Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181073 (2-(3-chloro-benzyloxy)-6-methyl-isonicotinonitrile...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM511435 ((-)-(1R,5S)-2-[5-(2,5-Difluoro-phenylethynyl)-pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X89SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 3.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM511433 ((-)-(1R,5S)-2-[5-(4-Fluoro-phenylethynyl)-pyridin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X89SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181066 (2-(3-(3-chlorobenzyloxy)-5-methylphenyl)isoindolin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181075 (2-(3-chlorobenzyloxy)-6-chloroisonicotinonitrile |...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM511432 ((-)-(1R,5S)-2-[5-(3-Fluoro-phenylethynyl)-pyridin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X89SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50122758 (2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50122758 (2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181076 (3-((3-(1,3-dioxoisoindolin-2-yl)-5-methylphenoxy)m...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 6 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM222815 (US11059766, WO2011128279 Ex. 106 | US9315498, 106) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X89SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM511431 ((-)-(1 S,5R)-2-methyl-4-(5-(phenylethynyl)pyridin-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X89SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181067 (2-chloro-6-((2-methylpyridin-4-yl)methoxy)isonicot...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181079 (CHEMBL207097 | N-(2-(3-chlorobenzyloxy)-6-methylpy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50122758 (2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 14.1 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM224627 (US9328070, 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 15 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an... | US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM143695 (US9682959, 3 | US9751856, 3) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
HOFFMANN-LA ROCHE INC. US Patent | Assay Description cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt... | US Patent US9682959 (2017) BindingDB Entry DOI: 10.7270/Q2TQ5ZPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Rattus norvegicus (Rat)) | BDBM143695 (US9682959, 3 | US9751856, 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
HOFFMANN-LA ROCHE INC. US Patent | Assay Description The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i... | US Patent US9751856 (2017) BindingDB Entry DOI: 10.7270/Q2G162ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071369 (CHEMBL3410220) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181065 (2-chloro-6-((2-chloropyridin-4-yl)methoxy)isonicot...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Rattus norvegicus (Rat)) | BDBM50122758 (2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 17.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181077 (CHEMBL204062 | N-(2-(3-chlorobenzyloxy)-6-methylpy...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071328 (CHEMBL3410213) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM143693 (US9682959, 1 | US9751856, 1) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
HOFFMANN-LA ROCHE INC. US Patent | Assay Description cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt... | US Patent US9682959 (2017) BindingDB Entry DOI: 10.7270/Q2TQ5ZPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Rattus norvegicus (Rat)) | BDBM143693 (US9682959, 1 | US9751856, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
HOFFMANN-LA ROCHE INC. US Patent | Assay Description The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i... | US Patent US9751856 (2017) BindingDB Entry DOI: 10.7270/Q2G162ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM199988 (US9227959, 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 19 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffman-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ... | US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071375 (CHEMBL3410223 | US10618900, No. CTEP) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071372 (CHEMBL1946770) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM199989 (US9227959, 3) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 23 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffman-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger ... | US Patent US9227959 (2016) BindingDB Entry DOI: 10.7270/Q25D8QNJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM234211 (US9359301, 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 24 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an... | US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181070 (1-(3-(3-chlorobenzyloxy)-5-methylphenyl)-2-methyl-...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181084 (2-(3-chlorobenzyloxy)-N,6-dimethyl-N-(pyridin-3-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 27 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071333 (CHEMBL3410215) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181083 ((5-(2-(3-chlorobenzyloxy)-6-methylpyridin-4-yl)oxa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM224626 (US9328070, 1) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 28 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an... | US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50084137 (2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM224623 (US9328070, Reference compound 1 | US9359301, Refer...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 29 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an... | US Patent US9359301 (2016) BindingDB Entry DOI: 10.7270/Q2KK99ND | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Homo sapiens (Human)) | BDBM224623 (US9328070, Reference compound 1 | US9359301, Refer...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 29 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Hoffmann-La Roche Inc. US Patent | Assay Description For binding experiments, cDNA encoding human mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger an... | US Patent US9328070 (2016) BindingDB Entry DOI: 10.7270/Q27943JT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071332 (CHEMBL3410214) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 29 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071371 (CHEMBL3410221) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50181078 (CHEMBL206998 | pentyl 3-(3-chlorobenzyloxy)-5-meth...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffman-La Roche Ltd Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from recombinant human mGlu5 receptor | Bioorg Med Chem Lett 16: 1892-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.088 BindingDB Entry DOI: 10.7270/Q2ZG6RT8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071376 (CHEMBL3410224) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM50071374 (Basimglurant | RG-7090 | RO-4917523) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Roche Pharmaceutical Research and Early Development Curated by ChEMBL | Assay Description Displacement of [3H]MPEP from mGlu5 receptor (unknown origin) expressed in HEK293 cells by competition binding assay | J Med Chem 58: 1358-71 (2015) Article DOI: 10.1021/jm501642c BindingDB Entry DOI: 10.7270/Q2J96825 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM222818 (US11059766, WO2011128279 Ex. 109 | US9315498, 109) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description For binding experiments, cDNA encoding human mGlu5a receptor was transiently transfected into EBNA cells using a procedure described by Schlaeger and... | Citation and Details BindingDB Entry DOI: 10.7270/Q23X89SX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM143694 (US9682959, 2 | US9751856, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
HOFFMANN-LA ROCHE INC. US Patent | Assay Description cDNA encoding rat mGlu 5a receptor was transiently transfected into EBNA cells using a procedure described by E.-J. Schlaeger and K. Christensen (Cyt... | US Patent US9682959 (2017) BindingDB Entry DOI: 10.7270/Q2TQ5ZPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Isoform 1 of Metabotropic glutamate receptor 5 (5a) (Rattus norvegicus (Rat)) | BDBM143694 (US9682959, 2 | US9751856, 2) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 38 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
HOFFMANN-LA ROCHE INC. US Patent | Assay Description The pharmacological activity of the compounds was tested using the following method: cDNA encoding rat mGlu 5a receptor was transiently transfected i... | US Patent US9751856 (2017) BindingDB Entry DOI: 10.7270/Q2G162ZZ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Metabotropic glutamate receptor 5 (Homo sapiens (Human)) | BDBM86716 (CAS_63540-28-3 | CHEMBL239800 | Fenobam | NSC_2162...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | 40.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Curated by PDSP Ki Database | J Pharmacol Exp Ther 315: 711-21 (2005) Article DOI: 10.1124/jpet.105.089839 BindingDB Entry DOI: 10.7270/Q2BC3X4M | ||||||||||||
More data for this Ligand-Target Pair |
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