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TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50415670
Substrate/Competitorn/a
Meas. Tech.ChEMBL_622562 (CHEMBL1117506)
EC50 79.43±n/a nM
Citation Bailey, JMScott, JSBasilla, JBBolton, VJBoyfield, IEvans, DGFleury, EHeightman, TDJarvie, EMLawless, KMatthews, KLMcKay, FMok, HMuir, AOrlek, BSSanger, GJStemp, GStevens, AJThompson, MWard, JVaidya, KWestaway, SM The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor. Bioorg Med Chem Lett19:6452-8 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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  Blast E-value cutoff:
BDBM50415670
n/a
NameBDBM50415670
Synonyms:CHEMBL1079311
TypeSmall organic molecule
Emp. Form.C21H23ClN4O2S
Mol. Mass.430.951
SMILESCc1ccc(cc1Cl)S(=O)(=O)Nc1ccc2CCN(Cc3ccn[nH]3)CCc2c1
Structure
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