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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fusion glycoprotein F0 | ||
| Ligand | BDBM50572452 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2116840 (CHEMBL4825906) | ||
| IC50 | 2.6±n/a nM | ||
| Citation |  Cockerill, GS; Angell, RM; Bedernjak, A; Chuckowree, I; Fraser, I; Gascon-Simorte, J; Gilman, MSA; Good, JAD; Harland, R; Johnson, SM; Ludes-Meyers, JH; Littler, E; Lumley, J; Lunn, G; Mathews, N; McLellan, JS; Paradowski, M; Peeples, ME; Scott, C; Tait, D; Taylor, G; Thom, M; Thomas, E; Villalonga Barber, C; Ward, SE; Watterson, D; Williams, G; Young, P; Powell, K Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion. J Med Chem64:3658-3676 (2021) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fusion glycoprotein F0 | |||
| Name: | Fusion glycoprotein F0 | ||
| Synonyms: | F | FUS_HRSVA | Fusion glycoprotein F0 | Fusion glycoprotein F1 | Fusion glycoprotein F2 | Intervening segment | Pep27 | Peptide 27 | p27 | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 63471.29 | ||
| Organism: | Human respiratory syncytial virus A (strain A2) | ||
| Description: | ChEMBL_116942 | ||
| Residue: | 574 | ||
| Sequence: |
| ||
| BDBM50572452 | |||
| n/a | |||
| Name | BDBM50572452 | ||
| Synonyms: | CHEMBL4873528 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H27FN4O2 | ||
| Mol. Mass. | 434.5059 | ||
| SMILES | NCc1ccc2n(C3CCC(O)CC3)c(CN3C(=O)C4(CC4)c4ccc(F)cc34)nc2c1 |(23.93,-12.4,;22.59,-11.64,;21.26,-12.41,;21.26,-13.96,;19.93,-14.74,;18.59,-13.97,;17.13,-14.45,;16.66,-15.91,;15.16,-16.23,;14.69,-17.69,;15.72,-18.84,;15.24,-20.3,;17.23,-18.52,;17.7,-17.05,;16.22,-13.21,;14.68,-13.21,;13.91,-11.88,;14.52,-10.48,;16.02,-10.15,;13.36,-9.45,;12.58,-8.11,;14.13,-8.11,;12.04,-10.23,;10.58,-9.76,;9.44,-10.79,;9.77,-12.3,;8.64,-13.34,;11.23,-12.76,;12.37,-11.73,;17.12,-11.96,;18.59,-12.43,;19.92,-11.65,)| | ||
| Structure | 
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