Reaction Details |
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Target | Tyrosyl-DNA phosphodiesterase 1 |
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Ligand | BDBM50257126 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEBML_1689436 |
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IC50 | >111000±n/a nM |
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Citation | Elsayed, MSA; Su, Y; Wang, P; Sethi, T; Agama, K; Ravji, A; Redon, CE; Kiselev, E; Horzmann, KA; Freeman, JL; Pommier, Y; Cushman, M Design and Synthesis of Chlorinated and Fluorinated 7-Azaindenoisoquinolines as Potent Cytotoxic Anticancer Agents That Inhibit Topoisomerase I. J Med Chem60:5364-5376 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosyl-DNA phosphodiesterase 1 |
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Name: | Tyrosyl-DNA phosphodiesterase 1 |
Synonyms: | TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1) |
Type: | Enzyme |
Mol. Mass.: | 68430.66 |
Organism: | Homo sapiens (Human) |
Description: | Q9NUW8 |
Residue: | 608 |
Sequence: | MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKI
SPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPN
DGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNS
GALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHA
QAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSP
LYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPG
RFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESM
LTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKW
SAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELG
VLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDT
HGNMWVPS
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BDBM50257126 |
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n/a |
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Name | BDBM50257126 |
Synonyms: | CHEMBL4101133 |
Type | Small organic molecule |
Emp. Form. | C24H24FN3O4 |
Mol. Mass. | 437.4635 |
SMILES | COc1cnc-2c(c1)C(=O)c1c-2n(CCCN2CCC(O)CC2)c(=O)c2cc(F)ccc12 |
Structure |
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