Reaction Details |
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Target | Stimulator of interferon genes protein |
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Ligand | BDBM50584872 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2160786 (CHEMBL5045536) |
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IC50 | 2300±n/a nM |
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Citation | Cherney, EC; Zhang, L; Lo, J; Huynh, T; Wei, D; Ahuja, V; Quesnelle, C; Schieven, GL; Futran, A; Locke, GA; Lin, Z; Monereau, L; Chaudhry, C; Blum, J; Li, S; Fereshteh, M; Li-Wang, B; Gangwar, S; Pan, C; Chong, C; Zhu, X; Posy, SL; Sack, JS; Zhang, P; Ruzanov, M; Harner, M; Akhtar, F; Schroeder, GM; Vite, G; Fink, B Discovery of Non-Nucleotide Small-Molecule STING Agonists J Med Chem65:3518-3538 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Stimulator of interferon genes protein |
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Name: | Stimulator of interferon genes protein |
Synonyms: | Endoplasmic reticulum interferon stimulator | Eris | MMITA | Mediator of IRF3 activation | Mita | Mpys | STING_MOUSE | Stimulator of interferon genes protein | Sting | Sting1 | Synonyms=Eris | Tmem173 | Transmembrane protein 173 | mSTING |
Type: | PROTEIN |
Mol. Mass.: | 42834.49 |
Organism: | Mus musculus |
Description: | ChEMBL_119061 |
Residue: | 378 |
Sequence: | MPYSNLHPAIPRPRGHRSKYVALIFLVASLMILWVAKDPPNHTLKYLALHLASHELGLLL
KNLCCLAEELCHVQSRYQGSYWKAVRACLGCPIHCMAMILLSSYFYFLQNTADIYLSWMF
GLLVLYKSLSMLLGLQSLTPAEVSAVCEEKKLNVAHGLAWSYYIGYLRLILPGLQARIRM
FNQLHNNMLSGAGSRRLYILFPLDCGVPDNLSVVDPNIRFRDMLPQQNIDRAGIKNRVYS
NSVYEILENGQPAGVCILEYATPLQTLFAMSQDAKAGFSREDRLEQAKLFCRTLEEILED
VPESRNNCRLIVYQEPTDGNSFSLSQEVLRHIRQEEKEEVTMNAPMTSVAPPPSVLSQEP
RLLISGMDQPLPLRTDLI
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BDBM50584872 |
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n/a |
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Name | BDBM50584872 |
Synonyms: | CHEMBL5090440 |
Type | Small organic molecule |
Emp. Form. | C19H12ClN3O4 |
Mol. Mass. | 381.769 |
SMILES | OC(=O)c1cc(Cl)cc2cc(CNC(=O)c3cncc4cccnc34)oc12 |
Structure |
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