| Reaction Details |
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 | Report a problem with these data |
| Target | Growth hormone secretagogue receptor type 1 |
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| Ligand | BDBM50415670 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_622562 (CHEMBL1117506) |
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| EC50 | 79.43±n/a nM |
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| Citation |  Bailey, JM; Scott, JS; Basilla, JB; Bolton, VJ; Boyfield, I; Evans, DG; Fleury, E; Heightman, TD; Jarvie, EM; Lawless, K; Matthews, KL; McKay, F; Mok, H; Muir, A; Orlek, BS; Sanger, GJ; Stemp, G; Stevens, AJ; Thompson, M; Ward, J; Vaidya, K; Westaway, SM The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor. Bioorg Med Chem Lett19:6452-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Growth hormone secretagogue receptor type 1 |
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| Name: | Growth hormone secretagogue receptor type 1 |
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| Synonyms: | GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a) |
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| Type: | Receptor |
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| Mol. Mass.: | 41334.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a. |
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| Residue: | 366 |
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| Sequence: | MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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| BDBM50415670 |
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| n/a |
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| Name | BDBM50415670 |
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| Synonyms: | CHEMBL1079311 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H23ClN4O2S |
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| Mol. Mass. | 430.951 |
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| SMILES | Cc1ccc(cc1Cl)S(=O)(=O)Nc1ccc2CCN(Cc3ccn[nH]3)CCc2c1 |
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| Structure | 
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