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USPatent US9169240

Compile data set for download or QSAR
Found 92 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Endothelial lipase


(Homo sapiens (Human))
BDBM187304
PNG
(US9169240, 44)
Show SMILES CC(C)(C)CN1CC(C1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C24H23FN4O2S/c1-24(2,3)13-29-11-16(12-29)21-27-28-22(31-21)20(30)23-26-18-9-6-15(10-19(18)32-23)14-4-7-17(25)8-5-14/h4-10,16H,11-13H2,1-3H3
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n/an/a 4.80n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187325
PNG
(US9169240, 64)
Show SMILES Fc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NCCc2ccc(Cl)cc2)o1
Show InChI InChI=1S/C24H16ClFN4O2S/c25-17-6-1-14(2-7-17)11-12-27-24-30-29-22(32-24)21(31)23-28-19-10-5-16(13-20(19)33-23)15-3-8-18(26)9-4-15/h1-10,13H,11-12H2,(H,27,30)
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n/an/a 6.60n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187311
PNG
(US9169240, 50)
Show SMILES O=C(Cc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1)NC1CC1
Show InChI InChI=1S/C21H16N4O3S/c26-17(22-14-7-8-14)11-18-24-25-20(28-18)19(27)21-23-15-9-6-13(10-16(15)29-21)12-4-2-1-3-5-12/h1-6,9-10,14H,7-8,11H2,(H,22,26)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187295
PNG
(US9169240, 35 | US9169240, 36 | US9169240, 37)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)NC(=O)NC1=O
Show InChI InChI=1S/C21H14FN5O4S/c1-21(19(29)24-20(30)25-21)9-15-26-27-17(31-15)16(28)18-23-13-7-4-11(8-14(13)32-18)10-2-5-12(22)6-3-10/h2-8H,9H2,1H3,(H2,24,25,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187263
PNG
(US9169240, 2)
Show SMILES O=C(c1nnc(CC2NC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C20H13N5O4S/c26-16(18-25-24-15(29-18)9-13-17(27)23-20(28)22-13)19-21-12-7-6-11(8-14(12)30-19)10-4-2-1-3-5-10/h1-8,13H,9H2,(H2,22,23,27,28)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187264
PNG
(US9169240, 3 | US9169240, 4)
Show SMILES O=C(c1nnc(CC2CCNC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H16N4O3S/c26-18(20-25-24-17(28-20)11-14-8-9-22-19(14)27)21-23-15-7-6-13(10-16(15)29-21)12-4-2-1-3-5-12/h1-7,10,14H,8-9,11H2,(H,22,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187314
PNG
(US9169240, 53)
Show SMILES O=C(c1nnc(N[C@H]2CCNC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H15N5O3S/c26-16(18-24-25-20(28-18)23-14-8-9-21-17(14)27)19-22-13-7-6-12(10-15(13)29-19)11-4-2-1-3-5-11/h1-7,10,14H,8-9H2,(H,21,27)(H,23,25)/t14-/m0/s1
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187292
PNG
(US9169240, 32 | US9169240, 33 | US9169240, 34)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)NC1=O
Show InChI InChI=1S/C21H15N5O4S/c1-21(19(28)23-20(29)24-21)10-15-25-26-17(30-15)16(27)18-22-13-8-7-12(9-14(13)31-18)11-5-3-2-4-6-11/h2-9H,10H2,1H3,(H2,23,24,28,29)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187272
PNG
(US9169240, 11)
Show SMILES O=C(c1nnc(o1)C1CCS(=O)(=O)N1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C19H14N4O4S2/c24-16(18-22-21-17(27-18)14-8-9-29(25,26)23-14)19-20-13-7-6-12(10-15(13)28-19)11-4-2-1-3-5-11/h1-7,10,14,23H,8-9H2
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187290
PNG
(US9169240, 30)
Show SMILES COC(=O)Nc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(CNS(N)(=O)=O)o1
Show InChI InChI=1S/C19H16N6O6S2/c1-30-19(27)22-12-5-2-10(3-6-12)11-4-7-13-14(8-11)32-18(23-13)16(26)17-25-24-15(31-17)9-21-33(20,28)29/h2-8,21H,9H2,1H3,(H,22,27)(H2,20,28,29)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187282
PNG
(US9169240, 21)
Show SMILES C[C@@H](NC(=O)OC(C)(C)C)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C23H22N4O4S/c1-13(24-22(29)31-23(2,3)4)19-26-27-20(30-19)18(28)21-25-16-11-10-15(12-17(16)32-21)14-8-6-5-7-9-14/h5-13H,1-4H3,(H,24,29)/t13-/m1/s1
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187275
PNG
(US9169240, 14)
Show SMILES Fc1cc(cc2sc(nc12)C(=O)c1nnc(CCc2nc3ccccc3[nH]2)o1)-c1ccccc1
Show InChI InChI=1S/C25H16FN5O2S/c26-16-12-15(14-6-2-1-3-7-14)13-19-22(16)29-25(34-19)23(32)24-31-30-21(33-24)11-10-20-27-17-8-4-5-9-18(17)28-20/h1-9,12-13H,10-11H2,(H,27,28)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187274
PNG
(US9169240, 13)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCC(CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C28H21F3N4O2S/c29-28(30,31)20-7-9-21(10-8-20)35-14-12-18(13-15-35)25-33-34-26(37-25)24(36)27-32-22-11-6-19(16-23(22)38-27)17-4-2-1-3-5-17/h1-11,16,18H,12-15H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187271
PNG
(US9169240, 10)
Show SMILES O=C(c1nnc(CC2SC(=O)NC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C20H12N4O4S2/c25-16(18-24-23-15(28-18)9-14-17(26)22-20(27)30-14)19-21-12-7-6-11(8-13(12)29-19)10-4-2-1-3-5-10/h1-8,14H,9H2,(H,22,26,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187268
PNG
(US9169240, 7)
Show SMILES O=C(c1nnc(o1)C1CCN(CC1)c1ncccn1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C25H20N6O2S/c32-21(24-28-19-8-7-18(15-20(19)34-24)16-5-2-1-3-6-16)23-30-29-22(33-23)17-9-13-31(14-10-17)25-26-11-4-12-27-25/h1-8,11-12,15,17H,9-10,13-14H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187292
PNG
(US9169240, 32 | US9169240, 33 | US9169240, 34)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)NC1=O
Show InChI InChI=1S/C21H15N5O4S/c1-21(19(28)23-20(29)24-21)10-15-25-26-17(30-15)16(27)18-22-13-8-7-12(9-14(13)31-18)11-5-3-2-4-6-11/h2-9H,10H2,1H3,(H2,23,24,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187279
PNG
(US9169240, 18)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C26H25FN4O4S/c1-26(2,3)35-25(33)31-12-10-16(11-13-31)22-29-30-23(34-22)21(32)24-28-19-9-6-17(14-20(19)36-24)15-4-7-18(27)8-5-15/h4-9,14,16H,10-13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187278
PNG
(US9169240, 17)
Show SMILES Fc1ccc(CN2CCC(CC2)c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)cc1
Show InChI InChI=1S/C28H23FN4O2S/c29-22-9-6-18(7-10-22)17-33-14-12-20(13-15-33)26-31-32-27(35-26)25(34)28-30-23-11-8-21(16-24(23)36-28)19-4-2-1-3-5-19/h1-11,16,20H,12-15,17H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187276
PNG
(US9169240, 15)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H29FN4O4S/c1-28(2,3)37-27(35)33-14-12-17(13-15-33)4-11-23-31-32-25(36-23)24(34)26-30-21-10-7-19(16-22(21)38-26)18-5-8-20(29)9-6-18/h5-10,16-17H,4,11-15H2,1-3H3
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187273
PNG
(US9169240, 12)
Show SMILES NS(=O)(=O)Cc1nnc(o1)C(=O)c1nc2c(F)cc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C17H11FN4O4S2/c18-11-6-10(9-4-2-1-3-5-9)7-12-14(11)20-17(27-12)15(23)16-22-21-13(26-16)8-28(19,24)25/h1-7H,8H2,(H2,19,24,25)
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n/an/a<10n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187345
PNG
(US9169240, 84)
Show SMILES FC(F)(F)CN(C1CCNC1=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C22H16F3N5O3S/c23-22(24,25)11-30(15-8-9-26-18(15)32)21-29-28-19(33-21)17(31)20-27-14-7-6-13(10-16(14)34-20)12-4-2-1-3-5-12/h1-7,10,15H,8-9,11H2,(H,26,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187316
PNG
(US9169240, 55)
Show SMILES Fc1cc(cc2sc(nc12)C(=O)c1nnc(N[C@H]2CCNC2=O)o1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H14FN5O3S/c21-12-8-11(10-4-2-1-3-5-10)9-14-15(12)24-19(30-14)16(27)18-25-26-20(29-18)23-13-6-7-22-17(13)28/h1-5,8-9,13H,6-7H2,(H,22,28)(H,23,26)/t13-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187281
PNG
(US9169240, 20)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C26H26N4O4S/c1-26(2,3)34-25(32)30-13-11-17(12-14-30)22-28-29-23(33-22)21(31)24-27-19-10-9-18(15-20(19)35-24)16-7-5-4-6-8-16/h4-10,15,17H,11-14H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187270
PNG
(US9169240, 9)
Show SMILES O=C(c1nnc(CCc2ncc(o2)-c2ccccc2)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C27H18N4O3S/c32-25(27-29-20-12-11-19(15-22(20)35-27)17-7-3-1-4-8-17)26-31-30-24(34-26)14-13-23-28-16-21(33-23)18-9-5-2-6-10-18/h1-12,15-16H,13-14H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187264
PNG
(US9169240, 3 | US9169240, 4)
Show SMILES O=C(c1nnc(CC2CCNC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H16N4O3S/c26-18(20-25-24-17(28-20)11-14-8-9-22-19(14)27)21-23-15-7-6-13(10-16(15)29-21)12-4-2-1-3-5-12/h1-7,10,14H,8-9,11H2,(H,22,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187312
PNG
(US9169240, 51)
Show SMILES NC(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NC2CCNC2=O)o1
Show InChI InChI=1S/C21H16N6O4S/c22-17(29)11-3-1-10(2-4-11)12-5-6-13-15(9-12)32-20(24-13)16(28)19-26-27-21(31-19)25-14-7-8-23-18(14)30/h1-6,9,14H,7-8H2,(H2,22,29)(H,23,30)(H,25,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187343
PNG
(US9169240, 82)
Show SMILES FC(F)Oc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(N[C@H]2CCNC2=O)o1 |r|
Show InChI InChI=1S/C21H15F2N5O4S/c22-20(23)31-12-4-1-10(2-5-12)11-3-6-13-15(9-11)33-19(25-13)16(29)18-27-28-21(32-18)26-14-7-8-24-17(14)30/h1-6,9,14,20H,7-8H2,(H,24,30)(H,26,28)/t14-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187315
PNG
(US9169240, 54)
Show SMILES Fc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(N[C@H]2CCNC2=O)o1 |r|
Show InChI InChI=1S/C20H14FN5O3S/c21-12-4-1-10(2-5-12)11-3-6-13-15(9-11)30-19(23-13)16(27)18-25-26-20(29-18)24-14-7-8-22-17(14)28/h1-6,9,14H,7-8H2,(H,22,28)(H,24,26)/t14-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187295
PNG
(US9169240, 35 | US9169240, 36 | US9169240, 37)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)NC(=O)NC1=O
Show InChI InChI=1S/C21H14FN5O4S/c1-21(19(29)24-20(30)25-21)9-15-26-27-17(31-15)16(28)18-23-13-7-4-11(8-14(13)32-18)10-2-5-12(22)6-3-10/h2-8H,9H2,1H3,(H2,24,25,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187266
PNG
(US9169240, 5)
Show SMILES NS(=O)(=O)Cc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C17H12N4O4S2/c18-27(23,24)9-14-20-21-16(25-14)15(22)17-19-12-7-6-11(8-13(12)26-17)10-4-2-1-3-5-10/h1-8H,9H2,(H2,18,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187284
PNG
(US9169240, 23)
Show SMILES FC(F)(F)Oc1ccc(CN2CCC(CC2)c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)cc1
Show InChI InChI=1S/C29H23F3N4O3S/c30-29(31,32)39-22-9-6-18(7-10-22)17-36-14-12-20(13-15-36)26-34-35-27(38-26)25(37)28-33-23-11-8-21(16-24(23)40-28)19-4-2-1-3-5-19/h1-11,16,20H,12-15,17H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187295
PNG
(US9169240, 35 | US9169240, 36 | US9169240, 37)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)NC(=O)NC1=O
Show InChI InChI=1S/C21H14FN5O4S/c1-21(19(29)24-20(30)25-21)9-15-26-27-17(31-15)16(28)18-23-13-7-4-11(8-14(13)32-18)10-2-5-12(22)6-3-10/h2-8H,9H2,1H3,(H2,24,25,29,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187299
PNG
(US9169240, 39)
Show SMILES CC(C)N1C(=O)NC(C)(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)C1=O
Show InChI InChI=1S/C24H21N5O4S/c1-13(2)29-22(31)24(3,26-23(29)32)12-18-27-28-20(33-18)19(30)21-25-16-10-9-15(11-17(16)34-21)14-7-5-4-6-8-14/h4-11,13H,12H2,1-3H3,(H,26,32)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187291
PNG
(US9169240, 31 | US9169240, 38 | US9169240, 40)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)N(CC(F)(F)F)C1=O
Show InChI InChI=1S/C23H16F3N5O4S/c1-22(20(33)31(21(34)28-22)11-23(24,25)26)10-16-29-30-18(35-16)17(32)19-27-14-8-7-13(9-15(14)36-19)12-5-3-2-4-6-12/h2-9H,10-11H2,1H3,(H,28,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187344
PNG
(US9169240, 83)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(N[C@H]2CCNC2=O)o1 |r|
Show InChI InChI=1S/C20H16N6O5S2/c21-33(29,30)12-4-1-10(2-5-12)11-3-6-13-15(9-11)32-19(23-13)16(27)18-25-26-20(31-18)24-14-7-8-22-17(14)28/h1-6,9,14H,7-8H2,(H,22,28)(H,24,26)(H2,21,29,30)/t14-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM123891
PNG
(US8754113, I-1-85 | US9169240, 24)
Show SMILES NS(=O)(=O)NCc1nnc(Cc2nc3ccc(cc3s2)-c2ccccc2)o1
Show InChI InChI=1S/C17H15N5O3S2/c18-27(23,24)19-10-16-22-21-15(25-16)9-17-20-13-7-6-12(8-14(13)26-17)11-4-2-1-3-5-11/h1-8,19H,9-10H2,(H2,18,23,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187289
PNG
(US9169240, 29)
Show SMILES NS(=O)(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)cc1
Show InChI InChI=1S/C17H12FN5O4S2/c18-11-4-1-9(2-5-11)10-3-6-12-13(7-10)28-17(21-12)15(24)16-23-22-14(27-16)8-20-29(19,25)26/h1-7,20H,8H2,(H2,19,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187291
PNG
(US9169240, 31 | US9169240, 38 | US9169240, 40)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)N(CC(F)(F)F)C1=O
Show InChI InChI=1S/C23H16F3N5O4S/c1-22(20(33)31(21(34)28-22)11-23(24,25)26)10-16-29-30-18(35-16)17(32)19-27-14-8-7-13(9-15(14)36-19)12-5-3-2-4-6-12/h2-9H,10-11H2,1H3,(H,28,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187269
PNG
(US9169240, 8)
Show SMILES O=C(c1nnc(CCc2ncc[nH]2)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H15N5O2S/c27-19(20-26-25-18(28-20)9-8-17-22-10-11-23-17)21-24-15-7-6-14(12-16(15)29-21)13-4-2-1-3-5-13/h1-7,10-12H,8-9H2,(H,22,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187348
PNG
(US9169240, 87)
Show SMILES BrN([C@H]1CCNC1=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H14BrN5O3S/c21-26(14-8-9-22-17(14)28)20-25-24-18(29-20)16(27)19-23-13-7-6-12(10-15(13)30-19)11-4-2-1-3-5-11/h1-7,10,14H,8-9H2,(H,22,28)/t14-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187291
PNG
(US9169240, 31 | US9169240, 38 | US9169240, 40)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)N(CC(F)(F)F)C1=O
Show InChI InChI=1S/C23H16F3N5O4S/c1-22(20(33)31(21(34)28-22)11-23(24,25)26)10-16-29-30-18(35-16)17(32)19-27-14-8-7-13(9-15(14)36-19)12-5-3-2-4-6-12/h2-9H,10-11H2,1H3,(H,28,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187280
PNG
(US9169240, 19)
Show SMILES O=C(c1nnc(CCC2CCN(CC3CC3)CC2)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C27H28N4O2S/c32-25(27-28-22-10-9-21(16-23(22)34-27)20-4-2-1-3-5-20)26-30-29-24(33-26)11-8-18-12-14-31(15-13-18)17-19-6-7-19/h1-5,9-10,16,18-19H,6-8,11-15,17H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187305
PNG
(US9169240, 45)
Show SMILES CC(C)(C)CN1CCC(CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C26H28N4O2S/c1-26(2,3)16-30-13-11-18(12-14-30)23-28-29-24(32-23)22(31)25-27-20-10-9-19(15-21(20)33-25)17-7-5-4-6-8-17/h4-10,15,18H,11-14,16H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187301
PNG
(US9169240, 41)
Show SMILES O=C(c1nnc(CC2NC(=O)N(C2=O)c2ccccc2)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C26H17N5O4S/c32-22(24-27-18-12-11-16(13-20(18)36-24)15-7-3-1-4-8-15)23-30-29-21(35-23)14-19-25(33)31(26(34)28-19)17-9-5-2-6-10-17/h1-13,19H,14H2,(H,28,34)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187303
PNG
(US9169240, 43)
Show SMILES CC(C)(C)CN1CC(C1)c1nnc(o1)C(=O)c1nc2c(F)cc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C24H23FN4O2S/c1-24(2,3)13-29-11-16(12-29)21-27-28-22(31-21)20(30)23-26-19-17(25)9-15(10-18(19)32-23)14-7-5-4-6-8-14/h4-10,16H,11-13H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187308
PNG
(US9169240, 47)
Show SMILES COc1nc(-c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)c(O)c(=O)[nH]1
Show InChI InChI=1S/C21H13N5O5S/c1-30-21-23-14(15(27)17(29)24-21)18-25-26-19(31-18)16(28)20-22-12-8-7-11(9-13(12)32-20)10-5-3-2-4-6-10/h2-9,27H,1H3,(H,23,24,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187302
PNG
(US9169240, 42)
Show SMILES CC(C)(C)CN1CC(C1)c1nnc(Cc2nc3ccc(cc3s2)-c2ccccc2)o1
Show InChI InChI=1S/C24H26N4OS/c1-24(2,3)15-28-13-18(14-28)23-27-26-21(29-23)12-22-25-19-10-9-17(11-20(19)30-22)16-7-5-4-6-8-16/h4-11,18H,12-15H2,1-3H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187292
PNG
(US9169240, 32 | US9169240, 33 | US9169240, 34)
Show SMILES CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)NC1=O
Show InChI InChI=1S/C21H15N5O4S/c1-21(19(28)23-20(29)24-21)10-15-25-26-17(30-15)16(27)18-22-13-8-7-12(9-14(13)31-18)11-5-3-2-4-6-11/h2-9H,10H2,1H3,(H2,23,24,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187331
PNG
(BDBM187332 | US9169240, 70)
Show SMILES CN1CCC(Nc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)C1=O
Show InChI InChI=1S/C21H17N5O3S/c1-26-10-9-15(20(26)28)23-21-25-24-18(29-21)17(27)19-22-14-8-7-13(11-16(14)30-19)12-5-3-2-4-6-12/h2-8,11,15H,9-10H2,1H3,(H,23,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187318
PNG
(US9169240, 57)
Show SMILES O=C(c1nnc(N[C@H]2CCOC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H14N4O4S/c25-16(17-23-24-20(28-17)22-14-8-9-27-19(14)26)18-21-13-7-6-12(10-15(13)29-18)11-4-2-1-3-5-11/h1-7,10,14H,8-9H2,(H,22,24)/t14-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187287
PNG
(US9169240, 27)
Show SMILES CN(Cc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1)S(N)(=O)=O
Show InChI InChI=1S/C18H15N5O4S2/c1-23(29(19,25)26)10-15-21-22-17(27-15)16(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-9H,10H2,1H3,(H2,19,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187310
PNG
(US9169240, 49)
Show SMILES NC(=O)NCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C18H13N5O3S/c19-18(25)20-9-14-22-23-16(26-14)15(24)17-21-12-7-6-11(8-13(12)27-17)10-4-2-1-3-5-10/h1-8H,9H2,(H3,19,20,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187338
PNG
(US9169240, 77 | US9169240, 78)
Show SMILES O=C(c1nnc(NC2CCCNC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H17N5O3S/c27-17(19-25-26-21(29-19)24-15-7-4-10-22-18(15)28)20-23-14-9-8-13(11-16(14)30-20)12-5-2-1-3-6-12/h1-3,5-6,8-9,11,15H,4,7,10H2,(H,22,28)(H,24,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187329
PNG
(US9169240, 68)
Show SMILES OCC[C@@H](Nc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1)C(O)=O |r|
Show InChI InChI=1S/C20H16N4O5S/c25-9-8-14(19(27)28)22-20-24-23-17(29-20)16(26)18-21-13-7-6-12(10-15(13)30-18)11-4-2-1-3-5-11/h1-7,10,14,25H,8-9H2,(H,22,24)(H,27,28)/t14-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187336
PNG
(US9169240, 75)
Show SMILES NC(=O)[C@@H](CCC(F)(F)F)Nc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H16F3N5O3S/c22-21(23,24)9-8-14(17(25)31)27-20-29-28-18(32-20)16(30)19-26-13-7-6-12(10-15(13)33-19)11-4-2-1-3-5-11/h1-7,10,14H,8-9H2,(H2,25,31)(H,27,29)/t14-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187350
PNG
(US9169240, 89)
Show SMILES Nc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C16H10N4O2S/c17-16-20-19-14(22-16)13(21)15-18-11-7-6-10(8-12(11)23-15)9-4-2-1-3-5-9/h1-8H,(H2,17,20)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187277
PNG
(US9169240, 16)
Show SMILES CC(C)(C)OC(=O)N[C@H]1CC[C@@H](CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r,wU:11.14,wD:8.7,(11.14,3.71,;9.81,4.48,;10.58,5.81,;9.04,3.15,;8.48,5.25,;7.14,4.48,;5.81,5.25,;7.14,2.94,;5.81,2.17,;4.48,2.94,;3.14,2.17,;3.14,.63,;4.48,-.14,;5.81,.63,;1.81,-.14,;.56,.76,;-.68,-.14,;-.21,-1.61,;1.33,-1.61,;-.98,-2.94,;-.21,-4.27,;-2.52,-2.94,;-3.42,-1.69,;-4.89,-2.17,;-6.22,-1.4,;-7.56,-2.17,;-7.56,-3.71,;-6.22,-4.48,;-4.89,-3.71,;-3.42,-4.19,;-8.89,-4.48,;-8.89,-6.02,;-10.22,-6.79,;-11.56,-6.02,;-11.56,-4.48,;-10.22,-3.71,)|
Show InChI InChI=1S/C27H28N4O4S/c1-27(2,3)35-26(33)28-19-12-9-17(10-13-19)23-30-31-24(34-23)22(32)25-29-20-14-11-18(15-21(20)36-25)16-7-5-4-6-8-16/h4-8,11,14-15,17,19H,9-10,12-13H2,1-3H3,(H,28,33)/t17-,19-
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187346
PNG
(US9169240, 85)
Show SMILES O=C(c1nnc(o1)N(Cc1n[nH]c(=O)o1)[C@H]1CCNC1=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187288
PNG
(US9169240, 28)
Show SMILES NS(=O)(=O)NCCc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C18H15N5O4S2/c19-29(25,26)20-9-8-15-22-23-17(27-15)16(24)18-21-13-7-6-12(10-14(13)28-18)11-4-2-1-3-5-11/h1-7,10,20H,8-9H2,(H2,19,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187337
PNG
(US9169240, 76)
Show SMILES O=C(c1nnc(NCCc2cccnc2)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C23H17N5O2S/c29-20(21-27-28-23(30-21)25-12-10-15-5-4-11-24-14-15)22-26-18-9-8-17(13-19(18)31-22)16-6-2-1-3-7-16/h1-9,11,13-14H,10,12H2,(H,25,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187317
PNG
(US9169240, 56)
Show SMILES O=C(c1nnc(N[C@@H]2CCNC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C20H15N5O3S/c26-16(18-24-25-20(28-18)23-14-8-9-21-17(14)27)19-22-13-7-6-12(10-15(13)29-19)11-4-2-1-3-5-11/h1-7,10,14H,8-9H2,(H,21,27)(H,23,25)/t14-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187320
PNG
(US9169240, 59)
Show SMILES Fc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NCCc2ccccc2)o1
Show InChI InChI=1S/C24H17FN4O2S/c25-18-9-6-16(7-10-18)17-8-11-19-20(14-17)32-23(27-19)21(30)22-28-29-24(31-22)26-13-12-15-4-2-1-3-5-15/h1-11,14H,12-13H2,(H,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187321
PNG
(US9169240, 60)
Show SMILES Fc1ccc(CCNc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C24H16F2N4O2S/c25-17-6-1-14(2-7-17)11-12-27-24-30-29-22(32-24)21(31)23-28-19-10-5-16(13-20(19)33-23)15-3-8-18(26)9-4-15/h1-10,13H,11-12H2,(H,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187283
PNG
(US9169240, 22)
Show SMILES C[C@H](NC(=O)OC(C)(C)C)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C23H22N4O4S/c1-13(24-22(29)31-23(2,3)4)19-26-27-20(30-19)18(28)21-25-16-11-10-15(12-17(16)32-21)14-8-6-5-7-9-14/h5-13H,1-4H3,(H,24,29)/t13-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187306
PNG
(US9169240, 46)
Show SMILES COc1nc(-c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)c(OCc2ccccc2)c(=O)[nH]1
Show InChI InChI=1S/C28H19N5O5S/c1-36-28-30-21(23(24(35)31-28)37-15-16-8-4-2-5-9-16)25-32-33-26(38-25)22(34)27-29-19-13-12-18(14-20(19)39-27)17-10-6-3-7-11-17/h2-14H,15H2,1H3,(H,30,31,35)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187285
PNG
(US9169240, 25)
Show SMILES C[C@@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187333
PNG
(US9169240, 72)
Show SMILES NS(=O)(=O)CCNc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C18H15N5O4S2/c19-29(25,26)9-8-20-18-23-22-16(27-18)15(24)17-21-13-7-6-12(10-14(13)28-17)11-4-2-1-3-5-11/h1-7,10H,8-9H2,(H,20,23)(H2,19,25,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187267
PNG
(US9169240, 6)
Show SMILES COC(=O)N[C@H]1CC[C@@H](CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r,wU:5.4,wD:8.11,(-11.94,1.82,;-10.69,2.73,;-9.29,2.1,;-9.12,.57,;-8.04,3.01,;-6.63,2.38,;-5.39,3.29,;-3.98,2.66,;-3.82,1.13,;-5.06,.22,;-6.47,.85,;-2.41,.5,;-1.08,1.27,;.07,.24,;-.56,-1.17,;-2.09,-1.01,;.21,-2.5,;-.56,-3.83,;1.75,-2.5,;2.65,-1.25,;4.12,-1.73,;5.45,-.96,;6.79,-1.73,;6.79,-3.27,;5.45,-4.04,;4.12,-3.27,;2.65,-3.75,;8.12,-4.04,;9.45,-3.27,;10.79,-4.04,;10.79,-5.58,;9.45,-6.35,;8.12,-5.58,)|
Show InChI InChI=1S/C24H22N4O4S/c1-31-24(30)25-17-10-7-15(8-11-17)21-27-28-22(32-21)20(29)23-26-18-12-9-16(13-19(18)33-23)14-5-3-2-4-6-14/h2-6,9,12-13,15,17H,7-8,10-11H2,1H3,(H,25,30)/t15-,17-
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187347
PNG
(US9169240, 86)
Show SMILES CN([C@H]1CCNC1=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C21H17N5O3S/c1-26(15-9-10-22-18(15)28)21-25-24-19(29-21)17(27)20-23-14-8-7-13(11-16(14)30-20)12-5-3-2-4-6-12/h2-8,11,15H,9-10H2,1H3,(H,22,28)/t15-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187319
PNG
(US9169240, 58)
Show SMILES NC(=O)CNc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C18H13N5O3S/c19-14(24)9-20-18-23-22-16(26-18)15(25)17-21-12-7-6-11(8-13(12)27-17)10-4-2-1-3-5-10/h1-8H,9H2,(H2,19,24)(H,20,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187313
PNG
(US9169240, 52)
Show SMILES COCCNc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C19H16N4O3S/c1-25-10-9-20-19-23-22-17(26-19)16(24)18-21-14-8-7-13(11-15(14)27-18)12-5-3-2-4-6-12/h2-8,11H,9-10H2,1H3,(H,20,23)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187309
PNG
(US9169240, 48)
Show SMILES COc1nc(-c2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)c(OCc2ccccc2)c(=O)[nH]1
Show InChI InChI=1S/C28H18FN5O5S/c1-37-28-31-21(23(24(36)32-28)38-14-15-5-3-2-4-6-15)25-33-34-26(39-25)22(35)27-30-19-12-9-17(13-20(19)40-27)16-7-10-18(29)11-8-16/h2-13H,14H2,1H3,(H,31,32,36)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187328
PNG
(US9169240, 67)
Show SMILES CC(C)(C)OC(=O)CNc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C22H20N4O4S/c1-22(2,3)30-17(27)12-23-21-26-25-19(29-21)18(28)20-24-15-10-9-14(11-16(15)31-20)13-7-5-4-6-8-13/h4-11H,12H2,1-3H3,(H,23,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187338
PNG
(US9169240, 77 | US9169240, 78)
Show SMILES O=C(c1nnc(NC2CCCNC2=O)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H17N5O3S/c27-17(19-25-26-21(29-19)24-15-7-4-10-22-18(15)28)20-23-14-9-8-13(11-16(14)30-20)12-5-2-1-3-6-12/h1-3,5-6,8-9,11,15H,4,7,10H2,(H,22,28)(H,24,26)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187322
PNG
(US9169240, 61)
Show SMILES COC(=O)[C@H](COC(C)(C)C)Nc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)cc1 |r|
Show InChI InChI=1S/C24H23FN4O5S/c1-24(2,3)33-12-17(22(31)32-4)27-23-29-28-20(34-23)19(30)21-26-16-10-7-14(11-18(16)35-21)13-5-8-15(25)9-6-13/h5-11,17H,12H2,1-4H3,(H,27,29)/t17-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187335
PNG
(US9169240, 74)
Show SMILES CC(C)NC(=O)CNc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C21H19N5O3S/c1-12(2)23-17(27)11-22-21-26-25-19(29-21)18(28)20-24-15-9-8-14(10-16(15)30-20)13-6-4-3-5-7-13/h3-10,12H,11H2,1-2H3,(H,22,26)(H,23,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187334
PNG
(US9169240, 73)
Show SMILES O=C(c1nnc(NCCc2ccncc2)o1)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C23H17N5O2S/c29-20(21-27-28-23(30-21)25-13-10-15-8-11-24-12-9-15)22-26-18-7-6-17(14-19(18)31-22)16-4-2-1-3-5-16/h1-9,11-12,14H,10,13H2,(H,25,28)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187331
PNG
(BDBM187332 | US9169240, 70)
Show SMILES CN1CCC(Nc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)C1=O
Show InChI InChI=1S/C21H17N5O3S/c1-26-10-9-15(20(26)28)23-21-25-24-18(29-21)17(27)19-22-14-8-7-13(11-16(14)30-19)12-5-3-2-4-6-12/h2-8,11,15H,9-10H2,1H3,(H,23,25)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187323
PNG
(US9169240, 62)
Show SMILES COc1ccc(CCNc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C25H19FN4O3S/c1-32-19-9-2-15(3-10-19)12-13-27-25-30-29-23(33-25)22(31)24-28-20-11-6-17(14-21(20)34-24)16-4-7-18(26)8-5-16/h2-11,14H,12-13H2,1H3,(H,27,30)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187286
PNG
(US9169240, 26)
Show SMILES C[C@H](NS(N)(=O)=O)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C18H15N5O4S2/c1-10(23-29(19,25)26)16-21-22-17(27-16)15(24)18-20-13-8-7-12(9-14(13)28-18)11-5-3-2-4-6-11/h2-10,23H,1H3,(H2,19,25,26)/t10-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187327
PNG
(US9169240, 66)
Show SMILES Fc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NC2CC2)o1
Show InChI InChI=1S/C19H13FN4O2S/c20-12-4-1-10(2-5-12)11-3-8-14-15(9-11)27-18(22-14)16(25)17-23-24-19(26-17)21-13-6-7-13/h1-5,8-9,13H,6-7H2,(H,21,24)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187324
PNG
(US9169240, 63)
Show SMILES Fc1ccc(cc1)-c1ccc2nc(sc2c1)C(=O)c1nnc(NCCc2ccccc2F)o1
Show InChI InChI=1S/C24H16F2N4O2S/c25-17-8-5-14(6-9-17)16-7-10-19-20(13-16)33-23(28-19)21(31)22-29-30-24(32-22)27-12-11-15-3-1-2-4-18(15)26/h1-10,13H,11-12H2,(H,27,30)
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n/an/a 290n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187340
PNG
(US9169240, 79)
Show SMILES O=C(c1nnc(o1)N1CC[C@H](C1)c1ccccc1)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H20N4O2S/c31-23(25-27-21-12-11-19(15-22(21)33-25)17-7-3-1-4-8-17)24-28-29-26(32-24)30-14-13-20(16-30)18-9-5-2-6-10-18/h1-12,15,20H,13-14,16H2/t20-/m1/s1
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n/an/a 310n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187330
PNG
(US9169240, 69)
Show SMILES COc1ccc(CNc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)c(OC)c1
Show InChI InChI=1S/C25H20N4O4S/c1-31-18-10-8-17(20(13-18)32-2)14-26-25-29-28-23(33-25)22(30)24-27-19-11-9-16(12-21(19)34-24)15-6-4-3-5-7-15/h3-13H,14H2,1-2H3,(H,26,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187351
PNG
(US9169240, 90)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C23H16N4O4S2/c1-14-7-10-17(11-8-14)33(29,30)27-23-26-25-21(31-23)20(28)22-24-18-12-9-16(13-19(18)32-22)15-5-3-2-4-6-15/h2-13H,1H3,(H,26,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187326
PNG
(US9169240, 65)
Show SMILES C[C@H](Nc1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccc(F)cc1)c1ccc(Cl)cc1 |r|
Show InChI InChI=1S/C24H16ClFN4O2S/c1-13(14-2-7-17(25)8-3-14)27-24-30-29-22(32-24)21(31)23-28-19-11-6-16(12-20(19)33-23)15-4-9-18(26)10-5-15/h2-13H,1H3,(H,27,30)/t13-/m0/s1
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n/an/a 420n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187341
PNG
(US9169240, 80)
Show SMILES O=C(c1nnc(o1)N1CC[C@@H](C1)c1ccccc1)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C26H20N4O2S/c31-23(25-27-21-12-11-19(15-22(21)33-25)17-7-3-1-4-8-17)24-28-29-26(32-24)30-14-13-20(16-30)18-9-5-2-6-10-18/h1-12,15,20H,13-14,16H2/t20-/m0/s1
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n/an/a 450n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187352
PNG
(US9169240, 91)
Show SMILES FC(F)(F)CN1CCC(Nc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)C1=O
Show InChI InChI=1S/C22H16F3N5O3S/c23-22(24,25)11-30-9-8-15(20(30)32)27-21-29-28-18(33-21)17(31)19-26-14-7-6-13(10-16(14)34-19)12-4-2-1-3-5-12/h1-7,10,15H,8-9,11H2,(H,27,29)
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n/an/a 490n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187342
PNG
(US9169240, 81)
Show SMILES O=C(c1nnc(o1)N1CC[C@@H](C1)OCc1ccccc1)c1nc2ccc(cc2s1)-c1ccccc1 |r|
Show InChI InChI=1S/C27H22N4O3S/c32-24(26-28-22-12-11-20(15-23(22)35-26)19-9-5-2-6-10-19)25-29-30-27(34-25)31-14-13-21(16-31)33-17-18-7-3-1-4-8-18/h1-12,15,21H,13-14,16-17H2/t21-/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM187349
PNG
(US9169240, 88)
Show SMILES FC(F)(F)c1ccc(cc1)N1CCN(CC1)c1nnc(o1)C(=O)c1nc2ccc(cc2s1)-c1ccccc1
Show InChI InChI=1S/C27H20F3N5O2S/c28-27(29,30)19-7-9-20(10-8-19)34-12-14-35(15-13-34)26-33-32-24(37-26)23(36)25-31-21-11-6-18(16-22(21)38-25)17-4-2-1-3-5-17/h1-11,16H,12-15H2
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n/an/a 494n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM181682
PNG
(US9139578, Reference 3 | US9169240, Reference 1)
Show SMILES CC(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C17H15FN6O3S2/c1-9(16-24-23-15(27-16)8-21-29(19,25)26)17-22-12-4-2-10(6-13(12)28-17)11-3-5-14(18)20-7-11/h2-7,9,21H,8H2,1H3,(H2,19,25,26)
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n/an/a 6.52E+3n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
Endothelial lipase


(Homo sapiens (Human))
BDBM181683
PNG
(US9139578, Reference 4 | US9169240, Reference 2)
Show SMILES CC(O)(c1nnc(CNS(N)(=O)=O)o1)c1nc2ccc(cc2s1)-c1ccc(F)nc1
Show InChI InChI=1S/C17H15FN6O4S2/c1-17(25,15-24-23-14(28-15)8-21-30(19,26)27)16-22-11-4-2-9(6-12(11)29-16)10-3-5-13(18)20-7-10/h2-7,21,25H,8H2,1H3,(H2,19,26,27)
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n/an/a 1.49E+4n/an/an/an/a8.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50...


US Patent US9169240 (2015)


BindingDB Entry DOI: 10.7270/Q2W66JK8
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%