| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Tec |
|---|
| Ligand | BDBM250058 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2291429 |
|---|
| IC50 | 2.9±n/a nM |
|---|
| Citation |  Guo, Y; Hu, N; Liu, Y; Zhang, W; Yu, D; Shi, G; Zhang, B; Yin, L; Wei, M; Yuan, X; Luo, L; Wang, F; Song, X; Xin, L; Wei, Q; Li, Y; Guo, Y; Chen, S; Zhang, T; Zhang, S; Zhou, X; Zhang, C; Su, D; Liu, J; Cheng, Z; Zhang, J; Xing, H; Sun, H; Li, X; Zhao, Y; He, M; Wu, Y; Guo, Y; Sun, X; Tian, A; Zhou, C; Young, S; Liu, X; Wang, L; Wang, Z Discovery of BGB-8035, a Highly Selective Covalent Inhibitor of Bruton's Tyrosine Kinase for B-Cell Malignancies and Autoimmune Diseases. J Med Chem66:4025-4044 (2023) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Tec |
|---|
| Name: | Tyrosine-protein kinase Tec |
|---|
| Synonyms: | PSCTK4 | TEC | TEC_HUMAN | Tyrosine-protein kinase TEC (TEC) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73597.00 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 631 |
|---|
| Sequence: | MNFNTILEEILIKRSQQKKKTSPLNYKERLFVLTKSMLTYYEGRAEKKYRKGFIDVSKIK
CVEIVKNDDGVIPCQNKYPFQVVHDANTLYIFAPSPQSRDLWVKKLKEEIKNNNNIMIKY
HPKFWTDGSYQCCRQTEKLAPGCEKYNLFESSIRKALPPAPETKKRRPPPPIPLEEEDNS
EEIVVAMYDFQAAEGHDLRLERGQEYLILEKNDVHWWRARDKYGNEGYIPSNYVTGKKSN
NLDQYEWYCRNMNRSKAEQLLRSEDKEGGFMVRDSSQPGLYTVSLYTKFGGEGSSGFRHY
HIKETTTSPKKYYLAEKHAFGSIPEIIEYHKHNAAGLVTRLRYPVSVKGKNAPTTAGFSY
EKWEINPSELTFMRELGSGLFGVVRLGKWRAQYKVAIKAIREGAMCEEDFIEEAKVMMKL
THPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGMEYL
ERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKFPVKWCPPEVFNYS
RFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQPKLASNYVYEVMLR
CWQEKPEGRPSFEDLLRTIDELVECEETFGR
|
|
|
|---|
| BDBM250058 |
|---|
| n/a |
|---|
| Name | BDBM250058 |
|---|
| Synonyms: | US10005782, Compound 183 | US9447106, 183 | US9556188, Compound 183 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H27F2N5O3 |
|---|
| Mol. Mass. | 507.5318 |
|---|
| SMILES | NC(=O)c1c2NCCC(C3CCN(CC3)C(=O)C=C)n2nc1-c1ccc(Oc2ccc(F)cc2F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
