| Reaction Details |
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 | Report a problem with these data |
| Target | Retinoic acid receptor RXR-alpha |
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| Ligand | BDBM50143836 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_196486 (CHEMBL798300) |
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| Ki | 7400±n/a nM |
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| Citation |  Haffner, CD; Lenhard, JM; Miller, AB; McDougald, DL; Dwornik, K; Ittoop, OR; Gampe, RT; Xu, HE; Blanchard, S; Montana, VG; Consler, TG; Bledsoe, RK; Ayscue, A; Croom, D Structure-based design of potent retinoid X receptor alpha agonists. J Med Chem47:2010-29 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Retinoic acid receptor RXR-alpha |
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| Name: | Retinoic acid receptor RXR-alpha |
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| Synonyms: | NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50820.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456363 |
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| Residue: | 462 |
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| Sequence: | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING
MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP
AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID
KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL
AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL
LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM
QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL
RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
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| BDBM50143836 |
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| n/a |
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| Name | BDBM50143836 |
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| Synonyms: | 5-[1-[5-(3-Trifluoromethyl-phenyl)-furan-2-yl]-meth-(Z)-ylidene]-thiazolidine-2,4-dione | CHEMBL62768 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H8F3NO3S |
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| Mol. Mass. | 339.289 |
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| SMILES | OC1=NC(=O)C(S1)=Cc1ccc(o1)-c1cccc(c1)C(F)(F)F |w:7.8,t:1| |
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| Structure | 
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