Reaction Details |
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Target | Lon protease homolog, mitochondrial |
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Ligand | BDBM50571507 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2114930 (CHEMBL4823871) |
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IC50 | 546±n/a nM |
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Citation | Kingsley, LJ; He, X; McNeill, M; Nelson, J; Nikulin, V; Ma, Z; Lu, W; Zhou, VW; Manuia, M; Kreusch, A; Gao, MY; Witmer, D; Vaillancourt, MT; Lu, M; Greenblatt, S; Lee, C; Vashisht, A; Bender, S; Spraggon, G; Michellys, PY; Jia, Y; Haling, JR; Lelais, G Structure-Based Design of Selective LONP1 Inhibitors for Probing J Med Chem64:4857-4869 (2021) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lon protease homolog, mitochondrial |
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Name: | Lon protease homolog, mitochondrial |
Synonyms: | 3.4.21.53 | LONHs | LONM_HUMAN | LONP | LONP1 | Lon protease homolog, mitochondrial | Lon protease-like protein | Mitochondrial ATP-dependent protease Lon | PRSS15 | Serine protease 15 |
Type: | PROTEIN |
Mol. Mass.: | 106485.52 |
Organism: | Homo sapiens |
Description: | ChEMBL_120400 |
Residue: | 959 |
Sequence: | MAASTGYVRLWGAARCWVLRRPMLAAAGGRVPTAAGAWLLRGQRTCDASPPWALWGRGPA
IGGQWRGFWEASSRGGGAFSGGEDASEGGAEEGAGGAGGSAGAGEGPVITALTPMTIPDV
FPHLPLIAITRNPVFPRFIKIIEVKNKKLVELLRRKVRLAQPYVGVFLKRDDSNESDVVE
SLDEIYHTGTFAQIHEMQDLGDKLRMIVMGHRRVHISRQLEVEPEEPEAENKHKPRRKSK
RGKKEAEDELSARHPAELAMEPTPELPAEVLMVEVENVVHEDFQVTEEVKALTAEIVKTI
RDIIALNPLYRESVLQMMQAGQRVVDNPIYLSDMGAALTGAESHELQDVLEETNIPKRLY
KALSLLKKEFELSKLQQRLGREVEEKIKQTHRKYLLQEQLKIIKKELGLEKDDKDAIEEK
FRERLKELVVPKHVMDVVDEELSKLGLLDNHSSEFNVTRNYLDWLTSIPWGKYSNENLDL
ARAQAVLEEDHYGMEDVKKRILEFIAVSQLRGSTQGKILCFYGPPGVGKTSIARSIARAL
NREYFRFSVGGMTDVAEIKGHRRTYVGAMPGKIIQCLKKTKTENPLILIDEVDKIGRGYQ
GDPSSALLELLDPEQNANFLDHYLDVPVDLSKVLFICTANVTDTIPEPLRDRMEMINVSG
YVAQEKLAIAERYLVPQARALCGLDESKAKLSSDVLTLLIKQYCRESGVRNLQKQVEKVL
RKSAYKIVSGEAESVEVTPENLQDFVGKPVFTVERMYDVTPPGVVMGLAWTAMGGSTLFV
ETSLRRPQDKDAKGDKDGSLEVTGQLGEVMKESARIAYTFARAFLMQHAPANDYLVTSHI
HLHVPEGATPKDGPSAGCTIVTALLSLAMGRPVRQNLAMTGEVSLTGKILPVGGIKEKTI
AAKRAGVTCIVLPAENKKDFYDLAAFITEGLEVHFVEHYREIFDIAFPDEQAEALAVER
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BDBM50571507 |
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n/a |
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Name | BDBM50571507 |
Synonyms: | CHEMBL4859172 |
Type | Small organic molecule |
Emp. Form. | C15H25BN4O4 |
Mol. Mass. | 336.194 |
SMILES | CC(C)C[C@H](NC(=O)[C@H](NC(=O)c1cnccn1)C(C)C)B(O)O |r| |
Structure |
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