| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-gamma |
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| Ligand | BDBM329726 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1838766 (CHEMBL4338899) |
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| IC50 | 2.0±n/a nM |
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| Citation |  Zhang, H; Lapointe, BT; Anthony, N; Azevedo, R; Cals, J; Correll, CC; Daniels, M; Deshmukh, S; van Eenenaam, H; Ferguson, H; Hegde, LG; Karstens, WJ; Maclean, J; Miller, JR; Moy, LY; Simov, V; Nagpal, S; Oubrie, A; Palte, RL; Parthasarathy, G; Sciammetta, N; van der Stelt, M; Woodhouse, JD; Trotter, BW; Barr, K Discovery of N-(Indazol-3-yl)piperidine-4-carboxylic Acids as ROR??t Allosteric Inhibitors for Autoimmune Diseases ACS Med Chem Lett11:114-119 (2020) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-gamma |
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| Name: | Nuclear receptor ROR-gamma |
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| Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 58218.40 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449 |
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| Residue: | 518 |
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| Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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| BDBM329726 |
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| n/a |
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| Name | BDBM329726 |
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| Synonyms: | (3S,4R)-1-(1-(2- chloro-6- (trifluoromethyl)benzoyl)- 4-fluoro-1H-indazol-3-yl)- 3-hydroxypiperidine-4- carboxylic acid | US9663522, 6D |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16ClF4N3O4 |
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| Mol. Mass. | 485.816 |
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| SMILES | O[C@@H]1CN(CC[C@H]1C(O)=O)c1nn(C(=O)c2c(Cl)cccc2C(F)(F)F)c2cccc(F)c12 |
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| Structure | 
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