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USPatent US9216988

Compile Data Set for Download or QSAR

Found 210 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197904
PNG
(US9216988, 174)
Show SMILES CC(C)CN(Cc1ccc(O[C@@H]2C[C@@H]3CC[C@H](C2)N3S(C)(=O)=O)cc1)S(=O)(=O)Cc1ccccc1 |r,TLB:19:18:11.12.17:15.14|
Show InChI InChI=1S/C26H36N2O5S2/c1-20(2)17-27(35(31,32)19-22-7-5-4-6-8-22)18-21-9-13-25(14-10-21)33-26-15-23-11-12-24(16-26)28(23)34(3,29)30/h4-10,13-14,20,23-24,26H,11-12,15-19H2,1-3H3/t23-,24+,26+
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n/an/a 4n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197886
PNG
(US9216988, 155)
Show SMILES CC(C)CN(Cc1ccc(NC2CCN(CC2)S(C)(=O)=O)cc1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C24H35N3O4S2/c1-20(2)17-27(33(30,31)19-22-7-5-4-6-8-22)18-21-9-11-23(12-10-21)25-24-13-15-26(16-14-24)32(3,28)29/h4-12,20,24-25H,13-19H2,1-3H3
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n/an/a 6n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50044247
PNG
(CHEMBL3314036 | US9216988, 159)
Show SMILES CC(C)CN(Cc1ccc(OC2CCN(CC2)S(C)(=O)=O)cc1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C24H34N2O5S2/c1-20(2)17-26(33(29,30)19-22-7-5-4-6-8-22)18-21-9-11-23(12-10-21)31-24-13-15-25(16-14-24)32(3,27)28/h4-12,20,24H,13-19H2,1-3H3
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n/an/a 6n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090104
PNG
(CHEMBL3581543 | US9216988, 97)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cc(Cl)cc(Cl)c2)c(F)c1
Show InChI InChI=1S/C20H21ClFNO2/c21-17-5-3-16(4-6-17)20(25)10-13-23(14-11-20)12-9-19(24)15-1-7-18(22)8-2-15/h1-8,25H,9-14H2
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Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50044248
PNG
(CHEMBL3314035 | US9216988, 98)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(Cl)c(Cl)c2)c(F)c1
Show InChI InChI=1S/C23H26Cl2FN3O3S/c1-16(30)27-9-11-28(12-10-27)19-6-5-17(23(26)13-19)15-29(18-3-2-4-18)33(31,32)20-7-8-21(24)22(25)14-20/h5-8,13-14,18H,2-4,9-12,15H2,1H3
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n/an/a 7n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197824
PNG
(US9216988, 73)
Show SMILES CC(C)CN(Cc1ccc(cc1F)N1CCN(CC1)C(C)=O)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C24H32FN3O3S/c1-19(2)16-28(32(30,31)18-21-7-5-4-6-8-21)17-22-9-10-23(15-24(22)25)27-13-11-26(12-14-27)20(3)29/h4-10,15,19H,11-14,16-18H2,1-3H3
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n/an/a 7n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090092
PNG
(CHEMBL3581539 | US9216988, 85)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2Cl)c(F)c1
Show InChI InChI=1S/C24H29ClFN3O3S/c1-18(30)27-11-13-28(14-12-27)22-10-9-19(24(26)15-22)16-29(21-6-4-7-21)33(31,32)17-20-5-2-3-8-23(20)25/h2-3,5,8-10,15,21H,4,6-7,11-14,16-17H2,1H3
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n/an/a 9n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197792
PNG
(US9216988, 14)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cc(Cl)ccc2Cl)c(F)c1
Show InChI InChI=1S/C23H26Cl2FN3O3S/c1-16(30)27-9-11-28(12-10-27)20-7-5-17(22(26)14-20)15-29(19-3-2-4-19)33(31,32)23-13-18(24)6-8-21(23)25/h5-8,13-14,19H,2-4,9-12,15H2,1H3
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n/an/a 9n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090086
PNG
(CHEMBL3581533 | US9216988, 92)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2F)c(F)c1
Show InChI InChI=1S/C24H29F2N3O3S/c1-18(30)27-11-13-28(14-12-27)22-10-9-19(24(26)15-22)16-29(21-6-4-7-21)33(31,32)17-20-5-2-3-8-23(20)25/h2-3,5,8-10,15,21H,4,6-7,11-14,16-17H2,1H3
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n/an/a 10n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197793
PNG
(BDBM197870 | US9216988, 15)
Show SMILES CC(c1ccccc1)S(=O)(=O)N(Cc1ccc(cc1F)N1CCN(CC1)C(C)=O)CC(F)(F)F
Show InChI InChI=1S/C23H27F4N3O3S/c1-17(19-6-4-3-5-7-19)34(32,33)30(16-23(25,26)27)15-20-8-9-21(14-22(20)24)29-12-10-28(11-13-29)18(2)31/h3-9,14,17H,10-13,15-16H2,1-2H3
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n/an/a 10n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197930
PNG
(US9216988, 200)
Show SMILES CC(C)CN(Cc1ccc(N[C@@H]2CCN(C[C@H]2F)S(C)(=O)=O)cc1)S(=O)(=O)Cc1ccccc1 |r|
Show InChI InChI=1S/C24H34FN3O4S2/c1-19(2)15-28(34(31,32)18-21-7-5-4-6-8-21)16-20-9-11-22(12-10-20)26-24-13-14-27(17-23(24)25)33(3,29)30/h4-12,19,23-24,26H,13-18H2,1-3H3/t23-,24-/m1/s1
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n/an/a 10n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197793
PNG
(BDBM197870 | US9216988, 15)
Show SMILES CC(c1ccccc1)S(=O)(=O)N(Cc1ccc(cc1F)N1CCN(CC1)C(C)=O)CC(F)(F)F
Show InChI InChI=1S/C23H27F4N3O3S/c1-17(19-6-4-3-5-7-19)34(32,33)30(16-23(25,26)27)15-20-8-9-21(14-22(20)24)29-12-10-28(11-13-29)18(2)31/h3-9,14,17H,10-13,15-16H2,1-2H3
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n/an/a 11n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197835
PNG
(US9216988, 88)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccc(F)cc2F)c(F)c1
Show InChI InChI=1S/C24H28F3N3O3S/c1-17(31)28-9-11-29(12-10-28)22-8-6-18(24(27)14-22)15-30(21-3-2-4-21)34(32,33)16-19-5-7-20(25)13-23(19)26/h5-8,13-14,21H,2-4,9-12,15-16H2,1H3
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n/an/a 11n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197833
PNG
(US9216988, 84)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2C(F)(F)F)c(F)c1
Show InChI InChI=1S/C25H29F4N3O3S/c1-18(33)30-11-13-31(14-12-30)22-10-9-19(24(26)15-22)16-32(21-6-4-7-21)36(34,35)17-20-5-2-3-8-23(20)25(27,28)29/h2-3,5,8-10,15,21H,4,6-7,11-14,16-17H2,1H3
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n/an/a 12n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197825
PNG
(US9216988, 74)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(CC(F)(F)F)S(=O)(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C22H25F4N3O3S/c1-17(30)27-9-11-28(12-10-27)20-8-7-19(21(23)13-20)14-29(16-22(24,25)26)33(31,32)15-18-5-3-2-4-6-18/h2-8,13H,9-12,14-16H2,1H3
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n/an/a 12n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197834
PNG
(US9216988, 87)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2cc(F)ccc2F)c(F)c1
Show InChI InChI=1S/C24H28F3N3O3S/c1-17(31)28-9-11-29(12-10-28)22-7-5-18(24(27)14-22)15-30(21-3-2-4-21)34(32,33)16-19-13-20(25)6-8-23(19)26/h5-8,13-14,21H,2-4,9-12,15-16H2,1H3
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n/an/a 13n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197832
PNG
(US9216988, 83)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccc(Cl)cc2Cl)c(F)c1
Show InChI InChI=1S/C24H28Cl2FN3O3S/c1-17(31)28-9-11-29(12-10-28)22-8-6-18(24(27)14-22)15-30(21-3-2-4-21)34(32,33)16-19-5-7-20(25)13-23(19)26/h5-8,13-14,21H,2-4,9-12,15-16H2,1H3
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n/an/a 15n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090083
PNG
(CHEMBL3581530 | US9216988, 96)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C24H30FN3O3S/c1-19(29)26-12-14-27(15-13-26)23-11-10-21(24(25)16-23)17-28(22-8-5-9-22)32(30,31)18-20-6-3-2-4-7-20/h2-4,6-7,10-11,16,22H,5,8-9,12-15,17-18H2,1H3
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n/an/a 15n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197794
PNG
(US9216988, 16)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(OC(F)(F)F)c2)c(F)c1
Show InChI InChI=1S/C24H27F4N3O4S/c1-17(32)29-10-12-30(13-11-29)20-9-8-18(23(25)14-20)16-31(19-4-2-5-19)36(33,34)22-7-3-6-21(15-22)35-24(26,27)28/h3,6-9,14-15,19H,2,4-5,10-13,16H2,1H3
PDB

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n/an/a 16n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197838
PNG
(US9216988, 95)
Show SMILES CC(=O)N1C[C@@H]2C[C@H]1CN2c1ccc(CN(CC(F)(F)F)S(=O)(=O)Cc2ccccc2)c(F)c1 |r|
Show InChI InChI=1S/C23H25F4N3O3S/c1-16(31)29-12-21-9-20(29)13-30(21)19-8-7-18(22(24)10-19)11-28(15-23(25,26)27)34(32,33)14-17-5-3-2-4-6-17/h2-8,10,20-21H,9,11-15H2,1H3/t20-,21-/m0/s1
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n/an/a 17n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090090
PNG
(CHEMBL3581537 | US9216988, 91)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccc(F)cc2)c(F)c1
Show InChI InChI=1S/C24H29F2N3O3S/c1-18(30)27-11-13-28(14-12-27)23-10-7-20(24(26)15-23)16-29(22-3-2-4-22)33(31,32)17-19-5-8-21(25)9-6-19/h5-10,15,22H,2-4,11-14,16-17H2,1H3
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n/an/a 17n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090175
PNG
(CHEMBL3581554 | US9216988, 17)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(cc2)C(C)(C)C)c(F)c1
Show InChI InChI=1S/C27H36FN3O3S/c1-20(32)29-14-16-30(17-15-29)24-11-8-21(26(28)18-24)19-31(23-6-5-7-23)35(33,34)25-12-9-22(10-13-25)27(2,3)4/h8-13,18,23H,5-7,14-17,19H2,1-4H3
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n/an/a 18n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090094
PNG
(CHEMBL3581541 | US9216988, 89)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2cccc(Cl)c2)c(F)c1
Show InChI InChI=1S/C24H29ClFN3O3S/c1-18(30)27-10-12-28(13-11-27)23-9-8-20(24(26)15-23)16-29(22-6-3-7-22)33(31,32)17-19-4-2-5-21(25)14-19/h2,4-5,8-9,14-15,22H,3,6-7,10-13,16-17H2,1H3
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n/an/a 19n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197816
PNG
(BDBM197817 | US9216988, 63)
Show SMILES CS(=O)(=O)NC1CCN(CC1)c1ccc(CN(CC(F)(F)F)S(=O)(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C22H27F4N3O4S2/c1-34(30,31)27-19-9-11-28(12-10-19)20-8-7-18(21(23)13-20)14-29(16-22(24,25)26)35(32,33)15-17-5-3-2-4-6-17/h2-8,13,19,27H,9-12,14-16H2,1H3
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n/an/a 20n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090093
PNG
(CHEMBL3581540 | US9216988, 18)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(Cl)c2)c(F)c1
Show InChI InChI=1S/C23H27ClFN3O3S/c1-17(29)26-10-12-27(13-11-26)21-9-8-18(23(25)15-21)16-28(20-5-3-6-20)32(30,31)22-7-2-4-19(24)14-22/h2,4,7-9,14-15,20H,3,5-6,10-13,16H2,1H3
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n/an/a 22n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197841
PNG
(US9216988, 104)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cc(C)cc(C)c2)c(F)c1
Show InChI InChI=1S/C25H32FN3O3S/c1-18-13-19(2)15-24(14-18)33(31,32)29(22-5-4-6-22)17-21-7-8-23(16-25(21)26)28-11-9-27(10-12-28)20(3)30/h7-8,13-16,22H,4-6,9-12,17H2,1-3H3
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n/an/a 24n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090088
PNG
(CHEMBL3581535 | US9216988, 90)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2cccc(F)c2)c(F)c1
Show InChI InChI=1S/C24H29F2N3O3S/c1-18(30)27-10-12-28(13-11-27)23-9-8-20(24(26)15-23)16-29(22-6-3-7-22)33(31,32)17-19-4-2-5-21(25)14-19/h2,4-5,8-9,14-15,22H,3,6-7,10-13,16-17H2,1H3
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n/an/a 25n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197842
PNG
(US9216988, 105)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(C)c2)c(F)c1
Show InChI InChI=1S/C24H30FN3O3S/c1-18-5-3-8-23(15-18)32(30,31)28(21-6-4-7-21)17-20-9-10-22(16-24(20)25)27-13-11-26(12-14-27)19(2)29/h3,5,8-10,15-16,21H,4,6-7,11-14,17H2,1-2H3
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n/an/a 25n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197843
PNG
(US9216988, 106)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(CC(F)(F)F)S(=O)(=O)C(C)(C)c2ccccc2)c(F)c1
Show InChI InChI=1S/C24H29F4N3O3S/c1-18(32)29-11-13-30(14-12-29)21-10-9-19(22(25)15-21)16-31(17-24(26,27)28)35(33,34)23(2,3)20-7-5-4-6-8-20/h4-10,15H,11-14,16-17H2,1-3H3
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n/an/a 26n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197935
PNG
(US9216988, 205)
Show SMILES CC(C)CN(Cc1ccc(N[C@@H]2CC[C@H](CC#N)C2)cc1)S(=O)(=O)Cc1ccccc1 |r|
Show InChI InChI=1S/C25H33N3O2S/c1-20(2)17-28(31(29,30)19-23-6-4-3-5-7-23)18-22-9-11-24(12-10-22)27-25-13-8-21(16-25)14-15-26/h3-7,9-12,20-21,25,27H,8,13-14,16-19H2,1-2H3/t21-,25-/m1/s1
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n/an/a 26n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197896
PNG
(US9216988, 166)
Show SMILES CC(C)CN(Cc1ccc(cc1)N1CCN(CC1)C(=O)[C@H](C)O)S(=O)(=O)Cc1ccccc1 |r|
Show InChI InChI=1S/C25H35N3O4S/c1-20(2)17-28(33(31,32)19-23-7-5-4-6-8-23)18-22-9-11-24(12-10-22)26-13-15-27(16-14-26)25(30)21(3)29/h4-12,20-21,29H,13-19H2,1-3H3/t21-/m0/s1
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n/an/a 27n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197929
PNG
(US9216988, 199)
Show SMILES CC(C)CN(Cc1ccc(N[C@@H]2CCN(C[C@@H]2F)S(C)(=O)=O)cc1)S(=O)(=O)Cc1ccccc1 |r|
Show InChI InChI=1S/C24H34FN3O4S2/c1-19(2)15-28(34(31,32)18-21-7-5-4-6-8-21)16-20-9-11-22(12-10-20)26-24-13-14-27(17-23(24)25)33(3,29)30/h4-12,19,23-24,26H,13-18H2,1-3H3/t23-,24+/m0/s1
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n/an/a 28n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50050086
PNG
(CHEMBL3317836 | US9216988, 55)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C24H31N3O3S/c1-20(28)25-14-16-26(17-15-25)23-12-10-21(11-13-23)18-27(24-8-5-9-24)31(29,30)19-22-6-3-2-4-7-22/h2-4,6-7,10-13,24H,5,8-9,14-19H2,1H3
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n/an/a 29n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197925
PNG
(US9216988, 195)
Show SMILES CC(C)CN(Cc1ccc(NC2(C)CCN(CC2)S(C)(=O)=O)cc1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C25H37N3O4S2/c1-21(2)18-28(34(31,32)20-23-8-6-5-7-9-23)19-22-10-12-24(13-11-22)26-25(3)14-16-27(17-15-25)33(4,29)30/h5-13,21,26H,14-20H2,1-4H3
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n/an/a 29n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090121
PNG
(CHEMBL3581544 | US9216988, 80)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2cc(Cl)cc(Cl)c2)c(F)c1
Show InChI InChI=1S/C24H28Cl2FN3O3S/c1-17(31)28-7-9-29(10-8-28)23-6-5-19(24(27)14-23)15-30(22-3-2-4-22)34(32,33)16-18-11-20(25)13-21(26)12-18/h5-6,11-14,22H,2-4,7-10,15-16H2,1H3
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n/an/a 29n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50050117
PNG
(CHEMBL3317843 | US9216988, 54)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(CC(F)(F)F)S(=O)(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C22H26F3N3O3S/c1-18(29)26-11-13-27(14-12-26)21-9-7-19(8-10-21)15-28(17-22(23,24)25)32(30,31)16-20-5-3-2-4-6-20/h2-10H,11-17H2,1H3
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n/an/a 30n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197805
PNG
(US9216988, 41)
Show SMILES CC(C)CN(Cc1ccc(cc1)N1CCN(CC1)C(=O)C1CC1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C26H35N3O3S/c1-21(2)18-29(33(31,32)20-23-6-4-3-5-7-23)19-22-8-12-25(13-9-22)27-14-16-28(17-15-27)26(30)24-10-11-24/h3-9,12-13,21,24H,10-11,14-20H2,1-2H3
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n/an/a 30n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090129
PNG
(CHEMBL3581552 | US9216988, 67)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(OC(F)(F)F)cc2)c(F)c1
Show InChI InChI=1S/C24H27F4N3O4S/c1-17(32)29-11-13-30(14-12-29)20-6-5-18(23(25)15-20)16-31(19-3-2-4-19)36(33,34)22-9-7-21(8-10-22)35-24(26,27)28/h5-10,15,19H,2-4,11-14,16H2,1H3
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n/an/a 31n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197827
PNG
(US9216988, 76)
Show SMILES CN(C)S(=O)(=O)N1CCN(CC1)c1ccc(CN(CC(F)(F)F)S(=O)(=O)Cc2ccccc2)c(F)c1
Show InChI InChI=1S/C22H28F4N4O4S2/c1-27(2)36(33,34)29-12-10-28(11-13-29)20-9-8-19(21(23)14-20)15-30(17-22(24,25)26)35(31,32)16-18-6-4-3-5-7-18/h3-9,14H,10-13,15-17H2,1-2H3
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UniChem
US Patent
n/an/a 32n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197798
PNG
(US9216988, 26)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(c2)C(C)(C)C)c(F)c1
Show InChI InChI=1S/C27H36FN3O3S/c1-20(32)29-13-15-30(16-14-29)24-12-11-21(26(28)18-24)19-31(23-8-6-9-23)35(33,34)25-10-5-7-22(17-25)27(2,3)4/h5,7,10-12,17-18,23H,6,8-9,13-16,19H2,1-4H3
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n/an/a 33n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197799
PNG
(US9216988, 27)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cccc(Cl)c2Cl)c(F)c1
Show InChI InChI=1S/C23H26Cl2FN3O3S/c1-16(30)27-10-12-28(13-11-27)19-9-8-17(21(26)14-19)15-29(18-4-2-5-18)33(31,32)22-7-3-6-20(24)23(22)25/h3,6-9,14,18H,2,4-5,10-13,15H2,1H3
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US Patent
n/an/a 34n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197800
PNG
(US9216988, 28)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N(Cc1ccc(cc1F)N1CCN(CC1)C(C)=O)C1CCC1
Show InChI InChI=1S/C26H34FN3O3S/c1-19(2)21-8-11-25(12-9-21)34(32,33)30(23-5-4-6-23)18-22-7-10-24(17-26(22)27)29-15-13-28(14-16-29)20(3)31/h7-12,17,19,23H,4-6,13-16,18H2,1-3H3
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US Patent
n/an/a 35n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197823
PNG
(US9216988, 72)
Show SMILES CC(C)CN(Cc1ccc(N2CCN(CC2)C(C)=O)c(C)c1)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C25H35N3O3S/c1-20(2)17-28(32(30,31)19-23-8-6-5-7-9-23)18-24-10-11-25(21(3)16-24)27-14-12-26(13-15-27)22(4)29/h5-11,16,20H,12-15,17-19H2,1-4H3
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n/an/a 35n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197850
PNG
(US9216988, 113)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2ccc(F)cc2F)c(F)c1
Show InChI InChI=1S/C23H26F3N3O3S/c1-16(30)27-9-11-28(12-10-27)20-7-5-17(21(25)14-20)15-29(19-3-2-4-19)33(31,32)23-8-6-18(24)13-22(23)26/h5-8,13-14,19H,2-4,9-12,15H2,1H3
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US Patent
n/an/a 36n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197849
PNG
(US9216988, 112)
Show SMILES CC(=O)N1C[C@H]2C[C@@H]1CN2c1ccc(CN(CC(F)(F)F)S(=O)(=O)Cc2ccccc2)c(F)c1 |r|
Show InChI InChI=1S/C23H25F4N3O3S/c1-16(31)29-12-21-9-20(29)13-30(21)19-8-7-18(22(24)10-19)11-28(15-23(25,26)27)34(32,33)14-17-5-3-2-4-6-17/h2-8,10,20-21H,9,11-15H2,1H3/t20-,21-/m1/s1
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n/an/a 36n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090096
PNG
(CHEMBL3580673 | US9216988, 86)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)Cc2ccc(Cl)cc2)c(F)c1
Show InChI InChI=1S/C29H33N5O3/c30-27(31)32-9-7-15-3-5-20-18(11-15)19-13-29(36)22-12-17-4-6-21(35)25-23(17)28(29,26(37-25)24(19)33-20)8-10-34(22)14-16-1-2-16/h3-6,11,16,22,26,33,35-36H,1-2,7-10,12-14H2,(H4,30,31,32)/t22?,26-,28-,29+/m0/s1
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US Patent
n/an/a 36n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM50090123
PNG
(CHEMBL3581546 | US9216988, 29)
Show SMILES COc1cccc(c1)S(=O)(=O)N(Cc1ccc(cc1F)N1CCN(CC1)C(C)=O)C1CCC1
Show InChI InChI=1S/C24H30FN3O4S/c1-18(29)26-11-13-27(14-12-26)21-10-9-19(24(25)15-21)17-28(20-5-3-6-20)33(30,31)23-8-4-7-22(16-23)32-2/h4,7-10,15-16,20H,3,5-6,11-14,17H2,1-2H3
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n/an/a 36n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197851
PNG
(US9216988, 114)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2c(Cl)cccc2Cl)c(F)c1
Show InChI InChI=1S/C23H26Cl2FN3O3S/c1-16(30)27-10-12-28(13-11-27)19-9-8-17(22(26)14-19)15-29(18-4-2-5-18)33(31,32)23-20(24)6-3-7-21(23)25/h3,6-9,14,18H,2,4-5,10-13,15H2,1H3
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US Patent
n/an/a 38n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197852
PNG
(US9216988, 115)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(CN(C2CCC2)S(=O)(=O)c2cc(F)ccc2F)c(F)c1
Show InChI InChI=1S/C23H26F3N3O3S/c1-16(30)27-9-11-28(12-10-27)20-7-5-17(22(26)14-20)15-29(19-3-2-4-19)33(31,32)23-13-18(24)6-8-21(23)25/h5-8,13-14,19H,2-4,9-12,15H2,1H3
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n/an/a 39n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
Nuclear receptor ROR-gamma


(Homo sapiens (Human))		BDBM197900
PNG
(US9216988, 170)
Show SMILES CO[C@@H](C)C(=O)N1CCN(CC1)c1ccc(CN(CC(C)C)S(=O)(=O)Cc2ccccc2)cc1 |r|
Show InChI InChI=1S/C26H37N3O4S/c1-21(2)18-29(34(31,32)20-24-8-6-5-7-9-24)19-23-10-12-25(13-11-23)27-14-16-28(17-15-27)26(30)22(3)33-4/h5-13,21-22H,14-20H2,1-4H3/t22-/m0/s1
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n/an/a 40n/an/an/an/a7.4n/a



Genentech, Inc.

US Patent


Assay Description
On day of the assay, 100 uL of 0.05% CHAPS (in deionized H2O) was added to all wells of the GFB Unifilter plate and allowed soak for 1 h. A wash bu...

US Patent US9216988 (2015)


BindingDB Entry DOI: 10.7270/Q2TB15QC
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%