Reaction Details |
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Target | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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Ligand | BDBM276750 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2187627 (CHEMBL5099709) |
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IC50 | >50000±n/a nM |
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Citation | Futatsugi, K; Cabral, S; Kung, DW; Huard, K; Lee, E; Boehm, M; Bauman, J; Clark, RW; Coffey, SB; Crowley, C; Dechert-Schmitt, AM; Dowling, MS; Dullea, R; Gosset, JR; Kalgutkar, AS; Kou, K; Li, Q; Lian, Y; Loria, PM; Londregan, AT; Niosi, M; Orozco, C; Pettersen, JC; Pfefferkorn, JA; Polivkova, J; Ross, TT; Sharma, R; Stock, IA; Tesz, G; Wisniewska, H; Goodwin, B; Price, DA Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis. J Med Chem65:15000-15013 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
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Name: | Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
Synonyms: | 2.4.1.101 | GNT-I | GlcNAc-T I | Gnt1 | MGAT1_MOUSE | Mgat1 | N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I |
Type: | PROTEIN |
Mol. Mass.: | 51701.64 |
Organism: | Mus musculus |
Description: | ChEMBL_119750 |
Residue: | 447 |
Sequence: | MLKKQTAGLVLWGAIIFVGWNALLLLFFWTRPAPGRLPSDSALGDDPASLTREVIHLAED
AEAELERQRGLLQQIKEHYALWRQRWRVPTVAPPAWPRVPVTPSPVQIPILVIACDRSTV
RRCLDKLLHYRPSAERFPIIVSQDCGHEETAQVIASYGTAVTHIRQPDLSNIAVQPDHRK
FQGYYKIARHYRWALGQIFNKFKFPAAVVVEDDLEVAPDFFEYFQATYPLLRTDPSLWCV
SAWNDNGKEQMVDSSKPELLYRTDFFPGLGWLLLADLWAELEPKWPKAFWDDWMRRPEQR
KGRACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVPFTQLDLSYLQQEAYDRDF
LAQVYGAPQLQVEKVRTNDQKELGEVRVQYTSRDSFKAFAKALGVMDDLKSGVPRAGYRG
IVTFQFRGRRVHLAPPQTWTGYDPSWN
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BDBM276750 |
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n/a |
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Name | BDBM276750 |
Synonyms: | (S)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-N-(tetrahydrofuran-3-yl)pyrimidine-5-carboxamide | US10071992, Example 1 | US10071992, Example 3.4 | US11034678, Example 1 | US11065249, WO2018033832-Ex.-1 | WO2018033832, Ex. 1 |
Type | Small organic molecule |
Emp. Form. | C21H21N5O4 |
Mol. Mass. | 407.4225 |
SMILES | CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CCOC1 |r| |
Structure |
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