| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acyl-CoA desaturase 1 |
|---|
| Ligand | BDBM50393165 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_852943 (CHEMBL2154127) |
|---|
| IC50 | 3070±n/a nM |
|---|
| Citation |  Oballa, RM; Belair, L; Black, WC; Bleasby, K; Chan, CC; Desroches, C; Du, X; Gordon, R; Guay, J; Guiral, S; Hafey, MJ; Hamelin, E; Huang, Z; Kennedy, B; Lachance, N; Landry, F; Li, CS; Mancini, J; Normandin, D; Pocai, A; Powell, DA; Ramtohul, YK; Skorey, K; Sørensen, D; Sturkenboom, W; Styhler, A; Waddleton, DM; Wang, H; Wong, S; Xu, L; Zhang, L Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia. J Med Chem54:5082-96 (2011) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acyl-CoA desaturase 1 |
|---|
| Name: | Acyl-CoA desaturase 1 |
|---|
| Synonyms: | ACOD1_RAT | Acyl-CoA desaturase 1 | Scd | Scd1 | Stearoyl-CoA desaturase 1 (SCD1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 41485.97 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P07308 |
|---|
| Residue: | 358 |
|---|
| Sequence: | MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQD
EEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHR
LWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSH
VGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGET
FLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYH
HAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
|
|
|
|---|
| BDBM50393165 |
|---|
| n/a |
|---|
| Name | BDBM50393165 |
|---|
| Synonyms: | CHEMBL2153600 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H13BrFN7OS |
|---|
| Mol. Mass. | 426.267 |
|---|
| SMILES | Fc1ccc(Br)c(OC2CCN(CC2)c2nnc(s2)-c2nnn[nH]2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
