Reaction Details |
![](/images/Email.png) | Report a problem with these data |
Target | Tyrosyl-DNA phosphodiesterase 1 |
---|
Ligand | BDBM50257099 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEBML_1689436 |
---|
IC50 | >111000±n/a nM |
---|
Citation | Elsayed, MSA; Su, Y; Wang, P; Sethi, T; Agama, K; Ravji, A; Redon, CE; Kiselev, E; Horzmann, KA; Freeman, JL; Pommier, Y; Cushman, M Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I. J Med Chem60:5364-5376 (2017) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Tyrosyl-DNA phosphodiesterase 1 |
---|
Name: | Tyrosyl-DNA phosphodiesterase 1 |
Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
Type: | Enzyme |
Mol. Mass.: | 68430.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9NUW8 |
Residue: | 608 |
Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
|
|
|
BDBM50257099 |
---|
n/a |
---|
Name | BDBM50257099 |
Synonyms: | CHEMBL4103520 |
Type | Small organic molecule |
Emp. Form. | C22H17ClN4O3 |
Mol. Mass. | 420.848 |
SMILES | COc1cnc-2c(c1)C(=O)c1c-2n(CCCn2ccnc2)c(=O)c2cc(Cl)ccc12 |
Structure |
|