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USPatent US10059720

Compile Data Set for Download or QSAR

Found 288 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271230
PNG
(US10059720, Example 45 | US10975091, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271290
PNG
(US10059720, Example 105 | US10975091, Example 105)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-8,-3.08,;-6.67,-2.31,;-5.33,-3.08,;-4,-2.31,;-2.67,-3.08,;-2.67,-4.62,;-1.33,-2.31,;-.56,-.98,;,-3.08,;1.33,-2.31,;1.33,-.77,;2.67,,;2.67,1.54,;4,2.31,;5.33,1.54,;6.67,2.31,;6.67,3.85,;8,4.62,;5.33,4.62,;4,3.85,;4,-.77,;4,-2.31,;2.67,-3.08,;-2.1,-.98,;-3.59,-1.37,;-1.33,.36,)|
Show InChI InChI=1S/C19H30N2O4S/c1-3-26-12-17(20)19(24,18(22)23)11-14-10-16(8-9-21-14)25-15-6-4-13(2)5-7-15/h8-10,13,15,17,24H,3-7,11-12,20H2,1-2H3,(H,22,23)/t13-,15-,17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271257
PNG
(US10059720, Example 72 | US10975091, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O |r|
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271330
PNG
(US10059720, Example 145 | US10975091, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Show InChI InChI=1S/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271230
PNG
(US10059720, Example 45 | US10975091, Example 45)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1ccc(cc1)[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C28H32N2O6S/c1-37(34,35)25-13-11-20(12-14-25)19-7-9-21(10-8-19)26(29)28(33,27(31)32)18-22-17-24(15-16-30-22)36-23-5-3-2-4-6-23/h7-17,23,26,33H,2-6,18,29H2,1H3,(H,31,32)/t26-,28+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271310
PNG
(US10059720, Example 125 | US10975091, Example 125)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)F)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-2.31,;-6,-4.62,;-7.34,-3.85,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Show InChI InChI=1S/C20H31FN2O4/c1-13-4-6-15(7-5-13)27-16-8-9-23-14(10-16)11-20(26,18(24)25)17(22)12-19(2,3)21/h8-10,13,15,17,26H,4-7,11-12,22H2,1-3H3,(H,24,25)/t13-,15-,17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271316
PNG
(US10059720, Example 131 | US10975091, Example 131)
Show SMILES CC(C)CC[C@H](N)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C21H30N2O4/c1-13(2)3-8-19(22)21(26,20(24)25)12-17-16-11-15(7-6-14-4-5-14)27-18(16)9-10-23-17/h9-11,13-14,19,26H,3-8,12,22H2,1-2H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271309
PNG
(US10059720, Example 124 | US10975091, Example 124)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)(C)C)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(7.34,4.62,;6,3.85,;6,2.31,;4.67,1.54,;3.33,2.31,;3.33,3.85,;4.67,4.62,;2,1.54,;2,,;3.33,-.77,;3.33,-2.31,;2,-3.08,;.67,-2.31,;-.67,-3.08,;-2,-2.31,;-1.23,-.98,;-3.33,-3.08,;-3.33,-4.62,;-4.67,-2.31,;-6,-3.08,;-7.34,-3.85,;-6.77,-1.75,;-5.23,-4.41,;-2.77,-.98,;-2,.36,;-4.26,-1.37,;.67,-.77,)|
Show InChI InChI=1S/C21H34N2O4/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,19(24)25)18(22)13-20(2,3)4/h9-11,14,16,18,26H,5-8,12-13,22H2,1-4H3,(H,24,25)/t14-,16-,18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271257
PNG
(US10059720, Example 72 | US10975091, Example 72)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC(C)(C)C)c(C)cn1)C(O)=O |r|
Show InChI InChI=1S/C20H34N2O4/c1-13(2)9-17(21)20(25,18(23)24)11-15-10-16(14(3)12-22-15)26-8-7-19(4,5)6/h10,12-13,17,25H,7-9,11,21H2,1-6H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271275
PNG
(US10059720, Example 90 | US10975091, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O |r|
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271275
PNG
(US10059720, Example 90 | US10975091, Example 90)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCC(C)(C)CC1)C(O)=O |r|
Show InChI InChI=1S/C20H33N3O3/c1-14(2)11-17(21)20(26,18(24)25)13-15-12-16(5-8-22-15)23-9-6-19(3,4)7-10-23/h5,8,12,14,17,26H,6-7,9-11,13,21H2,1-4H3,(H,24,25)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271288
PNG
(US10059720, Example 103 | US10975091, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:5.6,3.3,15.15,wD:12.11,5.5,(-7.34,-2.31,;-6,-3.08,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.26,-1.37,;-2,.36,)|
Show InChI InChI=1S/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271198
PNG
(US10059720, Example 13 | US10975091, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O |r|
Show InChI InChI=1S/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271318
PNG
(US10059720, Example 133 | US10975091, Example 133)
Show SMILES N[C@@H](CCC(F)(F)F)[C@](O)(Cc1nccc2oc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C19H23F3N2O4/c20-19(21,22)7-5-16(23)18(27,17(25)26)10-14-13-9-12(4-3-11-1-2-11)28-15(13)6-8-24-14/h6,8-9,11,16,27H,1-5,7,10,23H2,(H,25,26)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271258
PNG
(US10059720, Example 73 | US10975091, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;4.67,,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271277
PNG
(US10059720, Example 92 | US10975091, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271213
PNG
(US10059720, Example 28 | US10975091, Example 28)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2(C)CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C19H30N2O4/c1-13(2)10-16(20)19(24,17(22)23)12-14-11-15(4-8-21-14)25-9-7-18(3)5-6-18/h4,8,11,13,16,24H,5-7,9-10,12,20H2,1-3H3,(H,22,23)/t16-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271190
PNG
(US10059720, Example 6 | US10975091, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271260
PNG
(US10059720, Example 75 | US10975091, Example 75)
Show SMILES COCCCCC[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C21H34N2O5/c1-27-13-7-3-6-10-19(22)21(26,20(24)25)15-16-14-18(11-12-23-16)28-17-8-4-2-5-9-17/h11-12,14,17,19,26H,2-10,13,15,22H2,1H3,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271277
PNG
(US10059720, Example 92 | US10975091, Example 92)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H](C)Cc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H30N2O4/c1-15(2)11-20(23)22(27,21(25)26)14-18-13-19(9-10-24-18)28-16(3)12-17-7-5-4-6-8-17/h4-10,13,15-16,20,27H,11-12,14,23H2,1-3H3,(H,25,26)/t16-,20+,22-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271272
PNG
(US10059720, Example 87 | US10975091, Example 87)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCN(CC2)C(=O)OCc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C26H35N3O6/c1-18(2)14-23(27)26(33,24(30)31)16-20-15-22(8-11-28-20)35-21-9-12-29(13-10-21)25(32)34-17-19-6-4-3-5-7-19/h3-8,11,15,18,21,23,33H,9-10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271330
PNG
(US10059720, Example 145 | US10975091, Example 145)
Show SMILES CCCSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:7.8,5.5,17.17,wD:7.7,14.13,(-8.67,-2.31,;-7.34,-3.08,;-6,-2.31,;-4.67,-3.08,;-3.33,-2.31,;-2,-3.08,;-2,-4.62,;-.67,-2.31,;.1,-.98,;.67,-3.08,;2,-2.31,;2,-.77,;3.33,,;3.33,1.54,;4.67,2.31,;6,1.54,;7.34,2.31,;7.34,3.85,;8.67,4.62,;6,4.62,;4.67,3.85,;4.67,-.77,;4.67,-2.31,;3.33,-3.08,;-1.44,-.98,;-2.92,-1.37,;-.67,.36,)|
Show InChI InChI=1S/C20H32N2O4S/c1-3-10-27-13-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(2)5-7-16/h8-9,11,14,16,18,25H,3-7,10,12-13,21H2,1-2H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271190
PNG
(US10059720, Example 6 | US10975091, Example 6)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16-,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271243
PNG
(US10059720, Example 58 | US10975091, Example 58)
Show SMILES CC(C)C[C@@H](C)Oc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1 |r|
Show InChI InChI=1S/C19H32N2O4/c1-12(2)8-14(5)25-16-6-7-21-15(10-16)11-19(24,18(22)23)17(20)9-13(3)4/h6-7,10,12-14,17,24H,8-9,11,20H2,1-5H3,(H,22,23)/t14-,17+,19-/m1/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271198
PNG
(US10059720, Example 13 | US10975091, Example 13)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(ccn1)N1CCCCC1)C(O)=O |r|
Show InChI InChI=1S/C18H29N3O3/c1-13(2)10-16(19)18(24,17(22)23)12-14-11-15(6-7-20-14)21-8-4-3-5-9-21/h6-7,11,13,16,24H,3-5,8-10,12,19H2,1-2H3,(H,22,23)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271272
PNG
(US10059720, Example 87 | US10975091, Example 87)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCN(CC2)C(=O)OCc2ccccc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C26H35N3O6/c1-18(2)14-23(27)26(33,24(30)31)16-20-15-22(8-11-28-20)35-21-9-12-29(13-10-21)25(32)34-17-19-6-4-3-5-7-19/h3-8,11,15,18,21,23,33H,9-10,12-14,16-17,27H2,1-2H3,(H,30,31)/t23-,26+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271288
PNG
(US10059720, Example 103 | US10975091, Example 103)
Show SMILES CSC[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:5.6,3.3,15.15,wD:12.11,5.5,(-7.34,-2.31,;-6,-3.08,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.26,-1.37,;-2,.36,)|
Show InChI InChI=1S/C18H28N2O4S/c1-12-3-5-14(6-4-12)24-15-7-8-20-13(9-15)10-18(23,17(21)22)16(19)11-25-2/h7-9,12,14,16,23H,3-6,10-11,19H2,1-2H3,(H,21,22)/t12-,14-,16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271280
PNG
(US10059720, Example 95 | US10975091, Example 95)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCc2ccsc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C19H26N2O4S/c1-13(2)9-17(20)19(24,18(22)23)11-15-10-16(3-6-21-15)25-7-4-14-5-8-26-12-14/h3,5-6,8,10,12-13,17,24H,4,7,9,11,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271280
PNG
(US10059720, Example 95 | US10975091, Example 95)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCc2ccsc2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C19H26N2O4S/c1-13(2)9-17(20)19(24,18(22)23)11-15-10-16(3-6-21-15)25-7-4-14-5-8-26-12-14/h3,5-6,8,10,12-13,17,24H,4,7,9,11,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271232
PNG
(US10059720, Example 47 | US10975091, Example 47)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CC3CCC2C3)ccn1)C(O)=O |r|
Show InChI InChI=1S/C20H30N2O4/c1-12(2)7-18(21)20(25,19(23)24)11-15-10-16(5-6-22-15)26-17-9-13-3-4-14(17)8-13/h5-6,10,12-14,17-18,25H,3-4,7-9,11,21H2,1-2H3,(H,23,24)/t13?,14?,17?,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271311
PNG
(US10059720, Example 126 | US10975091, Example 126)
Show SMILES CCSC[C@H](N)[C@](O)(Cc1cc(OC2CCC3(CC3)CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C20H30N2O4S/c1-2-27-13-17(21)20(25,18(23)24)12-14-11-16(5-10-22-14)26-15-3-6-19(7-4-15)8-9-19/h5,10-11,15,17,25H,2-4,6-9,12-13,21H2,1H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271184
PNG
(US10059720, Example 1 | US10975091, Example 1)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCCC2CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C18H28N2O4/c1-12(2)9-16(19)18(23,17(21)22)11-14-10-15(5-7-20-14)24-8-6-13-3-4-13/h5,7,10,12-13,16,23H,3-4,6,8-9,11,19H2,1-2H3,(H,21,22)/t16-,18+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271199
PNG
(US10059720, Example 14 | US10975091, Example 14)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OCc2cccc3ccccc23)ccn1)C(O)=O |r|
Show InChI InChI=1S/C24H28N2O4/c1-16(2)12-22(25)24(29,23(27)28)14-19-13-20(10-11-26-19)30-15-18-8-5-7-17-6-3-4-9-21(17)18/h3-11,13,16,22,29H,12,14-15,25H2,1-2H3,(H,27,28)/t22-,24+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271218
PNG
(US10059720, Example 33 | US10975091, Example 33)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc2n(CCC3CCCCC3)cnc2cn1)C(O)=O |r|
Show InChI InChI=1S/C22H34N4O3/c1-15(2)10-20(23)22(29,21(27)28)12-17-11-19-18(13-24-17)25-14-26(19)9-8-16-6-4-3-5-7-16/h11,13-16,20,29H,3-10,12,23H2,1-2H3,(H,27,28)/t20-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271245
PNG
(US10059720, Example 60 | US10975091, Example 60)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CC(C)(C)OC(C)(C)C2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C22H36N2O5/c1-14(2)9-18(23)22(27,19(25)26)11-15-10-16(7-8-24-15)28-17-12-20(3,4)29-21(5,6)13-17/h7-8,10,14,17-18,27H,9,11-13,23H2,1-6H3,(H,25,26)/t18-,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271258
PNG
(US10059720, Example 73 | US10975091, Example 73)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@H](C)CC2)c(C)cn1)C(O)=O |r,wU:6.7,4.4,16.16,wD:13.12,6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;4.67,,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C21H34N2O4/c1-13(2)9-19(22)21(26,20(24)25)11-16-10-18(15(4)12-23-16)27-17-7-5-14(3)6-8-17/h10,12-14,17,19,26H,5-9,11,22H2,1-4H3,(H,24,25)/t14-,17-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271306
PNG
(US10059720, Example 121 | US10975091, Example 121)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(SC2CCCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C20H32N2O3S/c1-14(2)11-18(21)20(25,19(23)24)13-15-12-17(9-10-22-15)26-16-7-5-3-4-6-8-16/h9-10,12,14,16,18,25H,3-8,11,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271233
PNG
(US10059720, Example 48 | US10975091, Example 48)
Show SMILES N[C@@H](c1ccc(cc1)N1CCOCC1)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C25H33N3O5/c26-23(18-6-8-20(9-7-18)28-12-14-32-15-13-28)25(31,24(29)30)17-19-16-22(10-11-27-19)33-21-4-2-1-3-5-21/h6-11,16,21,23,31H,1-5,12-15,17,26H2,(H,29,30)/t23-,25+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271187
PNG
(US10059720, Example 3 | US10975091, Example 3)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C19H30N2O4/c1-13(2)10-17(20)19(24,18(22)23)12-14-11-16(8-9-21-14)25-15-6-4-3-5-7-15/h8-9,11,13,15,17,24H,3-7,10,12,20H2,1-2H3,(H,22,23)/t17-,19+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271292
PNG
(US10059720, Example 107 | US10975091, Example 107)
Show SMILES C[C@H]1CC[C@@H](CC1)Oc1ccnc(C[C@@](O)([C@@H](N)CSC2CCC2)C(O)=O)c1 |r,wU:14.14,16.17,1.0,wD:4.7,14.15,(8.28,4.62,;6.94,3.85,;6.94,2.31,;5.61,1.54,;4.28,2.31,;4.28,3.85,;5.61,4.62,;2.94,1.54,;2.94,,;4.28,-.77,;4.28,-2.31,;2.94,-3.08,;1.61,-2.31,;.28,-3.08,;-1.06,-2.31,;-.29,-.98,;-2.39,-3.08,;-2.39,-4.62,;-3.72,-2.31,;-5.06,-3.08,;-6.39,-2.31,;-6.79,-.82,;-8.28,-1.22,;-7.88,-2.71,;-1.83,-.98,;-3.32,-1.37,;-1.06,.36,;1.61,-.77,)|
Show InChI InChI=1S/C21H32N2O4S/c1-14-5-7-16(8-6-14)27-17-9-10-23-15(11-17)12-21(26,20(24)25)19(22)13-28-18-3-2-4-18/h9-11,14,16,18-19,26H,2-8,12-13,22H2,1H3,(H,24,25)/t14-,16-,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271188
PNG
(US10059720, Example 4 | US10975091, Example 4)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCC3(CC3)CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C21H32N2O4/c1-14(2)11-18(22)21(26,19(24)25)13-15-12-17(5-10-23-15)27-16-3-6-20(7-4-16)8-9-20/h5,10,12,14,16,18,26H,3-4,6-9,11,13,22H2,1-2H3,(H,24,25)/t18-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271194
PNG
(US10059720, Example 9 | US10975091, Example 9)
Show SMILES N[C@@H](CCC1CCC1)[C@](O)(Cc1cc(OCCC2CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C20H30N2O4/c21-18(7-6-14-2-1-3-14)20(25,19(23)24)13-16-12-17(8-10-22-16)26-11-9-15-4-5-15/h8,10,12,14-15,18,25H,1-7,9,11,13,21H2,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271244
PNG
(US10059720, Example 59 | US10975091, Example 59)
Show SMILES CCC(C)(C)CCOc1ccnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)c1 |r|
Show InChI InChI=1S/C20H34N2O4/c1-6-19(4,5)8-10-26-16-7-9-22-15(12-16)13-20(25,18(23)24)17(21)11-14(2)3/h7,9,12,14,17,25H,6,8,10-11,13,21H2,1-5H3,(H,23,24)/t17-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271226
PNG
(US10059720, Example 41 | US10975091, Example 41)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(OC2CCCCCC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C20H32N2O4/c1-14(2)11-18(21)20(25,19(23)24)13-15-12-17(9-10-22-15)26-16-7-5-3-4-6-8-16/h9-10,12,14,16,18,25H,3-8,11,13,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271317
PNG
(US10059720, Example 132 | US10975091, Example 132)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1nccc2sc(CCC3CC3)cc12)C(O)=O |r|
Show InChI InChI=1S/C20H28N2O3S/c1-12(2)9-18(21)20(25,19(23)24)11-16-15-10-14(6-5-13-3-4-13)26-17(15)7-8-22-16/h7-8,10,12-13,18,25H,3-6,9,11,21H2,1-2H3,(H,23,24)/t18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271210
PNG
(US10059720, Example 25 | US10975091, Example 25)
Show SMILES CCCCCCn1ccc2cnc(C[C@@](O)([C@@H](N)CC(C)C)C(O)=O)cc12 |r|
Show InChI InChI=1S/C21H33N3O3/c1-4-5-6-7-9-24-10-8-16-14-23-17(12-18(16)24)13-21(27,20(25)26)19(22)11-15(2)3/h8,10,12,14-15,19,27H,4-7,9,11,13,22H2,1-3H3,(H,25,26)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271246
PNG
(US10059720, Example 61 | US10975091, Example 61)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@H]2CC[C@]3(CCCO3)CC2)ccn1)C(O)=O |r,wU:6.7,13.12,4.4,16.20,wD:6.6,(-7.85,-2.93,;-6.52,-3.7,;-6.52,-5.24,;-5.19,-2.93,;-3.85,-3.7,;-3.85,-5.24,;-2.52,-2.93,;-1.75,-1.6,;-1.18,-3.7,;.15,-2.93,;.15,-1.39,;1.48,-.62,;1.48,.92,;2.82,1.69,;2.82,3.23,;4.15,4,;5.48,3.23,;6.95,2.75,;7.85,4,;6.95,5.24,;5.48,4.77,;5.48,1.69,;4.15,.92,;2.82,-1.39,;2.82,-2.93,;1.48,-3.7,;-3.29,-1.6,;-4.83,-1.6,;-2.52,-.27,)|
Show InChI InChI=1S/C22H34N2O5/c1-15(2)12-19(23)22(27,20(25)26)14-16-13-18(6-10-24-16)29-17-4-8-21(9-5-17)7-3-11-28-21/h6,10,13,15,17,19,27H,3-5,7-9,11-12,14,23H2,1-2H3,(H,25,26)/t17-,19-,21+,22+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271241
PNG
(US10059720, Example 56 | US10975091, Example 56)
Show SMILES CC(C)C[C@H](N)[C@](O)(Cc1cc(O[C@@H]2CC[C@H](C)CC2)ccn1)C(O)=O |r,wU:6.7,13.12,4.4,16.16,wD:6.6,(-7.34,-2.31,;-6,-3.08,;-6,-4.62,;-4.67,-2.31,;-3.33,-3.08,;-3.33,-4.62,;-2,-2.31,;-1.23,-.98,;-.67,-3.08,;.67,-2.31,;.67,-.77,;2,,;2,1.54,;3.33,2.31,;4.67,1.54,;6,2.31,;6,3.85,;7.34,4.62,;4.67,4.62,;3.33,3.85,;3.33,-.77,;3.33,-2.31,;2,-3.08,;-2.77,-.98,;-4.31,-.98,;-2,.36,)|
Show InChI InChI=1S/C20H32N2O4/c1-13(2)10-18(21)20(25,19(23)24)12-15-11-17(8-9-22-15)26-16-6-4-14(3)5-7-16/h8-9,11,13-14,16,18,25H,4-7,10,12,21H2,1-3H3,(H,23,24)/t14-,16+,18-,20+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Rattus norvegicus)		BDBM271185
PNG
(US10059720, Example 2(1) | US10975091, Example 2(1...)
Show SMILES CCC(Cl)CCCOC[C@H](N)[C@](O)(Cc1cc(OCCC2CC2)ccn1)C(O)=O |r|
Show InChI InChI=1S/C21H33ClN2O5/c1-2-16(22)4-3-10-28-14-19(23)21(27,20(25)26)13-17-12-18(7-9-24-17)29-11-8-15-5-6-15/h7,9,12,15-16,19,27H,2-6,8,10-11,13-14,23H2,1H3,(H,25,26)/t16?,19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
Rat epididymal fat pads were homogenized and subjected to ultracentrifugation at 100,000×g for 30 minutes to obtain microsomes containing IRAP. The m...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
Leucyl-cystinyl aminopeptidase


(Homo sapiens (Human))		BDBM271252
PNG
(US10059720, Example 67 | US10975091, Example 67)
Show SMILES [#7]-[#6@@H](\[#6]=[#6]-1\[#6]-[#6]-[#8]-[#6]-[#6]-1)[C@]([#8])([#6]-c1cc(-[#8]-[#6]-2-[#6]-[#6]-[#6]-[#6]-[#6]-2)ccn1)[#6](-[#8])=O |r|
Show InChI InChI=1S/C21H30N2O5/c22-19(12-15-7-10-27-11-8-15)21(26,20(24)25)14-16-13-18(6-9-23-16)28-17-4-2-1-3-5-17/h6,9,12-13,17,19,26H,1-5,7-8,10-11,14,22H2,(H,24,25)/t19-,21+/m0/s1
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Astellas Pharma Inc.; KOTOBUKI PHARMACEUTICALS CO., LTD.

US Patent


Assay Description
HEK293 cells forced to transiently express hP-LAP (J Biol Chem 1996; 271: 56-61) were prepared by lipofection, homogenized, and then subjected to ult...

US Patent US10059720 (2018)


BindingDB Entry DOI: 10.7270/Q2XD13Q5
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%