| Reaction Details |
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 | Report a problem with these data |
| Target | Fusion glycoprotein F0 |
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| Ligand | BDBM50572450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2116840 (CHEMBL4825906) |
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| IC50 | 0.900000±n/a nM |
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| Citation |  Cockerill, GS; Angell, RM; Bedernjak, A; Chuckowree, I; Fraser, I; Gascon-Simorte, J; Gilman, MSA; Good, JAD; Harland, R; Johnson, SM; Ludes-Meyers, JH; Littler, E; Lumley, J; Lunn, G; Mathews, N; McLellan, JS; Paradowski, M; Peeples, ME; Scott, C; Tait, D; Taylor, G; Thom, M; Thomas, E; Villalonga Barber, C; Ward, SE; Watterson, D; Williams, G; Young, P; Powell, K Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem64:3658-3676 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Fusion glycoprotein F0 |
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| Name: | Fusion glycoprotein F0 |
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| Synonyms: | F | FUS_HRSVA | Fusion glycoprotein F0 | Fusion glycoprotein F1 | Fusion glycoprotein F2 | Intervening segment | Pep27 | Peptide 27 | p27 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63471.29 |
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| Organism: | Human respiratory syncytial virus A (strain A2) |
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| Description: | ChEMBL_116942 |
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| Residue: | 574 |
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| Sequence: | MELLILKANAITTILTAVTFCFASGQNITEEFYQSTCSAVSKGYLSALRTGWYTSVITIE
LSNIKENKCNGTDAKVKLIKQELDKYKNAVTELQLLMQSTPPTNNRARRELPRFMNYTLN
NAKKTNVTLSKKRKRRFLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVS
LSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSISNIETVIEFQQKNNRLLEITREFSVN
AGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYV
VQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKV
QSNRVFCDTMNSLTLPSEINLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKT
KCTASNKNRGIIKTFSNGCDYVSNKGMDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDP
LVFPSDEFDASISQVNEKINQSLAFIRKSDELLHNVNAGKSTTNIMITTIIIVIIVILLS
LIAVGLLLYCKARSTPVTLSKDQLSGINNIAFSN
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| BDBM50572450 |
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| n/a |
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| Name | BDBM50572450 |
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| Synonyms: | Rv-521 | Rv521 | Sisunatovir |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22F4N4O |
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| Mol. Mass. | 446.4406 |
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| SMILES | NCc1ccc2n(CCCC(F)(F)F)c(CN3C(=O)C4(CC4)c4ccc(F)cc34)nc2c1 |
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| Structure | 
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