Reaction Details |
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Target | ATPase family AAA domain-containing protein 2 |
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Ligand | BDBM50584943 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2160899 (CHEMBL5045649) |
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IC50 | 40±n/a nM |
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Citation | Winter-Holt, JJ; Bardelle, C; Chiarparin, E; Dale, IL; Davey, PRJ; Davies, NL; Denz, C; Fillery, SM; Guérot, CM; Han, F; Hughes, SJ; Kulkarni, M; Liu, Z; Milbradt, A; Moss, TA; Niu, H; Patel, J; Rabow, AA; Schimpl, M; Shi, J; Sun, D; Yang, D; Guichard, S Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models. J Med Chem65:3306-3331 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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ATPase family AAA domain-containing protein 2 |
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Name: | ATPase family AAA domain-containing protein 2 |
Synonyms: | AAA nuclear coregulator cancer-associated protein | ANCCA | ATAD2 | ATAD2_HUMAN | PRO2000 |
Type: | PROTEIN |
Mol. Mass.: | 158546.30 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1500426 |
Residue: | 1390 |
Sequence: | MVVLRSSLELHNHSAASATGSLDLSSDFLSLEHIGRRRLRSAGAAQKKPAATTAKAGDGS
SVKEVETYHRTRALRSLRKDAQNSSDSSFEKNVEITEQLANGRHFTRQLARQQADKKKEE
HREDKVIPVTRSLRARNIVQSTEHLHEDNGDVEVRRSCRIRSRYSGVNQSMLFDKLITNT
AEAVLQKMDDMKKMRRQRMRELEDLGVFNETEESNLNMYTRGKQKDIQRTDEETTDNQEG
SVESSEEGEDQEHEDDGEDEDDEDDDDDDDDDDDDDDEDDEDEEDGEEENQKRYYLRQRK
ATVYYQAPLEKPRHQRKPNIFYSGPASPARPRYRLSSAGPRSPYCKRMNRRRHAIHSSDS
TSSSSSEDEQHFERRRKRSRNRAINRCLPLNFRKDELKGIYKDRMKIGASLADVDPMQLD
SSVRFDSVGGLSNHIAALKEMVVFPLLYPEVFEKFKIQPPRGCLFYGPPGTGKTLVARAL
ANECSQGDKRVAFFMRKGADCLSKWVGESERQLRLLFDQAYQMRPSIIFFDEIDGLAPVR
SSRQDQIHSSIVSTLLALMDGLDSRGEIVVIGATNRLDSIDPALRRPGRFDREFLFSLPD
KEARKEILKIHTRDWNPKPLDTFLEELAENCVGYCGADIKSICAEAALCALRRRYPQIYT
TSEKLQLDLSSINISAKDFEVAMQKMIPASQRAVTSPGQALSTVVKPLLQNTVDKILEAL
QRVFPHAEFRTNKTLDSDISCPLLESDLAYSDDDVPSVYENGLSQKSSHKAKDNFNFLHL
NRNACYQPMSFRPRILIVGEPGFGQGSHLAPAVIHALEKFTVYTLDIPVLFGVSTTSPEE
TCAQVIREAKRTAPSIVYVPHIHVWWEIVGPTLKATFTTLLQNIPSFAPVLLLATSDKPH
SALPEEVQELFIRDYGEIFNVQLPDKEERTKFFEDLILKQAAKPPISKKKAVLQALEVLP
VAPPPEPRSLTAEEVKRLEEQEEDTFRELRIFLRNVTHRLAIDKRFRVFTKPVDPDEVPD
YVTVIKQPMDLSSVISKIDLHKYLTVKDYLRDIDLICSNALEYNPDRDPGDRLIRHRACA
LRDTAYAIIKEELDEDFEQLCEEIQESRKKRGCSSSKYAPSYYHVMPKQNSTLVGDKRSD
PEQNEKLKTPSTPVACSTPAQLKRKIRKKSNWYLGTIKKRRKISQAKDDSQNAIDHKIES
DTEETQDTSVDHNETGNTGESSVEENEKQQNASESKLELRNNSNTCNIENELEDSRKTTA
CTELRDKIACNGDASSSQIIHISDENEGKEMCVLRMTRARRSQVEQQQLITVEKALAILS
QPTPSLVVDHERLKNLLKTVVKKSQNYNIFQLENLYAVISQCIYRHRKDHDKTSLIQKME
QEVENFSCSR
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BDBM50584943 |
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n/a |
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Name | BDBM50584943 |
Synonyms: | CHEMBL5086059 |
Type | Small organic molecule |
Emp. Form. | C25H30N8O2 |
Mol. Mass. | 474.5581 |
SMILES | [H][C@]12Cc3ccccc3[C@]([H])(CNC1=O)N2C(=O)c1cc(NCCCN2CCCC2)c2nnc(C)n2n1 |r,THB:16:15:11.12.13:3.8.2| |
Structure |
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