Reaction Details |
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Target | Growth hormone secretagogue receptor type 1 |
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Ligand | BDBM21947 |
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Substrate/Competitor | BDBM10852 |
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Meas. Tech. | Fluorescence Imaging Plate Reader (FLIPR) Assay |
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pH | 7.2±n/a |
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Temperature | 295.15±n/a K |
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EC50 | 10.1±n/a nM |
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Citation | Li, J; Chen, SY; Li, JJ; Wang, H; Hernandez, AS; Tao, S; Musial, CM; Qu, F; Swartz, S; Chao, ST; Flynn, N; Murphy, BJ; Slusarchyk, DA; Seethala, R; Yan, M; Sleph, P; Grover, G; Smith, MA; Beehler, B; Giupponi, L; Dickinson, KE; Zhang, H; Humphreys, WG; Patel, BP; Schwinden, M; Stouch, T; Cheng, PT; Biller, SA; Ewing, WR; Gordon, D; Robl, JA; Tino, JA Discovery of a tetrazole-based growth hormone secretagogue: 4-(hydroxybutyl)carbamic acid 2-{5-[1-(2-amino-2-methylpropionylamino)-2- benzyloxyethyl]tetrazol-1-yl}ethyl ester (BMS-317180). J Med Chem50:5890-3 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Growth hormone secretagogue receptor type 1 |
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Name: | Growth hormone secretagogue receptor type 1 |
Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
Type: | Receptor |
Mol. Mass.: | 41334.57 |
Organism: | Homo sapiens (Human) |
Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
Residue: | 366 |
Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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BDBM21947 |
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BDBM10852 |
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Name | BDBM21947 |
Synonyms: | 2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl]-1H-1,2,3,4-tetrazol-1-yl}ethyl 3-hydroxy-3-methylpyrrolidine-1-carboxylate | Tetrazole-based compound, 13 |
Type | Small organic molecule |
Emp. Form. | C22H33N7O5 |
Mol. Mass. | 475.5413 |
SMILES | CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)N1CCC(C)(O)C1 |r| |
Structure |
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