| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase ITK/TSK |
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| Ligand | BDBM50302165 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599565 (CHEMBL1038375) |
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| IC50 | >7000±n/a nM |
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| Citation |  Wu, JP; Fleck, R; Brickwood, J; Capolino, A; Catron, K; Chen, Z; Cywin, C; Emeigh, J; Foerst, M; Ginn, J; Hrapchak, M; Hickey, E; Hao, MH; Kashem, M; Li, J; Liu, W; Morwick, T; Nelson, R; Marshall, D; Martin, L; Nemoto, P; Potocki, I; Liuzzi, M; Peet, GW; Scouten, E; Stefany, D; Turner, M; Weldon, S; Zimmitti, C; Spero, D; Kelly, TA The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II. Bioorg Med Chem Lett19:5547-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase ITK/TSK |
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| Name: | Tyrosine-protein kinase ITK/TSK |
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| Synonyms: | EMT | ITK | ITK_HUMAN | Kinase EMT | LYK | T-cell-specific kinase | Tyrosine-protein kinase ITK | Tyrosine-protein kinase ITK (ITK) | Tyrosine-protein kinase Lyk |
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| Type: | Protein |
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| Mol. Mass.: | 71839.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08881 |
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| Residue: | 620 |
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| Sequence: | MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRI
KCVEIVKSDISIPCHYKYPFQVVHDNYLLYVFAPDRESRQRWVLALKEETRNNNSLVPKY
HPNFWMDGKWRCCSQLEKLATGCAQYDPTKNASKKPLPPTPEDNRRPLWEPEETVVIALY
DYQTNDPQELALRRNEEYCLLDSSEIHWWRVQDRNGHEGYVPSSYLVEKSPNNLETYEWY
NKSISRDKAEKLLLDTGKEGAFMVRDSRTAGTYTVSVFTKAVVSENNPCIKHYHIKETND
NPKRYYVAEKYVFDSIPLLINYHQHNGGGLVTRLRYPVCFGRQKAPVTAGLRYGKWVIDP
SELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIREGAMSEEDFIEEAEVMMKLSHPKLVQ
LYGVCLEQAPICLVFEFMEHGCLSDYLRTQRGLFAAETLLGMCLDVCEGMAYLEEACVIH
RDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSD
VWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPE
DRPAFSRLLRQLAEIAESGL
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| BDBM50302165 |
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| n/a |
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| Name | BDBM50302165 |
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| Synonyms: | 3-amino-6-(4-hydroxypiperidin-1-yl)-4-propylthieno[2,3-b]pyridine-2-carboxamide | CHEMBL576887 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H22N4O2S |
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| Mol. Mass. | 334.436 |
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| SMILES | CCCc1cc(nc2sc(C(N)=O)c(N)c12)N1CCC(O)CC1 |
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| Structure | 
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