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USPatent US10206907

Compile Data Set for Download or QSAR

Found 633 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349202
PNG
(Cyclopropanecarboxylic acid (5-{4-[(3,5-difluoro-p...)
Show SMILES Fc1cnc(NCc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c(F)c1
Show InChI InChI=1S/C22H18F2N6O/c23-16-10-17(24)20(26-12-16)25-11-13-4-6-14(7-5-13)18-2-1-3-19-27-22(29-30(18)19)28-21(31)15-8-9-15/h1-7,10,12,15H,8-9,11H2,(H,25,26)(H,28,29,31)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349146
PNG
(Cyclopropanecarboxylic acid {5-[4-(3-fluoro-piperi...)
Show SMILES FC1CCCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)C1
Show InChI InChI=1S/C22H24FN5O/c23-18-3-2-12-27(14-18)13-15-6-8-16(9-7-15)19-4-1-5-20-24-22(26-28(19)20)25-21(29)17-10-11-17/h1,4-9,17-18H,2-3,10-14H2,(H,25,26,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349162
PNG
(Cyclopropanecarboxylic acid (5-{4-[acetyl-(6-cyano...)
Show SMILES CC(=O)N(Cc1ccc(nc1)C#N)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C25H21N7O2/c1-16(33)31(15-17-5-10-20(13-26)27-14-17)21-11-8-18(9-12-21)22-3-2-4-23-28-25(30-32(22)23)29-24(34)19-6-7-19/h2-5,8-12,14,19H,6-7,15H2,1H3,(H,29,30,34)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM348979
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES FC(F)(F)c1ccc(CCNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1
Show InChI InChI=1S/C26H22F3N5O2/c27-26(28,29)20-12-4-16(5-13-20)14-15-30-23(35)18-8-6-17(7-9-18)21-2-1-3-22-31-25(33-34(21)22)32-24(36)19-10-11-19/h1-9,12-13,19H,10-11,14-15H2,(H,30,35)(H,32,33,36)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM348981
PNG
(N-(5-(4-((1,2,4-oxadiazol-3- yl)methoxy)phenyl)- [...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ncon4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C19H16N6O3/c26-18(13-4-5-13)22-19-21-17-3-1-2-15(25(17)23-19)12-6-8-14(9-7-12)27-10-16-20-11-28-24-16/h1-3,6-9,11,13H,4-5,10H2,(H,22,23,26)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM349038
PNG
(N-(5-(4-(4-benzyl-4- hydroxypiperidine-1- carbonyl...)
Show SMILES OC1(Cc2ccccc2)CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C29H29N5O3/c35-26(22-11-12-22)31-28-30-25-8-4-7-24(34(25)32-28)21-9-13-23(14-10-21)27(36)33-17-15-29(37,16-18-33)19-20-5-2-1-3-6-20/h1-10,13-14,22,37H,11-12,15-19H2,(H,31,32,35)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM348899
PNG
(N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)
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GALAPAGOS NV

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Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187]


(Homo sapiens (Human))		BDBM294916
PNG
(US10112907, Example 00027 | US10206907, Compound 1...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1
Show InChI InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)
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Assay Description
Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349000
PNG
(N-(5-(4-(2- (methyl(phenyl)amino)-2- oxoethoxy)phe...)
Show SMILES CN(C(=O)COc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12)c1ccccc1
Show InChI InChI=1S/C25H23N5O3/c1-29(19-6-3-2-4-7-19)23(31)16-33-20-14-12-17(13-15-20)21-8-5-9-22-26-25(28-30(21)22)27-24(32)18-10-11-18/h2-9,12-15,18H,10-11,16H2,1H3,(H,27,28,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349007
PNG
(N-(5-(4-(1H-pyrazol-1- yl)benzyloxy)phenyl)- [1,2,...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(cc4)-n4cccn4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C26H22N6O2/c33-25(20-7-8-20)29-26-28-24-4-1-3-23(32(24)30-26)19-9-13-22(14-10-19)34-17-18-5-11-21(12-6-18)31-16-2-15-27-31/h1-6,9-16,20H,7-8,17H2,(H,29,30,33)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM294916
PNG
(US10112907, Example 00027 | US10206907, Compound 1...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)C#N)cc3)n2n1)C1CC1
Show InChI InChI=1S/C23H18N6O2/c24-12-18-9-4-15(13-25-18)14-31-19-10-7-16(8-11-19)20-2-1-3-21-26-23(28-29(20)21)27-22(30)17-5-6-17/h1-4,7-11,13,17H,5-6,14H2,(H,27,28,30)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349065
PNG
(Cyclopropanecarboxylic Acid (5-{4-[6-(2H-tetrazol-...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccc(nc4)-c4nnn[nH]4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C23H19N9O2/c33-22(16-5-6-16)26-23-25-20-3-1-2-19(32(20)29-23)15-7-9-17(10-8-15)34-13-14-4-11-18(24-12-14)21-27-30-31-28-21/h1-4,7-12,16H,5-6,13H2,(H,26,29,33)(H,27,28,30,31)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349093
PNG
(Cyclopropanecarboxylic acid (5-{4-[(4-chloro-2-flu...)
Show SMILES Fc1cc(Cl)ccc1NCc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C23H19ClFN5O/c24-17-10-11-19(18(25)12-17)26-13-14-4-6-15(7-5-14)20-2-1-3-21-27-23(29-30(20)21)28-22(31)16-8-9-16/h1-7,10-12,16,26H,8-9,13H2,(H,28,29,31)
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GALAPAGOS NV

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Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM103737
PNG
(US10206907, Compound 234 | US11000528, Cpd # 11 | ...)
Show SMILES FC1(F)CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H23F2N5O/c23-22(24)10-12-28(13-11-22)14-15-4-6-16(7-5-15)18-2-1-3-19-25-21(27-29(18)19)26-20(30)17-8-9-17/h1-7,17H,8-14H2,(H,26,27,30)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349186
PNG
(Cyclopropanecarboxylic acid (5-{4-[2-(3-methoxy-az...)
Show SMILES COC1CN(C1)C(=O)Cc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C22H23N5O3/c1-30-17-12-26(13-17)20(28)11-14-5-7-15(8-6-14)18-3-2-4-19-23-22(25-27(18)19)24-21(29)16-9-10-16/h2-8,16-17H,9-13H2,1H3,(H,24,25,29)
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GALAPAGOS NV

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Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348902
PNG
(N-(5-(4-(benzyloxy)-3- fluorophenyl)- [1,2,4]triaz...)
Show SMILES Fc1cc(ccc1OCc1ccccc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C23H19FN4O2/c24-18-13-17(11-12-20(18)30-14-15-5-2-1-3-6-15)19-7-4-8-21-25-23(27-28(19)21)26-22(29)16-9-10-16/h1-8,11-13,16H,9-10,14H2,(H,26,27,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348943
PNG
(Cyclopropanecarboxylic Acid [5-(6-benzyloxy-pyridi...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)nc3)n2n1)C1CC1
Show InChI InChI=1S/C22H19N5O2/c28-21(16-9-10-16)25-22-24-19-8-4-7-18(27(19)26-22)17-11-12-20(23-13-17)29-14-15-5-2-1-3-6-15/h1-8,11-13,16H,9-10,14H2,(H,25,26,28)
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GALAPAGOS NV

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Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348970
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCc3ccccc3)n2n1)C1CC1
Show InChI InChI=1S/C25H23N5O2/c31-23(26-16-15-17-5-2-1-3-6-17)19-11-9-18(10-12-19)21-7-4-8-22-27-25(29-30(21)22)28-24(32)20-13-14-20/h1-12,20H,13-16H2,(H,26,31)(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348979
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES FC(F)(F)c1ccc(CCNC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1
Show InChI InChI=1S/C26H22F3N5O2/c27-26(28,29)20-12-4-16(5-13-20)14-15-30-23(35)18-8-6-17(7-9-18)21-2-1-3-22-31-25(33-34(21)22)32-24(36)19-10-11-19/h1-9,12-13,19H,10-11,14-15H2,(H,30,35)(H,32,33,36)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348990
PNG
(N-(5-(4-(3- phenoxypropanamido(phenyl)- [1,2,4]tri...)
Show SMILES O=C(CCOc1ccccc1)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C25H23N5O3/c31-23(15-16-33-20-5-2-1-3-6-20)26-19-13-11-17(12-14-19)21-7-4-8-22-27-25(29-30(21)22)28-24(32)18-9-10-18/h1-8,11-14,18H,9-10,15-16H2,(H,26,31)(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348991
PNG
(N-(5-(4-(3- phenylpropanamido)phenyl)- [1,2,4]tria...)
Show SMILES O=C(CCc1ccccc1)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C25H23N5O2/c31-23(16-9-17-5-2-1-3-6-17)26-20-14-12-18(13-15-20)21-7-4-8-22-27-25(29-30(21)22)28-24(32)19-10-11-19/h1-8,12-15,19H,9-11,16H2,(H,26,31)(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM348899
PNG
(N-(5-(4-(benzyloxy)phenyl)- [1,2,4]triazolo[1,5-a]...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ccccc4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C23H20N4O2/c28-22(18-9-10-18)25-23-24-21-8-4-7-20(27(21)26-23)17-11-13-19(14-12-17)29-15-16-5-2-1-3-6-16/h1-8,11-14,18H,9-10,15H2,(H,25,26,28)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349110
PNG
(Cyclopropanecarboxylic acid {5-[4-(pyrimidin-2- yl...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CNc4ncccn4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H19N7O/c29-19(16-9-10-16)26-21-25-18-4-1-3-17(28(18)27-21)15-7-5-14(6-8-15)13-24-20-22-11-2-12-23-20/h1-8,11-12,16H,9-10,13H2,(H,22,23,24)(H,26,27,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349114
PNG
(Cyclopropanecarboxylic acid {5-[4-(4-fluoro-piperi...)
Show SMILES FC1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C22H24FN5O/c23-18-10-12-27(13-11-18)14-15-4-6-16(7-5-15)19-2-1-3-20-24-22(26-28(19)20)25-21(29)17-8-9-17/h1-7,17-18H,8-14H2,(H,25,26,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349166
PNG
(Cyclopropanecarboxylic acid {5-[4-(4-cyanomethyl- ...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(COc4ccc(CC#N)cc4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C25H21N5O2/c26-15-14-17-6-12-21(13-7-17)32-16-18-4-8-19(9-5-18)22-2-1-3-23-27-25(29-30(22)23)28-24(31)20-10-11-20/h1-9,12-13,20H,10-11,14,16H2,(H,28,29,31)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2 [808-1132]


(Homo sapiens (Human))		BDBM349193
PNG
(Cyclopropanecarboxylic acid {5-[4-(3-cyano-azetidi...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CC(C3)C#N)n2n1)C1CC1
Show InChI InChI=1S/C21H18N6O2/c22-10-13-11-26(12-13)20(29)16-8-4-14(5-9-16)17-2-1-3-18-23-21(25-27(17)18)24-19(28)15-6-7-15/h1-5,8-9,13,15H,6-7,11-12H2,(H,24,25,28)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK2 catalytic domain (amino acids 808-1132; catalog number PV4210) was purchased from Invitrogen. 0.025 mU of JAK2 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM348902
PNG
(N-(5-(4-(benzyloxy)-3- fluorophenyl)- [1,2,4]triaz...)
Show SMILES Fc1cc(ccc1OCc1ccccc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C23H19FN4O2/c24-18-13-17(11-12-20(18)30-14-15-5-2-1-3-6-15)19-7-4-8-21-25-23(27-28(19)21)26-22(29)16-9-10-16/h1-8,11-13,16H,9-10,14H2,(H,26,27,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM348962
PNG
(N-(5-(4-(2- phenylethylsulfonamido) phenyl)-[1,2,4...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(NS(=O)(=O)CCc4ccccc4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C24H23N5O3S/c30-23(19-9-10-19)26-24-25-22-8-4-7-21(29(22)27-24)18-11-13-20(14-12-18)28-33(31,32)16-15-17-5-2-1-3-6-17/h1-8,11-14,19,28H,9-10,15-16H2,(H,26,27,30)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM349137
PNG
(Cyclopropanecarboxylic acid (5-[4-(3,3-difluoro- p...)
Show SMILES FC1(F)CCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C21H19F2N5O2/c22-21(23)10-11-27(12-21)19(30)15-8-4-13(5-9-15)16-2-1-3-17-24-20(26-28(16)17)25-18(29)14-6-7-14/h1-5,8-9,14H,6-7,10-12H2,(H,25,26,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3 [781-1124]


(Homo sapiens (Human))		BDBM128101
PNG
(US10206907, Compound 330 | US8796457, 1 | US950575...)
Show SMILES CC1(C)CN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK3 catalytic domain (amino acids 781-1124; catalog number PV3855) was purchased from Invitrogen. 0.025 mU of JAK3 was incubated w...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 [871-1187]


(Homo sapiens (Human))		BDBM349171
PNG
(2-{4-[2- (Cyclopropanecarbonyl- amino)-[1,2,4]tria...)
Show SMILES NC(=O)c1ccccc1NCc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C24H22N6O2/c25-22(31)18-4-1-2-5-19(18)26-14-15-8-10-16(11-9-15)20-6-3-7-21-27-24(29-30(20)21)28-23(32)17-12-13-17/h1-11,17,26H,12-14H2,(H2,25,31)(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human TYK2 catalytic domain (amino acids 871-1187; catalog number 08-147) was purchased from Carna biosciences. 5 ng of TYK2 was incubate...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348919
PNG
(N-(5-(4-(4- fluorophenylsulfonamido) phenyl)-[1,2,...)
Show SMILES Fc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C22H18FN5O3S/c23-16-8-12-18(13-9-16)32(30,31)27-17-10-6-14(7-11-17)19-2-1-3-20-24-22(26-28(19)20)25-21(29)15-4-5-15/h1-3,6-13,15,27H,4-5H2,(H,25,26,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348938
PNG
(N-(5-(4-((5-methylisoxazol-3- yl)methoxy)phenyl)- ...)
Show SMILES Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)no1
Show InChI InChI=1S/C21H19N5O3/c1-13-11-16(25-29-13)12-28-17-9-7-14(8-10-17)18-3-2-4-19-22-21(24-26(18)19)23-20(27)15-5-6-15/h2-4,7-11,15H,5-6,12H2,1H3,(H,23,24,27)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348948
PNG
(N-(5-(4-((1,5-dimethyl-1H- pyrazol-3-yl)methyldime...)
Show SMILES Cc1cc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)nn1C
Show InChI InChI=1S/C22H22N6O2/c1-14-12-17(25-27(14)2)13-30-18-10-8-15(9-11-18)19-4-3-5-20-23-22(26-28(19)20)24-21(29)16-6-7-16/h3-5,8-12,16H,6-7,13H2,1-2H3,(H,24,26,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348981
PNG
(N-(5-(4-((1,2,4-oxadiazol-3- yl)methoxy)phenyl)- [...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(OCc4ncon4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C19H16N6O3/c26-18(13-4-5-13)22-19-21-17-3-1-2-15(25(17)23-19)12-6-8-14(9-7-12)27-10-16-20-11-28-24-16/h1-3,6-9,11,13H,4-5,10H2,(H,22,23,26)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348988
PNG
(4-(2- (cyclopropanecarboxamido)- [1,2,4]triazolo[1...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)NCCc3cnn(c3)-c3ccccc3)n2n1)C1CC1
Show InChI InChI=1S/C28H25N7O2/c36-26(29-16-15-19-17-30-34(18-19)23-5-2-1-3-6-23)21-11-9-20(10-12-21)24-7-4-8-25-31-28(33-35(24)25)32-27(37)22-13-14-22/h1-12,17-18,22H,13-16H2,(H,29,36)(H,32,33,37)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348995
PNG
(N-(5-(4-(4-(3- chlorophenyl)piperazine-1- carbonyl...)
Show SMILES Clc1cccc(c1)N1CCN(CC1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C27H25ClN6O2/c28-21-3-1-4-22(17-21)32-13-15-33(16-14-32)26(36)20-11-7-18(8-12-20)23-5-2-6-24-29-27(31-34(23)24)30-25(35)19-9-10-19/h1-8,11-12,17,19H,9-10,13-16H2,(H,30,31,35)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM348998
PNG
(N-(5-(4-(2-(3- fluorophenylamino)-2- oxoethoxy)phe...)
Show SMILES Fc1cccc(NC(=O)COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)c1
Show InChI InChI=1S/C24H20FN5O3/c25-17-3-1-4-18(13-17)26-22(31)14-33-19-11-9-15(10-12-19)20-5-2-6-21-27-24(29-30(20)21)28-23(32)16-7-8-16/h1-6,9-13,16H,7-8,14H2,(H,26,31)(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349051
PNG
(N-(5-(4-(3-phenylpiperidine-1- carbonyl)phenyl)- [...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)C(=O)N3CCCC(C3)c3ccccc3)n2n1)C1CC1
Show InChI InChI=1S/C28H27N5O2/c34-26(21-13-14-21)30-28-29-25-10-4-9-24(33(25)31-28)20-11-15-22(16-12-20)27(35)32-17-5-8-23(18-32)19-6-2-1-3-7-19/h1-4,6-7,9-12,15-16,21,23H,5,8,13-14,17-18H2,(H,30,31,34)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349057
PNG
(N-(5-(4-(3,3- dimethylpiperidine-1- carbonyl)pheny...)
Show SMILES CC1(C)CCCN(C1)C(=O)c1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C24H27N5O2/c1-24(2)13-4-14-28(15-24)22(31)18-11-7-16(8-12-18)19-5-3-6-20-25-23(27-29(19)20)26-21(30)17-9-10-17/h3,5-8,11-12,17H,4,9-10,13-15H2,1-2H3,(H,26,27,30)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349060
PNG
(N-(5-(4-((6-(1-methyl-1H- pyrazol-4-yl)pyridin-3- ...)
Show SMILES Cn1cc(cn1)-c1ccc(COc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1
Show InChI InChI=1S/C26H23N7O2/c1-32-15-20(14-28-32)22-12-5-17(13-27-22)16-35-21-10-8-18(9-11-21)23-3-2-4-24-29-26(31-33(23)24)30-25(34)19-6-7-19/h2-5,8-15,19H,6-7,16H2,1H3,(H,30,31,34)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM103727
PNG
(US10112907, Example 00033 | US10206907, Compound 2...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CN4CCS(=O)(=O)CC4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349082
PNG
(Cyclopropanecarboxylic acid (5-{4-[2-(3,5-dimethyl...)
Show SMILES Cc1noc(C)c1CCOc1ccc(cc1)-c1cccc2nc(NC(=O)C3CC3)nn12
Show InChI InChI=1S/C23H23N5O3/c1-14-19(15(2)31-27-14)12-13-30-18-10-8-16(9-11-18)20-4-3-5-21-24-23(26-28(20)21)25-22(29)17-6-7-17/h3-5,8-11,17H,6-7,12-13H2,1-2H3,(H,25,26,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349084
PNG
(4-[2-(Cyclopropanecarbonyl- amino)-[1,2,4]triazolo...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cn1
Show InChI InChI=1S/C23H20N6O3/c1-32-20-12-11-17(13-24-20)25-21(30)15-7-5-14(6-8-15)18-3-2-4-19-26-23(28-29(18)19)27-22(31)16-9-10-16/h2-8,11-13,16H,9-10H2,1H3,(H,25,30)(H,27,28,31)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349105
PNG
(Cyclopropanecarboxylic acid (5-{4-[(4-cyanomethyl-...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CNc4ccc(CC#N)cc4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C25H22N6O/c26-15-14-17-6-12-21(13-7-17)27-16-18-4-8-19(9-5-18)22-2-1-3-23-28-25(30-31(22)23)29-24(32)20-10-11-20/h1-9,12-13,20,27H,10-11,14,16H2,(H,29,30,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349108
PNG
(4-{4-[2- (Cyclopropanecarbonyl- amino)-[1,2,4]tria...)
Show SMILES NC(=O)c1ccc(NCc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)cc1
Show InChI InChI=1S/C24H22N6O2/c25-22(31)17-10-12-19(13-11-17)26-14-15-4-6-16(7-5-15)20-2-1-3-21-27-24(29-30(20)21)28-23(32)18-8-9-18/h1-7,10-13,18,26H,8-9,14H2,(H2,25,31)(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349110
PNG
(Cyclopropanecarboxylic acid {5-[4-(pyrimidin-2- yl...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(CNc4ncccn4)cc3)n2n1)C1CC1
Show InChI InChI=1S/C21H19N7O/c29-19(16-9-10-16)26-21-25-18-4-1-3-17(28(18)27-21)15-7-5-14(6-8-15)13-24-20-22-11-2-12-23-20/h1-8,11-12,16H,9-10,13H2,(H,22,23,24)(H,26,27,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349120
PNG
(Cyclopropanecarboxylic Acid {5-[4-(6-cyano-pyridin...)
Show SMILES O=C(Nc1nc2cccc(-c3ccc(cc3)-c3ccc(nc3)C#N)n2n1)C1CC1
Show InChI InChI=1S/C22H16N6O/c23-12-18-11-10-17(13-24-18)14-4-6-15(7-5-14)19-2-1-3-20-25-22(27-28(19)20)26-21(29)16-8-9-16/h1-7,10-11,13,16H,8-9H2,(H,26,27,29)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349121
PNG
(Cyclopropanecarboxylic acid {5-[4-(4-trifluorometh...)
Show SMILES FC(F)(F)C1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C23H24F3N5O/c24-23(25,26)18-10-12-30(13-11-18)14-15-4-6-16(7-5-15)19-2-1-3-20-27-22(29-31(19)20)28-21(32)17-8-9-17/h1-7,17-18H,8-14H2,(H,28,29,32)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1 [850-1154]


(Homo sapiens (Human))		BDBM349122
PNG
(Cyclopropanecarboxylic acid (5-{4-[4-(2,2,2-triflu...)
Show SMILES FC(F)(F)CN1CCN(Cc2ccc(cc2)-c2cccc3nc(NC(=O)C4CC4)nn23)CC1
Show InChI InChI=1S/C23H25F3N6O/c24-23(25,26)15-31-12-10-30(11-13-31)14-16-4-6-17(7-5-16)19-2-1-3-20-27-22(29-32(19)20)28-21(33)18-8-9-18/h1-7,18H,8-15H2,(H,28,29,33)
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GALAPAGOS NV

US Patent


Assay Description
Recombinant human JAK1 catalytic domain (amino acids 850-1154; catalog number 08-144) was purchased from Carna Biosciences. 10 ng of JAK1 was incubat...

US Patent US10206907 (2019)


BindingDB Entry DOI: 10.7270/Q23J3G3B
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%