| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase protein |
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| Ligand | BDBM50479473 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_539251 (CHEMBL1025583) |
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| IC50 | 3.8±n/a nM |
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| Citation |  Tucker, TJ; Sisko, JT; Tynebor, RM; Williams, TM; Felock, PJ; Flynn, JA; Lai, MT; Liang, Y; McGaughey, G; Liu, M; Miller, M; Moyer, G; Munshi, V; Perlow-Poehnelt, R; Prasad, S; Reid, JC; Sanchez, R; Torrent, M; Vacca, JP; Wan, BL; Yan, Y Discovery of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridine-3-yl)methoxy]-2-chlorophenoxy}-5-chlorobenzonitrile (MK-4965): a potent, orally bioavailable HIV-1 non-nucleoside reverse transcriptase inhibitor with improved potency against key mutant viruses. J Med Chem51:6503-11 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase protein |
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| Name: | Reverse transcriptase protein |
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| Synonyms: | Reverse Transcriptase | Reverse Transcriptase (A62V) | Reverse Transcriptase (F61A) |
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| Type: | Protein |
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| Mol. Mass.: | 30203.56 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | Q9WJQ2 |
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| Residue: | 259 |
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| Sequence: | PISPIEPVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYEHHPDKWT
VQPIVLPEKDSWTVNDIQK
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| BDBM50479473 |
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| n/a |
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| Name | BDBM50479473 |
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| Synonyms: | CHEMBL491018 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H12Cl2N4O2 |
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| Mol. Mass. | 411.241 |
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| SMILES | Clc1cc(Oc2cc(OCc3n[nH]c4ccncc34)ccc2Cl)cc(c1)C#N |
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| Structure | 
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