| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C delta type |
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| Ligand | BDBM50573009 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2118779 (CHEMBL4827845) |
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| IC50 | 9800±n/a nM |
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| Citation |  Papa, P; Whitefield, B; Mortensen, DS; Cashion, D; Huang, D; Torres, E; Parnes, J; Sapienza, J; Hansen, J; Correa, M; Delgado, M; Harris, R; Hegde, S; Norris, S; Bahmanyar, S; Plantevin-Krenitsky, V; Liu, Z; Leftheris, K; Kulkarni, A; Bennett, B; Hur, EM; Ringheim, G; Khambatta, G; Chan, H; Muir, J; Blease, K; Burnett, K; LeBrun, L; Morrison, L; Celeridad, M; Khattri, R; Cathers, BE Discovery of the Selective Protein Kinase C-? Kinase Inhibitor, CC-90005. J Med Chem64:11886-11903 (2021) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C delta type |
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| Name: | Protein kinase C delta type |
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| Synonyms: | KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta |
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| Type: | Enzyme |
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| Mol. Mass.: | 77516.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells |
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| Residue: | 676 |
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| Sequence: | MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFD
AHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQY
FLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVW
GLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMS
PTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASR
RSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSF
GKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTK
DHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVL
LDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYE
MLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIH
PFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAF
AGFSFVNPKFEHLLED
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| BDBM50573009 |
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| n/a |
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| Name | BDBM50573009 |
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| Synonyms: | CHEMBL4861249 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F3N5O |
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| Mol. Mass. | 377.3636 |
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| SMILES | FC(F)(F)c1ccncc1CNc1cc(NC2CCOCC2)c(cn1)C#N |
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| Structure | 
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