| Reaction Details |
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 | Report a problem with these data |
| Target | Stimulator of interferon genes protein |
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| Ligand | BDBM50584874 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2160785 (CHEMBL5045535) |
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| IC50 | 2500±n/a nM |
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| Citation |  Cherney, EC; Zhang, L; Lo, J; Huynh, T; Wei, D; Ahuja, V; Quesnelle, C; Schieven, GL; Futran, A; Locke, GA; Lin, Z; Monereau, L; Chaudhry, C; Blum, J; Li, S; Fereshteh, M; Li-Wang, B; Gangwar, S; Pan, C; Chong, C; Zhu, X; Posy, SL; Sack, JS; Zhang, P; Ruzanov, M; Harner, M; Akhtar, F; Schroeder, GM; Vite, G; Fink, B Discovery of Non-Nucleotide Small-Molecule STING Agonists J Med Chem65:3518-3538 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Stimulator of interferon genes protein |
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| Name: | Stimulator of interferon genes protein |
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| Synonyms: | ERIS | Endoplasmic reticulum interferon stimulator | MITA | Mediator of IRF3 activation | STING | STING1 | STING_HUMAN | Synonyms=ERIS | TMEM173 | Transmembrane protein 173 | hMITA | hSTING |
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| Type: | Protein |
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| Mol. Mass.: | 42195.64 |
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| Organism: | Human |
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| Description: | Q86WV6 |
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| Residue: | 379 |
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| Sequence: | MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLL
NGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWM
LALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIR
TYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVY
SNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILA
DAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQE
PELLISGMEKPLPLRTDFS
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| BDBM50584874 |
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| n/a |
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| Name | BDBM50584874 |
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| Synonyms: | CHEMBL5081567 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H11ClN4O5 |
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| Mol. Mass. | 386.746 |
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| SMILES | OC(=O)c1c(O)c(Cl)cc2cc(CNC(=O)c3cnn4cccnc34)oc12 |
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| Structure | 
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