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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Peroxisome proliferator-activated receptor gamma | ||
| Ligand | BDBM50166293 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306696 (CHEMBL830853) | ||
| IC50 | 33±n/a nM | ||
| Citation |  Liu, K; Black, RM; Acton, JJ; Mosley, R; Debenham, S; Abola, R; Yang, M; Tschirret-Guth, R; Colwell, L; Liu, C; Wu, M; Wang, CF; MacNaul, KL; McCann, ME; Moller, DE; Berger, JP; Meinke, PT; Jones, AB; Wood, HB Selective PPARgamma modulators with improved pharmacological profiles. Bioorg Med Chem Lett15:2437-40 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Peroxisome proliferator-activated receptor gamma | |||
| Name: | Peroxisome proliferator-activated receptor gamma | ||
| Synonyms: | NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2 | ||
| Type: | Nuclear Receptor | ||
| Mol. Mass.: | 57613.46 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P37231 | ||
| Residue: | 505 | ||
| Sequence: |
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| BDBM50166293 | |||
| n/a | |||
| Name | BDBM50166293 | ||
| Synonyms: | (S)-2-{3-[1-(6-Chloro-benzo[d]isoxazol-3-yl)-2-methyl-5-trifluoromethoxy-1H-indol-3-ylmethyl]-phenoxy}-propionic acid | CHEMBL192646 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H18ClF3N2O6 | ||
| Mol. Mass. | 546.879 | ||
| SMILES | C[C@H](Oc1cccc(Oc2c(C)n(-c3noc4cc(Cl)ccc34)c3ccc(OC(F)(F)F)cc23)c1)C(O)=O |wU:1.0,(13.85,3.3,;13.37,1.84,;11.87,1.53,;10.83,2.67,;11.32,4.14,;10.28,5.27,;8.78,4.95,;8.3,3.48,;6.81,3.15,;6.33,1.67,;7.23,.42,;8.77,.42,;6.33,-.81,;6.74,-2.3,;5.77,-3.48,;6.62,-4.79,;8.09,-4.38,;9.39,-5.21,;10.76,-4.51,;12.04,-5.34,;10.83,-2.97,;9.55,-2.14,;8.19,-2.84,;4.86,-.33,;3.54,-1.12,;2.19,-.33,;2.19,1.2,;.84,1.97,;-.48,1.2,;-1.27,2.53,;.31,-.14,;-1.83,.41,;3.54,1.97,;4.86,1.21,;9.34,2.35,;14.41,.7,;13.92,-.77,;15.92,1.02,)| | ||
| Structure | 
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