10-16(18)14(3)4/h5-14H,1-4H3,(H3,20,21,22)
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n/an/a 88n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043947
PNG
(CHEMBL89344 | N-(2-Isopropyl-phenyl)-N'-naphthalen...)
Show SMILES CC(C)c1ccccc1N=C(N)Nc1cccc2ccccc12 |w:9.9|
Show InChI InChI=1S/C20H21N3/c1-14(2)16-10-5-6-12-18(16)22-20(21)23-19-13-7-9-15-8-3-4-11-17(15)19/h3-14H,1-2H3,(H3,21,22,23)
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n/an/a 91n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043970
PNG
(CHEMBL91791 | N,N'-Di-naphthalen-2-yl-guanidine)
Show SMILES NC(Nc1ccc2ccccc2c1)=Nc1ccc2ccccc2c1 |w:13.15|
Show InChI InChI=1S/C21H17N3/c22-21(23-19-11-9-15-5-1-3-7-17(15)13-19)24-20-12-10-16-6-2-4-8-18(16)14-20/h1-14H,(H3,22,23,24)
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Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010789
PNG
(CHEMBL82078 | N,N'-Bis-(3-isopropyl-phenyl)-guanid...)
Show SMILES CC(C)c1cccc(NC(N)=Nc2cccc(c2)C(C)C)c1 |w:11.11|
Show InChI InChI=1S/C19H25N3/c1-13(2)15-7-5-9-17(11-15)21-19(20)22-18-10-6-8-16(12-18)14(3)4/h5-14H,1-4H3,(H3,20,21,22)
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n/an/a 96n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010797
PNG
(CHEMBL81678 | N,N'-Bis-(3-iodo-phenyl)-guanidine)
Show SMILES NC(Nc1cccc(I)c1)=Nc1cccc(I)c1 |w:10.11|
Show InChI InChI=1S/C13H11I2N3/c14-9-3-1-5-11(7-9)17-13(16)18-12-6-2-4-10(15)8-12/h1-8H,(H3,16,17,18)
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Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043951
PNG
(CHEMBL90975 | N-Benzyl-N'-naphthalen-1-yl-guanidin...)
Show SMILES NC(NCc1ccccc1)=Nc1cccc2ccccc12 |w:10.11|
Show InChI InChI=1S/C18H17N3/c19-18(20-13-14-7-2-1-3-8-14)21-17-12-6-10-15-9-4-5-11-16(15)17/h1-12H,13H2,(H3,19,20,21)
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n/an/a 140n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010810
PNG
(CHEMBL79509 | N,N'-Di-naphthalen-1-yl-guanidine)
Show SMILES NC(Nc1cccc2ccccc12)=Nc1cccc2ccccc12 |w:13.15|
Show InChI InChI=1S/C21H17N3/c22-21(23-19-13-5-9-15-7-1-3-11-17(15)19)24-20-14-6-10-16-8-2-4-12-18(16)20/h1-14H,(H3,22,23,24)
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n/an/a 165n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043953
PNG
(CHEMBL430455 | N-Indan-2-yl-N'-naphthalen-1-yl-gua...)
Show SMILES NC(NC1Cc2ccccc2C1)=Nc1cccc2ccccc12 |w:12.14|
Show InChI InChI=1S/C20H19N3/c21-20(22-17-12-15-7-1-2-8-16(15)13-17)23-19-11-5-9-14-6-3-4-10-18(14)19/h1-11,17H,12-13H2,(H3,21,22,23)
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Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010754
PNG
(CHEMBL81626 | N,N'-Bis-(4-isopropyl-phenyl)-guanid...)
Show SMILES CC(C)c1ccc(NC(N)=Nc2ccc(cc2)C(C)C)cc1 |w:10.10|
Show InChI InChI=1S/C19H25N3/c1-13(2)15-5-9-17(10-6-15)21-19(20)22-18-11-7-16(8-12-18)14(3)4/h5-14H,1-4H3,(H3,20,21,22)
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n/an/a 242n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010736
PNG
(CHEMBL78083 | N,N'-Bis-(4-ethyl-phenyl)-guanidine)
Show SMILES CCc1ccc(NC(N)=Nc2ccc(CC)cc2)cc1 |w:9.9|
Show InChI InChI=1S/C17H21N3/c1-3-13-5-9-15(10-6-13)19-17(18)20-16-11-7-14(4-2)8-12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
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n/an/a 245n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043964
PNG
(CHEMBL330551 | N-Methyl-N,N'-di-m-tolyl-guanidine)
Show SMILES CN(C(N)=Nc1cccc(C)c1)c1cccc(C)c1 |w:4.4|
Show InChI InChI=1S/C16H19N3/c1-12-6-4-8-14(10-12)18-16(17)19(3)15-9-5-7-13(2)11-15/h4-11H,1-3H3,(H2,17,18)
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n/an/a 247n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043946
PNG
(CHEMBL314423 | N-(3-Ethyl-phenyl)-2,3-dihydro-indo...)
Show SMILES CCc1cccc(c1)N=C(N)N1CCc2ccccc12 |w:8.8|
Show InChI InChI=1S/C17H19N3/c1-2-13-6-5-8-15(12-13)19-17(18)20-11-10-14-7-3-4-9-16(14)20/h3-9,12H,2,10-11H2,1H3,(H2,18,19)
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n/an/a 341n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043980
PNG
(CHEMBL431214 | N-Naphthalen-1-yl-4-phenyl-piperidi...)
Show SMILES NC(=Nc1cccc2ccccc12)N1CCC(CC1)c1ccccc1 |w:2.2|
Show InChI InChI=1S/C22H23N3/c23-22(24-21-12-6-10-19-9-4-5-11-20(19)21)25-15-13-18(14-16-25)17-7-2-1-3-8-17/h1-12,18H,13-16H2,(H2,23,24)
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n/an/a 343n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043945
PNG
(CHEMBL91222 | N,N'-Bis-(3-methoxy-phenyl)-guanidin...)
Show SMILES COc1cccc(NC(N)=Nc2cccc(OC)c2)c1 |w:10.10|
Show InChI InChI=1S/C15H17N3O2/c1-19-13-7-3-5-11(9-13)17-15(16)18-12-6-4-8-14(10-12)20-2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 351n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010786
PNG
(CHEMBL78411 | N,N'-Bis-(2-tert-butyl-phenyl)-guani...)
Show SMILES CC(C)(C)c1ccccc1NC(N)=Nc1ccccc1C(C)(C)C |w:13.14|
Show InChI InChI=1S/C21H29N3/c1-20(2,3)15-11-7-9-13-17(15)23-19(22)24-18-14-10-8-12-16(18)21(4,5)6/h7-14H,1-6H3,(H3,22,23,24)
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n/an/a 356n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010769
PNG
(CHEMBL556117 | CHEMBL77675 | N,N'-Diphenyl-guanidi...)
Show SMILES NC(Nc1ccccc1)=Nc1ccccc1 |w:9.10|
Show InChI InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
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n/an/a 397n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010743
PNG
(N,N'-Di-p-tolyl-guanidine)
Show SMILES Cc1ccc(NC(N)=Nc2ccc(C)cc2)cc1 |w:8.8|
Show InChI InChI=1S/C15H17N3/c1-11-3-7-13(8-4-11)17-15(16)18-14-9-5-12(2)6-10-14/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 535n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043960
PNG
(CHEMBL328986 | N'-(3-Ethyl-phenyl)-N-methyl-N-naph...)
Show SMILES CCc1cccc(c1)N=C(N)N(C)c1cccc2ccccc12 |w:8.8|
Show InChI InChI=1S/C20H21N3/c1-3-15-8-6-11-17(14-15)22-20(21)23(2)19-13-7-10-16-9-4-5-12-18(16)19/h4-14H,3H2,1-2H3,(H2,21,22)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043954
PNG
(CHEMBL91145 | N-Naphthalen-1-yl-piperidine-1-carbo...)
Show SMILES NC(=Nc1cccc2ccccc12)N1CCCCC1 |w:2.2|
Show InChI InChI=1S/C16H19N3/c17-16(19-11-4-1-5-12-19)18-15-10-6-8-13-7-2-3-9-14(13)15/h2-3,6-10H,1,4-5,11-12H2,(H2,17,18)
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n/an/a 1.07E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043976
PNG
(CHEMBL89811 | N-(3-Ethyl-phenyl)-N,N'-dimethyl-N'-...)
Show SMILES CCc1cccc(c1)N(C)C(=N)N(C)c1cccc2ccccc12
Show InChI InChI=1S/C21H23N3/c1-4-16-9-7-12-18(15-16)23(2)21(22)24(3)20-14-8-11-17-10-5-6-13-19(17)20/h5-15,22H,4H2,1-3H3
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n/an/a 1.21E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043949
PNG
(C-[Bis-(3,4-dihydro-2H-quinolin-1-yl)]-methyleneam...)
Show SMILES N=C(N1CCCc2ccccc12)N1CCCc2ccccc12
Show InChI InChI=1S/C19H21N3/c20-19(21-13-5-9-15-7-1-3-11-17(15)21)22-14-6-10-16-8-2-4-12-18(16)22/h1-4,7-8,11-12,20H,5-6,9-10,13-14H2
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n/an/a 1.37E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043965
PNG
(CHEMBL314710 | N-Naphthalen-1-yl-azepane-1-carboxa...)
Show SMILES NC(=Nc1cccc2ccccc12)N1CCCCCC1 |w:2.2|
Show InChI InChI=1S/C17H21N3/c18-17(20-12-5-1-2-6-13-20)19-16-11-7-9-14-8-3-4-10-15(14)16/h3-4,7-11H,1-2,5-6,12-13H2,(H2,18,19)
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n/an/a 1.41E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043956
PNG
(CHEMBL420979 | N-Methyl-N'-naphthalen-1-yl-N-m-tol...)
Show SMILES CN(C(N)=Nc1cccc2ccccc12)c1cccc(C)c1 |w:4.4|
Show InChI InChI=1S/C19H19N3/c1-14-7-5-10-16(13-14)22(2)19(20)21-18-12-6-9-15-8-3-4-11-17(15)18/h3-13H,1-2H3,(H2,20,21)
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n/an/a 1.86E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010745
PNG
(CHEMBL310729 | N,N'-Bis-(2-methoxy-phenyl)-guanidi...)
Show SMILES COc1ccccc1NC(N)=Nc1ccccc1OC |w:11.12|
Show InChI InChI=1S/C15H17N3O2/c1-19-13-9-5-3-7-11(13)17-15(16)18-12-8-4-6-10-14(12)20-2/h3-10H,1-2H3,(H3,16,17,18)
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n/an/a 1.99E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043961
PNG
(CHEMBL92095 | N'-Anthracen-1-yl-N-methyl-N-naphtha...)
Show SMILES CN(C(N)=Nc1cccc2cc3ccccc3cc12)c1cccc2ccccc12 |w:4.4|
Show InChI InChI=1S/C26H21N3/c1-29(25-15-7-11-18-8-4-5-13-22(18)25)26(27)28-24-14-6-12-21-16-19-9-2-3-10-20(19)17-23(21)24/h2-17H,1H3,(H2,27,28)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043974
PNG
(CHEMBL420245 | N-Ethyl-N-(3-ethyl-phenyl)-N'-napht...)
Show SMILES CCN(C(N)=Nc1cccc2ccccc12)c1cccc(CC)c1 |w:5.5|
Show InChI InChI=1S/C21H23N3/c1-3-16-9-7-12-18(15-16)24(4-2)21(22)23-20-14-8-11-17-10-5-6-13-19(17)20/h5-15H,3-4H2,1-2H3,(H2,22,23)
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n/an/a 2.19E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043971
PNG
(CHEMBL88146 | N-Ethyl-N'-(3-ethyl-phenyl)-N'-methy...)
Show SMILES CCN(C(=N)N(C)c1cccc(CC)c1)c1cccc2ccccc12
Show InChI InChI=1S/C22H25N3/c1-4-17-10-8-13-19(16-17)24(3)22(23)25(5-2)21-15-9-12-18-11-6-7-14-20(18)21/h6-16,23H,4-5H2,1-3H3
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n/an/a 2.29E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043958
PNG
(CHEMBL554054 | CHEMBL92484 | N-(3-Ethyl-phenyl)-N-...)
Show SMILES CCc1cccc(c1)N(C)C(N)=Nc1cccc2ccccc12 |w:12.13|
Show InChI InChI=1S/C20H21N3/c1-3-15-8-6-11-17(14-15)23(2)20(21)22-19-13-7-10-16-9-4-5-12-18(16)19/h4-14H,3H2,1-2H3,(H2,21,22)
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n/an/a 2.54E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043944
PNG
(CHEMBL265549 | N-Methyl-N-naphthalen-1-yl-N'-(3-ni...)
Show SMILES C\[N+](=C(\[NH-])Nc1cccc(c1)[N+]([O-])=O)c1cccc2ccccc12
Show InChI InChI=1S/C18H15N4O2/c1-21(17-11-4-7-13-6-2-3-10-16(13)17)18(19)20-14-8-5-9-15(12-14)22(23)24/h2-12H,1H3,(H-,19,20)/q-1/p+1
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n/an/a 2.64E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043972
PNG
(CHEMBL91946 | N-(3-Amino-phenyl)-N-methyl-N'-napht...)
Show SMILES CN(C(N)=Nc1cccc2ccccc12)c1cccc(N)c1 |w:4.4|
Show InChI InChI=1S/C18H18N4/c1-22(15-9-5-8-14(19)12-15)18(20)21-17-11-4-7-13-6-2-3-10-16(13)17/h2-12H,19H2,1H3,(H2,20,21)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043969
PNG
(CHEMBL431462 | N'-(3-Azido-phenyl)-N-methyl-N-naph...)
Show SMILES CN(C(N)=Nc1cccc(c1)N=[N+]=[N-])c1cccc2ccccc12 |w:4.4|
Show InChI InChI=1S/C18H16N6/c1-24(17-11-4-7-13-6-2-3-10-16(13)17)18(19)21-14-8-5-9-15(12-14)22-23-20/h2-12H,1H3,(H2,19,21)
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n/an/a 2.74E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043983
PNG
(CHEMBL90643 | N-Methyl-N'-naphthalen-1-yl-N-phenyl...)
Show SMILES CN(C(N)=Nc1cccc2ccccc12)c1ccccc1 |w:4.4|
Show InChI InChI=1S/C18H17N3/c1-21(15-10-3-2-4-11-15)18(19)20-17-13-7-9-14-8-5-6-12-16(14)17/h2-13H,1H3,(H2,19,20)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043948
PNG
(CHEMBL90326 | N-(3-Azido-phenyl)-N-methyl-N'-napht...)
Show SMILES CN(C(N)=Nc1cccc2ccccc12)c1cccc(c1)N=[N+]=[N-] |w:4.4|
Show InChI InChI=1S/C18H16N6/c1-24(15-9-5-8-14(12-15)22-23-20)18(19)21-17-11-4-7-13-6-2-3-10-16(13)17/h2-12H,1H3,(H2,19,21)
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n/an/a 3.02E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043959
PNG
(CHEMBL88465 | N-Methyl-N,N'-di-naphthalen-1-yl-gua...)
Show SMILES CN(C(N)=Nc1cccc2ccccc12)c1cccc2ccccc12 |w:4.4|
Show InChI InChI=1S/C22H19N3/c1-25(21-15-7-11-17-9-3-5-13-19(17)21)22(23)24-20-14-6-10-16-8-2-4-12-18(16)20/h2-15H,1H3,(H2,23,24)
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n/an/a 4.80E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043952
PNG
(CHEMBL90809 | N-Ethyl-N,N'-di-naphthalen-1-yl-guan...)
Show SMILES CCN(C(N)=Nc1cccc2ccccc12)c1cccc2ccccc12 |w:5.5|
Show InChI InChI=1S/C23H21N3/c1-2-26(22-16-8-12-18-10-4-6-14-20(18)22)23(24)25-21-15-7-11-17-9-3-5-13-19(17)21/h3-16H,2H2,1H3,(H2,24,25)
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n/an/a 6.13E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043957
PNG
(CHEMBL421364 | N-Methyl-N'-naphthalen-1-yl-N-(3-ni...)
Show SMILES CN(\C([NH-])=[NH+]\c1cccc2ccccc12)c1cccc(c1)[N+]([O-])=O
Show InChI InChI=1S/C18H15N4O2/c1-21(14-8-5-9-15(12-14)22(23)24)18(19)20-17-11-4-7-13-6-2-3-10-16(13)17/h2-12H,1H3,(H-,19,20)/q-1/p+1
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n/an/a 6.26E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043966
PNG
(CHEMBL412674 | N-Methyl-N,N'-di-o-tolyl-guanidine)
Show SMILES CN(C(N)=Nc1ccccc1C)c1ccccc1C |w:4.4|
Show InChI InChI=1S/C16H19N3/c1-12-8-4-6-10-14(12)18-16(17)19(3)15-11-7-5-9-13(15)2/h4-11H,1-3H3,(H2,17,18)
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n/an/a 6.28E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043979
PNG
(C-[Bis-(2,3-dihydro-indol-1-yl)]-methyleneamine | ...)
Show SMILES N=C(N1CCc2ccccc12)N1CCc2ccccc12
Show InChI InChI=1S/C17H17N3/c18-17(19-11-9-13-5-1-3-7-15(13)19)20-12-10-14-6-2-4-8-16(14)20/h1-8,18H,9-12H2
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n/an/a 7.18E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043962
PNG
(CHEMBL91828 | N'-(2-Isopropyl-phenyl)-N-methyl-N-n...)
Show SMILES CC(C)c1ccccc1N=C(N)N(C)c1cccc2ccccc12 |w:9.9|
Show InChI InChI=1S/C21H23N3/c1-15(2)17-11-6-7-13-19(17)23-21(22)24(3)20-14-8-10-16-9-4-5-12-18(16)20/h4-15H,1-3H3,(H2,22,23)
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n/an/a 7.25E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043967
PNG
(CHEMBL313649 | N,N'-Di-naphthalen-1-yl-N-phenyl-gu...)
Show SMILES NC(=Nc1cccc2ccccc12)N(c1ccccc1)c1cccc2ccccc12 |w:2.2|
Show InChI InChI=1S/C27H21N3/c28-27(29-25-18-8-12-20-10-4-6-16-23(20)25)30(22-14-2-1-3-15-22)26-19-9-13-21-11-5-7-17-24(21)26/h1-19H,(H2,28,29)
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n/an/a 7.93E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50010792
PNG
(CHEMBL81594 | N,N'-Bis-biphenyl-2-yl-guanidine)
Show SMILES NC(Nc1ccccc1-c1ccccc1)=Nc1ccccc1-c1ccccc1 |w:15.17|
Show InChI InChI=1S/C25H21N3/c26-25(27-23-17-9-7-15-21(23)19-11-3-1-4-12-19)28-24-18-10-8-16-22(24)20-13-5-2-6-14-20/h1-18H,(H3,26,27,28)
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n/an/a 8.11E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043982
PNG
(CHEMBL314379 | N-Ethyl-N'-methyl-N,N'-di-naphthale...)
Show SMILES CCN(C(=N)N(C)c1cccc2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C24H23N3/c1-3-27(23-17-9-13-19-11-5-7-15-21(19)23)24(25)26(2)22-16-8-12-18-10-4-6-14-20(18)22/h4-17,25H,3H2,1-2H3
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n/an/a 8.48E+3n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043975
PNG
(CHEMBL88161 | N,N'-Dimethyl-N,N'-di-naphthalen-1-y...)
Show SMILES CN(C(=N)N(C)c1cccc2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C23H21N3/c1-25(21-15-7-11-17-9-3-5-13-19(17)21)23(24)26(2)22-16-8-12-18-10-4-6-14-20(18)22/h3-16,24H,1-2H3
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n/an/a 1.07E+4n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043973
PNG
(CHEMBL90288 | N-Methyl-N,N'-di-naphthalen-1-yl-N'-...)
Show SMILES CN(C(=N)N(c1ccccc1)c1cccc2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C28H23N3/c1-30(26-19-9-13-21-11-5-7-17-24(21)26)28(29)31(23-15-3-2-4-16-23)27-20-10-14-22-12-6-8-18-25(22)27/h2-20,29H,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
Sigma non-opioid intracellular receptor 1


(Homo sapiens (Human))		BDBM50043981
PNG
(CHEMBL88639 | N'-(3-Amino-phenyl)-N-methyl-N-napht...)
Show SMILES CN(C(N)=Nc1cccc(N)c1)c1cccc2ccccc12 |w:4.4|
Show InChI InChI=1S/C18H18N4/c1-22(18(20)21-15-9-5-8-14(19)12-15)17-11-4-7-13-6-2-3-10-16(13)17/h2-12H,19H2,1H3,(H2,20,21)
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n/an/a 1.30E+4n/an/an/an/an/an/a



Cambridge NeuroScience, Inc.

Curated by ChEMBL


Assay Description
Tested in vitro for the concentration required to inhibit specific [3H]-DTG radioligand binding to sigma receptor on guinea pig brain membrane

J Med Chem 37: 260-7 (1994)


BindingDB Entry DOI: 10.7270/Q2HX1BRZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%