| Reaction Details |
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 | Report a problem with these data |
| Target | D-amino-acid oxidase |
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| Ligand | BDBM50605594 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2252184 (CHEMBL5166394) |
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| EC50 | 780±n/a nM |
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| Citation |  Tang, H; Jensen, K; Houang, E; McRobb, FM; Bhat, S; Svensson, M; Bochevarov, A; Day, T; Dahlgren, MK; Bell, JA; Frye, L; Skene, RJ; Lewis, JH; Osborne, JD; Tierney, JP; Gordon, JA; Palomero, MA; Gallati, C; Chapman, RSL; Jones, DR; Hirst, KL; Sephton, M; Chauhan, A; Sharpe, A; Tardia, P; Dechaux, EA; Taylor, A; Waddell, RD; Valentine, A; Janssens, HB; Aziz, O; Bloomfield, DE; Ladha, S; Fraser, IJ; Ellard, JM Discovery of a Novel Class of d-Amino Acid Oxidase Inhibitors Using the Schrödinger Computational Platform. J Med Chem65:6775-6802 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D-amino-acid oxidase |
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| Name: | D-amino-acid oxidase |
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| Synonyms: | DAAO | DAMOX | Dao | Dao1 | OXDA_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 38667.41 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_947855 |
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| Residue: | 345 |
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| Sequence: | MRVAVIGAGVIGLSTALCIHERYHPTQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSN
PQEAEWSQQTFDYLLSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKNAVLGFRKLTPSE
MDLFPDYGYGWFNTSLLLEGKSYLPWLTERLTERGVKLIHRKVESLEEVARGVDVIINCT
GVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGIF
QLGNWSGLNSVRDHNTIWKSCCKLEPTLKNARIVGELTGFRPVRPQVRLEREWLRHGSSS
AEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKKLSRLPPSHL
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| BDBM50605594 |
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| n/a |
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| Name | BDBM50605594 |
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| Synonyms: | CHEMBL5186374 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H9N3O3S |
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| Mol. Mass. | 287.294 |
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| SMILES | O=c1[nH]cc([nH]c1=O)[C@@H]1COc2cc(ccc2S1)C#N |r| |
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| Structure | 
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