Found 102 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061441
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C25H25ClN4O/c26-21-5-6-22-20(17-21)4-3-19-2-1-9-28-24(19)25(22)30-14-12-29(13-15-30)23(31)16-18-7-10-27-11-8-18/h1-2,5-11,17,25H,3-4,12-16H2 | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061441
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C25H25ClN4O/c26-21-5-6-22-20(17-21)4-3-19-2-1-9-28-24(19)25(22)30-14-12-29(13-15-30)23(31)16-18-7-10-27-11-8-18/h1-2,5-11,17,25H,3-4,12-16H2 | PDB
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| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061469
(1-[4-(8-CHLORO-3-METHYL-5,6-DIHYDRO-BENZO[5,6]CYCL...)Show SMILES [#6]-c1cnc2c(-[#6]-[#6]-c3cc(Cl)ccc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C27H26ClN3O/c1-18-14-22-3-2-21-16-23(28)4-5-24(21)26(27(22)30-17-18)20-8-12-31(13-9-20)25(32)15-19-6-10-29-11-7-19/h4-7,10-11,14,16-17H,2-3,8-9,12-13,15H2,1H3 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061474
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2C(C3CCN(CC3)C(=O)Cc3ccncc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C26H26ClN3O/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-29-26(20)25(23)19-9-14-30(15-10-19)24(31)16-18-7-12-28-13-8-18/h1-2,5-8,11-13,17,19,25H,3-4,9-10,14-16H2 | PDB
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| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061446
(1-[(1R,2R)-1-(2-Chloro-thiophen-3-ylmethoxy)-1,2,6...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2ccc3CCCCc3c12 Show InChI InChI=1S/C21H21ClN2OS2/c22-21-15(7-10-26-21)12-25-20-18(11-24-9-8-23-13-24)27-17-6-5-14-3-1-2-4-16(14)19(17)20/h5-10,13,18,20H,1-4,11-12H2/t18-,20+/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061449
(1-[5-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro...)Show SMILES Clc1ccc2SC(Cn3ccnc3)C(OCc3ccc(Cl)cc3Cl)c2c1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-3-4-17-15(7-13)19(18(26-17)9-24-6-5-23-11-24)25-10-12-1-2-14(21)8-16(12)22/h1-8,11,18-19H,9-10H2 | PDB
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| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM14454
(1-(4-pyridylacetyl)-4-(8-chloro-5,6-dihydro-11H-be...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-29-26(20)25(23)19-9-14-30(15-10-19)24(31)16-18-7-12-28-13-8-18/h1-2,5-8,11-13,17H,3-4,9-10,14-16H2 | PDB
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| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061495
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccccn3)c3ncccc3CCc2c1 Show InChI InChI=1S/C25H25ClN4O/c26-20-8-9-22-19(16-20)7-6-18-4-3-11-28-24(18)25(22)30-14-12-29(13-15-30)23(31)17-21-5-1-2-10-27-21/h1-5,8-11,16,25H,6-7,12-15,17H2 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061458
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#8-]-[n+]1ccc(-[#6]-[#6](=O)-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2/c3ccc(Cl)cc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C26H24ClN3O2/c27-22-5-6-23-21(17-22)4-3-20-2-1-11-28-26(20)25(23)19-9-12-29(13-10-19)24(31)16-18-7-14-30(32)15-8-18/h1-2,5-8,11,14-15,17H,3-4,9-10,12-13,16H2 | PDB
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| n/a | n/a | 530 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061489
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2cccnc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-22-7-8-23-21(16-22)6-5-20-4-2-12-29-26(20)25(23)19-9-13-30(14-10-19)24(31)15-18-3-1-11-28-17-18/h1-4,7-8,11-12,16-17H,5-6,9-10,13-15H2 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061433
((R)-2-[(R)-2-((S)-2-Benzyl-3-phosphono-propionylam...)Show SMILES COC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)CP(O)(O)=O Show InChI InChI=1S/C31H34N3O7P/c1-41-31(37)28(17-22-12-6-3-7-13-22)34-30(36)27(18-23-19-32-26-15-9-8-14-25(23)26)33-29(35)24(20-42(38,39)40)16-21-10-4-2-5-11-21/h2-15,19,24,27-28,32H,16-18,20H2,1H3,(H,33,35)(H,34,36)(H2,38,39,40)/t24-,27-,28-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061425
(1-[(2R,3R)-3-(3,4-Dichloro-benzyloxy)-5-fluoro-2,3...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3ccc(Cl)c(Cl)c3)c2c1 Show InChI InChI=1S/C19H15Cl2FN2OS/c20-15-3-1-12(7-16(15)21)10-25-19-14-8-13(22)2-4-17(14)26-18(19)9-24-6-5-23-11-24/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061449
(1-[5-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro...)Show SMILES Clc1ccc2SC(Cn3ccnc3)C(OCc3ccc(Cl)cc3Cl)c2c1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-3-4-17-15(7-13)19(18(26-17)9-24-6-5-23-11-24)25-10-12-1-2-14(21)8-16(12)22/h1-8,11,18-19H,9-10H2 | PDB
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| n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061464
(1-(((2R,3R)-3-(2,4-dichlorobenzyloxy)-5-fluoro-2,3...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3ccc(Cl)cc3Cl)c2c1 Show InChI InChI=1S/C19H15Cl2FN2OS/c20-13-2-1-12(16(21)7-13)10-25-19-15-8-14(22)3-4-17(15)26-18(19)9-24-6-5-23-11-24/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061421
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccccc2)c1 Show InChI InChI=1S/C27H25ClN2O/c28-23-10-11-24-22(18-23)9-8-21-7-4-14-29-27(21)26(24)20-12-15-30(16-13-20)25(31)17-19-5-2-1-3-6-19/h1-7,10-11,14,18H,8-9,12-13,15-17H2 | PDB
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| n/a | n/a | 800 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061473
(4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,2-b...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#7]-c2ccncc2)c1 Show InChI InChI=1S/C25H23ClN4O/c26-20-5-6-22-19(16-20)4-3-18-2-1-11-28-24(18)23(22)17-9-14-30(15-10-17)25(31)29-21-7-12-27-13-8-21/h1-2,5-8,11-13,16H,3-4,9-10,14-15H2,(H,27,29,31) | PDB
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Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061490
(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Nc3ccncc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C24H24ClN5O/c25-19-5-6-21-18(16-19)4-3-17-2-1-9-27-22(17)23(21)29-12-14-30(15-13-29)24(31)28-20-7-10-26-11-8-20/h1-2,5-11,16,23H,3-4,12-15H2,(H,26,28,31) | PDB
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| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061486
(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Nc3ccccn3)c3ncccc3CCc2c1 Show InChI InChI=1S/C24H24ClN5O/c25-19-8-9-20-18(16-19)7-6-17-4-3-11-27-22(17)23(20)29-12-14-30(15-13-29)24(31)28-21-5-1-2-10-26-21/h1-5,8-11,16,23H,6-7,12-15H2,(H,26,28,31) | PDB
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| n/a | n/a | 950 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061475
((R)-2-[(R)-2-{2-[(1-Benzyloxycarbonylamino-2-pheny...)Show SMILES CC(C)C(CP(O)(=O)C(Cc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C)C(O)=O Show InChI InChI=1S/C36H43N4O8P/c1-23(2)29(33(41)39-31(34(42)38-24(3)35(43)44)19-27-20-37-30-17-11-10-16-28(27)30)22-49(46,47)32(18-25-12-6-4-7-13-25)40-36(45)48-21-26-14-8-5-9-15-26/h4-17,20,23-24,29,31-32,37H,18-19,21-22H2,1-3H3,(H,38,42)(H,39,41)(H,40,45)(H,43,44)(H,46,47)/t24-,29?,31-,32?/m1/s1 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061465
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3cccnc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C25H25ClN4O/c26-21-7-8-22-20(16-21)6-5-19-4-2-10-28-24(19)25(22)30-13-11-29(12-14-30)23(31)15-18-3-1-9-27-17-18/h1-4,7-10,16-17,25H,5-6,11-15H2 | PDB
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| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061450
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-d...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2ccccc12 Show InChI InChI=1S/C17H15ClN2OS2/c18-17-12(5-8-22-17)10-21-16-13-3-1-2-4-14(13)23-15(16)9-20-7-6-19-11-20/h1-8,11,15-16H,9-10H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061440
(1-[(2R,3R)-5-Bromo-3-(2-chloro-thiophen-3-ylmethox...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2ccc(Br)cc12 Show InChI InChI=1S/C17H14BrClN2OS2/c18-12-1-2-14-13(7-12)16(22-9-11-3-6-23-17(11)19)15(24-14)8-21-5-4-20-10-21/h1-7,10,15-16H,8-9H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061434
(1-[4-(10,11-Dihydro-dibenzo[a,d]cyclohepten-5-ylid...)Show SMILES O=[#6](-[#6]-c1ccncc1)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccccc2-[#6]-[#6]-c2ccccc-12 Show InChI InChI=1S/C27H26N2O/c30-26(19-20-11-15-28-16-12-20)29-17-13-23(14-18-29)27-24-7-3-1-5-21(24)9-10-22-6-2-4-8-25(22)27/h1-8,11-12,15-16H,9-10,13-14,17-19H2 | PDB
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| n/a | n/a | 1.14E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061435
(1-[(2R,3R)-6-Chloro-3-(3,4-dichloro-benzyloxy)-2,3...)Show SMILES Clc1ccc2[C@@H](OCc3ccc(Cl)c(Cl)c3)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-2-3-14-17(8-13)26-18(9-24-6-5-23-11-24)19(14)25-10-12-1-4-15(21)16(22)7-12/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061485
(2-Chloro-3-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl...)Show SMILES Clc1ccc2[C@@H](OCc3cccnc3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C18H15Cl2N3OS/c19-13-3-4-14-15(8-13)25-16(9-23-7-6-21-11-23)17(14)24-10-12-2-1-5-22-18(12)20/h1-8,11,16-17H,9-10H2/t16-,17-/m1/s1 | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061484
(4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Nc3cccnc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C24H24ClN5O/c25-19-7-8-21-18(15-19)6-5-17-3-1-10-27-22(17)23(21)29-11-13-30(14-12-29)24(31)28-20-4-2-9-26-16-20/h1-4,7-10,15-16,23H,5-6,11-14H2,(H,28,31) | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061424
(1-[(2R,3R)-4-Chloro-3-(2-chloro-thiophen-3-ylmetho...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cccc(Cl)c12 Show InChI InChI=1S/C17H14Cl2N2OS2/c18-12-2-1-3-13-15(12)16(22-9-11-4-7-23-17(11)19)14(24-13)8-21-6-5-20-10-21/h1-7,10,14,16H,8-9H2/t14-,16+/m1/s1 | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061460
(1-[4-Chloro-3-(4-chloro-benzyloxy)-2,3-dihydro-ben...)Show InChI InChI=1S/C19H16Cl2N2OS/c20-14-6-4-13(5-7-14)11-24-19-17(10-23-9-8-22-12-23)25-16-3-1-2-15(21)18(16)19/h1-9,12,17,19H,10-11H2 | PDB
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| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061426
(1-[4,6-Dichloro-3-(4-chloro-benzyloxy)-2,3-dihydro...)Show SMILES Clc1ccc(COC2C(Cn3ccnc3)Sc3cc(Cl)cc(Cl)c23)cc1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-3-1-12(2-4-13)10-25-19-17(9-24-6-5-23-11-24)26-16-8-14(21)7-15(22)18(16)19/h1-8,11,17,19H,9-10H2 | PDB
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061461
(8-Chloro-7-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl...)Show SMILES Clc1ccc2[C@@H](OCc3cnc4cc5OCOc5cc4c3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C23H17Cl2N3O3S/c24-14-1-2-15-20(5-14)32-21(9-28-4-3-26-11-28)23(15)29-10-13-8-27-17-7-19-18(30-12-31-19)6-16(17)22(13)25/h1-8,11,21,23H,9-10,12H2/t21-,23-/m1/s1 | PDB
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061432
(1-[5,6-Dichloro-3-(2-chloro-thiophen-3-ylmethoxy)-...)Show InChI InChI=1S/C17H13Cl3N2OS2/c18-12-5-11-14(6-13(12)19)25-15(7-22-3-2-21-9-22)16(11)23-8-10-1-4-24-17(10)20/h1-6,9,15-16H,7-8H2 | PDB
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| n/a | n/a | 1.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061453
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-d...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2c1ccc1ccccc21 Show InChI InChI=1S/C21H17ClN2OS2/c22-21-15(7-10-26-21)12-25-19-17-6-5-14-3-1-2-4-16(14)20(17)27-18(19)11-24-9-8-23-13-24/h1-10,13,18-19H,11-12H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061437
(1-[(2R,3R)-5,7-Dichloro-3-(2-chloro-thiophen-3-ylm...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2c1cc(Cl)cc2Cl Show InChI InChI=1S/C17H13Cl3N2OS2/c18-11-5-12-15(23-8-10-1-4-24-17(10)20)14(7-22-3-2-21-9-22)25-16(12)13(19)6-11/h1-6,9,14-15H,7-8H2/t14-,15-/m1/s1 | PDB
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| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061439
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-5-flu...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3ccsc3Cl)c2c1 Show InChI InChI=1S/C17H14ClFN2OS2/c18-17-11(3-6-23-17)9-22-16-13-7-12(19)1-2-14(13)24-15(16)8-21-5-4-20-10-21/h1-7,10,15-16H,8-9H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061481
((R)-17-Acetyl-2-bromo-6-chloro-17-hydroxy-10,13-di...)Show SMILES CC(=O)[C@@]1(O)C(=C)CC2C3C=C(Cl)C4=CC(=O)C(Br)CC4(C)C3CCC12C |t:10,13| Show InChI InChI=1S/C22H26BrClO3/c1-11-7-15-13-8-18(24)16-9-19(26)17(23)10-20(16,3)14(13)5-6-21(15,4)22(11,27)12(2)25/h8-9,13-15,17,27H,1,5-7,10H2,2-4H3/t13?,14?,15?,17?,20?,21?,22-/m0/s1 | PDB
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| n/a | n/a | 1.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061419
(1-[(2R,3R)-6-Chloro-3-(5-chloro-thiophen-2-ylmetho...)Show SMILES Clc1ccc(CO[C@H]2[C@@H](Cn3ccnc3)Sc3cc(Cl)ccc23)s1 Show InChI InChI=1S/C17H14Cl2N2OS2/c18-11-1-3-13-14(7-11)24-15(8-21-6-5-20-10-21)17(13)22-9-12-2-4-16(19)23-12/h1-7,10,15,17H,8-9H2/t15-,17-/m1/s1 | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061488
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccccn2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-21-8-9-23-20(16-21)7-6-19-4-3-13-29-26(19)25(23)18-10-14-30(15-11-18)24(31)17-22-5-1-2-12-28-22/h1-5,8-9,12-13,16H,6-7,10-11,14-15,17H2 | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061456
(1-[(2R,3R)-6-Chloro-3-(2-chloro-benzo[b]thiophen-3...)Show SMILES Clc1sc2ccccc2c1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cc(Cl)ccc12 Show InChI InChI=1S/C21H16Cl2N2OS2/c22-13-5-6-15-18(9-13)27-19(10-25-8-7-24-12-25)20(15)26-11-16-14-3-1-2-4-17(14)28-21(16)23/h1-9,12,19-20H,10-11H2/t19-,20-/m1/s1 | PDB
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| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061472
(1-[4-(8-Chloro-1-oxy-5,6-dihydro-benzo[5,6]cyclohe...)Show SMILES [#8-]-[n+]1cccc2-[#6]-[#6]-c3cc(Cl)ccc3\[#6](=[#6]-3/[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-[#6]-c3ccncc3)-c12 Show InChI InChI=1S/C26H24ClN3O2/c27-22-5-6-23-21(17-22)4-3-20-2-1-13-30(32)26(20)25(23)19-9-14-29(15-10-19)24(31)16-18-7-11-28-12-8-18/h1-2,5-8,11-13,17H,3-4,9-10,14-16H2 | PDB
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| n/a | n/a | 2.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061422
(1-[(2R,3R)-3-(2-Chloro-6-fluoro-benzyloxy)-5-fluor...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3c(F)cccc3Cl)c2c1 Show InChI InChI=1S/C19H15ClF2N2OS/c20-15-2-1-3-16(22)14(15)10-25-19-13-8-12(21)4-5-17(13)26-18(19)9-24-7-6-23-11-24/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061480
(1-[(2R,3R)-6-Chloro-3-(2-chloro-thiophen-3-ylmetho...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cc(Cl)ccc12 Show InChI InChI=1S/C17H14Cl2N2OS2/c18-12-1-2-13-14(7-12)24-15(8-21-5-4-20-10-21)16(13)22-9-11-3-6-23-17(11)19/h1-7,10,15-16H,8-9H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061447
(2-Pyridin-4-yl-1-[4-(11H-10-thia-dibenzo[a,d]cyclo...)Show SMILES O=[#6](-[#6]-c1ccncc1)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]-[#16]-c2ccccc-12 Show InChI InChI=1S/C26H24N2OS/c29-25(17-19-9-13-27-14-10-19)28-15-11-20(12-16-28)26-22-6-2-1-5-21(22)18-30-24-8-4-3-7-23(24)26/h1-10,13-14H,11-12,15-18H2 | PDB
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| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061448
(1-[4-(8-Chloro-10,11-dihydro-benzo[4,5]cyclohepta[...)Show SMILES Clc1ccc2c(-[#6]-[#6]-c3ncccc3\[#6]-2=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-[#6]-c2ccncc2)c1 Show InChI InChI=1S/C26H24ClN3O/c27-21-4-5-22-20(17-21)3-6-24-23(2-1-11-29-24)26(22)19-9-14-30(15-10-19)25(31)16-18-7-12-28-13-8-18/h1-2,4-5,7-8,11-13,17H,3,6,9-10,14-16H2 | PDB
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| n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061476
(1-[(2R,3R)-6-Chloro-3-(2,5-dichloro-thiophen-3-ylm...)Show SMILES Clc1cc(CO[C@H]2[C@@H](Cn3ccnc3)Sc3cc(Cl)ccc23)c(Cl)s1 Show InChI InChI=1S/C17H13Cl3N2OS2/c18-11-1-2-12-13(6-11)24-14(7-22-4-3-21-9-22)16(12)23-8-10-5-15(19)25-17(10)20/h1-6,9,14,16H,7-8H2/t14-,16-/m1/s1 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061487
(1-[5-Chloro-3-(2-chloro-thiophen-3-ylmethoxy)-2,3-...)Show InChI InChI=1S/C17H14Cl2N2OS2/c18-12-1-2-14-13(7-12)16(22-9-11-3-6-23-17(11)19)15(24-14)8-21-5-4-20-10-21/h1-7,10,15-16H,8-9H2 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061461
(8-Chloro-7-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl...)Show SMILES Clc1ccc2[C@@H](OCc3cnc4cc5OCOc5cc4c3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C23H17Cl2N3O3S/c24-14-1-2-15-20(5-14)32-21(9-28-4-3-26-11-28)23(15)29-10-13-8-27-17-7-19-18(30-12-31-19)6-16(17)22(13)25/h1-8,11,21,23H,9-10,12H2/t21-,23-/m1/s1 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061463
(4-((2R,3R)-6-Chloro-2-imidazol-1-ylmethyl-2,3-dihy...)Show SMILES Cc1onc(c1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cc(Cl)ccc12)-c1ccccc1 Show InChI InChI=1S/C23H20ClN3O2S/c1-15-19(22(26-29-15)16-5-3-2-4-6-16)13-28-23-18-8-7-17(24)11-20(18)30-21(23)12-27-10-9-25-14-27/h2-11,14,21,23H,12-13H2,1H3/t21-,23-/m1/s1 | PDB
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| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061457
(1-[4-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohept...)Show SMILES Clc1ccc2C(N3CCN(CC3)C(=O)Cc3ccccc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C26H26ClN3O/c27-22-10-11-23-21(18-22)9-8-20-7-4-12-28-25(20)26(23)30-15-13-29(14-16-30)24(31)17-19-5-2-1-3-6-19/h1-7,10-12,18,26H,8-9,13-17H2 | PDB
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061482
(1-[(2R,3R)-3-(2,6-Dichloro-benzyloxy)-5-fluoro-2,3...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3c(Cl)cccc3Cl)c2c1 Show InChI InChI=1S/C19H15Cl2FN2OS/c20-15-2-1-3-16(21)14(15)10-25-19-13-8-12(22)4-5-17(13)26-18(19)9-24-7-6-23-11-24/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061432
(1-[5,6-Dichloro-3-(2-chloro-thiophen-3-ylmethoxy)-...)Show InChI InChI=1S/C17H13Cl3N2OS2/c18-12-5-11-14(6-13(12)19)25-15(7-22-3-2-21-9-22)16(11)23-8-10-1-4-24-17(10)20/h1-6,9,15-16H,7-8H2 | PDB
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| n/a | n/a | 2.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061461
(8-Chloro-7-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl...)Show SMILES Clc1ccc2[C@@H](OCc3cnc4cc5OCOc5cc4c3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C23H17Cl2N3O3S/c24-14-1-2-15-20(5-14)32-21(9-28-4-3-26-11-28)23(15)29-10-13-8-27-17-7-19-18(30-12-31-19)6-16(17)22(13)25/h1-8,11,21,23H,9-10,12H2/t21-,23-/m1/s1 | PDB
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| n/a | n/a | 3.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase (FPT) in FPT Ras/TCA assay |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061443
(1-[(2R,3R)-6-Chloro-3-(5-chloro-benzo[1,3]dioxol-4...)Show SMILES Clc1ccc2[C@@H](OCc3c4OCOc4ccc3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C20H16Cl2N2O3S/c21-12-1-2-13-17(7-12)28-18(8-24-6-5-23-10-24)20(13)25-9-14-15(22)3-4-16-19(14)27-11-26-16/h1-7,10,18,20H,8-9,11H2/t18-,20-/m1/s1 | PDB
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| n/a | n/a | 3.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061485
(2-Chloro-3-((2R,3R)-6-chloro-2-imidazol-1-ylmethyl...)Show SMILES Clc1ccc2[C@@H](OCc3cccnc3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C18H15Cl2N3OS/c19-13-3-4-14-15(8-13)25-16(9-23-7-6-21-11-23)17(14)24-10-12-2-1-5-22-18(12)20/h1-8,11,16-17H,9-10H2/t16-,17-/m1/s1 | PDB
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| Article
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| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061454
(1-[(2R,3R)-6-Chloro-3-(2-chloro-6-fluoro-benzyloxy...)Show SMILES Fc1cccc(Cl)c1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cc(Cl)ccc12 Show InChI InChI=1S/C19H15Cl2FN2OS/c20-12-4-5-13-17(8-12)26-18(9-24-7-6-23-11-24)19(13)25-10-14-15(21)2-1-3-16(14)22/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061470
(1-{4-[3-((2R,3R)-5-tert-Butyl-2-imidazol-1-ylmethy...)Show SMILES CC(=O)N1CCN(CC1)c1nc(CO[C@H]2[C@@H](Cn3ccnc3)Sc3ccc(cc23)C(C)(C)C)ns1 Show InChI InChI=1S/C25H32N6O2S2/c1-17(32)30-9-11-31(12-10-30)24-27-22(28-35-24)15-33-23-19-13-18(25(2,3)4)5-6-20(19)34-21(23)14-29-8-7-26-16-29/h5-8,13,16,21,23H,9-12,14-15H2,1-4H3/t21-,23-/m1/s1 | PDB
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| n/a | n/a | 4.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061477
((4-Amino-cyclohexyl)-[4-(8-chloro-5,6-dihydro-benz...)Show SMILES NC1CCC(CC1)C(=O)N1CCC(CC1)=C1c2ccc(Cl)cc2CCc2cccnc12 |(14.43,-12.67,;13.51,-11.8,;12.17,-12.32,;11.06,-11.46,;11.25,-10.05,;12.56,-9.49,;13.69,-10.38,;10.11,-9.16,;8.79,-9.7,;10.31,-7.75,;9.18,-6.87,;9.37,-5.46,;10.71,-4.92,;11.83,-5.78,;11.63,-7.19,;10.89,-3.5,;12.53,-2.9,;13.78,-4.24,;15.54,-3.83,;16.08,-2.07,;17.85,-1.65,;14.82,-.76,;13.07,-1.17,;12.01,.35,;10.26,.36,;9.34,-.87,;7.67,-.28,;6.3,-1.43,;6.63,-3.2,;8.3,-3.8,;9.67,-2.63,)| Show InChI InChI=1S/C26H30ClN3O/c27-21-7-10-23-20(16-21)4-3-18-2-1-13-29-25(18)24(23)17-11-14-30(15-12-17)26(31)19-5-8-22(28)9-6-19/h1-2,7,10,13,16,19,22H,3-6,8-9,11-12,14-15,28H2 | PDB
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| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061419
(1-[(2R,3R)-6-Chloro-3-(5-chloro-thiophen-2-ylmetho...)Show SMILES Clc1ccc(CO[C@H]2[C@@H](Cn3ccnc3)Sc3cc(Cl)ccc23)s1 Show InChI InChI=1S/C17H14Cl2N2OS2/c18-11-1-3-13-14(7-11)24-15(8-21-6-5-20-10-21)17(13)22-9-12-2-4-16(19)23-12/h1-7,10,15,17H,8-9H2/t15-,17-/m1/s1 | PDB
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| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061491
(1-[5-Chloro-3-(2,6-dichloro-benzyloxy)-2,3-dihydro...)Show SMILES Clc1ccc2SC(Cn3ccnc3)C(OCc3c(Cl)cccc3Cl)c2c1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-12-4-5-17-13(8-12)19(18(26-17)9-24-7-6-23-11-24)25-10-14-15(21)2-1-3-16(14)22/h1-8,11,18-19H,9-10H2 | PDB
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| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061470
(1-{4-[3-((2R,3R)-5-tert-Butyl-2-imidazol-1-ylmethy...)Show SMILES CC(=O)N1CCN(CC1)c1nc(CO[C@H]2[C@@H](Cn3ccnc3)Sc3ccc(cc23)C(C)(C)C)ns1 Show InChI InChI=1S/C25H32N6O2S2/c1-17(32)30-9-11-31(12-10-30)24-27-22(28-35-24)15-33-23-19-13-18(25(2,3)4)5-6-20(19)34-21(23)14-29-8-7-26-16-29/h5-8,13,16,21,23H,9-12,14-15H2,1-4H3/t21-,23-/m1/s1 | PDB
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| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase (FPT) in FPT Ras/TCA assay |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061492
(4-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#8]-[#6](=O)-c1ccc(cc1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C27H23ClN2O3/c28-22-9-10-23-21(16-22)8-3-18-2-1-13-29-25(18)24(23)17-11-14-30(15-12-17)26(31)19-4-6-20(7-5-19)27(32)33/h1-2,4-7,9-10,13,16H,3,8,11-12,14-15H2,(H,32,33) | PDB
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| n/a | n/a | 5.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061462
(1-[6-Chloro-3-(2,4-dichloro-benzyloxy)-2,3-dihydro...)Show SMILES Clc1ccc2C(OCc3ccc(Cl)cc3Cl)C(Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-2-1-12(16(22)7-13)10-25-19-15-4-3-14(21)8-17(15)26-18(19)9-24-6-5-23-11-24/h1-8,11,18-19H,9-10H2 | PDB
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| n/a | n/a | 5.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061444
(4-(8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]c...)Show SMILES OC1(c2ccc(cc2)C(=O)Nc2ccncc2)c2ccc(Cl)cc2CCc2cccnc12 Show InChI InChI=1S/C26H20ClN3O2/c27-21-9-10-23-19(16-21)4-3-17-2-1-13-29-24(17)26(23,32)20-7-5-18(6-8-20)25(31)30-22-11-14-28-15-12-22/h1-2,5-16,32H,3-4H2,(H,28,30,31) | PDB
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| n/a | n/a | 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061438
(1-[(2R,3R)-7-Chloro-3-(2-chloro-thiophen-3-ylmetho...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2c1cccc2Cl Show InChI InChI=1S/C17H14Cl2N2OS2/c18-13-3-1-2-12-15(22-9-11-4-7-23-17(11)19)14(24-16(12)13)8-21-6-5-20-10-21/h1-7,10,14-15H,8-9H2/t14-,15-/m1/s1 | PDB
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| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061427
(1-((2R,3R)-3-Allyloxy-6-chloro-2,3-dihydro-benzo[b...)Show InChI InChI=1S/C15H15ClN2OS/c1-2-7-19-15-12-4-3-11(16)8-13(12)20-14(15)9-18-6-5-17-10-18/h2-6,8,10,14-15H,1,7,9H2/t14-,15-/m1/s1 | PDB
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| n/a | n/a | 8.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061483
(1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1...)Show SMILES Clc1ccc2C(N3CCC(CC3)C(=O)Nc3ccncc3)c3ncccc3CCc2c1 Show InChI InChI=1S/C25H25ClN4O/c26-20-5-6-22-19(16-20)4-3-17-2-1-11-28-23(17)24(22)30-14-9-18(10-15-30)25(31)29-21-7-12-27-13-8-21/h1-2,5-8,11-13,16,18,24H,3-4,9-10,14-15H2,(H,27,29,31) | PDB
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| n/a | n/a | 9.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061425
(1-[(2R,3R)-3-(3,4-Dichloro-benzyloxy)-5-fluoro-2,3...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3ccc(Cl)c(Cl)c3)c2c1 Show InChI InChI=1S/C19H15Cl2FN2OS/c20-15-3-1-12(7-16(15)21)10-25-19-14-8-13(22)2-4-17(14)26-18(19)9-24-6-5-23-11-24/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061468
(1-[4-(8-Chloro-5,6-dihydro-benzo[5,6]cyclohepta[1,...)Show SMILES [#6]C([#6])([#6])[#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C25H29ClN2O/c1-25(2,3)16-22(29)28-13-10-17(11-14-28)23-21-9-8-20(26)15-19(21)7-6-18-5-4-12-27-24(18)23/h4-5,8-9,12,15H,6-7,10-11,13-14,16H2,1-3H3 | PDB
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| n/a | n/a | 9.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061455
(CHEMBL435215 | [4-(8-Chloro-11H-10-oxa-4-aza-diben...)Show SMILES [#8-]-[n+]1ccc(cc1)-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1\c2ccc(Cl)cc2-[#8]-[#6]-c2cccnc-12 Show InChI InChI=1S/C24H20ClN3O3/c25-19-3-4-20-21(14-19)31-15-18-2-1-9-26-23(18)22(20)16-5-10-27(11-6-16)24(29)17-7-12-28(30)13-8-17/h1-4,7-9,12-14H,5-6,10-11,15H2 | PDB
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| n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061431
(4-((2R,3R)-6-Chloro-2-imidazol-1-ylmethyl-2,3-dihy...)Show SMILES Clc1ccc2[C@@H](OCc3cscn3)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C16H14ClN3OS2/c17-11-1-2-13-14(5-11)23-15(6-20-4-3-18-9-20)16(13)21-7-12-8-22-10-19-12/h1-5,8-10,15-16H,6-7H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061466
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-6-tri...)Show SMILES FC(F)(F)c1ccc2[C@@H](OCc3ccsc3Cl)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C18H14ClF3N2OS2/c19-17-11(3-6-26-17)9-25-16-13-2-1-12(18(20,21)22)7-14(13)27-15(16)8-24-5-4-23-10-24/h1-7,10,15-16H,8-9H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 1.07E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061428
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3,5...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cc3CCCCc3cc12 Show InChI InChI=1S/C21H21ClN2OS2/c22-21-16(5-8-26-21)12-25-20-17-9-14-3-1-2-4-15(14)10-18(17)27-19(20)11-24-7-6-23-13-24/h5-10,13,19-20H,1-4,11-12H2/t19-,20-/m1/s1 | PDB
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| n/a | n/a | 1.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061479
(1-[4,6-Dichloro-3-(2,4-dichloro-benzyloxy)-2,3-dih...)Show SMILES Clc1ccc(COC2C(Cn3ccnc3)Sc3cc(Cl)cc(Cl)c23)c(Cl)c1 Show InChI InChI=1S/C19H14Cl4N2OS/c20-12-2-1-11(14(22)5-12)9-26-19-17(8-25-4-3-24-10-25)27-16-7-13(21)6-15(23)18(16)19/h1-7,10,17,19H,8-9H2 | PDB
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| n/a | n/a | 1.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061435
(1-[(2R,3R)-6-Chloro-3-(3,4-dichloro-benzyloxy)-2,3...)Show SMILES Clc1ccc2[C@@H](OCc3ccc(Cl)c(Cl)c3)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-2-3-14-17(8-13)26-18(9-24-6-5-23-11-24)19(14)25-10-12-1-4-15(21)16(22)7-12/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061494
(1-[(2R,3R)-6-Fluoro-3-(thiophen-3-ylmethoxy)-2,3-d...)Show SMILES Fc1ccc2[C@@H](OCc3ccsc3)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C17H15FN2OS2/c18-13-1-2-14-15(7-13)23-16(8-20-5-4-19-11-20)17(14)21-9-12-3-6-22-10-12/h1-7,10-11,16-17H,8-9H2/t16-,17-/m1/s1 | PDB
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| n/a | n/a | 1.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061440
(1-[(2R,3R)-5-Bromo-3-(2-chloro-thiophen-3-ylmethox...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2ccc(Br)cc12 Show InChI InChI=1S/C17H14BrClN2OS2/c18-12-1-2-14-13(7-12)16(22-9-11-3-6-23-17(11)19)15(24-14)8-21-5-4-20-10-21/h1-7,10,15-16H,8-9H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061429
(1-{4-[(4-Chloro-phenyl)-pyridin-2-yl-methylene]-pi...)Show SMILES Clc1ccc(cc1)-[#6](=[#6]-1\[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6]-c1ccncc1)\c1ccccn1 Show InChI InChI=1S/C24H22ClN3O/c25-21-6-4-19(5-7-21)24(22-3-1-2-12-27-22)20-10-15-28(16-11-20)23(29)17-18-8-13-26-14-9-18/h1-9,12-14H,10-11,15-17H2 | PDB
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| n/a | n/a | 1.49E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061453
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-d...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2c1ccc1ccccc21 Show InChI InChI=1S/C21H17ClN2OS2/c22-21-15(7-10-26-21)12-25-19-17-6-5-14-3-1-2-4-16(14)20(17)27-18(19)11-24-9-8-23-13-24/h1-10,13,18-19H,11-12H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061460
(1-[4-Chloro-3-(4-chloro-benzyloxy)-2,3-dihydro-ben...)Show InChI InChI=1S/C19H16Cl2N2OS/c20-14-6-4-13(5-7-14)11-24-19-17(10-23-9-8-22-12-23)25-16-3-1-2-15(21)18(16)19/h1-9,12,17,19H,10-11H2 | PDB
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| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibition of Farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061445
(1-[(2R,3R)-6-Chloro-3-(thiophen-3-ylmethoxy)-2,3-d...)Show SMILES Clc1ccc2[C@@H](OCc3ccsc3)[C@@H](Cn3ccnc3)Sc2c1 Show InChI InChI=1S/C17H15ClN2OS2/c18-13-1-2-14-15(7-13)23-16(8-20-5-4-19-11-20)17(14)21-9-12-3-6-22-10-12/h1-7,10-11,16-17H,8-9H2/t16-,17-/m1/s1 | PDB
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| n/a | n/a | 1.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061437
(1-[(2R,3R)-5,7-Dichloro-3-(2-chloro-thiophen-3-ylm...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2c1cc(Cl)cc2Cl Show InChI InChI=1S/C17H13Cl3N2OS2/c18-11-5-12-15(23-8-10-1-4-24-17(10)20)14(7-22-3-2-21-9-22)25-16(12)13(19)6-11/h1-6,9,14-15H,7-8H2/t14-,15-/m1/s1 | PDB
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| n/a | n/a | 1.62E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061446
(1-[(1R,2R)-1-(2-Chloro-thiophen-3-ylmethoxy)-1,2,6...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2ccc3CCCCc3c12 Show InChI InChI=1S/C21H21ClN2OS2/c22-21-15(7-10-26-21)12-25-20-18(11-24-9-8-23-13-24)27-17-6-5-14-3-1-2-4-16(14)19(17)20/h5-10,13,18,20H,1-4,11-12H2/t18-,20+/m1/s1 | PDB
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| n/a | n/a | 1.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061464
(1-(((2R,3R)-3-(2,4-dichlorobenzyloxy)-5-fluoro-2,3...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3ccc(Cl)cc3Cl)c2c1 Show InChI InChI=1S/C19H15Cl2FN2OS/c20-13-2-1-12(16(21)7-13)10-25-19-15-8-14(22)3-4-17(15)26-18(19)9-24-6-5-23-11-24/h1-8,11,18-19H,9-10H2/t18-,19-/m1/s1 | PDB
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| n/a | n/a | 1.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061426
(1-[4,6-Dichloro-3-(4-chloro-benzyloxy)-2,3-dihydro...)Show SMILES Clc1ccc(COC2C(Cn3ccnc3)Sc3cc(Cl)cc(Cl)c23)cc1 Show InChI InChI=1S/C19H15Cl3N2OS/c20-13-3-1-12(2-4-13)10-25-19-17(9-24-6-5-23-11-24)26-16-8-14(21)7-15(22)18(16)19/h1-8,11,17,19H,9-10H2 | PDB
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| n/a | n/a | 1.88E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061442
(1-[(2R,3R)-6-Chloro-3-(2-chloro-thiophen-3-ylmetho...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)S(=O)c2cc(Cl)ccc12 Show InChI InChI=1S/C17H14Cl2N2O2S2/c18-12-1-2-13-14(7-12)25(22)15(8-21-5-4-20-10-21)16(13)23-9-11-3-6-24-17(11)19/h1-7,10,15-16H,8-9H2/t15-,16-,25?/m1/s1 | PDB
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| n/a | n/a | 2.08E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061436
(CHEMBL337835 | [4-(8-Chloro-6-hydroxy-5,6-dihydro-...)Show SMILES [#8]-[#6]-1-[#6]-c2cccnc2\[#6](=[#6]-2/[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-c2cc[n+](-[#8-])cc2)-c2ccc(Cl)cc-12 Show InChI InChI=1S/C25H22ClN3O3/c26-19-3-4-20-21(15-19)22(30)14-18-2-1-9-27-24(18)23(20)16-5-10-28(11-6-16)25(31)17-7-12-29(32)13-8-17/h1-4,7-9,12-13,15,22,30H,5-6,10-11,14H2 | PDB
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| n/a | n/a | 3.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061430
(CHEMBL335161 | [4-(8-Chloro-5-hydroxy-5,6-dihydro-...)Show SMILES [#8]-[#6]-1-[#6]-c2cc(Cl)ccc2\[#6](=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](=O)-c2cc[n+](-[#8-])cc2)-c2ncccc-12 Show InChI InChI=1S/C25H22ClN3O3/c26-19-3-4-20-18(14-19)15-22(30)21-2-1-9-27-24(21)23(20)16-5-10-28(11-6-16)25(31)17-7-12-29(32)13-8-17/h1-4,7-9,12-14,22,30H,5-6,10-11,15H2 | PDB
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| n/a | n/a | 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061439
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-5-flu...)Show SMILES Fc1ccc2S[C@H](Cn3ccnc3)[C@H](OCc3ccsc3Cl)c2c1 Show InChI InChI=1S/C17H14ClFN2OS2/c18-17-11(3-6-23-17)9-22-16-13-7-12(19)1-2-14(13)24-15(16)8-21-5-4-20-10-21/h1-7,10,15-16H,8-9H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 3.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061424
(1-[(2R,3R)-4-Chloro-3-(2-chloro-thiophen-3-ylmetho...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cccc(Cl)c12 Show InChI InChI=1S/C17H14Cl2N2OS2/c18-12-2-1-3-13-15(12)16(22-9-11-4-7-23-17(11)19)14(24-13)8-21-6-5-20-10-21/h1-7,10,14,16H,8-9H2/t14-,16+/m1/s1 | PDB
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| n/a | n/a | 3.65E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061456
(1-[(2R,3R)-6-Chloro-3-(2-chloro-benzo[b]thiophen-3...)Show SMILES Clc1sc2ccccc2c1CO[C@H]1[C@@H](Cn2ccnc2)Sc2cc(Cl)ccc12 Show InChI InChI=1S/C21H16Cl2N2OS2/c22-13-5-6-15-18(9-13)27-19(10-25-8-7-24-12-25)20(15)26-11-16-14-3-1-2-4-17(14)28-21(16)23/h1-9,12,19-20H,10-11H2/t19-,20-/m1/s1 | PDB
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| n/a | n/a | 3.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061452
(1-{4-[(4-Chloro-phenyl)-pyridin-2-yl-methyl]-piper...)Show SMILES Clc1ccc(cc1)C(N1CCN(CC1)C(=O)Cc1cccnc1)c1ccccn1 Show InChI InChI=1S/C23H23ClN4O/c24-20-8-6-19(7-9-20)23(21-5-1-2-11-26-21)28-14-12-27(13-15-28)22(29)16-18-4-3-10-25-17-18/h1-11,17,23H,12-16H2 | PDB
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| n/a | n/a | 3.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061470
(1-{4-[3-((2R,3R)-5-tert-Butyl-2-imidazol-1-ylmethy...)Show SMILES CC(=O)N1CCN(CC1)c1nc(CO[C@H]2[C@@H](Cn3ccnc3)Sc3ccc(cc23)C(C)(C)C)ns1 Show InChI InChI=1S/C25H32N6O2S2/c1-17(32)30-9-11-31(12-10-30)24-27-22(28-35-24)15-33-23-19-13-18(25(2,3)4)5-6-20(19)34-21(23)14-29-8-7-26-16-29/h5-8,13,16,21,23H,9-12,14-15H2,1-4H3/t21-,23-/m1/s1 | PDB
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| n/a | n/a | >3.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061467
(1-[4-(8-Chloro-3-hydroxymethyl-5,6-dihydro-benzo[5...)Show SMILES [#6]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccc(Cl)cc2-[#6]-[#6]-c2cc(-[#6]-[#8])cnc-12 Show InChI InChI=1S/C22H23ClN2O2/c1-14(27)25-8-6-16(7-9-25)21-20-5-4-19(23)11-17(20)2-3-18-10-15(13-26)12-24-22(18)21/h4-5,10-12,26H,2-3,6-9,13H2,1H3 | PDB
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| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061420
(1-[6-Chloro-3-(2,4-dichloro-benzyloxy)-1,1-dioxo-2...)Show SMILES Clc1ccc2C(OCc3ccc(Cl)cc3Cl)C(Cn3ccnc3)S(=O)(=O)c2c1 Show InChI InChI=1S/C19H15Cl3N2O3S/c20-13-2-1-12(16(22)7-13)10-27-19-15-4-3-14(21)8-17(15)28(25,26)18(19)9-24-6-5-23-11-24/h1-8,11,18-19H,9-10H2 | PDB
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| n/a | n/a | 4.59E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50061450
(1-[(2R,3R)-3-(2-Chloro-thiophen-3-ylmethoxy)-2,3-d...)Show SMILES Clc1sccc1CO[C@H]1[C@@H](Cn2ccnc2)Sc2ccccc12 Show InChI InChI=1S/C17H15ClN2OS2/c18-17-12(5-8-22-17)10-21-16-13-3-1-2-4-14(13)23-15(16)9-20-7-6-19-11-20/h1-8,11,15-16H,9-10H2/t15-,16-/m1/s1 | PDB
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| n/a | n/a | 4.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against Geranylgeranyl transferase type I |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061496
(1-(4-Benzhydrylidene-piperidin-1-yl)-2-pyridin-4-y...)Show SMILES O=[#6](-[#6]-c1ccncc1)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6](/c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C25H24N2O/c28-24(19-20-11-15-26-16-12-20)27-17-13-23(14-18-27)25(21-7-3-1-4-8-21)22-9-5-2-6-10-22/h1-12,15-16H,13-14,17-19H2 | PDB
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| n/a | n/a | 4.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50007456
(1-[4-(8-Methoxy-5,6-dihydro-benzo[5,6]cyclohepta[1...)Show SMILES [#6]-[#8]-c1ccc2c(-[#6]-[#6]-c3cccnc3\[#6]-2=[#6]-2\[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6](-[#6])=O)c1 Show InChI InChI=1S/C22H24N2O2/c1-15(25)24-12-9-16(10-13-24)21-20-8-7-19(26-2)14-18(20)6-5-17-4-3-11-23-22(17)21/h3-4,7-8,11,14H,5-6,9-10,12-13H2,1-2H3 | PDB
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| n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061493
((2S,3S)-2-Imidazol-1-ylmethyl-2,3,5,6,7,8-hexahydr...)Show InChI InChI=1S/C16H18N2OS/c19-16-13-7-11-3-1-2-4-12(11)8-14(13)20-15(16)9-18-6-5-17-10-18/h5-8,10,15-16,19H,1-4,9H2/t15-,16-/m0/s1 | PDB
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| n/a | n/a | >7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061478
(5-Chloro-2-imidazol-1-ylmethyl-2,3-dihydro-benzo[b...)Show InChI InChI=1S/C12H11ClN2OS/c13-8-1-2-10-9(5-8)12(16)11(17-10)6-15-4-3-14-7-15/h1-5,7,11-12,16H,6H2 | PDB
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| n/a | n/a | >7.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061459
(4-(5,6-Dihydro-benzo[5,6]cyclohepta[1,2-b]pyridin-...)Show SMILES [#6]-[#7](-[#6])-[#6]-[#6]-[#8]-[#6](=O)-[#7]-1-[#6]-[#6]\[#6](-[#6]-[#6]-1)=[#6]-1/c2ccccc2-[#6]-[#6]-c2cccnc-12 Show InChI InChI=1S/C24H29N3O2/c1-26(2)16-17-29-24(28)27-14-11-19(12-15-27)22-21-8-4-3-6-18(21)9-10-20-7-5-13-25-23(20)22/h3-8,13H,9-12,14-17H2,1-2H3 | PDB
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| n/a | n/a | 7.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061423
((2R,3R)-2-((1H-imidazol-1-yl)methyl)-4-methyl-2,3-...)Show InChI InChI=1S/C13H14N2OS/c1-9-3-2-4-10-12(9)13(16)11(17-10)7-15-6-5-14-8-15/h2-6,8,11,13,16H,7H2,1H3/t11-,13+/m1/s1 | PDB
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| n/a | n/a | 2.66E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061451
(11-(1-Methyl-piperidin-4-yl)-6,11-dihydro-5H-benzo...)Show InChI InChI=1S/C20H24N2/c1-22-13-10-16(11-14-22)19-18-7-3-2-5-15(18)8-9-17-6-4-12-21-20(17)19/h2-7,12,16,19H,8-11,13-14H2,1H3 | PDB
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| n/a | n/a | 7.24E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
Dimer of Protein farnesyltransferase subunit beta
(Homo sapiens (Human)) | BDBM50061471
(11-[1-(1-Oxy-pyridin-4-ylmethyl)-piperidin-4-ylide...)Show SMILES [#8-]-[n+]1ccc(-[#6]-[#7]-2-[#6]-[#6]\[#6](-[#6]-[#6]-2)=[#6]-2\c3ccccc3-[#6]-[#6]-c3cccnc-23)cc1 Show InChI InChI=1S/C25H25N3O/c29-28-16-9-19(10-17-28)18-27-14-11-21(12-15-27)24-23-6-2-1-4-20(23)7-8-22-5-3-13-26-25(22)24/h1-6,9-10,13,16-17H,7-8,11-12,14-15,18H2 | PDB
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| n/a | n/a | 1.83E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Schering-Plough Research Institute
Curated by ChEMBL
| Assay Description
Inhibitory activity against recombinant human farnesyltransferase |
J Med Chem 40: 4103-12 (1998)
Article DOI: 10.1021/jm970291v
BindingDB Entry DOI: 10.7270/Q2T152R0 |
More data for this
Ligand-Target Pair | |
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