| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50362595 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_798318 (CHEMBL1943806) |
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| EC50 | 10000±n/a nM |
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| Citation |  Huang, X; Su, J; Rao, AU; Tang, H; Zhou, W; Zhu, X; Chen, X; Liu, Z; Huang, Y; Degrado, S; Xiao, D; Qin, J; Aslanian, R; McKittrick, BA; Greenfeder, S; Heek, Mv; Chintala, M; Palani, A SAR studies of C2 ethers of 2H-pyrano[2,3-d]pyrimidine-2,4,7(1H,3H)-triones as nicotinic acid receptor (NAR) agonist. Bioorg Med Chem Lett22:854-8 (2012) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50362595 |
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| n/a |
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| Name | BDBM50362595 |
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| Synonyms: | CHEMBL1939012 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12N2O4 |
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| Mol. Mass. | 236.224 |
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| SMILES | CCOc1nc2oc(=O)cc(CC)c2c(=O)[nH]1 |
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| Structure | 
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