BindingDB logo
myBDB logout

USPatent US8536165

Compile data set for download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102482
PNG
(US8536165, 81)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(-c2ccccc2)c(c1)C(F)(F)F)C1CC1
Show InChI InChI=1S/C22H17F3N2O2/c23-22(24,25)18-11-16(12-26-20(18)14-4-2-1-3-5-14)27-19-9-8-15(13-6-7-13)10-17(19)21(28)29/h1-5,8-13,27H,6-7H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 2n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102488
PNG
(US8536165, 92)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1ccccc1Cl)C1CC1
Show InChI InChI=1S/C20H16ClN3O2/c21-17-4-2-1-3-15(17)19-22-10-14(11-23-19)24-18-8-7-13(12-5-6-12)9-16(18)20(25)26/h1-4,7-12,24H,5-6H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 3n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102485
PNG
(US8536165, 86)
Show SMILES OC(=O)c1cc(ccc1Nc1ccc(nc1)-c1ccccc1Cl)C1CC1
Show InChI InChI=1S/C21H17ClN2O2/c22-18-4-2-1-3-16(18)19-10-8-15(12-23-19)24-20-9-7-14(13-5-6-13)11-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 4n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102476
PNG
(US8536165, 73)
Show SMILES Cc1cc(Nc2ccc(cc2C(O)=O)C2CC2)cnc1-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C23H19F3N2O3/c1-13-9-17(28-20-8-7-15(14-5-6-14)11-19(20)22(29)30)12-27-21(13)16-3-2-4-18(10-16)31-23(24,25)26/h2-4,7-12,14,28H,5-6H2,1H3,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102480
PNG
(US8536165, 77)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2ccccc2F)c(c1)C(O)=O
Show InChI InChI=1S/C20H17FN2O2/c1-12-7-8-18(16(9-12)20(24)25)23-14-10-13(2)19(22-11-14)15-5-3-4-6-17(15)21/h3-11,23H,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 5n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102477
PNG
(US8536165, 74)
Show SMILES Cc1cc(Nc2ccc(cc2C(O)=O)C2CC2)cnc1-c1ccccc1
Show InChI InChI=1S/C22H20N2O2/c1-14-11-18(13-23-21(14)16-5-3-2-4-6-16)24-20-10-9-17(15-7-8-15)12-19(20)22(25)26/h2-6,9-13,15,24H,7-8H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 6n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102483
PNG
(US8536165, 82)
Show SMILES COc1cccc(c1)-c1ncc(Nc2ccc(cc2C(O)=O)C2CC2)cc1C(F)(F)F
Show InChI InChI=1S/C23H19F3N2O3/c1-31-17-4-2-3-15(9-17)21-19(23(24,25)26)11-16(12-27-21)28-20-8-7-14(13-5-6-13)10-18(20)22(29)30/h2-4,7-13,28H,5-6H2,1H3,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 7n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102497
PNG
(US8536165, 107)
Show SMILES OC(=O)c1cc(ccc1Nc1ccc(nc1)-c1ccccc1F)C1CC1
Show InChI InChI=1S/C21H17FN2O2/c22-18-4-2-1-3-16(18)19-10-8-15(12-23-19)24-20-9-7-14(13-5-6-13)11-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 8n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102490
PNG
(US8536165, 94)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2cccc(c2)C(=O)N2CCCC2)c(c1)C(O)=O
Show InChI InChI=1S/C25H25N3O3/c1-16-8-9-22(21(12-16)25(30)31)27-20-13-17(2)23(26-15-20)18-6-5-7-19(14-18)24(29)28-10-3-4-11-28/h5-9,12-15,27H,3-4,10-11H2,1-2H3,(H,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102493
PNG
(US8536165, 97)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1ccccc1C(F)(F)F)C1CC1
Show InChI InChI=1S/C21H16F3N3O2/c22-21(23,24)17-4-2-1-3-15(17)19-25-10-14(11-26-19)27-18-8-7-13(12-5-6-12)9-16(18)20(28)29/h1-4,7-12,27H,5-6H2,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 9n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102454
PNG
(US8536165, 19)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(-c2ccccc2)c(c1)-c1ccccc1)C1CC1
Show InChI InChI=1S/C27H22N2O2/c30-27(31)24-15-21(18-11-12-18)13-14-25(24)29-22-16-23(19-7-3-1-4-8-19)26(28-17-22)20-9-5-2-6-10-20/h1-10,13-18,29H,11-12H2,(H,30,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102479
PNG
(US8536165, 76)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2cccc(Cl)c2)c(c1)C(O)=O
Show InChI InChI=1S/C20H17ClN2O2/c1-12-6-7-18(17(8-12)20(24)25)23-16-9-13(2)19(22-11-16)14-4-3-5-15(21)10-14/h3-11,23H,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102492
PNG
(US8536165, 96)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1ccccc1F)C1CC1
Show InChI InChI=1S/C20H16FN3O2/c21-17-4-2-1-3-15(17)19-22-10-14(11-23-19)24-18-8-7-13(12-5-6-12)9-16(18)20(25)26/h1-4,7-12,24H,5-6H2,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 10n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102469
PNG
(US8536165, 62)
Show SMILES CC(C)Oc1cccc(c1)-c1ncc(Nc2ccc(C)cc2C(O)=O)cc1C
Show InChI InChI=1S/C23H24N2O3/c1-14(2)28-19-7-5-6-17(12-19)22-16(4)11-18(13-24-22)25-21-9-8-15(3)10-20(21)23(26)27/h5-14,25H,1-4H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 11n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102473
PNG
(US8536165, 67)
Show SMILES COc1cccc(c1)-c1ncc(Nc2ccc(C)cc2C(O)=O)cc1C(F)(F)F
Show InChI InChI=1S/C21H17F3N2O3/c1-12-6-7-18(16(8-12)20(27)28)26-14-10-17(21(22,23)24)19(25-11-14)13-4-3-5-15(9-13)29-2/h3-11,26H,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 12n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102491
PNG
(US8536165, 95)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2cccc(c2)C(=O)NC2CC2)c(c1)C(O)=O
Show InChI InChI=1S/C24H23N3O3/c1-14-6-9-21(20(10-14)24(29)30)26-19-11-15(2)22(25-13-19)16-4-3-5-17(12-16)23(28)27-18-7-8-18/h3-6,9-13,18,26H,7-8H2,1-2H3,(H,27,28)(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 12n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102494
PNG
(US8536165, 98)
Show SMILES Cc1ccccc1-c1ncc(Nc2ccc(cc2C(O)=O)C2CC2)cn1
Show InChI InChI=1S/C21H19N3O2/c1-13-4-2-3-5-17(13)20-22-11-16(12-23-20)24-19-9-8-15(14-6-7-14)10-18(19)21(25)26/h2-5,8-12,14,24H,6-7H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 12n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102470
PNG
(US8536165, 64)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2ccccc2Cl)c(c1)C(O)=O
Show InChI InChI=1S/C20H17ClN2O2/c1-12-7-8-18(16(9-12)20(24)25)23-14-10-13(2)19(22-11-14)15-5-3-4-6-17(15)21/h3-11,23H,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 14n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102450
PNG
(US8536165, 8)
Show SMILES Cc1ccc(Nc2cnc(c(F)c2)-c2ccccc2)c(c1)C(O)=O
Show InChI InChI=1S/C19H15FN2O2/c1-12-7-8-17(15(9-12)19(23)24)22-14-10-16(20)18(21-11-14)13-5-3-2-4-6-13/h2-11,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 18n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102465
PNG
(US8536165, 54)
Show SMILES CCOc1ccc(F)c(c1)-c1ccc(Nc2ccc(C)cc2C(O)=O)cn1
Show InChI InChI=1S/C21H19FN2O3/c1-3-27-15-6-7-18(22)16(11-15)19-9-5-14(12-23-19)24-20-8-4-13(2)10-17(20)21(25)26/h4-12,24H,3H2,1-2H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 19n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102487
PNG
(US8536165, 91)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2c(F)cccc2F)c(c1)C(O)=O
Show InChI InChI=1S/C19H14F2N2O2/c1-11-5-7-16(13(9-11)19(24)25)23-12-6-8-17(22-10-12)18-14(20)3-2-4-15(18)21/h2-10,23H,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 19n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102478
PNG
(US8536165, 75)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2ccccc2C(F)(F)F)c(c1)C(O)=O
Show InChI InChI=1S/C21H17F3N2O2/c1-12-7-8-18(16(9-12)20(27)28)26-14-10-13(2)19(25-11-14)15-5-3-4-6-17(15)21(22,23)24/h3-11,26H,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 20n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102464
PNG
(US8536165, 51)
Show SMILES COc1cccc(c1)-c1ncc(Nc2ccc(C)cc2C(O)=O)cc1C
Show InChI InChI=1S/C21H20N2O3/c1-13-7-8-19(18(9-13)21(24)25)23-16-10-14(2)20(22-12-16)15-5-4-6-17(11-15)26-3/h4-12,23H,1-3H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 21n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102496
PNG
(US8536165, 104)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1cc(ccc1F)C(F)(F)F)C1CC1
Show InChI InChI=1S/C21H15F4N3O2/c22-17-5-4-13(21(23,24)25)8-15(17)19-26-9-14(10-27-19)28-18-6-3-12(11-1-2-11)7-16(18)20(29)30/h3-11,28H,1-2H2,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 21n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102468
PNG
(US8536165, 61)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(Nc2ccc(C)cc2C(O)=O)cn1
Show InChI InChI=1S/C22H21FN2O3/c1-13(2)28-16-6-7-19(23)17(11-16)20-9-5-15(12-24-20)25-21-8-4-14(3)10-18(21)22(26)27/h4-13,25H,1-3H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 28n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102456
PNG
(US8536165, 25)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(C2CC2)c(c1)-c1ccccc1)C1CC1
Show InChI InChI=1S/C24H22N2O2/c27-24(28)21-12-18(15-6-7-15)10-11-22(21)26-19-13-20(16-4-2-1-3-5-16)23(25-14-19)17-8-9-17/h1-5,10-15,17,26H,6-9H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 28n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102461
PNG
(US8536165, 42)
Show SMILES CCOc1cccc(c1)-c1ncc(Nc2ccc(C)cc2C(O)=O)cc1C
Show InChI InChI=1S/C22H22N2O3/c1-4-27-18-7-5-6-16(12-18)21-15(3)11-17(13-23-21)24-20-9-8-14(2)10-19(20)22(25)26/h5-13,24H,4H2,1-3H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 30n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102475
PNG
(US8536165, 71)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2ccccc2Cl)c(c1)C(O)=O
Show InChI InChI=1S/C19H15ClN2O2/c1-12-6-8-18(15(10-12)19(23)24)22-13-7-9-17(21-11-13)14-4-2-3-5-16(14)20/h2-11,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 32n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102474
PNG
(US8536165, 68)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1ncc(Nc2ccc(C)cc2C(O)=O)cc1C
Show InChI InChI=1S/C23H23N3O3/c1-14-8-9-20(19(10-14)23(28)29)25-18-11-15(2)21(24-13-18)16-6-5-7-17(12-16)22(27)26(3)4/h5-13,25H,1-4H3,(H,28,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 33n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102481
PNG
(US8536165, 79)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2ccncc2F)c(c1)C(O)=O
Show InChI InChI=1S/C19H16FN3O2/c1-11-3-4-17(15(7-11)19(24)25)23-13-8-12(2)18(22-9-13)14-5-6-21-10-16(14)20/h3-10,23H,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 37n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102495
PNG
(US8536165, 100)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1cc(F)ccc1F)C1CC1
Show InChI InChI=1S/C20H15F2N3O2/c21-13-4-5-17(22)15(8-13)19-23-9-14(10-24-19)25-18-6-3-12(11-1-2-11)7-16(18)20(26)27/h3-11,25H,1-2H2,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 38n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102457
PNG
(US8536165, 30)
Show SMILES Cc1ccc(Nc2cnc(N3CCCCC3)c(C)c2)c(c1)C(O)=O
Show InChI InChI=1S/C19H23N3O2/c1-13-6-7-17(16(10-13)19(23)24)21-15-11-14(2)18(20-12-15)22-8-4-3-5-9-22/h6-7,10-12,21H,3-5,8-9H2,1-2H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 41n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102500
PNG
(US8536165, 117)
Show SMILES COc1ccc(F)cc1-c1ncc(Nc2ccc(C)cc2C(O)=O)cc1C
Show InChI InChI=1S/C21H19FN2O3/c1-12-4-6-18(16(8-12)21(25)26)24-15-9-13(2)20(23-11-15)17-10-14(22)5-7-19(17)27-3/h4-11,24H,1-3H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 46n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102449
PNG
(US8536165, 7)
Show SMILES COc1ncc(Nc2ccc(cc2C(O)=O)C2CC2)cc1-c1ccccc1
Show InChI InChI=1S/C22H20N2O3/c1-27-21-18(15-5-3-2-4-6-15)12-17(13-23-21)24-20-10-9-16(14-7-8-14)11-19(20)22(25)26/h2-6,9-14,24H,7-8H2,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 49n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102467
PNG
(US8536165, 58)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2ccccc2)c(c1)C(O)=O
Show InChI InChI=1S/C20H18N2O2/c1-13-8-9-18(17(10-13)20(23)24)22-16-11-14(2)19(21-12-16)15-6-4-3-5-7-15/h3-12,22H,1-2H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 53n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102489
PNG
(US8536165, 93)
Show SMILES Cc1ccc(Nc2cnc(nc2)-c2ccccc2Cl)c(c1)C(O)=O
Show InChI InChI=1S/C18H14ClN3O2/c1-11-6-7-16(14(8-11)18(23)24)22-12-9-20-17(21-10-12)13-4-2-3-5-15(13)19/h2-10,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 57n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102451
PNG
(US8536165, 14)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1ccccc1C1CC1)C1CC1
Show InChI InChI=1S/C23H21N3O2/c27-23(28)20-11-16(14-5-6-14)9-10-21(20)26-17-12-24-22(25-13-17)19-4-2-1-3-18(19)15-7-8-15/h1-4,9-15,26H,5-8H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 57n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102448
PNG
(US8536165, 6)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1c(F)cc(O)cc1F)C1CC1
Show InChI InChI=1S/C20H15F2N3O3/c21-15-6-13(26)7-16(22)18(15)19-23-8-12(9-24-19)25-17-4-3-11(10-1-2-10)5-14(17)20(27)28/h3-10,25-26H,1-2H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 57n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102453
PNG
(US8536165, 18)
Show SMILES Cc1ccc(Nc2cc(Cl)cnc2-c2ccccc2)c(c1)C(O)=O
Show InChI InChI=1S/C19H15ClN2O2/c1-12-7-8-16(15(9-12)19(23)24)22-17-10-14(20)11-21-18(17)13-5-3-2-4-6-13/h2-11,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 62n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102499
PNG
(US8536165, 113)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2c(F)ccc(F)c2F)c(c1)C(O)=O
Show InChI InChI=1S/C19H13F3N2O2/c1-10-2-6-15(12(8-10)19(25)26)24-11-3-7-16(23-9-11)17-13(20)4-5-14(21)18(17)22/h2-9,24H,1H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 77n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102462
PNG
(US8536165, 44)
Show SMILES CCOc1cccc(c1)-c1cc(C)c(Nc2ccc(C)cc2C(O)=O)cn1
Show InChI InChI=1S/C22H22N2O3/c1-4-27-17-7-5-6-16(12-17)20-11-15(3)21(13-23-20)24-19-9-8-14(2)10-18(19)22(25)26/h5-13,24H,4H2,1-3H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 78n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102486
PNG
(US8536165, 89)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2ccncc2F)c(c1)C(O)=O
Show InChI InChI=1S/C18H14FN3O2/c1-11-2-4-17(14(8-11)18(23)24)22-12-3-5-16(21-9-12)13-6-7-20-10-15(13)19/h2-10,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 90n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102466
PNG
(US8536165, 56)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2ccccc2F)c(c1)C(O)=O
Show InChI InChI=1S/C19H15FN2O2/c1-12-6-8-18(15(10-12)19(23)24)22-13-7-9-17(21-11-13)14-4-2-3-5-16(14)20/h2-11,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 91n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102472
PNG
(US8536165, 66)
Show SMILES COc1ccc(F)c(c1)-c1cc(C)c(Nc2ccc(C)cc2C(O)=O)cn1
Show InChI InChI=1S/C21H19FN2O3/c1-12-4-7-18(16(8-12)21(25)26)24-20-11-23-19(9-13(20)2)15-10-14(27-3)5-6-17(15)22/h4-11,24H,1-3H3,(H,25,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 97n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102447
PNG
(US8536165, 4)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2cccc(c2)C(F)(F)F)c(c1)C(O)=O
Show InChI InChI=1S/C20H15F3N2O2/c1-12-5-7-18(16(9-12)19(26)27)25-15-6-8-17(24-11-15)13-3-2-4-14(10-13)20(21,22)23/h2-11,25H,1H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 98n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102446
PNG
(US8536165, 1)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1ccccc1)C1CC1
Show InChI InChI=1S/C20H17N3O2/c24-20(25)17-10-15(13-6-7-13)8-9-18(17)23-16-11-21-19(22-12-16)14-4-2-1-3-5-14/h1-5,8-13,23H,6-7H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 105n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102459
PNG
(US8536165, 34)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2ccncc2Cl)c(c1)C(O)=O
Show InChI InChI=1S/C18H14ClN3O2/c1-11-2-4-17(14(8-11)18(23)24)22-12-3-5-16(21-9-12)13-6-7-20-10-15(13)19/h2-10,22H,1H3,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 109n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102452
PNG
(US8536165, 15)
Show SMILES OC(=O)c1cc(ccc1Nc1cncc(c1)-c1ccccc1)C1CC1
Show InChI InChI=1S/C21H18N2O2/c24-21(25)19-11-16(15-6-7-15)8-9-20(19)23-18-10-17(12-22-13-18)14-4-2-1-3-5-14/h1-5,8-13,15,23H,6-7H2,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 113n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102455
PNG
(US8536165, 22)
Show SMILES OC(=O)c1cc(ccc1Nc1cnc(nc1)-c1cccc(OC2CC2)c1)C1CC1
Show InChI InChI=1S/C23H21N3O3/c27-23(28)20-11-15(14-4-5-14)6-9-21(20)26-17-12-24-22(25-13-17)16-2-1-3-19(10-16)29-18-7-8-18/h1-3,6,9-14,18,26H,4-5,7-8H2,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 114n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102458
PNG
(US8536165, 31)
Show SMILES Cc1ccc(Nc2cnc(N3CCCCCC3)c(C)c2)c(c1)C(O)=O
Show InChI InChI=1S/C20H25N3O2/c1-14-7-8-18(17(11-14)20(24)25)22-16-12-15(2)19(21-13-16)23-9-5-3-4-6-10-23/h7-8,11-13,22H,3-6,9-10H2,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 119n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102463
PNG
(US8536165, 50)
Show SMILES COc1cccc(c1)-c1ncc(Nc2ccc(cc2C(O)=O)C(F)(F)F)cc1C
Show InChI InChI=1S/C21H17F3N2O3/c1-12-8-15(11-25-19(12)13-4-3-5-16(9-13)29-2)26-18-7-6-14(21(22,23)24)10-17(18)20(27)28/h3-11,26H,1-2H3,(H,27,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 138n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102484
PNG
(US8536165, 84)
Show SMILES OC(=O)c1cc(Cl)ccc1Nc1ccc(nc1)-c1ccccc1Cl
Show InChI InChI=1S/C18H12Cl2N2O2/c19-11-5-7-17(14(9-11)18(23)24)22-12-6-8-16(21-10-12)13-3-1-2-4-15(13)20/h1-10,22H,(H,23,24)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 145n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM8661
PNG
(US8536165, 110)
Show SMILES Cc1ccc(Nc2ccc(nc2)-c2ccc(F)cc2F)c(c1)C(O)=O
Show InChI InChI=1S/C19H14F2N2O2/c1-11-2-6-18(15(8-11)19(24)25)23-13-4-7-17(22-10-13)14-5-3-12(20)9-16(14)21/h2-10,23H,1H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 146n/an/an/an/an/an/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102471
PNG
(US8536165, 65)
Show SMILES Cc1ccc(Nc2cnc(c(C)c2)-c2cccc(c2)C(N)=O)c(c1)C(O)=O
Show InChI InChI=1S/C21H19N3O3/c1-12-6-7-18(17(8-12)21(26)27)24-16-9-13(2)19(23-11-16)14-4-3-5-15(10-14)20(22)25/h3-11,24H,1-2H3,(H2,22,25)(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 190n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial


(Homo sapiens (Human))		BDBM102460
PNG
(US8536165, 41)
Show SMILES CCOc1cccc(c1)-c1ccc(Nc2ccc(C)cc2C(O)=O)cn1
Show InChI InChI=1S/C21H20N2O3/c1-3-26-17-6-4-5-15(12-17)19-10-8-16(13-22-19)23-20-9-7-14(2)11-18(20)21(24)25/h4-13,23H,3H2,1-2H3,(H,24,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
US Patent
n/an/a 190n/an/an/an/a8.0n/a



Almirall, S.A.

US Patent


Assay Description
Inhibition of human DHODH activity assay: DHODH activity and its inhibition were studied using a chromogen reduction assay with DCIP (2,6-dichloroph...

US Patent US8536165 (2013)


BindingDB Entry DOI: 10.7270/Q2C24V2G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%