| Reaction Details |
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 | Report a problem with these data |
| Target | Proteasome subunit beta type-5 |
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| Ligand | BDBM50600763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2234794 (CHEMBL5148566) |
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| IC50 | 26300±n/a nM |
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| Citation |  Zhang, H; Ginn, J; Zhan, W; Liu, YJ; Leung, A; Toita, A; Okamoto, R; Wong, TT; Imaeda, T; Hara, R; Yukawa, T; Michino, M; Vendome, J; Beuming, T; Sato, K; Aso, K; Meinke, PT; Nathan, CF; Kirkman, LA; Lin, G Design, Synthesis, and Optimization of Macrocyclic Peptides as Species-Selective Antimalaria Proteasome Inhibitors. J Med Chem65:9350-9375 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Proteasome subunit beta type-5 |
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| Name: | Proteasome subunit beta type-5 |
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| Synonyms: | 20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X |
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| Type: | Protein |
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| Mol. Mass.: | 28480.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 263 |
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| Sequence: | MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGT
TTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLAR
QCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRI
SGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVRE
DGWIRVSSDNVADLHEKYSGSTP
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| BDBM50600763 |
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| n/a |
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| Name | BDBM50600763 |
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| Synonyms: | CHEMBL5194112 | US20240043470, Compound 1-56 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H35F3N4O5 |
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| Mol. Mass. | 636.6607 |
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| SMILES | FC(F)(F)CNC(=O)[C@@H]1Cc2cccc(Oc3cccc(C[C@H](N4CCCC4=O)C(=O)N[C@@H](CCc4ccccc4)C(=O)N1)c3)c2 |r| |
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| Structure | 
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