| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor subfamily 4 group A member 2 |
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| Ligand | BDBM50517826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1869814 (CHEMBL4370880) |
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| EC50 | 1.000000±n/a nM |
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| Citation |  Lesuisse, D; Malanda, A; Peyronel, JF; Evanno, Y; Lardenois, P; De-Peretti, D; Abécassis, PY; Barnéoud, P; Brunel, P; Burgevin, MC; Cegarra, C; Auger, F; Dommergue, A; Lafon, C; Even, L; Tsi, J; Luc, TPH; Almario, A; Olivier, A; Castel, MN; Taupin, V; Rooney, T; Vigé, X Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease. Bioorg Med Chem Lett29:929-932 (2019) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor subfamily 4 group A member 2 |
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| Name: | Nuclear receptor subfamily 4 group A member 2 |
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| Synonyms: | NR4A2_MOUSE | NUR-related factor 1 | Nr4a2 | Nuclear receptor subfamily 4 group A member 2 | Nurr1 | Orphan nuclear receptor NURR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 66605.74 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_116964 |
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| Residue: | 598 |
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| Sequence: | MPCVQAQYGSSPQGASPASQSYSYHSSGEYSSDFLTPEFVKFSMDLTNTEITATTSLPSF
STFMDNYSTGYDVKPPCLYQMPLSGQQSSIKVEDIQMHNYQQHSHLPPQSEEMMPHSGSV
YYKPSSPPTPSTPSFQVQHSPMWDDPGSLHNFHQNYVATTHMIEQRKTPVSRLSLFSFKQ
SPPGTPVSSCQMRFDGPLHVPMNPEPAGSHHVVDGQTFAVPNPIRKPASMGFPGLQIGHA
SQLLDTQVPSPPSRGSPSNEGLCAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCL
ANKNCPVDKRRRNRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPSKPKSPQDPSPPSP
PVSLISALVRAHVDSNPAMTSLDYSRFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGW
AEKIPGFADLPKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG
EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIVNCLKDHVT
FNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLEDLVPPPAIIDKLFLDTLPF
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| BDBM50517826 |
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| n/a |
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| Name | BDBM50517826 |
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| Synonyms: | CHEMBL4453191 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12F2N4O |
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| Mol. Mass. | 350.3216 |
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| SMILES | Fc1ccc(F)c(NC(=O)c2cn3cc(ccc3n2)-c2ccccn2)c1 |
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| Structure | 
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