| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-8 subunit |
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| Ligand | BDBM426093 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1839474 (CHEMBL4339689) |
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| IC50 | <10000±n/a nM |
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| Citation |  Savall, BM; Wu, D; Swanson, DM; Seierstad, M; Wu, N; Vives Martinez, J; García Olmos, B; Lord, B; Coe, K; Koudriakova, T; Lovenberg, TW; Carruthers, NI; Maher, MP; Ameriks, MK Discovery of Imidazo[1,2- ACS Med Chem Lett10:267-272 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel gamma-8 subunit |
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| Name: | Voltage-dependent calcium channel gamma-8 subunit |
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| Synonyms: | CCG8_RAT | Cacng8 | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8 | Voltage-dependent calcium channel gamma-8 subunit |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43282.90 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_119160 |
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| Residue: | 421 |
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| Sequence: | MESLKRWNEERGLWCEKGVQVLLTTIGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
DDGPPHRGGSGSSEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYL
LRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYI
SANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSD
LLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRGSSEASPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLASAGGGGGGAGVGAYGGAAGAAGGGGTGSERDRGSSAG
FLTLHNAFPKEAASGVTVTVTGPPAAPAPAPPAPAAPAPGTLSKEAAASNTNTLNRKTTP
V
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| BDBM426093 |
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| n/a |
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| Name | BDBM426093 |
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| Synonyms: | 5-[2-(4-Fluorophenyl)-8-(3-oxopiperazin-1-yl)imidazo[1,2-a]pyrazin-3- | US10513523, Example 32 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19FN6O2 |
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| Mol. Mass. | 442.4451 |
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| SMILES | Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCNC(=O)C1 |
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| Structure | 
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