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Compile Data Set for Download or QSAR

Found 309 hits with Last Name = 'maher' and Initial = 'mp'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM20461
PNG
((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Show SMILES COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O
Show InChI InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+
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 6n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant TRPV1

Bioorg Med Chem Lett 20: 7137-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.023
BindingDB Entry DOI: 10.7270/Q29W0FQ5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50052442
PNG
((4-Hydroxy-3-methoxy-phenyl)-acetic acid (2R,3S,3a...)
Show SMILES COc1cc(CC(=O)OCC2=C[C@H]3[C@H]4O[C@]5(Cc6ccccc6)O[C@]4(C[C@@H](C)[C@]3(O5)[C@@H]3C=C(C)C(=O)[C@@]3(O)C2)C(C)=C)ccc1O |r,t:10,35,THB:23:15:26.25.24:12|
Show InChI InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1
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 14n/an/an/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant TRPV1

Bioorg Med Chem Lett 20: 7137-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.023
BindingDB Entry DOI: 10.7270/Q29W0FQ5
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426135
PNG
(5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...)
Show SMILES FC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)29-20)32-12-9-28-24(25(32)30-22)31-10-7-19(27)8-11-31/h1-6,9,12-13,19H,7-8,10-11,14H2,(H,29,33)
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n/an/a 0.100n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426135
PNG
(5-[2-(4-Fluorophenyl)-8-(4-fluoro-1-piperidyl)imid...)
Show SMILES FC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)29-20)32-12-9-28-24(25(32)30-22)31-10-7-19(27)8-11-31/h1-6,9,12-13,19H,7-8,10-11,14H2,(H,29,33)
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n/an/a 0.100n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426226
PNG
(5-[2-(4-Fluorophenyl)-7-(4-hydroxy-1-piperidyl)pyr...)
Show SMILES OC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C25H22FN5O2/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)28-20)21-7-10-27-25(31(21)29-24)30-11-8-19(32)9-12-30/h1-7,10,13,19,32H,8-9,11-12,14H2,(H,28,33)
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n/an/a 0.200n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459036
PNG
(CHEMBL4211865)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(Cl)cccc1OC(F)(F)F
Show InChI InChI=1S/C16H11ClF3NO2/c1-8-5-9(6-10-7-13(22)21-15(8)10)14-11(17)3-2-4-12(14)23-16(18,19)20/h2-6H,7H2,1H3,(H,21,22)
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n/an/a 0.200n/an/an/an/an/an/a



Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426232
PNG
(5-[7-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)py...)
Show SMILES CC(=O)N1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C26H23FN6O2/c1-16(34)31-10-12-32(13-11-31)26-28-9-8-22-24(18-4-7-21-19(14-18)15-23(35)29-21)25(30-33(22)26)17-2-5-20(27)6-3-17/h2-9,14H,10-13,15H2,1H3,(H,29,35)
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n/an/a 0.251n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426098
PNG
(5-[2-(4-Fluorophenyl)-8-(4-hydroxy-1-piperidyl)imi...)
Show SMILES OC1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C25H22FN5O2/c26-18-4-1-15(2-5-18)22-23(16-3-6-20-17(13-16)14-21(33)28-20)31-12-9-27-24(25(31)29-22)30-10-7-19(32)8-11-30/h1-6,9,12-13,19,32H,7-8,10-11,14H2,(H,28,33)
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n/an/a 0.398n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426073
PNG
(5-[8-(4-Acetylpiperazin-1-yl)-2-(4-fluorophenyl)im...)
Show SMILES CC(=O)N1CCN(CC1)c1nccn2c(c(nc12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C26H23FN6O2/c1-16(34)31-10-12-32(13-11-31)25-26-30-23(17-2-5-20(27)6-3-17)24(33(26)9-8-28-25)18-4-7-21-19(14-18)15-22(35)29-21/h2-9,14H,10-13,15H2,1H3,(H,29,35)
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n/an/a 0.398n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254080
PNG
((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Show SMILES OCc1cc(Cl)c(Nc2nc3c(Nc4ccc(cc4)C(F)(F)F)ncnc3s2)c(Cl)c1
Show InChI InChI=1S/C19H12Cl2F3N5OS/c20-12-5-9(7-30)6-13(21)14(12)28-18-29-15-16(25-8-26-17(15)31-18)27-11-3-1-10(2-4-11)19(22,23)24/h1-6,8,30H,7H2,(H,28,29)(H,25,26,27)
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n/an/a 0.5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254419
PNG
(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Show SMILES Clc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)S(=O)(=O)N3CCCC3)ncnc2s1
Show InChI InChI=1S/C21H18Cl2N6O2S2/c22-15-4-3-5-16(23)17(15)27-21-28-18-19(24-12-25-20(18)32-21)26-13-6-8-14(9-7-13)33(30,31)29-10-1-2-11-29/h3-9,12H,1-2,10-11H2,(H,27,28)(H,24,25,26)
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n/an/a 0.5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426224
PNG
(5-[2-(4-Fluorophenyl)-7-morpholino-pyrazolo[1,5-c]...)
Show SMILES Fc1ccc(cc1)-c1nn2c(nccc2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1
Show InChI InChI=1S/C24H20FN5O2/c25-18-4-1-15(2-5-18)23-22(16-3-6-19-17(13-16)14-21(31)27-19)20-7-8-26-24(30(20)28-23)29-9-11-32-12-10-29/h1-8,13H,9-12,14H2,(H,27,31)
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n/an/a 0.501n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426093
PNG
(5-[2-(4-Fluorophenyl)-8-(3-oxopiperazin-1-yl)imida...)
Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCNC(=O)C1
Show InChI InChI=1S/C24H19FN6O2/c25-17-4-1-14(2-5-17)21-22(15-3-6-18-16(11-15)12-19(32)28-18)31-10-8-27-23(24(31)29-21)30-9-7-26-20(33)13-30/h1-6,8,10-11H,7,9,12-13H2,(H,26,33)(H,28,32)
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n/an/a 0.501n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426069
PNG
(5-[2-(4-Fluorophenyl)-8-morpholino-imidazo[1,2-a]p...)
Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2NC(=O)Cc2c1)N1CCOCC1
Show InChI InChI=1S/C24H20FN5O2/c25-18-4-1-15(2-5-18)21-22(16-3-6-19-17(13-16)14-20(31)27-19)30-8-7-26-23(24(30)28-21)29-9-11-32-12-10-29/h1-8,13H,9-12,14H2,(H,27,31)
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n/an/a 0.501n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426071
PNG
(4-[2-(4-Fluorophenyl)-3-(1H-indazol-5-yl)imidazo[1...)
Show SMILES Fc1ccc(cc1)-c1nc2c(nccn2c1-c1ccc2[nH]ncc2c1)N1CCOCC1
Show InChI InChI=1S/C23H19FN6O/c24-18-4-1-15(2-5-18)20-21(16-3-6-19-17(13-16)14-26-28-19)30-8-7-25-22(23(30)27-20)29-9-11-31-12-10-29/h1-8,13-14H,9-12H2,(H,26,28)
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n/an/a 0.631n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254419
PNG
(CHEMBL511391 | N2-(2,6-dichlorophenyl)-N7-(4-(pyrr...)
Show SMILES Clc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)S(=O)(=O)N3CCCC3)ncnc2s1
Show InChI InChI=1S/C21H18Cl2N6O2S2/c22-15-4-3-5-16(23)17(15)27-21-28-18-19(24-12-25-20(18)32-21)26-13-6-8-14(9-7-13)33(30,31)29-10-1-2-11-29/h3-9,12H,1-2,10-11H2,(H,27,28)(H,24,25,26)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254080
PNG
((3,5-dichloro-4-(7-(4-(trifluoromethyl)phenylamino...)
Show SMILES OCc1cc(Cl)c(Nc2nc3c(Nc4ccc(cc4)C(F)(F)F)ncnc3s2)c(Cl)c1
Show InChI InChI=1S/C19H12Cl2F3N5OS/c20-12-5-9(7-30)6-13(21)14(12)28-18-29-15-16(25-8-26-17(15)31-18)27-11-3-1-10(2-4-11)19(22,23)24/h1-6,8,30H,7H2,(H,28,29)(H,25,26,27)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254325
PNG
(CHEMBL469302 | N7-(4-tert-butylphenyl)-N2-(2,6-dic...)
Show SMILES CC(C)(C)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C21H19Cl2N5S/c1-21(2,3)12-7-9-13(10-8-12)26-18-17-19(25-11-24-18)29-20(28-17)27-16-14(22)5-4-6-15(16)23/h4-11H,1-3H3,(H,27,28)(H,24,25,26)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254077
PNG
(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)
Show SMILES CC(C)CNc1nc(Nc2ccc(cc2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1
Show InChI InChI=1S/C22H19Cl2F3N6S/c1-11(2)10-28-20-32-18(29-13-8-6-12(7-9-13)22(25,26)27)17-19(33-20)34-21(31-17)30-16-14(23)4-3-5-15(16)24/h3-9,11H,10H2,1-2H3,(H,30,31)(H2,28,29,32,33)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254154
PNG
(CHEMBL468470 | N2-(2-chloro-6-methylphenyl)-N7-(4-...)
Show SMILES Cc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)C(F)(F)F)ncnc2s1
Show InChI InChI=1S/C19H13ClF3N5S/c1-10-3-2-4-13(20)14(10)27-18-28-15-16(24-9-25-17(15)29-18)26-12-7-5-11(6-8-12)19(21,22)23/h2-9H,1H3,(H,27,28)(H,24,25,26)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254421
PNG
(CHEMBL465990 | N7-(3-chloro-4-(trifluoromethyl)phe...)
Show SMILES Cc1nc(Nc2ccc(c(Cl)c2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1
Show InChI InChI=1S/C19H11Cl3F3N5S/c1-8-26-16(28-9-5-6-10(13(22)7-9)19(23,24)25)15-17(27-8)31-18(30-15)29-14-11(20)3-2-4-12(14)21/h2-7H,1H3,(H,29,30)(H,26,27,28)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254326
PNG
(2-(4-(2-(2,6-dichlorophenylamino)thiazolo[5,4-d]py...)
Show SMILES CC(C)(C(O)=O)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C21H17Cl2N5O2S/c1-21(2,19(29)30)11-6-8-12(9-7-11)26-17-16-18(25-10-24-17)31-20(28-16)27-15-13(22)4-3-5-14(15)23/h3-10H,1-2H3,(H,27,28)(H,29,30)(H,24,25,26)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254077
PNG
(CHEMBL517566 | N2-(2,6-dichlorophenyl)-N5-isobutyl...)
Show SMILES CC(C)CNc1nc(Nc2ccc(cc2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1
Show InChI InChI=1S/C22H19Cl2F3N6S/c1-11(2)10-28-20-32-18(29-13-8-6-12(7-9-13)22(25,26)27)17-19(33-20)34-21(31-17)30-16-14(23)4-3-5-15(16)24/h3-9,11H,10H2,1-2H3,(H,30,31)(H2,28,29,32,33)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459021
PNG
(CHEMBL4212408 | US10611730, Example 76)
Show SMILES FC(F)(F)Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)sc2c1
Show InChI InChI=1S/C14H7ClF3NO2S/c15-8-2-1-3-10(21-14(16,17)18)12(8)7-4-5-9-11(6-7)22-13(20)19-9/h1-6H,(H,19,20)
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n/an/a 2.5n/an/an/an/an/an/a



Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459031
PNG
(CHEMBL4216837)
Show SMILES Fc1cc(cc2CC(=O)Nc12)-c1c(Cl)cccc1OC(F)(F)F
Show InChI InChI=1S/C15H8ClF4NO2/c16-9-2-1-3-11(23-15(18,19)20)13(9)7-4-8-6-12(22)21-14(8)10(17)5-7/h1-5H,6H2,(H,21,22)
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n/an/a 2.5n/an/an/an/an/an/a



Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459020
PNG
(CHEMBL4203681)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(Cl)cncc1OC(F)(F)F
Show InChI InChI=1S/C15H10ClF3N2O2/c1-7-2-8(3-9-4-12(22)21-14(7)9)13-10(16)5-20-6-11(13)23-15(17,18)19/h2-3,5-6H,4H2,1H3,(H,21,22)
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Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254078
PNG
(CHEMBL460373 | N5-(cyclopropylmethyl)-N2-(2,6-dich...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(NCC3CC3)nc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C22H17Cl2F3N6S/c23-14-2-1-3-15(24)16(14)30-21-31-17-18(29-13-8-6-12(7-9-13)22(25,26)27)32-20(33-19(17)34-21)28-10-11-4-5-11/h1-3,6-9,11H,4-5,10H2,(H,30,31)(H2,28,29,32,33)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254078
PNG
(CHEMBL460373 | N5-(cyclopropylmethyl)-N2-(2,6-dich...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(NCC3CC3)nc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C22H17Cl2F3N6S/c23-14-2-1-3-15(24)16(14)30-21-31-17-18(29-13-8-6-12(7-9-13)22(25,26)27)32-20(33-19(17)34-21)28-10-11-4-5-11/h1-3,6-9,11H,4-5,10H2,(H,30,31)(H2,28,29,32,33)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254376
PNG
(CHEMBL467851 | N2-(2,6-dichlorophenyl)-N7-(4-(meth...)
Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C18H13Cl2N5O2S2/c1-29(26,27)11-7-5-10(6-8-11)23-16-15-17(22-9-21-16)28-18(25-15)24-14-12(19)3-2-4-13(14)20/h2-9H,1H3,(H,24,25)(H,21,22,23)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254136
PNG
(CHEMBL469297 | N2-(2,6-dichlorophenyl)-N7-(4-(trif...)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C18H10Cl2F3N5S/c19-11-2-1-3-12(20)13(11)27-17-28-14-15(24-8-25-16(14)29-17)26-10-6-4-9(5-7-10)18(21,22)23/h1-8H,(H,27,28)(H,24,25,26)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254421
PNG
(CHEMBL465990 | N7-(3-chloro-4-(trifluoromethyl)phe...)
Show SMILES Cc1nc(Nc2ccc(c(Cl)c2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1
Show InChI InChI=1S/C19H11Cl3F3N5S/c1-8-26-16(28-9-5-6-10(13(22)7-9)19(23,24)25)15-17(27-8)31-18(30-15)29-14-11(20)3-2-4-12(14)21/h2-7H,1H3,(H,29,30)(H,26,27,28)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254324
PNG
(CHEMBL512298 | N2-(2,6-dichlorophenyl)-N7-(4-isopr...)
Show SMILES CC(C)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C20H17Cl2N5S/c1-11(2)12-6-8-13(9-7-12)25-18-17-19(24-10-23-18)28-20(27-17)26-16-14(21)4-3-5-15(16)22/h3-11H,1-2H3,(H,26,27)(H,23,24,25)
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Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254322
PNG
(CHEMBL467007 | N2-(2,6-dichlorophenyl)-N7-(6-(trif...)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cn1
Show InChI InChI=1S/C17H9Cl2F3N6S/c18-9-2-1-3-10(19)12(9)27-16-28-13-14(24-7-25-15(13)29-16)26-8-4-5-11(23-6-8)17(20,21)22/h1-7H,(H,27,28)(H,24,25,26)
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n/an/a 4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254136
PNG
(CHEMBL469297 | N2-(2,6-dichlorophenyl)-N7-(4-(trif...)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C18H10Cl2F3N5S/c19-11-2-1-3-12(20)13(11)27-17-28-14-15(24-8-25-16(14)29-17)26-10-6-4-9(5-7-10)18(21,22)23/h1-8H,(H,27,28)(H,24,25,26)
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n/an/a 4n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Displacement of [3H]RTX from rat TRPV1 expressed in HEK293 cells

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426228
PNG
(5-[2-(4-Fluorophenyl)-7-(3-oxopiperazin-1-yl)pyraz...)
Show SMILES Fc1ccc(cc1)-c1nn2c(nccc2c1-c1ccc2NC(=O)Cc2c1)N1CCNC(=O)C1
Show InChI InChI=1S/C24H19FN6O2/c25-17-4-1-14(2-5-17)23-22(15-3-6-18-16(11-15)12-20(32)28-18)19-7-8-27-24(31(19)29-23)30-10-9-26-21(33)13-30/h1-8,11H,9-10,12-13H2,(H,26,33)(H,28,32)
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n/an/a 5n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM426250
PNG
(5-[2-(4-Fluorophenyl)-7-(4-fluoro-1-piperidyl)pyra...)
Show SMILES FC1CCN(CC1)c1nccc2c(c(nn12)-c1ccc(F)cc1)-c1ccc2NC(=O)Cc2c1
Show InChI InChI=1S/C25H21F2N5O/c26-18-4-1-15(2-5-18)24-23(16-3-6-20-17(13-16)14-22(33)29-20)21-7-10-28-25(32(21)30-24)31-11-8-19(27)9-12-31/h1-7,10,13,19H,8-9,11-12,14H2,(H,29,33)
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n/an/a 5n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254376
PNG
(CHEMBL467851 | N2-(2,6-dichlorophenyl)-N7-(4-(meth...)
Show SMILES CS(=O)(=O)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C18H13Cl2N5O2S2/c1-29(26,27)11-7-5-10(6-8-11)23-16-15-17(22-9-21-16)28-18(25-15)24-14-12(19)3-2-4-13(14)20/h2-9H,1H3,(H,24,25)(H,21,22,23)
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n/an/a 5n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254136
PNG
(CHEMBL469297 | N2-(2,6-dichlorophenyl)-N7-(4-(trif...)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C18H10Cl2F3N5S/c19-11-2-1-3-12(20)13(11)27-17-28-14-15(24-8-25-16(14)29-17)26-10-6-4-9(5-7-10)18(21,22)23/h1-8H,(H,27,28)(H,24,25,26)
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n/an/a 6n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of low pH-induced calcium influx

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254153
PNG
(CHEMBL511589 | N2-(2,6-dimethylphenyl)-N7-(4-(trif...)
Show SMILES Cc1cccc(C)c1Nc1nc2c(Nc3ccc(cc3)C(F)(F)F)ncnc2s1
Show InChI InChI=1S/C20H16F3N5S/c1-11-4-3-5-12(2)15(11)27-19-28-16-17(24-10-25-18(16)29-19)26-14-8-6-13(7-9-14)20(21,22)23/h3-10H,1-2H3,(H,27,28)(H,24,25,26)
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n/an/a 6n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50331116
PNG
(2-morpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(t...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCOCC2)cc1
Show InChI InChI=1S/C25H24F6N6O/c26-24(27,28)16-3-5-17(6-4-16)33-21-18-7-10-36(22-19(25(29,30)31)2-1-9-32-22)11-8-20(18)34-23(35-21)37-12-14-38-15-13-37/h1-6,9H,7-8,10-15H2,(H,33,34,35)
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n/an/a 6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assay

Bioorg Med Chem Lett 20: 7137-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.023
BindingDB Entry DOI: 10.7270/Q29W0FQ5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50331116
PNG
(2-morpholino-N-(4-(trifluoromethyl)phenyl)-7-(3-(t...)
Show SMILES FC(F)(F)c1ccc(Nc2nc(nc3CCN(CCc23)c2ncccc2C(F)(F)F)N2CCOCC2)cc1
Show InChI InChI=1S/C25H24F6N6O/c26-24(27,28)16-3-5-17(6-4-16)33-21-18-7-10-36(22-19(25(29,30)31)2-1-9-32-22)11-8-20(18)34-23(35-21)37-12-14-38-15-13-37/h1-6,9H,7-8,10-15H2,(H,33,34,35)
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n/an/a 6n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced intracellular Ca2+ level by FLIPR assay

Bioorg Med Chem Lett 20: 7142-6 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.006
BindingDB Entry DOI: 10.7270/Q26Q1XH0
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459028
PNG
(CHEMBL4216045 | US10611730, Example 160)
Show SMILES Clc1cccc(C2CC2)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C16H13ClN2O/c17-12-3-1-2-11(9-4-5-9)15(12)10-6-7-13-14(8-10)19-16(20)18-13/h1-3,6-9H,4-5H2,(H2,18,19,20)
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n/an/a 6.30n/an/an/an/an/an/a



Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459032
PNG
(CHEMBL4215352)
Show SMILES Cc1cc(cc2CC(=O)Nc12)-c1c(Cl)cncc1OC(F)F
Show InChI InChI=1S/C15H11ClF2N2O2/c1-7-2-8(3-9-4-12(21)20-14(7)9)13-10(16)5-19-6-11(13)22-15(17)18/h2-3,5-6,15H,4H2,1H3,(H,20,21)
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n/an/a 7.90n/an/an/an/an/an/a



Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50331150
PNG
(CHEMBL1290369 | N-(4-tert-butylphenyl)-7-(3-(trifl...)
Show SMILES CC(C)(C)c1ccc(Nc2ncnc3CN(CCc23)c2ncccc2C(F)(F)F)cc1
Show InChI InChI=1S/C23H24F3N5/c1-22(2,3)15-6-8-16(9-7-15)30-20-17-10-12-31(13-19(17)28-14-29-20)21-18(23(24,25)26)5-4-11-27-21/h4-9,11,14H,10,12-13H2,1-3H3,(H,28,29,30)
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n/an/a 9n/an/an/an/an/an/a



Johnson& Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant TRPV1 assessed as inhibition of capsaicin-induced in intracellular calcium levels by cell-based FLIPR assay

Bioorg Med Chem Lett 20: 7137-41 (2010)


Article DOI: 10.1016/j.bmcl.2010.09.023
BindingDB Entry DOI: 10.7270/Q29W0FQ5
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254154
PNG
(CHEMBL468470 | N2-(2-chloro-6-methylphenyl)-N7-(4-...)
Show SMILES Cc1cccc(Cl)c1Nc1nc2c(Nc3ccc(cc3)C(F)(F)F)ncnc2s1
Show InChI InChI=1S/C19H13ClF3N5S/c1-10-3-2-4-13(20)14(10)27-18-28-15-16(24-9-25-17(15)29-18)26-12-7-5-11(6-8-12)19(21,22)23/h2-9H,1H3,(H,27,28)(H,24,25,26)
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n/an/a 9n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254054
PNG
(CHEMBL462276 | N2-(2,6-dichlorophenyl)-N5-isopropy...)
Show SMILES CC(C)Nc1nc(Nc2ccc(cc2)C(F)(F)F)c2nc(Nc3c(Cl)cccc3Cl)sc2n1
Show InChI InChI=1S/C21H17Cl2F3N6S/c1-10(2)27-19-31-17(28-12-8-6-11(7-9-12)21(24,25)26)16-18(32-19)33-20(30-16)29-15-13(22)4-3-5-14(15)23/h3-10H,1-2H3,(H,29,30)(H2,27,28,31,32)
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n/an/a 9n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Rattus norvegicus (rat))		BDBM50254420
PNG
(CHEMBL517044 | N7-(3-chloro-4-(trifluoromethyl)phe...)
Show SMILES FC(F)(F)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1Cl
Show InChI InChI=1S/C18H9Cl3F3N5S/c19-10-2-1-3-11(20)13(10)28-17-29-14-15(25-7-26-16(14)30-17)27-8-4-5-9(12(21)6-8)18(22,23)24/h1-7H,(H,28,29)(H,25,26,27)
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n/an/a 9n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at rat TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-2 subunit


(Homo sapiens (Human))		BDBM50509857
PNG
(CHEMBL4474333)
Show SMILES Oc1ccc(cc1)-c1c(nc2c(nccn12)N1CCOCC1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H19ClN4O2/c23-17-5-1-15(2-6-17)19-20(16-3-7-18(28)8-4-16)27-10-9-24-21(22(27)25-19)26-11-13-29-14-12-26/h1-10,28H,11-14H2
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n/an/a 10n/an/an/an/an/an/a



Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL


Assay Description
Negative allosteric modulation of recombinant human GluA1 flop isoform/TARPgamma2 expressed in HEK293 cells assessed as inhibition of glutamate-induc...

ACS Med Chem Lett 10: 267-272 (2019)


Article DOI: 10.1021/acsmedchemlett.8b00599
BindingDB Entry DOI: 10.7270/Q26H4MRG
More data for this
Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1


(Homo sapiens (Human))		BDBM50254324
PNG
(CHEMBL512298 | N2-(2,6-dichlorophenyl)-N7-(4-isopr...)
Show SMILES CC(C)c1ccc(Nc2ncnc3sc(Nc4c(Cl)cccc4Cl)nc23)cc1
Show InChI InChI=1S/C20H17Cl2N5S/c1-11(2)12-6-8-13(9-7-12)25-18-17-19(24-10-23-18)28-20(27-17)26-16-14(21)4-3-5-15(16)22/h3-11H,1-2H3,(H,26,27)(H,23,24,25)
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n/an/a 10n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at human TRPV1 expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium flux

Bioorg Med Chem Lett 19: 40-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.11.024
BindingDB Entry DOI: 10.7270/Q28052G3
More data for this
Ligand-Target Pair
Glutamate receptor 1/Voltage-dependent calcium channel gamma-8 subunit


(Homo sapiens (Human))		BDBM50459026
PNG
(CHEMBL4214902 | US10611730, Example 31)
Show SMILES FC(F)(F)Oc1cccc(Cl)c1-c1ccc2[nH]c(=O)[nH]c2c1
Show InChI InChI=1S/C14H8ClF3N2O2/c15-8-2-1-3-11(22-14(16,17)18)12(8)7-4-5-9-10(6-7)20-13(21)19-9/h1-6H,(H2,19,20,21)
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n/an/a 10n/an/an/an/an/an/a



Janssen Research & Development L.L.C.

Curated by ChEMBL


Assay Description
Modulation of recombinant human GluA1 flop isoform/TARPgamma8 expressed in HEK293F cells assessed as blockade of glutamate-induced calcium flux by ca...

ACS Med Chem Lett 9: 821-826 (2018)


Article DOI: 10.1021/acsmedchemlett.8b00215
BindingDB Entry DOI: 10.7270/Q2ZW1PJ3
More data for this
Ligand-Target Pair
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