Reaction Details |
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Target | 5-hydroxytryptamine receptor 6 |
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Ligand | BDBM328410 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2205602 (CHEMBL5118310) |
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Ki | 0.870000±n/a nM |
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Citation | Yi, C; Xue, Y; Chen, K; Wang, T; Yu, J; Wang, Z; Jin, C Novel difluoromethyl-containing 1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-1H-indole scaffold as potent 5-HT Bioorg Med Chem70:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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5-hydroxytryptamine receptor 6 |
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Name: | 5-hydroxytryptamine receptor 6 |
Synonyms: | 5-HT-6 | 5-HT6 | 5-hydroxytryptamine receptor 6 (5-HT-6) | 5-hydroxytryptamine receptor 6 (5-HT6R) | 5-hydroxytryptamine receptor 6 (5HT6) | 5HT6R_HUMAN | HTR6 | Serotonin (5-HT3) receptor | Serotonin 6 (5-HT6) receptor | Serotonin Receptor 6 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46968.43 |
Organism: | Homo sapiens (Human) |
Description: | P50406 |
Residue: | 440 |
Sequence: | MVPEPGPTANSTPAWGAGPPSAPGGSGWVAAALCVVIALTAAANSLLIALICTQPALRNT
SNFFLVSLFTSDLMVGLVVMPPAMLNALYGRWVLARGLCLLWTAFDVMCCSASILNLCLI
SLDRYLLILSPLRYKLRMTPLRALALVLGAWSLAALASFLPLLLGWHELGHARPPVPGQC
RLLASLPFVLVASGLTFFLPSGAICFTYCRILLAARKQAVQVASLTTGMASQASETLQVP
RTPRPGVESADSRRLATKHSRKALKASLTLGILLGMFFVTWLPFFVANIVQAVCDCISPG
LFDVLTWLGYCNSTMNPIIYPLFMRDFKRALGRFLPCPRCPRERQASLASPSLRTSHSGP
RPGLSLQQVLPLPLPPDSDSDSDAGSGGSSGLRLTAQLLLPGEATQDPPLPTRAAAAVNF
FNIDPAEPELRPHPLGIPTN
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BDBM328410 |
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n/a |
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Name | BDBM328410 |
Synonyms: | 5-bromo-1-((4-methoxy-3-(piperazin-1-yl)phenyl)sulfonyl)-3-methyl-1H-indole | US9663498, Example 62 |
Type | Small organic molecule |
Emp. Form. | C20H22BrN3O3S |
Mol. Mass. | 464.376 |
SMILES | COc1ccc(cc1N1CCNCC1)S(=O)(=O)n1cc(C)c2cc(Br)ccc12 |
Structure |
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