| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50182338 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_344385 (CHEMBL865437) |
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| IC50 | 3400±n/a nM |
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| Citation |  Cheng, H; Lundy DeMello, KM; Li, J; Sakya, SM; Ando, K; Kawamura, K; Kato, T; Rafka, RJ; Jaynes, BH; Ziegler, CB; Stevens, R; Lund, LA; Mann, DW; Kilroy, C; Haven, ML; Nimz, EL; Dutra, JK; Li, C; Minich, ML; Kolosko, NL; Petras, C; Silvia, AM; Seibel, SB Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors. Bioorg Med Chem Lett16:2076-80 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | COX1 | Cyclooxygenase-1 | PGH synthase 1 | PGH1_CANLF | PGHS-1 | PHS 1 | PTGS1 | Prostaglandin G/H synthase 1 | Prostaglandin H2 synthase 1 | Prostaglandin-endoperoxide synthase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 69314.28 |
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| Organism: | Canis familiaris |
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| Description: | ChEMBL_327426 |
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| Residue: | 603 |
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| Sequence: | MSRGSRLHRWPLLLLLLLLLPPPPVLPAEARTPAPVNPCCYYPCQHQGICVRFGLDRYQC
DCTRTGYSGPNCTIPELWTWLRNSLRPSPSFLHFLLTHGRWFWEFINATFIRDMLMRLVL
TARSNLIPSPPTYNIAHDYISWESFSNVSYYTRVLPSVPQDCPTPMGTKGKKQLPDAQLL
GRRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDN
LDRQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGILPQSQMAVGQEVFGLLPG
LMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTARLILIGETIKIVIEEYVQQLSGYFL
QLKFDPELLFSAQFQYRNRIAMEFNQLYHWHPLMPDSFWVGSQEYSYEQFLFNTSMLTHY
GIEALVDAFSRQSAGRIGGGRNIDHHVLHVAVETIKESRELRLQPFNEYRKRFGMRPYMS
FQELTGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGN
PICSPEYWKPSTFGGEMGFNMVKTATLKKLVCLNTKTCPYVSFRVPDPHQDGGPGVERPS
TEL
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| BDBM50182338 |
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| n/a |
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| Name | BDBM50182338 |
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| Synonyms: | 2-(5-(4-(furan-2-yl)-3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-5-(methylsulfonyl)pyridine | CHEMBL378649 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16F3N3O3S |
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| Mol. Mass. | 447.43 |
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| SMILES | Cc1cc(ccc1-c1ccco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F |
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| Structure | 
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