| Reaction Details |
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 | Report a problem with these data |
| Target | Renin |
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| Ligand | BDBM50077681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_195787 |
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| IC50 | >1000000±n/a nM |
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| Citation |  Vieira, E; Binggeli, A; Breu, V; Bur, D; Fischli, W; Güller, R; Hirth, G; Märki, HP; Müller, M; Oefner, C; Scalone, M; Stadler, H; Wilhelm, M; Wostl, W Substituted piperidines--highly potent renin inhibitors due to induced fit adaptation of the active site. Bioorg Med Chem Lett9:1397-402 (1999) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Renin |
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| Name: | Renin |
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| Synonyms: | Angiotensinogenase | REN | RENI_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 45058.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 406 |
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| Sequence: | MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
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| BDBM50077681 |
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| n/a |
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| Name | BDBM50077681 |
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| Synonyms: | 4-Methoxy-N-{4-[(3R,4R)-3-(naphthalen-2-ylmethoxy)-piperidin-4-yl]-benzyl}-benzamide | CHEMBL417673 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32N2O3 |
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| Mol. Mass. | 480.5974 |
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| SMILES | COc1ccc(cc1)C(=O)NCc1ccc(cc1)[C@H]1CCNC[C@@H]1OCc1ccc2ccccc2c1 |
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| Structure | 
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